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Targeting the KRAS variant for treatment of non-small cell lung cancer: potential therapeutic applications

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Yan Liu, Hui Li, Jing Zhu, Yang Zhang, Xianhong Liu, Rixin Li, Qiang Zhang & Ying Cheng. (2021) The Prevalence and Concurrent Pathogenic Mutations of KRAS in Northeast Chinese Non-small-cell Lung Cancer Patients. Cancer Management and Research 13, pages 2447-2454.
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Hai-bo Shen, Jie Li, Yuan-shan Yao, Zhen-hua Yang, Yin-jie Zhou, Wei Chen & Tian-jun Hu. (2020) Impact of Somatic Mutations in Non-Small-Cell Lung Cancer: A Retrospective Study of a Chinese Cohort. Cancer Management and Research 12, pages 7427-7437.
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Kamya Sankar, Shirish M Gadgeel & Angel Qin. (2020) Molecular therapeutic targets in non-small cell lung cancer. Expert Review of Anticancer Therapy 20:8, pages 647-661.
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Daniel Massó-Vallés, Marie-Eve Beaulieu & Laura Soucek. (2020) MYC, MYCL, and MYCN as therapeutic targets in lung cancer. Expert Opinion on Therapeutic Targets 24:2, pages 101-114.
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Anneloes L. Noordhof, Esther M. Swart, Ronald A.M. Damhuis, Lizza E.L. Hendriks, Peter W.A. Kunst, Mieke J. Aarts & Wouter H. van Geffen. (2023) Prognostic Implication of KRAS G12C Mutation in a Real-World KRAS-Mutated Stage IV NSCLC Cohort Treated With Immunotherapy in The Netherlands. JTO Clinical and Research Reports 4:9, pages 100543.
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Jhanelle E. Gray, Hil Hsu, Diana Younan, Gaurav Suri, Victoria Chia, Alexander Spira & Melissa Johnson. (2023) Real-world outcomes in patients with KRAS G12C–mutated advanced non-small cell lung cancer treated with docetaxel in second-line or beyond. Lung Cancer 181, pages 107260.
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Man Wang, Lijie Zhu, Xiaoxu Yang, Jiahui Li, Yu’e Liu & Ying Tang. (2023) Targeting immune cell types of tumor microenvironment to overcome resistance to PD-1/PD-L1 blockade in lung cancer. Frontiers in Pharmacology 14.
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Daqi Jia, Leilei Li, Peng Wang, Qiang Feng, Xinyan Pan, Peng Lin, Shuling Song, Lilin Yang & Julun Yang. (2022) ZNF24 regulates the progression of KRAS mutant lung adenocarcinoma by promoting SLC7A5 translation. Frontiers in Oncology 12.
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Jeffrey Mathew Boby, Nurul Nadia Mohd Ghazali, Anita Mani & Mathew George. (2022) Complete response to nivolumab in Kirsten rat sarcoma virus oncogene KRAS-G12C mutant metastatic lung adenocarcinoma: a case report. Journal of Medical Case Reports 16:1.
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Yifan Kong, Derek B. Allison, Qiongsi ZhangDaheng HeYuntong LiFengyi MaoChaohao LiZhiguo LiYanquan Zhang, Jianlin WangChi Wang, Christine F. Brainson & Xiaoqi Liu. (2022) The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET . Science Signaling 15:754.
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Adelina Plangger, Barbara Rath, Sandra Stickler, Maximilian Hochmair, Clemens Lang, Lukas Weigl, Martin Funovics & Gerhard Hamilton. (2022) Cytotoxicity of combinations of the pan-KRAS SOS1 inhibitor BAY-293 against pancreatic cancer cell lines. Discover Oncology 13:1.
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Serena Ceddia, Lorenza Landi & Federico Cappuzzo. (2022) KRAS-Mutant Non-Small-Cell Lung Cancer: From Past Efforts to Future Challenges. International Journal of Molecular Sciences 23:16, pages 9391.
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Manuela Spinelli, Persephone Du Parcq, Nandita Gupta, Jamshid Khorashad & Patrizia Viola. (2022) Coexistence of two missense mutations in the KRAS gene in adenocarcinoma of the lung: a possible indicator of poor prognosis. Pathologica 114:3, pages 221-227.
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Jiaqi Liang, Guoshu Bi, Guangyao Shan, Xing Jin, Yunyi Bian & Qun Wang. (2022) Tumor-Associated Regulatory T Cells in Non-Small-Cell Lung Cancer: Current Advances and Future Perspectives. Journal of Immunology Research 2022, pages 1-8.
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Jing Han, Yang Liu, Sen Yang, Xuan Wu, Hongle Li & Qiming Wang. (2021) MEK inhibitors for the treatment of non-small cell lung cancer. Journal of Hematology & Oncology 14:1.
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Adelina Plangger, Barbara Rath, Maximilian Hochmair, Martin Funovics & Gerhard Hamilton. (2021) Cytotoxicity of combinations of the pan-KRAS inhibitor BAY-293 against primary non-small lung cancer cells. Translational Oncology 14:12, pages 101230.
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A.L. Noordhof, R.A.M. Damhuis, L.E.L. Hendriks, A.J. de Langen, W. Timens, B.J.W. Venmans & W.H. van Geffen. (2021) Prognostic impact of KRAS mutation status for patients with stage IV adenocarcinoma of the lung treated with first-line pembrolizumab monotherapy. Lung Cancer 155, pages 163-169.
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Giorgia Maroni, Mahmoud A. Bassal, Indira Krishnan, Chee Wai Fhu, Virginia Savova, Rapolas Zilionis, Valerie A. Maymi, Nicole Pandell, Eva Csizmadia, Junyan Zhang, Barbara Storti, Julio Castaño, Riccardo Panella, Jia Li, Corinne E. Gustafson, Sam Fox, Rachel D. Levy, Claire V. Meyerovitz, Peter J. Tramontozzi, Kimberly Vermilya, Assunta De Rienzo, Stefania Crucitta, Daniela S. Bassères, Marla Weetall, Art Branstrom, Alessandra Giorgetti, Raffaele Ciampi, Marzia Del Re, Romano Danesi, Ranieri Bizzarri, Henry Yang, Olivier Kocher, Allon M. Klein, Robert S. Welner, Raphael Bueno, Maria Cristina Magli, John G. Clohessy, Azhar Ali, Daniel G. Tenen & Elena Levantini. (2021) Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. Communications Biology 4:1.
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Kyaw Z. TheinAmadeo B. BiterDavid S. Hong. (2021) Therapeutics Targeting Mutant KRAS. Annual Review of Medicine 72:1, pages 349-364.
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Jing Zheng, Lisha Shen, Nan Jiang, Yanping Zhu, Lihua Wu, He Cao, Wenjia Sun, Jianya Zhou & Jianying Zhou. (2020) First-in-Human Phase 1 Study of ES-072, an Oral Mutant-Selective EGFR T790M Inhibitor, in Non–Small-Cell Lung Cancer. Clinical Lung Cancer 21:6, pages 509-519.e1.
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Pilar Garrido, María Eugenia Olmedo, Ana Gómez, Luis Paz Ares, Fernando López-Ríos, Juan Manuel Rosa-Rosa & José Palacios. (2017) Treating KRAS -mutant NSCLC: latest evidence and clinical consequences . Therapeutic Advances in Medical Oncology 9:9, pages 589-597.
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