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The role of T regulatory cells in immunopathogenesis of myasthenia gravis: implications for therapeutics

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Sruthi S Nair & Saiju Jacob. (2023) Novel Immunotherapies for Myasthenia Gravis. ImmunoTargets and Therapy 12, pages 25-45.
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Zhan-Xia Xue, Yong-Shan Gao & Xue-Liang Wu. (2021) Suppression of the CD28/B7 pathway reduces the occurrence and development of myasthenia gravis and cytokine levels. International Journal of Neuroscience 131:9, pages 854-863.
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Zahra Telikani, Vida Sheikh, Alireza Zamani, Shiva Borzouei, Iraj Salehi, Mohammad Ali Amirzargar & Mahdi Alahgholi-Hajibehzad. (2019) Effects of sitagliptin and vitamin D3 on T helper cell transcription factors and cytokine production in clinical subgroups of type 2 diabetes mellitus: highlights upregulation of FOXP3 and IL-37. Immunopharmacology and Immunotoxicology 41:2, pages 299-311.
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Shuhui Wang, Iva Breskovska, Shreya Gandhy, Anna Rostedt Punga, Jeffery T. Guptill & Henry J. Kaminski. (2018) Advances in autoimmune myasthenia gravis management. Expert Review of Neurotherapeutics 18:7, pages 573-588.
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Articles from other publishers (23)

Giuseppe Schirò, Salvatore Iacono & Carmela Rita Balistreri. (2023) The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review. Neurology International 15:1, pages 392-404.
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D.A. García Estévez, L.M. López Díaz, M. Pardo Parrado, G. Pérez Lorenzo, N.A. Sabbagh Casado, G. Ozaita Arteche & D. Rodríguez Gómez. (2023) Epidemiology of myasthenia gravis in the province of Ourense (Galicia, Spain). Neurología (English Edition) 38:2, pages 75-81.
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D.A. García Estévez, L.M. López Díaz, M. Pardo Parrado, G. Pérez Lorenzo, N.A. Sabbagh Casado, G. Ozaita Arteche & D. Rodríguez Gómez. (2023) Epidemiología de la miastenia gravis en la provincia de Ourense (Galicia, noroeste de España). Neurología 38:2, pages 75-81.
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Yuan Chen, Xue-Song Zhang, Yuan-Guo Wang, Chao Lu, Jian Li & Peng Zhang. (2021) Imbalance of Th17 and Tregs in thymoma may be a pathological mechanism of myasthenia gravis. Molecular Immunology 133, pages 67-76.
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Na Wang, Jiang Yuan, Md Rezaul Karim, Ping Zhong, Yan-Peng Sun, Hong-Yan Zhang & Yun-Fu Wang. (2020) Effects of Mitophagy on Regulatory T Cell Function in Patients With Myasthenia Gravis. Frontiers in Neurology 11.
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Giulia Nicocia, Carmen Bonanno, Antonino Lupica, Antonio Toscano & Carmelo Rodolico. (2020) Myasthenia gravis after etanercept and ustekinumab treatment for psoriatic arthritis: A case report. Neuromuscular Disorders 30:3, pages 246-249.
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Wenhua Xu, Mingshan Ren, Swagata Ghosh, Kai Qian, Zhaofeng Luo, Aimei Zhang, Cuiping Zhang & Jiajun Cui. (2020) Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy. Mediators of Inflammation 2020, pages 1-13.
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Zahra Telikani, Vida Sheikh, Alireza zamani, Shiva Borzouei, Iraj Salehi, Mohammad Ali Amirzargar & Mahdi Alahgholi-Hajibehzad. (2020) Effect of sitagliptin on serum levels of TNF-α, IL-1β and IL-10 in patients with type 2 diabetes mellitus. Koomesh Journal 22:1, pages 71-77.
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Xiaoming Yan, Yanzheng Gu, Caiqin Wang, Simao Sun, Xiaozhu Wang, Jingluan Tian, Mingyuan Wang, Xiaopei Ji, Xiaoyu Duan, Hanqing Gao, Qi Fang, Wanli Dong, Xueguang Zhang & Qun Xue. (2019) Unbalanced expression of membrane-bound and soluble inducible costimulator and programmed cell death 1 in patients with myasthenia gravis. Clinical Immunology 207, pages 68-78.
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Elham Mahabadi-Ashtiyani, Vida Sheikh, Shiva Borzouei, Iraj Salehi & Mahdi Alahgholi-Hajibehzad. (2019) The increased T helper cells proliferation and inflammatory responses in patients with type 2 diabetes mellitus is suppressed by sitagliptin and vitamin D3 in vitro. Inflammation Research 68:10, pages 857-866.
