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Expert Review of Proteomics Volume 12, 2015 - Issue 6
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Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

Ruth NussinovBasic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, USA;Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Aviv University, Tel Aviv, IsraelCorrespondence[email protected]
,
Chung-Jung TsaiBasic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, USA
,
Serena MuratciogluDepartments of Chemical & Biological Engineering, Koc University, Istanbul, Turkey
,
Hyunbum JangBasic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, USA
,
Attila GursoyComputer Engineering, Koc University, Istanbul, Turkey
&
Ozlem KeskinDepartments of Chemical & Biological Engineering, Koc University, Istanbul, Turkey
Pages 669-682 | Published online: 23 Oct 2015

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Ruth Nussinov, Chung-Jung Tsai & Hyunbum Jang. (2016) Independent and core pathways in oncogenic KRAS signaling. Expert Review of Proteomics 13:8, pages 711-716.
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Articles from other publishers (35)

Yanqing Zhang, Xin Zhang, Yi Zhang, Han Xu, Zichen Wei, Xin Wang, Yan Li, Junrong Guo, Fan Wu, Xiao Fang, Lei Pang, Bin Deng & Duonan Yu. (2023) c-Myc inhibits LAPTM5 expression in B-cell lymphomas. Annals of Hematology 102:12, pages 3499-3513.
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Jimi Kim. (2023) Nucleic Acid-Based Approaches to Tackle KRAS Mutant Cancers. International Journal of Molecular Sciences 24:23, pages 16933.
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Yasmeen Dodin. (2023) Integrated Bioinformatics Approach for Disclosing Autophagy Pathway as a Therapeutic Target in Advanced KRAS Mutated/Positive Lung Adenocarcinoma. The Open Bioinformatics Journal 16:1.
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Kevin M. Brown, Mai Xu, Michael Sargen, Hyunbum Jang, Mingzhen Zhang, Tongwu Zhang, Bin Zhu, Kristie Jones, Jung Kim, Laura Mendoza, Nicholas K. Hayward, Margaret A. Tucker, Alisa M. Goldstein, Xiaohong Rose Yang, Douglas R. Stewart, Belynda Hicks, Dario Consonni, Angela C. Pesatori, Maria Concetta Fargnoli, Ketty Peris, Alex Stratigos, Chiara Menin, Paola Ghiorzo, Susana Puig, Eduardo Nagore, Thorkell Andresson, Ruth Nussinov, Donato Calista & Maria Teresa Landi. (2021) Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family. Familial Cancer 21:3, pages 347-355.
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Mingzhen Zhang, Hyunbum Jang & Ruth Nussinov. (2021) PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective. Cancer Research 81:2, pages 237-247.
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Soheila Rezaei Adariani, Neda S. Kazemein Jasemi, Farhad Bazgir, Christoph Wittich, Ehsan Amin, Claus A.M. Seidel, Radovan Dvorsky & Mohammad R. Ahmadian. (2021) A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners. Journal of Biological Chemistry 296, pages 100626.
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Kai Chen, Zhongjun Shang, Ai-lin Dai & Pei-ling Dai. (2020) Novel PI3K/Akt/mTOR pathway inhibitors plus radiotherapy: Strategy for non-small cell lung cancer with mutant RAS gene. Life Sciences 255, pages 117816.
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Cunzhi Lin, Xinhong Zhu, Qing Jin, Aihua Sui, Jinfeng Li & Liyan Shen. (2020) Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy. Integrative Cancer Therapies 19, pages 153473542091143.
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Mingzhen Zhang, Zhigang Li, Hyunbum Jang, Andrew C. Hedman, David B. Sacks & Ruth Nussinov. (2019) Ca 2+ -Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1 . Biochemistry 58:49, pages 4903-4911.
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Chung-Jung Tsai & Ruth Nussinov. (2019) Emerging Allosteric Mechanism of EGFR Activation in Physiological and Pathological Contexts. Biophysical Journal 117:1, pages 5-13.
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Mingzhen Zhang, Hyunbum Jang & Ruth Nussinov. (2019) The structural basis for Ras activation of PI3Kα lipid kinase. Physical Chemistry Chemical Physics 21:22, pages 12021-12028.
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Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai & Feixiong Cheng. (2019) Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers. PLOS Computational Biology 15:3, pages e1006658.
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Shira Perez, Michael Gevor, Ateret Davidovich, Antony Kaspi, Katreena Yamin, Tom Domovich, Tomer Meirson, Avi Matityahu, Yehuda Brody, Salomon M Stemmer, Assam El-Osta, Izhak Haviv, Itay Onn & Meital Gal-Tanamy. (2019) Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host–virus interactions. Nucleic Acids Research 47:5, pages 2455-2471.
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Pinar Erkekoglu. 2019. Oncogenes and Carcinogenesis. Oncogenes and Carcinogenesis.
