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Expert Review of Medical Devices Volume 4, 2007 - Issue 3
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Review

Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift

Benjamin JRF Bolland Specialist Registrar Trauma & Orthopaedics, Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, General Hospital, Southampton, SO16 6YD, UK. [email protected]
,
Simon Tilley Specialist Registrar Trauma & Orthopaedics, Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, General Hospital, Southampton, SO16 6YD, UK. [email protected]
,
Andrew MR New Lecturer, Bioengineering Research Group, School of Engineering Sciences, University of Southampton, Southampton SO17 2LR, UK. [email protected]
,
Douglas G Dunlop Consultant Orthopaedic Surgeon, Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, General Hospital, Southampton, SO16 6YD, UK. [email protected]
&
Richard OC Oreffo Chair in Musculoskeletal Science, Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, S016 6YD, UK. [email protected] www.mesenchymalstemcells.org
Pages 393-404 | Published online: 09 Jan 2014

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Lingyan Cao, Xiangjun Kong, Shuxian Lin, Shuang Zhang, Jing Wang, Changsheng Liu & Xinquan Jiang. (2018) Synergistic effects of dual growth factor delivery from composite hydrogels incorporating 2-N,6-O-sulphated chitosan on bone regeneration. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 1-17.
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Ys Choi, Mw Im, Cs Kim, Mh Lee, Se Noh, Sm Lim, Sl Kim, Cg Cho & Di Kim. (2008) Chondrogenic differentiation of human umbilical cord blood-derived multilineage progenitor cells in atelocollagen. Cytotherapy 10:2, pages 165-173.
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Articles from other publishers (23)

Qi Gan, Hao Pan, Wenjing Zhang, Yuan Yuan, Jiangchao Qian & Changsheng Liu. (2022) Fabrication and evaluation of a BMP-2/dexamethasone co-loaded gelatin sponge scaffold for rapid bone regeneration. Regenerative Biomaterials 9.
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Vitali Goriainov, Josephine K McEwan, Richard OC Oreffo & Doug G Dunlop. (2018) Application of 3D-printed patient-specific skeletal implants augmented with autologous skeletal stem cells. Regenerative Medicine 13:3, pages 283-294.
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Nilüfer Çakır-Özkan, Sinan Eğri, Esengül Bekar, B. Zuhal Altunkaynak, Yonca Betil Kabak & Elfide Gizem Kıvrak. (2017) The Use of Sequential VEGF- and BMP2-Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects. Journal of Oral and Maxillofacial Surgery 75:1, pages 221.e1-221.e14.
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M. J. WilsonS. HookS. L. WhitehouseA. J. TimperleyG. A. Gie. (2016) Femoral impaction bone grafting in revision hip arthroplasty. The Bone & Joint Journal 98-B:12, pages 1611-1619.
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J. O. Smith, B. G. Sengers, A. Aarvold, E. R. Tayton, D. G. Dunlop & R. O. C. Oreffo. (2014) Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application. Journal of Tissue Engineering and Regenerative Medicine 8:4, pages 304-313.
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Lingyan Cao, Jing Wang, Juan Hou, Wanli Xing & Changsheng Liu. (2014) Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2. Biomaterials 35:2, pages 684-698.
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Seung-Hoon Baek & Shin-Yoon Kim. 2014. Osteonecrosis. Osteonecrosis 297 306 .
R. Binato, T. de Souza Fernandez, C. Lazzarotto‐Silva, B. Du Rocher, A. Mencalha, L. Pizzatti, L. F. Bouzas & E. Abdelhay. (2012) Stability of human mesenchymal stem cells during in vitro culture: considerations for cell therapy . Cell Proliferation 46:1, pages 10-22.
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Anna Bajek, Mateusz Czerwinski, Joanna Olkowska, Natalia Gurtowska, Tomasz Kloskowski & Tomasz Drewa. (2013) Does aging of mesenchymal stem cells limit their potential application in clinical practice?. Aging Clinical and Experimental Research 24:5, pages 404-411.
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Patricia A Comeau, Hanspeter Frei, Chiming Yang, Goran Fernlund & Fabio M Rossi. (2011) In vivo evaluation of calcium polyphosphate for bone regeneration . Journal of Biomaterials Applications 27:3, pages 267-275.
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Erzsébet Bartolák-Suki. 2012. Cell and Tissue Engineering. Cell and Tissue Engineering 179 196 .
James Oliver SmithAlexander AarvoldEdward R. TaytonDouglas G. DunlopRichard O.C. Oreffo. (2011) Skeletal Tissue Regeneration: Current Approaches, Challenges, and Novel Reconstructive Strategies for an Aging Population. Tissue Engineering Part B: Reviews 17:5, pages 307-320.
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Janos M. Kanczler, Patrick J. Ginty, Lisa White, Nicholas M.P. Clarke, Steven M. Howdle, Kevin M. Shakesheff & Richard O.C. Oreffo. (2010) The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 31:6, pages 1242-1250.
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Iain R. McNamara. (2010) Impaction bone grafting in revision hip surgery: past, present and future. Cell and Tissue Banking 11:1, pages 57-73.
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F. Consolo, F. Mastrangelo, G. Ciardelli, F. M. Montevecchi, U. Morbiducci, M. Sassi & C. Bignardi. 2010. Scanning Probe Microscopy in Nanoscience and Nanotechnology. Scanning Probe Microscopy in Nanoscience and Nanotechnology 425 486 .
Leen Trommelmans, Joseph Selling & Kris Dierickx. (2009) Is tissue engineering a new paradigm in medicine? Consequences for the ethical evaluation of tissue engineering research. Medicine, Health Care and Philosophy 12:4, pages 459-467.
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David W. Green, Benjamin J.R.F. Bolland, Janos M. Kanczler, Stuart A. Lanham, Dominic Walsh, Stephen Mann & Richard O.C. Oreffo. (2009) Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites. Biomaterials 30:10, pages 1918-1927.
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Günter Lepperdinger, Regina Brunauer, Angelika Jamnig, Gerhard Laschober & Moustapha Kassem. (2008) Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies?. Experimental Gerontology 43:11, pages 1018-1023.
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B. G. OchsU. SchmidJ. RiethA. AteschrangK. WeiseU. Ochs. (2008) Acetabular bone reconstruction in revision arthroplasty. The Journal of Bone and Joint Surgery. British volume 90-B:9, pages 1164-1171.
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B.J.R.F. Bolland, J.M. Kanczler, D.G. Dunlop & R.O.C. Oreffo. (2008) Development of in vivo μCT evaluation of neovascularisation in tissue engineered bone constructs. Bone 43:1, pages 195-202.
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Chris MasonPeter Dunnill. (2008) The strong financial case for regenerative medicine and the regen industry. Regenerative Medicine 3:3, pages 351-363.
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Jonathan I. Dawson & Richard O.C. Oreffo. (2008) Bridging the regeneration gap: Stem cells, biomaterials and clinical translation in bone tissue engineering. Archives of Biochemistry and Biophysics 473:2, pages 124-131.
Crossref
Janos M. Kanczler, Patrick J. Ginty, John J.A. Barry, Nicholas M.P. Clarke, Steve M. Howdle, Kevin M. Shakesheff & Richard O.C. Oreffo. (2008) The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation. Biomaterials 29:12, pages 1892-1900.
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