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Review

An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma

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Pages 375-386 | Published online: 10 Jan 2014

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Hila Yousefi, Jianda Yuan, Mahsa Keshavarz-Fathi, Joseph F Murphy & Nima Rezaei. (2017) Immunotherapy of cancers comes of age. Expert Review of Clinical Immunology 13:10, pages 1001-1015.
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Carter M Suryadevara, Patrick C Gedeon, Luis Sanchez-Perez, Terence Verla, Christopher Alvarez-Breckenridge, Bryan D Choi, Peter E Fecci & John H Sampson. (2015) Are BiTEs the “missing link” in cancer therapy?. OncoImmunology 4:6.
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Bryan D Choi, Patrick C Gedeon, Luis Sanchez-Perez, Darell D Bigner & John H Sampson. (2013) Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. OncoImmunology 2:12.
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Articles from other publishers (17)

Xiaohan Guo, Yi Wu, Ying Xue, Na Xie & Guobo Shen. (2023) Revolutionizing cancer immunotherapy: unleashing the potential of bispecific antibodies for targeted treatment. Frontiers in Immunology 14.
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Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O’Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang & David B. Weiner. (2022) A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy. JCI Insight 7:22.
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Gabriele Hintzen, Holger J. Dulat & Erich Rajkovic. (2022) Engaging innate immunity for targeting the epidermal growth factor receptor: Therapeutic options leveraging innate immunity versus adaptive immunity versus inhibition of signaling. Frontiers in Oncology 12.
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Shuhang Wang, Kun Chen, Qi Lei, Peiwen Ma, Andy Qingan Yuan, Yong Zhao, Youwei Jiang, Hong Fang, Shujun Xing, Yuan Fang, Ning Jiang, Huilei Miao, Minghui Zhang, Shujun Sun, Zicheng Yu, Wei Tao, Qi Zhu, Yingjie Nie & Ning Li. (2021) The state of the art of bispecific antibodies for treating human malignancies. EMBO Molecular Medicine 13:9.
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Rui Sun, Yuexian Zhou, Lei Han, Zhidi Pan, Jie Chen, Huifang Zong, Yanlin Bian, Hua Jiang, Baohong Zhang & Jianwei Zhu. (2021) A Rational Designed Novel Bispecific Antibody for the Treatment of GBM. Biomedicines 9:6, pages 640.
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Fiona A. Desland & Adília Hormigo. (2020) The CNS and the Brain Tumor Microenvironment: Implications for Glioblastoma Immunotherapy. International Journal of Molecular Sciences 21:19, pages 7358.
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David S Kim. (2020) Cancer stem cell plasticity in glioblastoma multiforme: a perspective on future directions in oncolytic virotherapy. Future Oncology 16:28, pages 2251-2264.
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Karie Runcie, Daniel R. Budman, Veena John & Nagashree Seetharamu. (2018) Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics. Molecular Medicine 24:1.
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Yingying Wang & Yongjie Tian. (2018) miR-206 Inhibits Cell Proliferation, Migration, and Invasion by Targeting BAG3 in Human Cervical Cancer. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26:6, pages 923-931.
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Kristen A. Batich, Alexa N. Bramall, Carter M. Suryadevara & John H. Sampson. 2018. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy 693 705 .
Dehua Li, Wei Shan, Yan Fang, Pan Wang & Jicheng Li. (2017) miR-137 acts as a tumor suppressor via inhibiting CXCL12 in human glioblastoma. Oncotarget 8:60, pages 101262-101270.
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Lucas A. Horn, Nicholas G. Ciavattone, Ryan Atkinson, Netsanet Woldergerima, Julia Wolf, Virginia K. Clements, Pratima Sinha, Munanchu Poudel & Suzanne Ostrand-Rosenberg. (2017) CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1+ tumor cells, and extends the survival of tumor-bearing humanized mice. Oncotarget 8:35, pages 57964-57980.
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Kristina Ellwanger, Uwe Reusch, Ivica Fucek, Stefan Knackmuss, Michael Weichel, Thorsten Gantke, Vera Molkenthin, Eugene A. Zhukovsky, Michael Tesar & Martin Treder. (2017) Highly Specific and Effective Targeting of EGFRvIII-Positive Tumors with TandAb Antibodies. Frontiers in Oncology 7.
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J.M. Redman, E.M. Hill, D. AlDeghaither & L.M. Weiner. (2015) Mechanisms of action of therapeutic antibodies for cancer. Molecular Immunology 67:2, pages 28-45.
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Heba Samaha, Shahenda El Naggar & Nabil Ahmed. (2015) Armed hunter killers: discerning the role of adoptive T-cell transfer for glioblastoma. Immunotherapy 7:5, pages 481-485.
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John H. Rossmeisl. (2014) New Treatment Modalities for Brain Tumors in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 44:6, pages 1013-1038.
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Patrick C. Gedeon, Katherine A. Riccione, Peter E. Fecci & John H. Sampson. (2014) Antibody-Based Immunotherapy for Malignant Glioma. Seminars in Oncology 41:4, pages 496-510.
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