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Expert Review of Proteomics Volume 4, 2007 - Issue 6
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Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin

Heping Cao US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, 10300 Baltimore Avenue, Beltsville, MD 20705, USA. [email protected]; [email protected]
,
Leesa J Deterding US Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Laboratory of Structural Biology, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. [email protected]
&
Perry J Blackshear US Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Scientific Director, Office of Clinical Research, and Laboratory of Signal Transduction, Mail Box A2–05, PO Box 12233, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. [email protected]
Pages 711-726 | Published online: 09 Jan 2014

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Wi S. Lai, Deborah J. Stumpo, Lianqun Qiu, Roberta Faccio & Perry J. Blackshear. (2018) A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency. Molecular and Cellular Biology 38:4.
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Long Vo Ngoc, Corinne Wauquier, Romuald Soin, Sabrina Bousbata, Laure Twyffels, Véronique Kruys & Cyril Gueydan. (2014) Rapid Proteasomal Degradation of Posttranscriptional Regulators of the TIS11/Tristetraprolin Family Is Induced by an Intrinsically Unstructured Region Independently of Ubiquitination. Molecular and Cellular Biology 34:23, pages 4315-4328.
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Sandra L. Clement, Claudia Scheckel, Georg Stoecklin & Jens Lykke-Andersen. (2011) Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment. Molecular and Cellular Biology 31:2, pages 256-266.
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Articles from other publishers (36)

