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Toll-like receptor signaling in neonatal sepsis and inflammation: a matter of orchestration and conditioning

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Pages 1239-1252 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Ying Dong, Christian P. Speer & Kirsten Glaser. (2018) Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity. Virulence 9:1, pages 621-633.
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Kirsten Glaser, Markus Fehrholz, Birgit Henrich, Heike Claus, Michael Papsdorf & Christian P. Speer. (2017) Anti-inflammatory effects of the new generation synthetic surfactant CHF5633 on Ureaplasma-induced cytokine responses in human monocytes. Expert Review of Anti-infective Therapy 15:2, pages 181-189.
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Kirsten Glaser & Christian P Speer. (2015) Neonatal CNS infection and inflammation caused by Ureaplasma species: rare or relevant?. Expert Review of Anti-infective Therapy 13:2, pages 233-248.
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Articles from other publishers (27)

Kirsten Glaser, David Kern, Christian P. Speer, Nicolas Schlegel, Michael Schwab, Ulrich H. Thome, Christoph Härtel & Clyde J. Wright. (2023) Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14+CD16+ Subset upon Toll-like Receptor Stimulation. International Journal of Molecular Sciences 24:5, pages 4919.
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Sem Ezinmegnon, Marine Mommert, Francois Bartolo, Gino Agbota, Sossou Darius, Valérie Briand, Marceline d’Almeida, Maroufou Jules Alao, Ida Dossou-Dagba, Achille Massougbodji, Ulrik Lausten-Thomsen, Alexandre Pachot, Laurence Vachot, Javier Yugueros-Marcos, Karen Brengel-Pesce, Nadine Fievet & Pierre Tissieres. (2022) Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa. Scientific Reports 12:1.
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Sarah A. Coggins & Kirsten Glaser. (2022) Updates in Late-Onset Sepsis: Risk Assessment, Therapy, and Outcomes. NeoReviews 23:11, pages 738-755.
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Umar Salimi, Krishna Dummula, Megan H. Tucker, Charles S. Dela Cruz & Venkatesh Sampath. (2022) Postnatal Sepsis and Bronchopulmonary Dysplasia in Premature Infants: Mechanistic Insights into “New BPD”. American Journal of Respiratory Cell and Molecular Biology 66:2, pages 137-145.
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Maria L. Dias, Karen M. O’Connor, Eugene M. Dempsey, Ken D. O’Halloran & Fiona B. McDonald. (2021) Targeting the Toll-like receptor pathway as a therapeutic strategy for neonatal infection. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321:6, pages R879-R902.
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Fleur M. Keij, Bjørn E. V. Koch, Fernando Lozano Vigario, Sinno H. P. Simons, Johan G. C. van Hasselt, H. Rob Taal, C. A. J. Knibbe, Herman P. Spaink, Irwin K. M. Reiss & Elke H. J. Krekels. (2021) Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis. Journal of Clinical and Translational Science 5:1.
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Nadine Fievet, Sem Ezinmegnon, Gino Agbota, Darius Sossou, Rodolphe Ladekpo, Komi Gbedande, Valerie Briand, Gilles Cottrell, Laurence Vachot, Javier Yugueros Marcos, Alexandre Pachot, Julien Textoris, Sophie Blein, Ulrik Lausten-Thomsen, Achille Massougbodji, Lehila Bagnan, Nicole Tchiakpe, Marceline d'Almeida, Jules Alao, Ida Dossou-Dagba & Pierre Tissieres. (2020) SEPSIS project: a protocol for studying biomarkers of neonatal sepsis and immune responses of infants in a malaria-endemic region. BMJ Open 10:7, pages e036905.
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Ankita Sharma, Anup Thakur, Chitra Bhardwaj, Neelam Kler, Pankaj Garg, Manvender Singh & Sangeeta Choudhury. (2020) Potential biomarkers for diagnosing neonatal sepsis. Current Medicine Research and Practice 10:1, pages 12-17.
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Ying Dong, Kirsten Glaser, Nicolas Schlegel, Heike Claus & Christian P. Speer. (2019) An underestimated pathogen: Staphylococcus epidermidis induces pro-inflammatory responses in human alveolar epithelial cells. Cytokine 123, pages 154761.
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Yaling Xu, Ying Dong, Xiaojing Guo & Bo Sun. (2019) Suppression of pulmonary group B streptococcal proliferation and translocation by surfactants in ventilated near-term newborn rabbits. Pediatric Research 86:2, pages 208-215.
