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Expert Review of Clinical Immunology Volume 12, 2016 - Issue 2
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Editorials

Why, why, why de-lupus (does so badly in clinical trials)

David A IsenbergCentre for Rheumatology, Department of Medicine, University College London, London, UKCorrespondence[email protected]
&
Joan T MerrillClinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Pages 95-98 | Received 14 Sep 2015, Accepted 21 Oct 2015, Published online: 19 Jan 2016

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Jacqueline L. Paredes & Timothy B. Niewold. (2020) Type I interferon antagonists in clinical development for lupus. Expert Opinion on Investigational Drugs 29:9, pages 1025-1041.
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Farhana Muhammad Yusoff, Kah Keng Wong & Norhanani Mohd Redzwan. (2020) Th1, Th2, and Th17 cytokines in systemic lupus erythematosus. Autoimmunity 53:1, pages 8-20.
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Zdenka Hruskova & Vladimir Tesar. (2018) Lessons learned from the failure of several recent trials with biologic treatment in systemic lupus erythematosus. Expert Opinion on Biological Therapy 18:9, pages 989-996.
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Pedro Mota, Venkat Reddy & David Isenberg. (2017) Improving B-cell depletion in systemic lupus erythematosus and rheumatoid arthritis. Expert Review of Clinical Immunology 13:7, pages 667-676.
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Vladimir Tesar & Zdenka Hruskova. (2017) Belimumab in the management of systemic lupus erythematosus – an update. Expert Opinion on Biological Therapy 17:7, pages 901-908.
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Massimo Radin, Irene Cecchi, Karen Schreiber, Simone Baldovino, Daniela Rossi, Elisa Menegatti, Dario Roccatello & Savino Sciascia. (2017) Immunotherapies in phase II and III trials for the treatment of systemic lupus erythematosus. Expert Opinion on Orphan Drugs 5:1, pages 55-69.
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Articles from other publishers (12)

Joan T. Merrill, Joel Guthridge, Miles Smith, Joshua June, Fotios Koumpouras, Wambui Machua, Anca Askanase, Arezou Khosroshahi, Saira Z. Sheikh, Gaurav Rathi, Bart Burington, Paul Foster, Mark Matijevic, Sujata Arora, Xiaodong Wang, Minggeng Gao, Stephen Wax, Judith A. James & Debra J. Zack. (2023) Obexelimab in Systemic Lupus Erythematosus With Exploration of Response Based on Gene Pathway Co‐Expression Patterns: A Double‐Blind , Randomized, Placebo‐Controlled , Phase 2 Trial . Arthritis & Rheumatology 75:12, pages 2185-2194.
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Chandra Mohan, Ting Zhang & Chaim Putterman. (2023) Pathogenic cellular and molecular mediators in lupus nephritis. Nature Reviews Nephrology 19:8, pages 491-508.
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Fulvia Ceccarelli, Francesco Natalucci, Licia Picciariello, Claudia Ciancarella, Giulio Dolcini, Angelica Gattamelata, Cristiano Alessandri & Fabrizio Conti. (2023) Application of Machine Learning Models in Systemic Lupus Erythematosus. International Journal of Molecular Sciences 24:5, pages 4514.
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Maud Tusseau & Alexandre Belot. (2022) “P2RY8-son” break of tolerance promotes SLE. Journal of Experimental Medicine 219:1.
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George A. Robinson, Junjie Peng, Ines Pineda-Torra, Coziana Ciurtin & Elizabeth C. Jury. (2021) Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk. Metabolites 12:1, pages 3.
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Rishi R. Goel, Sergei V. Kotenko & Mariana J. Kaplan. (2021) Interferon lambda in inflammation and autoimmune rheumatic diseases. Nature Reviews Rheumatology 17:6, pages 349-362.
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George A. Robinson, Kirsty E. Waddington, Leda Coelewij, Junjie Peng, Meena Naja, Chris Wincup, Anna Radziszewska, Hannah Peckham, David A. Isenberg, Yiannis Ioannou, Coziana Ciurtin, Ines Pineda-Torra & Elizabeth C. Jury. (2021) Increased apolipoprotein-B:A1 ratio predicts cardiometabolic risk in patients with juvenile onset SLE. EBioMedicine 65, pages 103243.
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Konstantinos Tselios, Laura Wakani, Dafna D Gladman, Jiandong Su & Murray B Urowitz. (2021) Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic review and pooled analysis. Rheumatology 60:1, pages 73-80.
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S. K. Solovyev, E. A. Aseeva, T. V. Popkova, A. M. Lila, V. I. Mazurov & E. L. Nasonov. (2020) Systemic lupus erythematosus: new horizons for diagnosis and therapy. Rheumatology Science and Practice 58:1, pages 5-14.
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E L. Nasonov, T. V. Beketova, L. P. Ananyeva, V. I. Vasilyev, S. K. Solovyev & A. S. Avdeeva. (2019) PROSPECTS FOR ANTI-B-CELL THERAPY IN IMMUNO-INFLAMMATORY RHEUMATIC DISEASES. Rheumatology Science and Practice 57, pages 1-40.
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Alexis Jones, Patrick Muller, Caroline J Dore, Felicia Ikeji, Emilia Caverly, Kashfia Chowdhury, David A Isenberg, Caroline Gordon & Michael R Ehrenstein. (2019) Belimumab after B cell depletion therapy in patients with systemic lupus erythematosus (BEAT Lupus) protocol: a prospective multicentre, double-blind, randomised, placebo-controlled, 52-week phase II clinical trial. BMJ Open 9:12, pages e032569.
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Robert I. Fox & Carla M. Fox. (2016) Sj?gren Syndrome. Rheumatic Disease Clinics of North America 42:3, pages 519-530.
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