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Metformin in the treatment of non-alcoholic fatty liver disease: safety, efficacy and mechanism

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Mina Zare, Ghodratollah Panahi, Mehdi Koushki, Zohreh Mostafavi-Pour & Reza Meshkani. (2022) Metformin reduces lipid accumulation in HepG2 cells via downregulation of miR-33b. Archives of Physiology and Biochemistry 128:2, pages 333-340.
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Sara Ezazi-Toroghi, Sana Abdul-Jabbar Ali, Dmitry Olegovich Bokov, Maryam Dareini, Malihe Bahadori, Parisa Mokaberi, Zeinab Amiri-Tehranizadeh, Mohammad Reza Saberi & Jamshidkhan Chamani. (2022) Interaction behavior between glycated human serum albumin and metformin in the presence of silver nanoparticles: a combination study of spectroscopic, calorimetric and molecular dynamic. Journal of the Iranian Chemical Society 19:12, pages 4569-4588.
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Jiayao Feng, Shuting Qiu, Shipeng Zhou, Yue Tan, Yan Bai, Hua Cao, Jiao Guo & Zhengquan Su. (2022) mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences 23:16, pages 9196.
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Wenjing Liao, Suyu Liu, Yunxi Chen, Yashuai Kong, Dongxu Wang, Yijun Wang, Tiejun Ling, Zhongwen Xie, Irada Khalilova & Jinbao Huang. (2022) Effects of Keemun and Dianhong Black Tea in Alleviating Excess Lipid Accumulation in the Liver of Obese Mice: A Comparative Study. Frontiers in Nutrition 9.
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Tao-tao Zhang, Yong Wang, Xiang-wen Zhang, Ke-yu Yang, Xiu-qin Miao & Guo-hua Zhao. (2022) MiR-200c-3p Regulates DUSP1/MAPK Pathway in the Nonalcoholic Fatty Liver After Laparoscopic Sleeve Gastrectomy. Frontiers in Endocrinology 13.
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Carlo Smirne, Eleonora Croce, Davide Di Benedetto, Vincenzo Cantaluppi, Cristoforo Comi, Pier Paolo Sainaghi, Rosalba Minisini, Elena Grossini & Mario Pirisi. (2022) Oxidative Stress in Non-Alcoholic Fatty Liver Disease. Livers 2:1, pages 30-76.
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Arezoo Gowhari Shabgah, Fatemeh Norouzi, Mahdiyeh Hedayati-Moghadam, Davood Soleimani, Naseh Pahlavani & Jamshid Gholizadeh Navashenaq. (2021) A comprehensive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease. Nutrition & Metabolism 18:1.
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Bo Shen & Lun Gen Lu. (2021) Efficacy and safety of drugs for nonalcoholic steatohepatitis. Journal of Digestive Diseases 22:2, pages 72-82.
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Johanna C. Arroyave-Ospina, Zongmei Wu, Yana Geng & Han Moshage. (2021) Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy. Antioxidants 10:2, pages 174.
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Nada Saewanee, Theethawat Praputpittaya, Nawaphat Malaiwong, Pawanrat Chalorak & Krai Meemon. (2021) Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson’s disease. Neuroscience Research 162, pages 13-21.
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Chukwuebuka H. Ozoude, Chukwuemeka P. Azubuike, Modupe O. Ologunagba, Sejoro S. Tonuewa & Cecilia I. Igwilo. (2020) Formulation and development of metformin-loaded microspheres using Khaya senegalensis (Meliaceae) gum as co-polymer. Future Journal of Pharmaceutical Sciences 6:1.
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Kun Xie, Xi He, Keyu Chen, Kozue Sakao & De-Xing Hou. (2020) Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. Food & Function 11:7, pages 5976-5991.
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Minjuan Ma, Rui Duan, Lulu Shen, Mengting Liu, Yaya Ji, Hao Zhou, Changxian Li, Tingming Liang, Xiangcheng Li & Li Guo. (2020) The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice. Journal of Lipid Research 61:7, pages 1052-1064.
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Xiaodan Lv, Yongqiang Dong, Lingling Hu, Feiyu Lu, Changyu Zhou & Shaoyou Qin. (2020) Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) for the management of nonalcoholic fatty liver disease (NAFLD): A systematic review. Endocrinology, Diabetes & Metabolism 3:3.
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P. O. Bogomolov, A. O. Bueverov, A. V. Dreval, O. A. Nechaeva, A. Yu. Mayorov, E. E. Mishina, E. A. Fedosina, S. V. Koblov, O. V. Sumtsova, A. Jallow, D. A. Dubrovina, E. A. Troshina, K. A. Komshilova, M. V. Arapova, N. G. Vacheishvili & E. O. Liusina. (2020) Preliminary results of dulaglutide treatment in patients with non-alcoholic fatty liver disease (DEMOS study). Experimental and Clinical Gastroenterology:9, pages 4-10.
