Advanced search
Publication Cover
Expert Review of Proteomics Volume 12, 2015 - Issue 6
Submit an article Journal homepage
464
Views
50
CrossRef citations to date
0
Altmetric
Reviews

Development of M2BPGi: a novel fibrosis serum glyco-biomarker for chronic hepatitis/cirrhosis diagnostics

Hisashi NarimatsuResearch Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki, 305-8568, JapanCorrespondence[email protected]
Pages 683-693 | Published online: 22 Sep 2015

Citations (50)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Hisashi Narimatsu & Takashi Sato. (2018) Wisteria floribunda agglutinin positive glycobiomarkers: a unique lectin as a serum biomarker probe in various diseases. Expert Review of Proteomics 15:2, pages 183-190.
Read now

Articles from other publishers (49)

Hoang Huu Bui, Suong Thi-Bang Nguyen, Sang The Phan, Khue Minh Nguyen & Chuong Dinh Nguyen. (2023) Evaluating M2BPGi as a Marker for Liver Fibrosis in Patients with Chronic Hepatitis B. Digestive Diseases and Sciences 68:12, pages 4407-4417.
Crossref
Haruki Uojima, Kadzuki Nakabayashi, Kazumi Yamasaki, Masaya Sugiyama, Norihiro Ishii, Ken Shirabe, Takuya Kyoutou, Koji Ueda, Yoichi Takahama, Nobuharu Tamaki, Masayuki Kurosaki, Hisashi Hidaka, Chika Kusano, Keisuke Amano, Takumi Kawaguchi, Akinobu Taketomi, Satoru Joshita, Takeji Umemura, Miyako Murakawa, Yasuhiro Asahina, Takanori Suzuki, Kentaro Matsuura, Takashi Nishimura, Hiroko Iijima, Kazumasa Sakamoto, Kiyoaki Ito, Sohji Nishina, Keisuke Hino, Hidenori Toyoda, Hiroshi Yatsuhashi, Masayoshi Kage & Masashi Mizokami. (2023) New chemiluminescent enzyme immunoassay for quantitative measurement of Mac-2 binding protein glycosylation isomer in chronic liver disease. Journal of Gastroenterology 58:12, pages 1252-1260.
Crossref
Mika Masuda, Tatsuya Asuka, Naoko Terao, Shinsuke Nishino, Shun Ikeda, Shinji Takamatsu, Jumpei Kondo & Eiji Miyoshi. (2023) Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies. The Journal of Biochemistry 173:6, pages 487-495.
Crossref
Shuuji Mawaribuchi, Osamu Shimomura, Tatsuya Oda, Keiko Hiemori, Kayoko Shimizu, Kenya Yamase, Mutsuhiro Date & Hiroaki Tateno. (2023) rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma. Glycobiology 33:4, pages 342-352.
Crossref
Takako Inoue & Yasuhito Tanaka. 2023. Comprehensive Guide to Hepatitis Advances. Comprehensive Guide to Hepatitis Advances 31 60 .
Hyun Joon Park, Kwang Il Seo, Sang Uk Lee, Byung Hoon Han, Byung Cheol Yun, Eun Taek Park, Jinwook Lee, Hyunyong Hwang & Myunghee Yoon. (2022) Clinical usefulness of Mac-2 binding protein glycosylation isomer for diagnosing liver cirrhosis and significant fibrosis in patients with chronic liver disease: A retrospective single-center study. Medicine 101:40, pages e30489.
Crossref
Lalhaba Oinam, Ryoma Hayashi, Keiko Hiemori, Kayo Kiyoi, Kimiyo Sage‐Ono, Kenji Miura, Michiyuki Ono & Hiroaki Tateno. (2022) Quantitative evaluation of glycan‐binding specificity of recombinant concanavalin A produced in lettuce ( Lactuca sativa ) . Biotechnology and Bioengineering 119:7, pages 1781-1791.
Crossref
Kwang Il Seo, Hyunyong Hwang, Byung Cheol Yun, Hyung Hwan Moon, Young Il Choi, Dong Hoon Shin & Myunghee Yoon. (2022) A prospective study of the correlation between hepatic fibrosis and noninvasively measured fibrosis markers including serum M2BPGi and acoustic radiation force impulse elastography. Kosin Medical Journal 37:2, pages 146-153.
Crossref
Mina Hur, Mikyoung Park, Hee-Won Moon, Won Hyeok Choe & Chae Hoon Lee. (2022) Comparison of Non-Invasive Clinical Algorithms for Liver Fibrosis in Patients With Chronic Hepatitis B to Reduce the Need for Liver Biopsy: Application of Enhanced Liver Fibrosis and Mac-2 Binding Protein Glycosylation Isomer. Annals of Laboratory Medicine 42:2, pages 249-257.
