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Review

Pharmacological treatment of refractory breathlessness

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Pages 21-36 | Published online: 09 Jan 2014

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Read on this site (4)

N. Lovell, A Wilcock, S Bajwah, S. N. Etkind, C. J. Jolley, M Maddocks & I. J. Higginson. (2019) Mirtazapine for chronic breathlessness? A review of mechanistic insights and therapeutic potential. Expert Review of Respiratory Medicine 13:2, pages 173-180.
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Denis E. O’Donnell, Katherine A. Webb, Ingrid Harle & J. Alberto Neder. (2016) Pharmacological management of breathlessness in COPD: recent advances and hopes for the future. Expert Review of Respiratory Medicine 10:7, pages 823-834.
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Miriam J Johnson, David C Currow & Sara Booth. (2014) Prevalence and assessment of breathlessness in the clinical setting. Expert Review of Respiratory Medicine 8:2, pages 151-161.
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Donald A Mahler. (2013) Opioids for refractory dyspnea. Expert Review of Respiratory Medicine 7:2, pages 123-135.
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Articles from other publishers (37)

Deokhee Yi, Charles C Reilly, Gao Wei & Irene J Higginson. (2023) Optimising breathlessness triggered services for older people with advanced diseases: a multicentre economic study (OPTBreathe). Thorax 78:5, pages 489-495.
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Rachelle Aucoin, Hayley Lewthwaite, Magnus Ekström, Andreas von Leupoldt & Dennis Jensen. (2023) Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness. Respiratory Physiology & Neurobiology 311, pages 104036.
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Irene J. Higginson, Charles C. Reilly & Matthew Maddocks. 2021. Palliative Care in Lung Disease. Palliative Care in Lung Disease 89 113 .
Nishant Jaiswal, Meenu Singh, Amit Agarwal, Anil Chauhan & Nikita Jaiswal. (2020) Palliative drug treatments for breathlessness in cystic fibrosis. Cochrane Database of Systematic Reviews.
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Nesrine Kallel, Ilhem Yangui, Walid Feki, Hajeur Ayedi & Samy Kammoun. (2020) Place des opiacés dans le traitement de la dyspnée en soins palliatifs. Médecine Palliative 19:2, pages 114-120.
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Natasha Lovell, Simon Noah Etkind, Sabrina Bajwah, Matthew Maddocks & Irene Julie Higginson. (2019) To What Extent Do the NRS and CRQ Capture Change in Patients' Experience of Breathlessness in Advanced Disease? Findings From a Mixed-Methods Double-Blind Randomized Feasibility Trial. Journal of Pain and Symptom Management 58:3, pages 369-381.e7.
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Matthew Maddocks, Lisa Jane Brighton, Morag Farquhar, Sara Booth, Sophie Miller, Lara Klass, India Tunnard, Deokhee Yi, Wei Gao, Sabrina Bajwah, William D-C Man & Irene J Higginson. (2019) Holistic services for people with advanced disease and chronic or refractory breathlessness: a mixed-methods evidence synthesis. Health Services and Delivery Research 7:22, pages 1-104.
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Joanna C. Grogono, Clare Butler, Hooshang Izadi & Shakeeb H. Moosavi. (2018) Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trial. Respiratory Research 19:1.
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G. Skopp. (2017) Medikamente und toxische Substanzen in der SterbehilfePharmaceutical and toxic substances in euthanasia. Rechtsmedizin 28:2, pages 98-103.
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Nishant Jaiswal, Meenu Singh, Amit Agarwal & Kiran K Thumburu. (2017) Palliative drug treatments for breathlessness in cystic fibrosis. Cochrane Database of Systematic Reviews.
