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Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases

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Guojia Du, Dangmurenjiafu Geng, Kai Zhou, Yandong Fan, Riqing Su, Qingjiu Zhou, Bo Liu & Serick Duysenbi. (2020) Identification of potential key pathways, genes and circulating markers in the development of intracranial aneurysm based on weighted gene co-expression network analysis. Artificial Cells, Nanomedicine, and Biotechnology 48:1, pages 999-1007.
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Yuetiva Deming, Zeran Li, Bruno A. Benitez & Carlos Cruchaga. (2018) Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?. Expert Opinion on Therapeutic Targets 22:7, pages 587-598.
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Courtney P. Rudick, Takanari Miyamoto, Melissa S. Lang & Devendra K. Agrawal. (2017) Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies. Expert Review of Clinical Immunology 13:12, pages 1189-1197.
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Finosh G. Thankam, Matthew F. Dilisio, Kaitlin A. Dougherty, Nicholas E. Dietz & Devendra K. Agrawal. (2016) Triggering receptor expressed on myeloid cells and 5’adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target. Expert Review of Clinical Immunology 12:11, pages 1239-1249.
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Jörn F. Dopheide, Jennifer Rubrech, Amelie Trumpp, Philip Geissler, Geraldine C. Zeller, Karsten Bock, Friedrich Dünschede, Tran Tong Trinh, Bernhard Dorweiler, Thomas Münzel, Markus P. Radsak & Christine Espinola-Klein. (2016) Leukocyte–platelet aggregates—a phenotypic characterization of different stages of peripheral arterial disease. Platelets 27:7, pages 658-667.
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Austin Huy Nguyen, Ilya G Berim & Devendra K Agrawal. (2015) Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells. Expert Review of Clinical Immunology 11:7, pages 849-857.
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Christopher J Pelham, Amit N Pandya & Devendra K Agrawal. (2014) Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Expert Opinion on Therapeutic Patents 24:12, pages 1383-1395.
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Articles from other publishers (52)

Vikrant Rai, Juan A. Asensio & Devendra K. Agrawal. 2024. Current Therapy of Trauma and Surgical Critical Care. Current Therapy of Trauma and Surgical Critical Care 682.e2 682.e8 .
Parth Patel, Vikrant Rai & Devendra K. Agrawal. (2023) Role of oncostatin-M in ECM remodeling and plaque vulnerability. Molecular and Cellular Biochemistry 478:11, pages 2451-2460.
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Susmita Sinha, Santosh Kumar, Mahendra Narwaria, Arya Singh & Mainul Haque. (2023) Severe Acute Bronchial Asthma with Sepsis: Determining the Status of Biomarkers in the Diagnosis of the Disease. Diagnostics 13:16, pages 2691.
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Chuntian Liang, Lirong Liu, Shuangjin Bao, Zhenjia Yao, Qinqin Bai, Pengcheng Fu, Xiangyu Liu, John H. Zhang & Gaiqing Wang. (2023) Neuroprotection by Nrf2 via modulating microglial phenotype and phagocytosis after intracerebral hemorrhage. Heliyon 9:2, pages e13777.
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Lina Ji, Shenglong Wang, Shan Wu, Jie Bao, Guanqun Xie, Yan Zhang, Liping Xu, Na Lin, Jian Wang, Yongsheng Fan, Danqing Fu & Qiaoding Dai. (2022) Paeoniflorin Inhibits LPS-Induced Activation of Splenic CD4+ T Lymphocytes and Relieves Pathological Symptoms in MRL/lpr Mice by Suppressing IRAK1 Signaling. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-17.
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Wenjie Xu, Yuxiang Zheng, Zizheng Suo, Kailun Fei, Yalong Wang, Chao Liu, Shuai Li, Mingzhu Zhang, Yefan Zhang, Zhaoxu Zheng, Cheng Ni & Hui Zheng. (2022) Effect of dexmedetomidine on postoperative systemic inflammation and recovery in patients undergoing digest tract cancer surgery: A meta-analysis of randomized controlled trials. Frontiers in Oncology 12.
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Xu Han, Jingzhe Han, Ning Wang, Guang Ji, Ruoyi Guo, Jing Li, Hongran Wu, Shaojuan Ma, Pingping Fang & Xueqin Song. (2022) Identification of Auxiliary Biomarkers and Description of the Immune Microenvironmental Characteristics in Duchenne Muscular Dystrophy by Bioinformatical Analysis and Experiment. Frontiers in Neuroscience 16.
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Albert C Sek, Caroline M Percopo, Arun K Boddapati, Michelle Ma, Wendy E Geslewitz, Julia O Krumholz, Justin B Lack & Helene F Rosenberg. (2021) Differential expression of Triggering Receptor Expressed on Myeloid cells 2 ( Trem2 ) in tissue eosinophils . Journal of Leukocyte Biology 110:4, pages 679-691.