Crossref
Pei-Shan Wu, Yun-Cheng Hsieh, Kuei-Chuan Lee, Yi-Hsiang Huang, Ming-Chih Hou & Han-Chieh Lin. (2021) Mac-2 binding protein glycosylation isomer is a potential biomarker to predict portal hypertension and bacterial infection in cirrhotic patients. PLOS ONE 16:10, pages e0258589.
Crossref
Yuji Eso, Shigeharu Nakano, Masako Mishima, Soichi Arasawa, Eriko Iguchi, Haruhiko Takeda, Atsushi Takai, Ken Takahashi, Kojiro Taura & Hiroshi Seno. (2021) Mac‐2 binding protein glycosylation isomer predicts tolerability and clinical outcome of lenvatinib therapy for hepatocellular carcinoma. Journal of Hepato-Biliary-Pancreatic Sciences 28:6, pages 498-507.
Crossref
Alessia Virzì, Victor Gonzalez-Motos, Simona Tripon, Thomas F. Baumert & Joachim Lupberger. (2021) Profibrotic Signaling and HCC Risk during Chronic Viral Hepatitis: Biomarker Development. Journal of Clinical Medicine 10:5, pages 977.
Crossref
Hung-Chih Yang & Tung-Hung Su. 2021. Hepatitis B Virus and Liver Disease. Hepatitis B Virus and Liver Disease 205 230 .
Gantumur Dolgormaa, Norifumi Harimoto, Norihiro Ishii, Takahiro Yamanaka, Kei Hagiwara, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Tadashi Handa, Takehiko Yokobori, Tetsunari Oyama, Hiroyuki Kuwano & Ken Shirabe. (2020) Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling. British Journal of Cancer 123:7, pages 1145-1153.
Crossref
Yoshio Sumida, Masashi Yoneda, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Hideki Hayashi, Takashi Kobayashi, Kento Imajo, Masato Yoneda, Toshifumi Tada, Takumi Kawaguchi, Yuichiro Eguchi, Satoshi Oeda, Hirokazu Takahashi, Eiichi Tomita, Takeshi Okanoue & Atsushi Nakajima. (2020) Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. Diagnostics 10:8, pages 579.
Crossref
Ryota Masuzaki, Tatsuo Kanda, Reina Sasaki, Naoki Matsumoto, Masahiro Ogawa, Shunichi Matsuoka, Seth J. Karp & Mitsuhiko Moriyama. (2020) Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives. International Journal of Molecular Sciences 21:14, pages 4906.
Crossref
Takako Inoue & Yasuhito Tanaka. (2020) Novel biomarkers for the management of chronic hepatitis B. Clinical and Molecular Hepatology 26:3, pages 261-279.
Crossref
Shu Feng, Zhonghao Wang, Yanhua Zhao & Chuanmin Tao. (2020) Wisteria floribunda agglutinin-positive Mac-2-binding protein as a diagnostic biomarker in liver cirrhosis: an updated meta-analysis. Scientific Reports 10:1.
Crossref
Shohei Tsuji, Yoshihito Uchida, Hayato Uemura, Jun‐Ichi Kouyama, Kayoko Naiki, Masamitsu Nakao, Daisuke Motoya, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya & Satoshi Mochida. (2020) Involvement of portosystemic shunts in impaired improvement of liver function after direct‐acting antiviral therapies in cirrhotic patients with hepatitis C virus. Hepatology Research 50:4, pages 512-523.
Crossref
Kai Dang, Wenjuan Zhang, Shanfeng Jiang, Xiao Lin & Airong Qian. (2020) Application of Lectin Microarrays for Biomarker Discovery. ChemistryOpen 9:3, pages 285-300.
Crossref
Ian Baudi, Takako Inoue & Yasuhito Tanaka. (2020) Novel Biomarkers of Hepatitis B and Hepatocellular Carcinoma: Clinical Significance of HBcrAg and M2BPGi. International Journal of Molecular Sciences 21:3, pages 949.
Crossref
Kotaro Matsunaga, Chiaki Okuse, Sarika Nakamura, Keigo Suetani, Shinya Ishigooka, Fumio Itoh & Michihiro Suzuki. (2020) Current Status of Hepatocellular Carcinoma Occurrence after Achieving a Sustained Virologic Response with Direct-Acting Antiviral Drug Treatment for Type C Chronic Liver Disease: A Study at Kawasaki Municipal Tama Hospital. Journal of St. Marianna University 11:2, pages 143-152.