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Seon Ju Mun, Jae-Sung Ryu, Mi-Ok Lee, Ye Seul Son, Soo Jin Oh, Hyun-Soo Cho, Mi-Young Son, Dae-Soo Kim, Su Jung Kim, Hyun Ju Yoo, Ho-Joon Lee, Janghwan Kim, Cho-Rok Jung, Kyung-Sook Chung & Myung Jin Son. (2019) Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids. Journal of Hepatology 71:5, pages 970-985.
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Wenjia Yang, Xiaoling Cai, Haiya Wu & Linong Ji. (2019) Associations between metformin use and vitamin B 12 levels, anemia, and neuropathy in patients with diabetes: a meta‐analysis . Journal of Diabetes 11:9, pages 729-743.
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Yong-li Li, Xiang-qian Li, Ya-dong Wang, Chuan Shen & Cai-yan Zhao. (2019) Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo. Biochemical and Biophysical Research Communications 513:1, pages 64-72.
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Eric P. Stahl, Devinder S. Dhindsa, Suegene K. Lee, Pratik B. Sandesara, Naga P. Chalasani & Laurence S. Sperling. (2019) Nonalcoholic Fatty Liver Disease and the Heart. Journal of the American College of Cardiology 73:8, pages 948-963.
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Xiaopeng Zhu, Hongmei Yan, Mingfeng Xia, Xinxia Chang, Xi Xu, Liu Wang, Xiaoyang Sun, Yan Lu, Hua Bian, Xiaoying Li & Xin Gao. (2018) Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression. Lipids in Health and Disease 17:1.
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Qiao Wu, Juan Liu, Lijin Liu, Yu Chen, Jie Wang, Ling Leng, Qunfang Yu, Zhongping Duan & Yunfang Wang. (2018) Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver. ACS Biomaterials Science & Engineering 4:8, pages 3016-3026.
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Giulio Calza, Elisabeth Nyberg, Matias Mäkinen, Rabah Soliymani, Annunziata Cascone, Dan Lindholm, Emanuele Barborini, Marc Baumann, Maciej Lalowski & Ove Eriksson. (2018) Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver. Frontiers in Pharmacology 9.
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Kunal Maniar, Amal Moideen, Ankur Mittal, Amol Patil, Amitava Chakrabarti & Dibyajyoti Banerjee. (2017) A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?. Pharmacological Research 117, pages 103-128.
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Rong Zhang, Keran Cheng, Shizan Xu, Sainan Li, Yuqing Zhou, Shunfeng Zhou, Rui Kong, Linqiang Li, Jingjing Li, Jiao Feng, Liwei Wu, Tong Liu, Yujing Xia, Jie Lu, Chuanyong Guo & Yingqun Zhou. (2017) Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Gastroenterology Research and Practice 2017, pages 1-11.
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QUELSON COELHO LISBOA, SILVIA MARINHO FEROLLA COSTA & CLÁUDIA ALVES COUTO. (2016) Current management of non-alcoholic fatty liver disease. Revista da Associação Médica Brasileira 62:9, pages 872-878.
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Niki Katsiki, Dimitri P. Mikhailidis & Christos S. Mantzoros. (2016) Non-alcoholic fatty liver disease and dyslipidemia: An update. Metabolism 65:8, pages 1109-1123.
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Amedeo Lonardo, Silvia Sookoian, Carlos J. Pirola & Giovanni Targher. (2016) Non-alcoholic fatty liver disease and risk of cardiovascular disease. Metabolism 65:8, pages 1136-1150.
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Peiqiu Cao, Guidong Huang, Qingyun Yang, Jiao Guo & Zhengquan Su. (2016) The effect of chitooligosaccharides on oleic acid-induced lipid accumulation in HepG 2 cells. Saudi Pharmaceutical Journal 24:3, pages 292-298.
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Byung-Hak Kim, Songhee Han, Haeri Lee, Chi Hye Park, Young Mee Chung, Kyungmin Shin, Hyun Gyu Lee & Sang-Kyu Ye. (2015) Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling. Biochemical and Biophysical Research Communications 456:1, pages 173-178.
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Ludovico Abenavoli, Valentina Peta & Natasa Milic. (2015) Lifestyle changes associated with a new antioxidant formulation in non-alcoholic fatty liver disease: a case series. Annals of Hepatology 14:1, pages 121-126.
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