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QiXing Chen, Yang Yang, XiaoLiang Wu, ShiYue Yang, Yan Zhang, Qiang Shu & XiangMing Fang. (2021) Triggering Receptor Expressed on Myeloid Cells-2 Protects Aged Mice Against Sepsis by Mitigating the IL-23/IL-17A Response. Shock 56:1, pages 98-107.
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Xin-Gang Sun, Mi-Mi Zhang, Shao-Yu Liu, Xue-Hong Chu, Guo-Qiang Xue, Bao-Chen Zhang, Jia-Bao Zhu, Ivan Steve Godje Godje, Li-Juan Zhu, Hui-Yu Hu, Hai-Wang, Ying-Jie Shen & Gai-Qing Wang. (2021) Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage. Experimental Neurology 341, pages 113692.
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Zhenjun Ji, Rui Zhang, Mingming Yang, Wenjie Zuo, Yuyu Yao, Yangyang Qu, Yamin Su, Zhuyuan Liu, Ziran Gu & Genshan Ma. (2021) Accuracy of triggering receptor expressed on myeloid cells 1 in diagnosis and prognosis of acute myocardial infarction: a prospective cohort study. PeerJ 9, pages e11655.
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Jyun-Bin Huang, Nai-Ching Chen, Chien-Liang Chen, Mu-Hui Fu, Hsiu-Yung Pan, Chung-Yao Hsu, Shang-Der Chen & Yao-Chung Chuang. (2020) Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 Associated with the Severity and Outcome of Acute Ischemic Stroke. Journal of Clinical Medicine 10:1, pages 61.
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Wei-Jia Lu, Li Zhou, Fan-Xiang Gao, Yu-Lin Zhou, Zhi Li, Xiao-Juan Zhang, Yang Wang & Jian-Fang Gui. (2020) Dynamic and Differential Expression of Duplicated Cxcr4/Cxcl12 Genes Facilitates Antiviral Response in Hexaploid Gibel Carp. Frontiers in Immunology 11.
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Leilei Qin, Xinyu Li, Jiawei Wang, Xuan Gong, Ning Hu & Wei Huang. (2020) Improved diagnosis of chronic hip and knee prosthetic joint infection using combined serum and synovial IL-6 tests. Bone & Joint Research 9:9, pages 587-592.
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Alexander B. Sigalov. (2020) SCHOOL of nature: ligand-independent immunomodulatory peptides. Drug Discovery Today 25:8, pages 1298-1306.
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Muzamil Olamide Hassan, Therese Dix-Peek, Raquel Duarte, Caroline Dickens, Sagren Naidoo, Ahmed Vachiat, Sacha Grinter, Pravin Manga & Saraladevi Naicker. (2020) Association of chronic inflammation and accelerated atherosclerosis among an indigenous black population with chronic kidney disease. PLOS ONE 15:7, pages e0232741.
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K. Kluckova, J. Kozak, K. Szaboova, B. Rychly, M. Svajdler, M. Suchankova, E. Tibenska, B. Filova, J. Steno, V. Matejcik, M. Homolova & M. Bucova. (2020) TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients. Mediators of Inflammation 2020, pages 1-13.
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Ruijing Zhang, Jason Saredy, Ying Shao, Tian Yao, Lu Liu, Fatma Saaoud, William Y. Yang, Yu Sun, Candice Johnson, Charles DrummerIVIV, Hangfei Fu, Yifan Lu, Keman Xu, Ming Liu, Jirong Wang, Elizabeth Cutler, Daohai Yu, Xiaohua Jiang, Yafeng Li, Rongshan Li, Lihua Wang, Eric T. Choi, Hong Wang & Xiaofeng Yang. (2020) End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression. Redox Biology 34, pages 101460.
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Zhenbang Zhu, Xiaoxiao Zhang, Wenjuan Dong, Xiaoying Wang, Sheng He, Hui Zhang, Xun Wang, Ruiping Wei, Yaosheng Chen, Xiaohong Liu & Chunhe Guo. (2020) TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling. PLOS Pathogens 16:5, pages e1008543.
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Yao Yao, Chunguang Yang, Xing Yi, Shaobing Xie & Hong Sun. (2020) Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis. Bioscience Reports 40:2.
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Eun-Hye HongJae-Hyoung SongSeong-Ryeol KimJaewon ChoBirang JeongHeejung Yang, Jae-Hyeon JeongJae-Hee AhnHyunjin JeongSeong-Eun KimSun-Young Chang & Hyun-Jeong Ko. (2020) Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenza-infected Mice. Immune Network 20:4.