Crossref
Masahide Hiyoshi, Koichi Yano, Atsushi Nanashima, Makoto Ikenoue, Naoya Imamura, Yoshiro Fujii, Takeomi Hamada & Takahiro Nishida. (2019) Usefulness of serum Mac-2 binding protein glycosylation isomer in patients undergoing hepatectomy: A case controlled study. Annals of Medicine and Surgery 48, pages 17-22.
Crossref
Yu Akahoshi, Hideki Nakasone, Koji Kawamura, Machiko Kusuda, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Kazuki Yoshimura, Ayumi Gomyo, Aki Tanihara, Masaharu Tamaki, Shun-ichi Kimura, Shinichi Kako & Yoshinobu Kanda. (2019) Increased Mac-2 binding protein glycan isomer in patients at risk for late nonrelapse mortality after HSCT. Blood Advances 3:21, pages 3287-3296.
Crossref
Chiaki Nagai-Okatani, Mitsuhiro Nishigori, Takashi Sato, Naoto Minamino, Hiroyuki Kaji & Atsushi Kuno. (2019) Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy. Laboratory Investigation 99:11, pages 1749-1765.
Crossref
Tung-Hung Su, Cheng-Yuan Peng, Tai-Chung Tseng, Hung-Chih Yang, Chun-Jen Liu, Chen-Hua Liu, Pei-Jer Chen, Ding-Shinn Chen & Jia-Horng Kao. (2019) Serum Mac-2-Binding Protein Glycosylation Isomer at Virological Remission Predicts Hepatocellular Carcinoma and Death in Chronic Hepatitis B-Related Cirrhosis. The Journal of Infectious Diseases.
Crossref
Masataka Kanno, Kazunori Kawaguchi, Masao Honda, Rika Horii, Hajime Takatori, Tetsuro Shimakami, Kazuya Kitamura, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi & Shuichi Kaneko. (2019) Serum aldo–keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. Journal of Gastroenterology 54:6, pages 549-557.
Crossref
Yuji Eso, Atsushi Takai, Ken Takahashi, Yoshihide Ueda, Kojiro Taura, Hiroyuki Marusawa & Hiroshi Seno. (2019) Combination of Mac-2 Binding Protein Glycosylation Isomer and Up-To-Seven Criteria as a Useful Predictor for Child-Pugh Grade Deterioration after Transarterial Chemoembolization for Hepatocellular Carcinoma. Cancers 11:3, pages 405.
Crossref
Norihiro Nishijima, Akihiro Nasu, Toru Kimura & Yukio Osaki. (2019) Two Cases of Hepatocellular Carcinoma Occurring Immediately after Direct-acting Antiviral Agents against Hepatitis C Virus. Internal Medicine 58:2, pages 225-231.
Crossref
Katsumi Maezawa, Rieko Furushima-Shimogawara, Akio Yasukawa, Nobuo Ohta & Shiro Iwanaga. (2018) Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicum infection using high-resolution ultrasound imaging. Tropical Medicine and Health 46:1.
Crossref
Yutaka Yasui, Masayuki Kurosaki, Yasuyuki Komiyama, Hitomi Takada, Nobuharu Tamaki, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Yohei Kubota, Mayu Higuchi, Kenta Takaura, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Jun Itakura, Nobuyuki Enomoto & Namiki Izumi. (2018) Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct-acting antivirals for hepatitis C virus . Hepatology Research 48:13, pages 1131-1139.
Crossref
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai & Yasuhiro Takikawa. (2018) Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease. Journal of Gastroenterology 53:12, pages 1285-1291.
Crossref
Yao-Chun Hsu, Tomi Jun, Yen-Tsung Huang, Ming-Lun Yeh, Chia-Long Lee, Shintaro Ogawa, Shu-Hsien Cho, Jaw-Town Lin, Ming-Lung Yu, Mindie H. Nguyen & Yasuhito Tanaka. (2018) Serum M2BPGi level and risk of hepatocellular carcinoma after oral anti-viral therapy in patients with chronic hepatitis B. Alimentary Pharmacology & Therapeutics 48:10, pages 1128-1137.
Crossref
Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Mika Takasumi, Takuto Hikichi & Hiromasa Ohira. (2018) Non‑specific elevation of serum Mac‑2 binding protein glycosylation isomer levels in patients with biliary disease. Molecular and Clinical Oncology.
Crossref
Yuji Eso, Atsushi Takai, Kojiro Taura, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa & Hiroshi Seno. (2018) Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease. Journal of Gastroenterology and Hepatology 33:9, pages 1649-1658.
Crossref
Kohei Kotani, Joji Kawabe, Shigeaki Higashiyama, Atsushi Yoshida, Etsushi Kawamura, Akihiro Tamori, Susumu Shiomi & Norifumi Kawada. (2018) Heterogeneous liver uptake of Tc-99m-GSA as quantified through SPECT/CT helps to evaluate the degree of liver fibrosis. Medicine 97:31, pages e11765.
