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SPECIAL FOCUS: 10-year anniversary issue - Review

Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future

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Joanne L. Welton, Samantha Loveless, Timothy Stone, Chris von Ruhland, Neil P. Robertson & Aled Clayton. (2017) Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis. Journal of Extracellular Vesicles 6:1.
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Thomas G Forsthuber & Timothy RDJ Radstake. (2015) Expert Review of Clinical Immunology 10-year anniversary issue. Expert Review of Clinical Immunology 11:1, pages 1-3.
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Articles from other publishers (37)

Nadia Barizzone, Maurizio Leone, Alessandro Pizzino, Ingrid Kockum, Filippo Martinelli-Boneschi & Sandra D’Alfonso. (2022) A Scoping Review on Body Fluid Biomarkers for Prognosis and Disease Activity in Patients with Multiple Sclerosis. Journal of Personalized Medicine 12:9, pages 1430.
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Andrew Pachner. (2022) The Brave New World of Early Treatment of Multiple Sclerosis: Using the Molecular Biomarkers CXCL13 and Neurofilament Light to Optimize Immunotherapy. Biomedicines 10:9, pages 2099.
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Borros Arneth & Jörg Kraus. (2022) Laboratory biomarkers of Multiple Sclerosis (MS). Clinical Biochemistry 99, pages 1-8.
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Meng Li, Hongping Chen, Pengqi Yin, Jihe Song, Fangchao Jiang, Zhanbin Tang, Xuehui Fan, Chen Xu, Yingju Wang, Yang Xue, Baichao Han, Haining Wang, Guozhong Li & Di Zhong. (2021) Identification and Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Relapsing-Remitting Multiple Sclerosis. Frontiers in Immunology 12.
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Monokesh K. Sen, Mohammed S. M. Almuslehi, Peter J. Shortland, David A. Mahns & Jens R. Coorssen. (2021) Proteomics of Multiple Sclerosis: Inherent Issues in Defining the Pathoetiology and Identifying (Early) Biomarkers. International Journal of Molecular Sciences 22:14, pages 7377.
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Lachlan Porter, Alireza Shoushtarizadeh, George A. Jelinek, Chelsea R. Brown, Chai K. Lim, Alysha M. de Livera, Kelly R. Jacobs & Tracey J. Weiland. (2020) Metabolomic Biomarkers of Multiple Sclerosis: A Systematic Review. Frontiers in Molecular Biosciences 7.
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Hossein Zeinali, Tourandokht Baluchnejadmojarad & Mehrdad Roghani. (2020) Effect of Oral Administration of S-allyl Cysteine (the Active Ingredient in the Aged Garlic Extract) on the Symptoms of Multiple Sclerosis in the Experimental Model. Qom Univ Med Sci J 14:10, pages 76-84.
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Carol Chase Huizar, Itay Raphael & Thomas G. Forsthuber. (2020) Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis. Cellular Immunology 358, pages 104219.
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Marco Puthenparampil, Erica Stropparo, Sofia Zywicki, Francesca Bovis, Chiara Cazzola, Lisa Federle, Francesca Grassivaro, Francesca Rinaldi, Paola Perini, Maria Pia Sormani & Paolo Gallo. (2020) Wide Cytokine Analysis in Cerebrospinal Fluid at Diagnosis Identified CCL-3 as a Possible Prognostic Factor for Multiple Sclerosis. Frontiers in Immunology 11.
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Heidi Högel, Eero Rissanen, Christian Barro, Markus Matilainen, Marjo Nylund, Jens Kuhle & Laura Airas. (2018) Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity. Multiple Sclerosis Journal 26:2, pages 210-219.
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Eiman MA Mohammed. (2020) Environmental Influencers, MicroRNA, and Multiple Sclerosis. Journal of Central Nervous System Disease 12, pages 117957351989495.
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A. Podlecka-Piętowska, A. Kacka, B. Zakrzewska-Pniewska, M. Nojszewska, E. Zieminska, M. Chalimoniuk & B. Toczylowska. (2019) Altered Cerebrospinal Fluid Concentrations of Hydrophobic and Hydrophilic Compounds in Early Stages of Multiple Sclerosis—Metabolic Profile Analyses. Journal of Molecular Neuroscience 69:1, pages 94-105.
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Joanna Saluk-Bijak, Angela Dziedzic & Michal Bijak. (2019) Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis. Cells 8:2, pages 110.
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Tania Islam, Md. Rezanur Rahman, Md. Rezaul Karim, Fazlul Huq, Julian M.W. Quinn & Mohammad Ali Moni. (2019) Detection of multiple sclerosis using blood and brain cells transcript profiles: Insights from comprehensive bioinformatics approach. Informatics in Medicine Unlocked 16, pages 100201.
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Kira Groen, Vicki E. Maltby, Rodney A. Lea, Katherine A. Sanders, J. Lynn Fink, Rodney J. Scott, Lotti Tajouri & Jeannette Lechner-Scott. (2018) Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis. BMC Medical Genomics 11:1.
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Elizabeth A Mills, Joel A Begay, Caitlyn Fisher & Yang Mao-Draayer. (2018) Impact of trial design and patient heterogeneity on the identification of clinically effective therapies for progressive MS. Multiple Sclerosis Journal 24:14, pages 1795-1807.
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Ciro De Luca, Anna Maria Colangelo, Lilia Alberghina & Michele Papa. (2018) Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System. Frontiers in Cellular Neuroscience 12.