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Jie Song, Jian-Ying Xi, Wen-Bo Yu, Chong Yan, Su-Shan Luo, Lei Zhou, Wen-Hua Zhu, Jia-Hong Lu, Qiang Dong, Bao-Guo Xiao & Chong-Bo Zhao. (2019) Inhibition of ROCK activity regulates the balance of Th1, Th17 and Treg cells in myasthenia gravis. Clinical Immunology 203, pages 142-153.
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Shiva BorzoueiVida SheikhMorteza GhasemiAlireza ZamaniZahra TelikaniZohre ZareighaneIraj SalehiAzadeh MozayanimonfaredMohammad Ali AmirzargarMahdi Alahgholi-Hajibehzad. (2019) Anti-Inflammatory Effect of Combined Sitagliptin and Vitamin D3 on Cytokines Profile in Patients with Type 2 Diabetes Mellitus. Journal of Interferon & Cytokine Research 39:5, pages 293-301.
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Loulwah Mukharesh & Henry J. Kaminski. (2019) A Neurologist’s Perspective on Understanding Myasthenia Gravis. Thoracic Surgery Clinics 29:2, pages 133-141.
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Vida Sheikh, Alireza Zamani, Elham Mahabadi-Ashtiyani, Hanieh Tarokhian, Shiva Borzouei & Mahdi Alahgholi-Hajibehzad. (2018) Decreased regulatory function of CD4 + CD25 + CD45RA + T cells and impaired IL-2 signalling pathway in patients with type 2 diabetes mellitus . Scandinavian Journal of Immunology 88:4, pages e12711.
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Shuang Chen, Meng-Bei Xu, Xiao-Li Zhou, Pei-Qing Rong, Ting-Yu Jin & Guo-Qing Zheng. (2018) Chinese Herbal Medicine for Myasthenia Gravis: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology 9.
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Vida Sheikh, Pinar Kasapoglu, Alireza Zamani, Zahra Basiri, Ahmad Tahamoli-Roudsari & Mahdi Alahgholi-Hajibehzad. (2018) Vitamin D3 inhibits the proliferation of T helper cells, downregulate CD4+ T cell cytokines and upregulate inhibitory markers. Human Immunology 79:6, pages 439-445.
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Saiju Jacob. (2018) Myasthenia Gravis – A Review of Current Therapeutic Options. European Neurological Review 13:2, pages 86.
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Sapna Sharma, Clas Malmeström, Christopher Lindberg, Sarah Meisel, Karin Schön, Martina Verolin & Nils Yngve Lycke. (2017) A Sensitive Method for Detecting Peptide-specific CD4+ T Cell Responses in Peripheral Blood from Patients with Myasthenia Gravis. Frontiers in Immunology 8.
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M Alahgholi-Hajibehzad, H Durmuş, F Aysal, Y Gülşen-Parman, P Oflazer, F Deymeer & G Saruhan-Direskeneli. (2017) The effect of interleukin (IL)-21 and CD4+CD25++ T cells on cytokine production of CD4+ responder T cells in patients with myasthenia gravis. Clinical and Experimental Immunology 190:2, pages 201-207.
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Amelia Evoli. (2017) Myasthenia gravis: new developments in research and treatment. Current Opinion in Neurology 30:5, pages 464-470.
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Alessandra Consonni, Sapna Sharma, Karin Schön, Cristina Lebrero-Fernández, Elena Rinaldi, Nils Yngve Lycke & Fulvio Baggi. (2017) A Novel Approach to Reinstating Tolerance in Experimental Autoimmune Myasthenia Gravis Using a Targeted Fusion Protein, mCTA1–T146. Frontiers in Immunology 8.
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Hongfei Tai, Liying Cui, Yuzhou Guan, Mingsheng Liu, Xiaoguang Li, Yan Huang, Jing Yuan, Dongchao Shen, Dawei Li & Feifei Zhai. (2017) Amyotrophic Lateral Sclerosis and Myasthenia Gravis Overlap Syndrome: A Review of Two Cases and the Associated Literature. Frontiers in Neurology 8.
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Alireza ZamaniIraj SalehiMahdi Alahgholi-Hajibehzad. (2017) Moderate Exercise Enhances the Production of Interferon-γ and Interleukin-12 in Peripheral Blood Mononuclear Cells. Immune Network 17:3, pages 186.
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