Crossref
Sun Young Cho & Mina Hur. (2018) Mac-2 Binding Protein Glycosylation Isomer: Emerging Non-Invasive Serum Marker for Liver Fibrosis. Annals of Laboratory Medicine 38:4, pages 289-290.
Crossref
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu & Masashi Mizokami. (2018) Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis. Journal of Gastroenterology 53:7, pages 819-826.
Crossref
Noboru Shinkai, Masanori Nojima, Etsuko Iio, Kayoko Matsunami, Hidenori Toyoda, Shuko Murakami, Takako Inoue, Shintaro Ogawa, Takashi Kumada & Yasuhito Tanaka. (2017) High levels of serum Mac-2-binding protein glycosylation isomer (M2BPGi) predict the development of hepatocellular carcinoma in hepatitis B patients treated with nucleot(s)ide analogues. Journal of Gastroenterology 53:7, pages 883-889.
Crossref
Atsushi Okada, Hideaki Kanzaki, Yasuhiro Hamatani, Seiji Takashio, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Satoshi Yasuda & Toshihisa Anzai. (2017) Increased serum Wisteria floribunda agglutinin positive Mac-2 binding protein (Mac-2 binding protein glycosylation isomer) in chronic heart failure: a pilot study. Heart and Vessels 33:4, pages 385-392.
Crossref
Guosheng Chen, Siming Huang, Xiaoxue Kou, Jin’ge Zhang, Fuxin Wang, Fang Zhu & Gangfeng Ouyang. (2018) Novel Magnetic Microprobe with Benzoboroxole-Modified Flexible Multisite Arm for High-Efficiency cis -Diol Biomolecule Detection . Analytical Chemistry 90:5, pages 3387-3394.
Crossref
Bin Wei, Shu Feng, Enqiang Chen, Dongdong Li, Tingting Wang, Yu Gou, Tingting Yang, Dongmei Zhang, Chuanmin Tao & Hong Tang. (2018) M2BPGi as a potential diagnostic tool of cirrhosis in Chinese patients with Hepatitis B virus infection. Journal of Clinical Laboratory Analysis 32:2, pages e22261.
Crossref
Dong Wook JekarlHyunyu ChoiSeungok LeeJung Hyun KwonSung Won LeeHein YuMyungshin KimYonggoo KimPil Soo SungSeung Kew Yoon. (2018) Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA-M2BP) Among Chronic Hepatitis B Patients . Annals of Laboratory Medicine 38:4, pages 348.
Crossref
Delin Zhang, Jianzhao Huang, Dan Luo, Xinfu Feng, Yan Liu & Yan Liu. (2017) Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis. Biomarkers in Medicine 11:5, pages 423-430.
Crossref
Xia Zou, Ming-Yu Zhu, De-Min Yu, Wei Li, Dong-Hua Zhang, Fei-Jie Lu, Qi-Ming Gong, Feng Liu, Jie-Hong Jiang, Min-Hua Zheng, Atsushi Kuno, Hisashi Narimatsu, Yan Zhang & Xin-Xin Zhang. (2017) Serum WFA + -M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection . Liver International 37:1, pages 35-44.
Crossref
Takuya Kubo, Hayato Furuta, Toyohiro Naito, Tomoharu Sano & Koji Otsuka. (2017) Selective adsorption of carbohydrates and glycoproteins via molecularly imprinted hydrogels: application to visible detection by a boronic acid monomer. Chemical Communications 53:53, pages 7290-7293.
Crossref
Mattia Bellan, Gabriele Pogliani, Cecilia Marconi, Rosalba Minisini, Lisa Franzosi, Federica Alciato, Andrea Magri, Gian Carlo Avanzi, Mario Pirisi & Pier Paolo Sainaghi. (2016) Gas6 as a putative noninvasive biomarker of hepatic fibrosis. Biomarkers in Medicine 10:12, pages 1241-1249.
Crossref
Jeong Gu Kang, Jeong‐Heon Ko & Yong‐Sam Kim. (2016) Application of cancer‐associated glycoforms and glycan‐binding probes to an in vitro diagnostic multivariate index assay for precise diagnoses of cancer. PROTEOMICS 16:24, pages 3062-3072.
Crossref
Omid Haji-Ghassemi, Michel Gilbert, Jenifer Spence, Melissa J. Schur, Matthew J. Parker, Meredith L. Jenkins, John E. Burke, Henk van Faassen, N. Martin Young & Stephen V. Evans. (2016) Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin. Journal of Biological Chemistry 291:46, pages 24085-24095.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.