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Hala G El Nady, Lobna S. Sherif, Naglaa Kholoussi, Nevine R. El Baroudy, Amira S. El Refay, Rania Fawzy Mahmoud Abdelkawy, Assem Abo-Shanab & Amr AbdElAziz ElMekkawy. (2019) Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as a New Marker in Ventilated Children with Pneumonia. Biomedical and Pharmacology Journal 12:04, pages 1951-1959.
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Yonatan Edel, Vitaly Kliminski, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Yael Pri-Paz Basson, Mohammad Egbaria & Yair Molad. (2019) Elevated plasma level of soluble triggering receptor expressed on myeloid cells-1 is associated with inflammation activity and is a potential biomarker of thrombosis in primary antiphospholipid syndrome. Arthritis Research & Therapy 21:1.
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Gianfranco Natale, Francesca Biagioni, Carla Letizia Busceti, Stefano Gambardella, Fiona Limanaqi & Francesco Fornai. (2019) TREM Receptors Connecting Bowel Inflammation to Neurodegenerative Disorders. Cells 8:10, pages 1124.
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Xi Li, Qunyan Yao, Jiying Huang, Qianwen Jin, Beili Xu, Fangyuan Chen & Chuantao Tu. (2019) Morin Hydrate Inhibits TREM-1/TLR4-Mediated Inflammatory Response in Macrophages and Protects Against Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Frontiers in Pharmacology 10.
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Gang Liu, Subhashini Arimilli, Evan Savage & G. L. Prasad. (2019) Cigarette smoke preparations, not moist snuff, impair expression of genes involved in immune signaling and cytolytic functions. Scientific Reports 9:1.
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Xin-gang Sun, Hongling Duan, Gang Jing, Gaiqing Wang, Yazhi Hou & Mimi Zhang. (2019) Inhibition of TREM-1 attenuates early brain injury after subarachnoid hemorrhage via downregulation of p38MAPK/MMP-9 and preservation of ZO-1. Neuroscience 406, pages 369-375.
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Wenqing Tang, Bei Lv, Biwei Yang, Yukai Chen, Feifei Yuan, Lijie Ma, She Chen, Si Zhang & Jinglin Xia. (2019) TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway. Oncogenesis 8:2.
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Kouassi Kouassi, Palanikumar Gunasekar, Devendra Agrawal & Gopal Jadhav. (2018) TREM-1; Is It a Pivotal Target for Cardiovascular Diseases?. Journal of Cardiovascular Development and Disease 5:3, pages 45.
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Monica Gioia Marazzi, Filippo Randelli, Marco Brioschi, Lorenzo Drago, Carlo Luca Romanò, Giuseppe Banfi, Luca Massaccesi, Calogero Crapanzano, Franca Morelli, Massimiliano Marco Corsi Romanelli & Emanuela Galliera. (2017) Presepsin: A potential biomarker of PJI? A comparative analysis with known and new infection biomarkers. International Journal of Immunopathology and Pharmacology 31, pages 039463201774935.
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Alexander B. Sigalov. 2018. Protein-Protein Interactions in Human Disease, Part B. Protein-Protein Interactions in Human Disease, Part B 61 99 .
Zu T. Shen & Alexander B. Sigalov. (2017) Novel TREM-1 Inhibitors Attenuate Tumor Growth and Prolong Survival in Experimental Pancreatic Cancer. Molecular Pharmaceutics 14:12, pages 4572-4582.
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Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal & Kalyana C. Nandipati. (2017) RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population. Journal of Translational Medicine 15:1.
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Vikrant RaiDevendra K. Agrawal. (2017) The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques. Canadian Journal of Physiology and Pharmacology 95:10, pages 1245-1253.
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Sannette C. Hall & Devendra K. Agrawal. (2017) Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation. Scientific Reports 7:1.
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James D. Mills, Anand M. Iyer, Jackelien van Scheppingen, Anika Bongaarts, Jasper J. Anink, Bart Janssen, Till S. Zimmer, Wim G. Spliet, Peter C. van Rijen, Floor E. Jansen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Jansen, Lieven Lagae, Paolo Curatolo, David J. Kwiatkowski, R. Jeroen Pasterkamp, Ketharini Senthilkumar, Lars von Oerthel, Marco F. Hoekman, Jan A. Gorter, Peter B. Crino, Angelika Mühlebner, Brendon P. Scicluna & Eleonora Aronica. (2017) Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. Scientific Reports 7:1.
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Gerardo Rosciszewski, Vanesa Cadena, Veronica Murta, Jeronimo Lukin, Alejandro Villarreal, Thierry Roger & Alberto Javier Ramos. (2017) Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype. Molecular Neurobiology.