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Brian DellaValle, Alba Manresa-Arraut, Henrik Hasseldam, Allan Stensballe, Jørgen Rungby, Agnete Larsen & Casper Hempel. (2018) Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers?. Frontiers in Immunology 9.
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Donna M. Barten, Gregory W. Cadelina & Michael R. Weed. 2018. Cerebrospinal Fluid in Neurologic Disorders. Cerebrospinal Fluid in Neurologic Disorders 47 64 .
C.E. Teunissen, C. Verheul & E.A.J. Willemse. 2018. Cerebrospinal Fluid in Neurologic Disorders. Cerebrospinal Fluid in Neurologic Disorders 3 20 .
Sirajul Salekin, Mehrab Ghanat Bari, Itay Raphael, Thomas G. Forsthuber & Jianqiu (Michelle) Zhang. (2017) Early response index: a statistic to discover potential early stage disease biomarkers. BMC Bioinformatics 18:1.
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Wessam E. Sharaf-Eldin, Nirmeen A. Kishk, Yehia Z. Gad, Heba Hassan, Mohamed A.M. Ali, Maha S. Zaki, Mohamed R. Mohamed & Mona L. Essawi. (2017) Extracellular miR-145, miR-223 and miR-326 expression signature allow for differential diagnosis of immune-mediated neuroinflammatory diseases. Journal of the Neurological Sciences 383, pages 188-198.
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Walter Verrusio, V. M. Magro, M. L. Summa, U. Angeloni, N. Gueli & M. Cacciafesta. (2017) Acute disseminated encephalomyelitis in an elderly patient. Neurological Sciences 38:11, pages 2045-2047.
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Ciro De Luca, Assunta Virtuoso, Nicola Maggio & Michele Papa. (2017) Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases. International Journal of Molecular Sciences 18:10, pages 2128.
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Andrew J. Solomon & John R. Corboy. (2017) The tension between early diagnosis and misdiagnosis of multiple sclerosis. Nature Reviews Neurology 13:9, pages 567-572.
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Itay Raphael, Johanna WebbM.S.M.S., Francisco Gomez-RiveraM.S.M.S., Carol A. Chase Huizar, Rishein Gupta, Bernard P. ArulanandamPh.D.Ph.D., Yufeng Wang, William E. Haskins & Thomas G. Forsthuber. (2017) Serum Neuroinflammatory Disease-Induced Central Nervous System Proteins Predict Clinical Onset of Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology 8.
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Astrid Guldbrandsen, Yehia Farag, Ann Cathrine Kroksveen, Eystein Oveland, Ragnhild R. Lereim, Jill A. Opsahl, Kjell-Morten Myhr, Frode S. Berven & Harald Barsnes. (2017) CSF-PR 2.0: An Interactive Literature Guide to Quantitative Cerebrospinal Fluid Mass Spectrometry Data from Neurodegenerative Disorders. Molecular & Cellular Proteomics 16:2, pages 300-309.
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Nabil K. El Ayoubi & Samia J. Khoury. (2016) Blood Biomarkers as Outcome Measures in Inflammatory Neurologic Diseases. Neurotherapeutics 14:1, pages 135-147.
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Katherine A. Sanders, Miles C. Benton, Rod A. Lea, Vicki E. Maltby, Susan Agland, Nathan Griffin, Rodney J. Scott, Lotti Tajouri & Jeannette Lechner-Scott. (2016) Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells. Clinical Epigenetics 8:1.
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Sandra Hellberg, Daniel Eklund, Danuta R. Gawel, Mattias Köpsén, Huan Zhang, Colm E. Nestor, Ingrid Kockum, Tomas Olsson, Thomas Skogh, Alf Kastbom, Christopher Sjöwall, Magnus Vrethem, Irene Håkansson, Mikael Benson, Maria C. Jenmalm, Mika Gustafsson & Jan Ernerudh. (2016) Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis. Cell Reports 16:11, pages 2928-2939.
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Richard Ibitoye, Kevin Kemp, Claire Rice, Kelly Hares, Neil Scolding & Alastair Wilkins. (2016) Oxidative stress-related biomarkers in multiple sclerosis: a review. Biomarkers in Medicine 10:8, pages 889-902.
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Daniel Golan, Elsebeth Staun-Ram & Ariel Miller. (2016) Shifting paradigms in multiple sclerosis. Current Opinion in Neurology 29:3, pages 354-361.
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Ludwig Rasche, Lisa Heiserich, Janina Ruth Behrens, Klaus Lenz, Catherina Pfuhl, Katharina Wakonig, René Markus Gieß, Erik Freitag, Caroline Eberle, Jens Wuerfel, Jan Dörr, Peter Bauer, Judith Bellmann-Strobl, Friedemann Paul, Dirk Roggenbuck & Klemens Ruprecht. (2016) Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study. PLOS ONE 11:1, pages e0147968.
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Selvarasu Vaitheeshvaran & ManickamAgaath Hedina. (2016) Remarkable achievements in multiple sclerosis. Clinical and Translational Degenerative Diseases 1:2, pages 77.
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William J. Housley, David Pitt & David A. Hafler. (2015) Biomarkers in multiple sclerosis. Clinical Immunology 161:1, pages 51-58.
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Reza Khorooshi, Nasrin Asgari, Marlene Thorsen Mørch, Carsten Tue Berg & Trevor Owens. (2015) Hypersensitivity Responses in the Central Nervous System. Frontiers in Immunology 6.
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Helen Tremlett, Darlene L.Y. Dai, Zsuzsanna Hollander, Anita Kapanen, Tariq Aziz, Janet E. Wilson-McManus, Scott J. Tebbutt, Christoph H. Borchers, Joel Oger & Gabriela V. Cohen Freue. (2015) Serum proteomics in multiple sclerosis disease progression. Journal of Proteomics 118, pages 2-11.
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