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Christine Silwedel, Christian P. Speer, Axel Haarmann, Markus Fehrholz, Heike Claus, Mathias Buttmann & Kirsten Glaser. (2018) Novel insights into neuroinflammation: bacterial lipopolysaccharide, tumor necrosis factor α, and Ureaplasma species differentially modulate atypical chemokine receptor 3 responses in human brain microvascular endothelial cells. Journal of Neuroinflammation 15:1.
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Shujuan Chen & Robert H. Tukey. (2018) Humanized UGT1 Mice, Regulation of UGT1A1 , and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice . Drug Metabolism and Disposition 46:11, pages 1745-1755.
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David Twapokera Mzinza, Henrike Fleige, Kristin Laarmann, Stefanie Willenzon, Jasmin Ristenpart, Julia Spanier, Gerd Sutter, Ulrich Kalinke, Peter Valentin-Weigand & Reinhold Förster. (2018) Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice. Cellular & Molecular Immunology 15:10, pages 875-887.
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Rima Tapader, Dipro Bose, Pujarini Dutta, Santasabuj Das & Amit Pal. (2018) SslE (YghJ), a Cell-Associated and Secreted Lipoprotein of Neonatal Septicemic Escherichia coli, Induces Toll-Like Receptor 2-Dependent Macrophage Activation and Proinflammation through NF-κB and MAP Kinase Signaling. Infection and Immunity 86:9.
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Ying Dong, Kirsten Glaser & Christian P. Speer. (2018) New Threats from an Old Foe: Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> Infections in Neonates. Neonatology 114:2, pages 127-134.
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Linda S. de Vries & Joseph J. Volpe. 2018. Volpe's Neurology of the Newborn. Volpe's Neurology of the Newborn 1050 1089.e10 .
Kirsten Glaser & Christian P. Speer. 2018. Neonatology. Neonatology 73 94 .
Markus Fehrholz, Kirsten Glaser, Christian P. Speer, Silvia Seidenspinner, Barbara Ottensmeier & Steffen Kunzmann. (2017) Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts. Respiratory Research 18:1.
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Kirsten Glaser, Christine Silwedel, Markus Fehrholz, Ana M. Waaga-Gasser, Birgit Henrich, Heike Claus & Christian P. Speer. (2017) Ureaplasma Species Differentially Modulate Pro- and Anti-Inflammatory Cytokine Responses in Newborn and Adult Human Monocytes Pushing the State Toward Pro-Inflammation. Frontiers in Cellular and Infection Microbiology 7.
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Sharon A. McGrath-Morrow, Roland Ndeh, Joseph M. Collaco, Amy K. Poupore, Dustin Dikeman, Qiong Zhong, Benjamin D. Singer, Franco D'Alessio & Alan Scott. (2017) The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice. Cytokine 97, pages 108-116.
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Shujuan ChenWenqi LuMei-Fei YuehEva RettenmeierMiao LiuMiles PaszekJohan AuwerxRuth T. YuRonald M. EvansKepeng Wang, Michael Karin & Robert H. Tukey. (2017) Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proceedings of the National Academy of Sciences 114:8.
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Heather L. Menden, Sheng Xia, Sherry M. Mabry, Angels Navarro, Michael F. Nyp & Venkatesh Sampath. (2016) Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung. American Journal of Respiratory Cell and Molecular Biology 55:6, pages 767-778.
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Kirsten Glaser, Markus Fehrholz, Tore Curstedt, Steffen Kunzmann & Christian P. Speer. (2016) Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes. PLOS ONE 11:1, pages e0146898.
Crossref
YingYing He, Nathan T Lawlor & David S Newburg. (2016) Human Milk Components Modulate Toll-Like Receptor–Mediated Inflammation. Advances in Nutrition 7:1, pages 102-111.
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Kirsten Glaser & Christian P. Speer. 2016. Bronchopulmonary Dysplasia. Bronchopulmonary Dysplasia 55 77 .
K. Glaser & C. P. Speer. 2016. Neonatology. Neonatology 1 21 .
Ying Dong & Christian P. Speer. (2014) The role of Staphylococcus epidermidis in neonatal sepsis: Guarding angel or pathogenic devil?. International Journal of Medical Microbiology 304:5-6, pages 513-520.
Crossref

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