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Xin-Gang Sun, Qian Ma, Gang Jing, Li Wang, Xu-Dong Hao & Gai-Qing Wang. (2017) Early elevated levels of soluble triggering receptor expressed on myeloid cells-1 in subarachnoid hemorrhage patients. Neurological Sciences 38:5, pages 873-877.
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Saravanan Subramanian, Pradeep K. Pallati, Vikrant Rai, Poonam Sharma, Devendra K. Agrawal & Kalyana C. Nandipati. (2017) Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance. Obesity 25:3, pages 527-538.
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Xin-Gang Sun, Qian Ma, Gang Jing, Gai-Qing Wang, Xu-Dong Hao & Li Wang. (2017) Increased levels of soluble triggering receptor expressed on myeloid cells-1 in cerebrospinal fluid of subarachnoid hemorrhage patients. Journal of Clinical Neuroscience 35, pages 139-143.
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Vikrant Rai, Nicholas E. Dietz, Matthew F. Dilisio, Mohamed M. Radwan & Devendra K. Agrawal. (2016) Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine. Arthritis Research & Therapy 18:1.
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Finosh G. Thankam, Matthew F. Dilisio, Nicholas E. Dietz & Devendra K. Agrawal. (2016) TREM-1, HMGB1 and RAGE in the Shoulder Tendon: Dual Mechanisms for Inflammation Based on the Coincidence of Glenohumeral Arthritis. PLOS ONE 11:10, pages e0165492.
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Anton G. Kutikhin, Anastasia V. Ponasenko, Maria V. Khutornaya, Arseniy E. Yuzhalin, Irina I. Zhidkova, Ramil R. Salakhov, Alexey S. Golovkin, Olga L. Barbarash & Leonid S. Barbarash. (2016) Association of TLR and TREM-1 gene polymorphisms with atherosclerosis severity in a Russian population. Meta Gene 9, pages 76-89.
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Vikrant Rai, Velidi H. Rao, Zhifei Shao & Devendra K. Agrawal. (2016) Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis. PLOS ONE 11:5, pages e0154802.
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Yan Ding, Wang Liao, Xiaojie He, Wei Xiang & Qianjin Lu. (2016) CSTMP Exerts Anti-Inflammatory Effects on LPS-Induced Human Renal Proximal Tubular Epithelial Cells by Inhibiting TLR4-Mediated NF-κB Pathways. Inflammation 39:2, pages 849-859.
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Ivan Rodriguez-Nunez, Dustin J. Wcisel, Ronda T. Litman, Gary W. Litman & Jeffrey A. Yoder. (2016) The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes. Immunogenetics 68:4, pages 295-312.
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Houxuan Li, Feifei Hong, Shengbo Pan, Lang Lei & Fuhua Yan. (2015) Silencing Triggering Receptors Expressed on Myeloid Cells-1 Impaired the Inflammatory Response to Oxidized Low-Density Lipoprotein in Macrophages. Inflammation 39:1, pages 199-208.
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Arie J. Hoogendijk, Dana C. Blok, M. Isabel Garcia Laorden, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Paul Bresser, Jaring S. van der Zee, Aniruddha Ghose, Caroline E. Visser, Menno D. de Jong, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Ahmed Hossain, Md Abu Tayab, Rene Lutter, Nick Day, Arjen M. Dondorp, Cornelis van't Veer, Alex F. de Vos & Tom van der Poll. (2015) Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis. Journal of Infection 71:6, pages 706-709.
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Austin Huy Nguyen, Carleigh Koenck, Shannon K. Quirk, Victoria M. Lim, Mario V. Mitkov, Ryan M. Trowbridge, William J. HunterIIIIII & Devendra K. Agrawal. (2015) Triggering Receptor Expressed on Myeloid Cells in Cutaneous Melanoma. Clinical and Translational Science 8:5, pages 441-444.
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Irene Hinterseher, Charles Schworer, John Lillvis, Elizabeth Stahl, Robert Erdman, Zoran Gatalica, Gerard Tromp & Helena Kuivaniemi. (2015) Immunohistochemical Analysis of the Natural Killer Cell Cytotoxicity Pathway in Human Abdominal Aortic Aneurysms. International Journal of Molecular Sciences 16:12, pages 11196-11212.
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Maria Bucova, Magda Suchankova, Elena Tibenska, Eva Tedlova, Juraj Demian, Ivan Majer, Helena Novosadova & Miroslav Tedla. (2015) TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis. Mediators of Inflammation 2015, pages 1-7.
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Lirong Liu, Shuangjin Bao, Zhenjia Yao, Qinqin Bai, Chuntian Liang, Pengcheng Fu, Xiangyu Liu, John-H. Zhang & gaiqing Wang. (2022) Nrf2 Regulates Microglia-Mediated Phagocytosis and Neuroinflammation after Intracerebral Hemorrhage. SSRN Electronic Journal.
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