Seema Shah, Ethan J. Brock, Kyungmin Ji & Raymond R. Mattingly. (2019) Ras and Rap1: A tale of two GTPases. Seminars in Cancer Biology 54, pages 29-39.
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Ruth Nussinov, Chung-Jung Tsai & Hyunbum Jang. (2019) Oncogenic KRas mobility in the membrane and signaling response. Seminars in Cancer Biology 54, pages 109-113.
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Ruth Nussinov, Chung-Jung Tsai & Hyunbum Jang. (2019) Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?. Seminars in Cancer Biology 54, pages 114-120.
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Ruth Nussinov, Mingzhen Zhang, Chung-Jung Tsai, Tsung-Jen Liao, David Fushman & Hyunbum Jang. (2018) Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention. Biophysical Reviews 10:5, pages 1263-1282.
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Wen‑Juan Jiang, Yun‑Chuan Peng & Kai‑Ming Yang. (2018) Cellular signaling pathways regulating β‑cell proliferation as a promising therapeutic target in the treatment of diabetes (Review). Experimental and Therapeutic Medicine.
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E. Sila Ozdemir, Hyunbum Jang, Attila Gursoy, Ozlem Keskin & Ruth Nussinov. (2018) Arl2-Mediated Allosteric Release of Farnesylated KRas4B from Shuttling Factor PDEδ. The Journal of Physical Chemistry B 122:30, pages 7503-7513.
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In Seok Yang & Sangwoo Kim. (2018) Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients. BMC Bioinformatics 19:S1.
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Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, Tsung-Jen Liao, Shuai Li, David Fushman & Jian Zhang. (2017) Intrinsic protein disorder in oncogenic KRAS signaling. Cellular and Molecular Life Sciences 74:17, pages 3245-3261.
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H. Billur Engin, Daniel Carlin, Dexter Pratt & Hannah Carter. (2017) Modeling of RAS complexes supports roles in cancer for less studied partners. BMC Biophysics 10:S1.
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Serena Muratcioglu, Hyunbum Jang, Attila Gursoy, Ozlem Keskin & Ruth Nussinov. (2017) PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization. The Journal of Physical Chemistry B 121:24, pages 5917-5927.
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Ruth Nussinov, Chung-Jung Tsai & Hyunbum Jang. (2017) A New View of Pathway-Driven Drug Resistance in Tumor Proliferation. Trends in Pharmacological Sciences 38:5, pages 427-437.
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Ruth Nussinov, Guanqiao Wang, Chung-Jung Tsai, Hyunbum Jang, Shaoyong Lu, Avik Banerjee, Jian Zhang & Vadim Gaponenko. (2017) Calmodulin and PI3K Signaling in KRAS Cancers. Trends in Cancer 3:3, pages 214-224.
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Tsung-Jen Liao, Hyunbum Jang, Chung-Jung Tsai, David Fushman & Ruth Nussinov. (2017) The dynamic mechanism of RASSF5 and MST kinase activation by Ras. Physical Chemistry Chemical Physics 19:9, pages 6470-6480.
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Hossein Nakhaeizadeh, Ehsan Amin, Saeideh Nakhaei-Rad, Radovan Dvorsky & Mohammad Reza Ahmadian. (2016) The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLOS ONE 11:12, pages e0167145.
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Tsung-Jen Liao, Chung-Jung Tsai, Hyunbum Jang, David Fushman & Ruth Nussinov. (2016) RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro. Current Opinion in Structural Biology 41, pages 217-224.
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Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang, Tamás Korcsmáros & Peter Csermely. (2016) Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation. Seminars in Cell & Developmental Biology 58, pages 79-85.
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H. Jang, S. Muratcioglu, A. Gursoy, O. Keskin & R. Nussinov. (2016) Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers. Biochemical Journal 473:12, pages 1719-1732.
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Shaoyong Lu, Hyunbum Jang, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Ruth Nussinov & Jian Zhang. (2016) Ras Conformational Ensembles, Allostery, and Signaling. Chemical Reviews 116:11, pages 6607-6665.
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Shaoyong Lu, Hyunbum Jang, Jian Zhang & Ruth Nussinov. (2016) Inhibitors of Ras-SOS Interactions. ChemMedChem 11:8, pages 814-821.
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Mayukh Chakrabarti, Hyunbum Jang & Ruth Nussinov. (2016) Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences . The Journal of Physical Chemistry B 120:4, pages 667-679.
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Shaoyong Lu, Hyunbum Jang, Shuo Gu, Jian Zhang & Ruth Nussinov. (2016) Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view. Chemical Society Reviews 45:18, pages 4929-4952.
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