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David Currow, Gareth John Watts, Miriam Johnson, Christine F McDonald, John O Miners, Andrew A Somogyi, Linda Denehy, Nicola McCaffrey, Danny J Eckert, Philip McCloud, Sandra Louw, Lawrence Lam, Aine Greene, Belinda Fazekas, Katherine C Clark, Kwun Fong, Meera R Agar, Rohit Joshi, Sharon Kilbreath, Diana Ferreira & Magnus Ekström. (2017) A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol. BMJ Open 7:7, pages e018100.
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Miriam J. Johnson, Janelle Yorke, John Hansen-Flaschen, Robert Lansing, Magnus Ekström, Thomas Similowski & David C. Currow. (2017) Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness. European Respiratory Journal 49:5, pages 1602277.
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Claudia Bausewein. (2017) Palliative Therapie der Atemnot bei fortgeschrittenen ErkrankungenManagement of refractory breathlessness in patients with advanced disease. Wiener klinisches Magazin 20:1, pages 30-34.
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Steffen T. Simon, Marianne Kloke, Bernd Alt-Epping, Jan Gärtner, Martin Hellmich, Rebecca Hein, Maren Piel, Oliver A. Cornely, Friedemann Nauck & Raymond Voltz. (2016) EffenDys—Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Patients With Advanced Cancer: A Multicenter, Open-Label, Randomized, Morphine-Controlled, Crossover, Phase II Trial. Journal of Pain and Symptom Management 52:5, pages 617-625.
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Alexander K. Smith, David C. Currow, Amy P. Abernethy, Miriam J. Johnson, Yinghui Miao, W. John Boscardin & Christine S. Ritchie. (2016) Prevalence and Outcomes of Breathlessness in Older Adults: A National Population Study. Journal of the American Geriatrics Society 64:10, pages 2035-2041.
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C. Bausewein. (2016) Palliative Therapie der Atemnot bei fortgeschrittenen ErkrankungenManagement of refractory breathlessness in patients with advanced disease. Der Internist 57:10, pages 978-982.
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Richella Ryan, Anna Spathis, Angela Clow & Sara Booth. (2016) Breathlessness and inflammation: potential relationships and implications. Current Opinion in Supportive & Palliative Care 10:3, pages 242-248.
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Sara Booth, Sarah Galbraith, Richella Ryan, Richard A Parker & Miriam Johnson. (2015) The importance of the feasibility study: Lessons from a study of the hand-held fan used to relieve dyspnea in people who are breathless at rest. Palliative Medicine 30:5, pages 504-509.
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Miriam J Johnson, Mona Kanaan, Gerry Richardson, Samantha Nabb, David Torgerson, Anne English, Rachael Barton & Sara Booth. (2015) A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease. BMC Medicine 13:1.
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Eric E. Prommer. (2015) Palliative Pharmacotherapy: State-of-the-Art Management of Symptoms in Patients with Cancer. Cancer Control 22:4, pages 403-411.
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Nishant Jaiswal, Meenu Singh, Amit Agarwal & Kiran K Thumburu. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Vera Weingärtner, Christine Scheve, Verena Gerdes, Michael Schwarz-Eywill, Regina Prenzel, Burkhard Otremba, Juliane Mühlenbrock, Claudia Bausewein, Irene J Higginson, Raymond Voltz, Lena Herich & Steffen T Simon. (2015) Characteristics of episodic breathlessness as reported by patients with advanced chronic obstructive pulmonary disease and lung cancer: Results of a descriptive cohort study. Palliative Medicine 29:5, pages 420-428.
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Christine Dunger, Irene J. Higginson, Marjolein Gysels, Sara Booth, Steffen T. Simon & Claudia Bausewein. (2014) Breathlessness and crises in the context of advanced illness: A comparison between COPD and lung cancer patients. Palliative and Supportive Care 13:2, pages 229-237.
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Emma Loveman, Vicky R Copley, Jill Colquitt, David A Scott, Andy Clegg, Jeremy Jones, Katherine MA O’Reilly, Sally Singh, Claudia Bausewein & Athol Wells. (2015) The clinical effectiveness and cost-effectiveness of treatments for idiopathic pulmonary fibrosis: a systematic review and economic evaluation. Health Technology Assessment 19:20, pages 1-336.
