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Review

Kinase signaling pathways as potential targets in the treatment of Parkinson’s disease

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Pages 783-792 | Published online: 09 Jan 2014

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Subhashree Sahoo, Amrita Arpita Padhy, Varsha Kumari, Kummari Shivani & Parul Mishra. 2022. Protein Kinase Inhibitors. Protein Kinase Inhibitors 623 655 .
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Sara Saez-Atienzar, Luis Bonet-Ponce, Carmen da Casa, Laura Perez-Dolz, Jose R. Blesa, Eduardo Nava, Maria F. Galindo & Joaquín Jordan. (2016) Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1862:1, pages 20-31.
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A. Raquel Esteves, Russell H. Swerdlow & Sandra M. Cardoso. (2014) LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis. Experimental Neurology 261, pages 206-216.
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Lauran Reyniers, Maria Grazia Del Giudice, Laura Civiero, Elisa Belluzzi, Evy Lobbestael, Alexandra Beilina, Giorgio Arrigoni, Rita Derua, Etienne Waelkens, Yan Li, Claudia Crosio, Ciro Iaccarino, Mark R. Cookson, Veerle Baekelandt, Elisa Greggio & Jean-Marc Taymans. (2014) Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. Journal of Neurochemistry 131:2, pages 239-250.
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Renée Vancraenenbroeck, Joren De Raeymaecker, Evy Lobbestael, Fangye Gao, Marc De Maeyer, Arnout Voet, Veerle Baekelandt & Jean-Marc Taymans. (2014) In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2. Frontiers in Molecular Neuroscience 7.
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Jean-Marc Taymans. (2012) The GTPase function of LRRK2. Biochemical Society Transactions 40:5, pages 1063-1069.
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Elisa Greggio. (2012) Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease. Biochemical Society Transactions 40:5, pages 1058-1062.
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Gang Wang, Jing Pan & Sheng-Di Chen. (2012) Kinases and kinase signaling pathways: Potential therapeutic targets in Parkinson's disease. Progress in Neurobiology 98:2, pages 207-221.
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A. Minarini, A. Milelli, V. Tumiatti, M. Rosini, E. Simoni, M.L. Bolognesi, V. Andrisano, M. Bartolini, E. Motori, C. Angeloni & S. Hrelia. (2012) Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment. Neuropharmacology 62:2, pages 997-1003.
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Hélène Plun-Favreau, Patrick A. Lewis, John Hardy, L. Miguel Martins & Nicholas W. Wood. (2010) Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea. PLoS Genetics 6:12, pages e1001257.
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Mark J. Millan. (2010) From the cell to the clinic: A comparative review of the partial D2/D3 receptor agonist and α2-adrenoceptor antagonist, piribedil, in the treatment of Parkinson's disease. Pharmacology & Therapeutics 128:2, pages 229-273.
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Min-Kyoung Kim, Sang-Cheol Kim, Jung-Il Kang, Hye-Jin Boo, Jin-Won Hyun, Young-Sang Koh, Deok-Bae Park, Eun-Sook Yoo, Ji-Hoon Kang & Hee-Kyoung Kang. (2010) Neuroprotective Effects of Carpinus tschonoskii MAX on 6-Hydroxydopamine-Induced Death of PC12 Cells. Biomolecules and Therapeutics 18:4, pages 454-462.
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David Vauzour, Maria Buonfiglio, Giulia Corona, Joselita Chirafisi, Katerina Vafeiadou, Cristina Angeloni, Silvana Hrelia, Patrizia Hrelia & Jeremy P. E. Spencer. (2010) Sulforaphane protects cortical neurons against 5- S -cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes . Molecular Nutrition & Food Research 54:4, pages 532-542.
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Jean‐Marc Taymans & Mark R. Cookson. (2010) Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α‐synuclein, and tau. BioEssays 32:3, pages 227-235.
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Ali Sharma, Charles A. Hoeffer, Yukihiro Takayasu, Takahiro Miyawaki, Sean M. McBride, Eric Klann & R. Suzanne Zukin. (2010) Dysregulation of mTOR Signaling in Fragile X Syndrome. The Journal of Neuroscience 30:2, pages 694-702.
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Carola Schiesling, Nicole Kieper, Kay Seidel & Rejko Krüger. (2008) Review: Familial Parkinson's disease – genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathology and Applied Neurobiology 34:3, pages 255-271.
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Lizhen Wang, Chengsong Xie, Elisa Greggio, Loukia Parisiadou, Hoon Shim, Lixin Sun, Jayanth Chandran, Xian Lin, Chen Lai, Wan-Jou Yang, Darren J. Moore, Ted M. Dawson, Valina L. Dawson, Gabriela Chiosis, Mark R. Cookson & Huaibin Cai. (2008) The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2. The Journal of Neuroscience 28:13, pages 3384-3391.
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