Yuran Tang, Bo Zhang, Haixia Shi, Zunqiang Yan, Pengfei Wang, Qiaoli Yang, Xiaoyu Huang & Shuangbao Gun. (2023) Molecular characterization, expression patterns and cellular localization of BCAS2 gene in male Hezuo pig . PeerJ 11, pages e16341.
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Francesco Nucera, Ilaria Salvato, Luca Ricciardi, Jessica Dal Col, Francesco Monaco, Phil M. Hansbro, Ian M. Adcock, Vincenzo Casolaro, Cristiana Stellato & Gaetano Caramori. 2023.
Brittany L. Snyder & Perry J. Blackshear. (2022) Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases. Pharmacology & Therapeutics 239, pages 108198.
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Lucia Suarez-Lopez, Bing Shui, Douglas K. Brubaker, Marza Hill, Alexander Bergendorf, Paul S. Changelian, Aisha Laguna, Alina Starchenko, Douglas A. Lauffenburger & Kevin M. Haigis. (2021) Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation. iScience 24:12, pages 103406.
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Xiaoke Yang, Bo Chen, Mingyue Zhang, Shengqian Xu & Zongwen Shuai. (2021) Tristetraprolin Gene Single-Nucleotide Polymorphisms and mRNA Level in Patients With Rheumatoid Arthritis. Frontiers in Pharmacology 12.
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Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell, Kevin M. Haigis & Michael B. Yaffe. (2021) MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Frontiers in Immunology 11.
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Heping Cao & Kandan Sethumadhavan. (2020) Regulation of Cell Viability and Anti-inflammatory Tristetraprolin Family Gene Expression in Mouse Macrophages by Cottonseed Extracts. Scientific Reports 10:1.
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Wi S. Lai, Melissa L. Wells, Lalith Perera & Perry J. Blackshear. (2019) The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family. WIREs RNA 10:4.
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Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten & Timothy R. D. J. Radstake. (2018) Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation. Arthritis Research & Therapy 20:1.
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Jian Guo, Huiheng Qu, Ye Chen & Jiazeng Xia. (2017) The role of RNA-binding protein tristetraprolin in cancer and immunity. Medical Oncology 34:12.
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Pranathi Meda Krishnamurthy, Shirish Shukla, Paramita Ray, Rohit Mehra, Mukesh K. Nyati, Theodore S. Lawrence & Dipankar Ray. (2017) Involvement of p38-βTrCP-Tristetraprolin-TNFα axis in radiation pneumonitis. Oncotarget 8:29, pages 47767-47779.
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Xue-Ke Zhao, Pulin Che, Ming-Liang Cheng, Quan Zhang, Mao Mu, Hong Li, Yuan Luo, Yue-Dong Liang, Xin-Hua Luo, Chang-Qing Gao, Patricia L. Jackson, J. Michael Wells, Yong Zhou, Meng Hu, Guoqiang Cai, Victor J. Thannickal, Chad Steele, J. Edwin Blalock, Xiaosi Han, Ching-Yi Chen & Qiang Ding. (2016) Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism. PLOS ONE 11:12, pages e0167451.
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Andrew R. ClarkJonathan L.E. Dean. (2016) The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases. Biochemical Society Transactions 44:5, pages 1321-1337.
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Liangqian Huang, Zhenhai Yu, Zhenchao Zhang, Wenjing Ma, Shaoli Song & Gang Huang. (2016) Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer. Scientific Reports 6:1.
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Pavan Prabhala & Alaina J. Ammit. (2015) Tristetraprolin and Its Role in Regulation of Airway Inflammation. Molecular Pharmacology 87:4, pages 629-638.
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Ulrike Resch, Angélica Cuapio, Caterina Sturtzel, Erhard Hofer, Rainer de Martin & Yvonne M. Holper-Schichl. (2014) Polyubiquitinated Tristetraprolin Protects from TNF-induced, Caspase-mediated Apoptosis. Journal of Biological Chemistry 289:36, pages 25088-25100.
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Heping Cao, Leesa J. Deterding & Perry J. Blackshear. (2014) Identification of a Major Phosphopeptide in Human Tristetraprolin by Phosphopeptide Mapping and Mass Spectrometry. PLoS ONE 9:7, pages e100977.
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Seth A. Brooks & Perry J. Blackshear. (2013) Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:6-7, pages 666-679.
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Esther A. Suswam, John J. Shacka, Kiera Walker, Liang Lu, Xuelin Li, Ying Si, Xiaowen Zhang, Lei Zheng, L. Burt Nabors, Heping Cao & Peter H. King. (2013) Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth. Journal of Neuro-Oncology 113:2, pages 195-205.
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Dipankar Ray, Shirish Shukla, Uday Sankar Allam, Abigail Helman, Susmita Gurjar Ramanand, Linda Tran, Michael Bassetti, Pranathi Meda Krishnamurthy, Matthew Rumschlag, Michelle Paulsen, Lei Sun, Thomas P. Shanley, Mats Ljungman, Mukesh K. Nyati, Ming Zhang & Theodore S. Lawrence. (2013) Tristetraprolin Mediates Radiation-Induced TNF-α Production in Lung Macrophages. PLoS ONE 8:2, pages e57290.
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Caroline Vindry, Aurélien Lauwers, David Hutin, Romuald Soin, Corinne Wauquier, Véronique Kruys & Cyril Gueydan. (2012) dTIS11 Protein-dependent Polysomal Deadenylation Is the Key Step in AU-rich Element-mediated mRNA Decay in Drosophila Cells. Journal of Biological Chemistry 287:42, pages 35527-35538.
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Vishram P. Kedar, Beth E. Zucconi, Gerald M. Wilson & Perry J. Blackshear. (2012) Direct Binding of Specific AUF1 Isoforms to Tandem Zinc Finger Domains of Tristetraprolin (TTP) Family Proteins. Journal of Biological Chemistry 287:8, pages 5459-5471.
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Richipal Singh Bindra, Jason T. L. Wang & Paramjeet Singh Bagga. 2012. Computational Knowledge Discovery for Bioinformatics Research. Computational Knowledge Discovery for Bioinformatics Research 156 173 .
Heping Cao. (2011) Structure-Function Analysis of Diacylglycerol Acyltransferase Sequences from 70 Organisms. BMC Research Notes 4:1.
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Christopher von Roretz, Sergio Di Marco, Rachid Mazroui & Imed-Eddine Gallouzi. (2011) Turnover of AU-rich-containing mRNAs during stress: a matter of survival. Wiley Interdisciplinary Reviews: RNA 2:3, pages 336-347.
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Sandhya Sanduja, Fernando F. Blanco & Dan A. Dixon. (2011) The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdisciplinary Reviews: RNA 2:1, pages 42-57.
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Gillian L. Drury, Sergio Di Marco, Virginie Dormoy-Raclet, Julie Desbarats & Imed-Eddine Gallouzi. (2010) FasL Expression in Activated T Lymphocytes Involves HuR-mediated Stabilization. Journal of Biological Chemistry 285:41, pages 31130-31138.
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Khalid S. A. Khabar. (2010) Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements. Cellular and Molecular Life Sciences 67:17, pages 2937-2955.
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Richipal Singh Bindra, Jason T. L. Wang & Paramjeet Singh Bagga. (2010) Bioinformatics Methods for Studying MicroRNA and ARE-Mediated Regulation of Post-Transcriptional Gene Expression. International Journal of Knowledge Discovery in Bioinformatics 1:3, pages 97-112.
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Paul Anderson. (2010) Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nature Reviews Immunology 10:1, pages 24-35.
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Heping Cao. 2010. Dietary Components and Immune Function. Dietary Components and Immune Function 553 565 .
Heping Cao & Rui Lin. (2009) Quantitative evaluation of His‐tag purification and immunoprecipitation of tristetraprolin and its mutant proteins from transfected human cells. Biotechnology Progress 25:2, pages 461-467.
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Manoël Prouteau, Marie-Claire Daugeron & Bertrand Séraphin. (2008) Regulation of ARE transcript 3′ end processing by the yeast Cth2 mRNA decay factor. The EMBO Journal 27:22, pages 2966-2976.
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Heping Cao, Joseph F. UrbanJr.Jr. & Richard A. Anderson. (2008) Insulin Increases Tristetraprolin and Decreases VEGF Gene Expression in Mouse 3T3-L1 Adipocytes. Obesity 16:6, pages 1208-1218.
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Heping Cao, Joseph F. UrbanJrJr & Richard A. Anderson. (2008) Cinnamon Polyphenol Extract Affects Immune Responses by Regulating Anti- and Proinflammatory and Glucose Transporter Gene Expression in Mouse Macrophages , ,3. The Journal of Nutrition 138:5, pages 833-840.
Crossref
Heping Cao & Rui Lin. (2007) Phosphorylation of Recombinant Tristetraprolin In vitro. The Protein Journal 27:3, pages 163-169.
Crossref

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