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Jackelyn Y. BoydenStephen R. ConnorLily OtolorinSteven D. NathanPerry G. FineMalene S. DavisJ. Cameron Muir. (2015) Nebulized Medications for the Treatment of Dyspnea: A Literature Review. Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:1, pages 1-19.
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Vera Weingaertner, Christine Scheve, Verena Gerdes, Michael Schwarz-Eywill, Regina Prenzel, Claudia Bausewein, Irene J. Higginson, Raymond Voltz, Lena Herich, Steffen T. Simon, Birgit Kannenberg-Otremba, Nicole Sowinsky, Burkhard Otremba, Alexander Jüptner, Jochen Meyer, Julia Cortis, Juliane Mühlenbrock, Andreas Wagner-Neidig, Andreas Hein, Dietmar Reichert, Marion Jessen, Melina Frenken & Thomas Frenken. (2014) Breathlessness, Functional Status, Distress, and Palliative Care Needs Over Time in Patients With Advanced Chronic Obstructive Pulmonary Disease or Lung Cancer: A Cohort Study. Journal of Pain and Symptom Management 48:4, pages 569-581.e1.
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Kyle T.S. Pattinson & Miriam J. Johnson. (2014) Neuroimaging of central breathlessness mechanisms. Current Opinion in Supportive & Palliative Care 8:3, pages 225-233.
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Hana Müllerová, Chao Lu, Hao Li & Maggie Tabberer. (2014) Prevalence and Burden of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease Managed in Primary Care. PLoS ONE 9:1, pages e85540.
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David C Currow, Irene J Higginson & Miriam J Johnson. (2013) Breathlessness – current and emerging mechanisms, measurement and management: A discussion from an European Association of Palliative Care workshop. Palliative Medicine 27:10, pages 932-938.
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Steffen T. Simon, Peyla Köskeroglu, Jan Gaertner & Raymond Voltz. (2013) Fentanyl for the Relief of Refractory Breathlessness: A Systematic Review. Journal of Pain and Symptom Management 46:6, pages 874-886.
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Rolando Grave de Peralta, Sara Gonzalez Andino & Stephen Perrig. (2013) Patient Machine Interface for the Control of Mechanical Ventilation Devices. Brain Sciences 3:4, pages 1554-1568.
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Huong Q. Nguyen, DorAnne Donesky, Lynn F. Reinke, Seth Wolpin, Lawrence Chyall, Joshua O. Benditt, Steven M. Paul & Virginia Carrieri-Kohlman. (2013) Internet-Based Dyspnea Self-Management Support for Patients With Chronic Obstructive Pulmonary Disease. Journal of Pain and Symptom Management 46:1, pages 43-55.
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Robert Horton & Graeme Rocker. 2013. Evidence-Based Practice in Palliative Medicine. Evidence-Based Practice in Palliative Medicine 111 119 .
Chris D Bailey, Richard Wagland, Rasha Dabbour, Ann Caress, Jaclyn Smith & Alex Molassiotis. (2010) An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses. BMC Pulmonary Medicine 10:1.
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Yvonne CartwrightSara Booth. (2010) Extending palliative care to patients with respiratory disease. British Journal of Hospital Medicine 71:1, pages 16-20.
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Steffen T. Simon & Claudia Bausewein. (2009) Management of refractory breathlessness in patients with advanced cancerBehandlung der therapierefraktären Atemnot bei Patienten mit fortgeschrittenen Tumorerkrankungen. Wiener Medizinische Wochenschrift 159:23-24, pages 591-598.
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Deokhee Yi, Charles Reilly, Wei Gao & Irene Higginson. (2021) Better Breathlessness Services for Older People with Advanced Diseases: A Multicentre Discrete Choice Experiment and Economic Modelling (OPRBreathe). SSRN Electronic Journal.
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