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Expert Review of Clinical Pharmacology Volume 6, 2013 - Issue 4
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Drug Profile

Dimethyl fumarate (BG-12) for the treatment of multiple sclerosis

Martin Stangel Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neubert-Str. 1, 30625 Hannover, Germany. [email protected]; Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neubert-Str. 1, 30625 Hannover, Germany. [email protected]
&
Ralf A Linker Department of Neurology, Friedrich-Alexander University, Erlangen, Germany; Department of Neurology, Friedrich-Alexander University, Erlangen, Germany
Pages 355-362 | Published online: 10 Jan 2014

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Bifeng Gao, An Doan & Brooks M Hybertson. (2014) The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clinical Pharmacology: Advances and Applications 6, pages 19-34.
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Clara Herrera-Arozamena, Martín Estrada-Valencia, Patricia López-Caballero, Concepción Pérez, José A. Morales-García, Ana Pérez-Castillo, Eric del Sastre, Cristina Fernández-Mendívil, Pablo Duarte, Patrycja Michalska, José Lombardía, Sergio Senar, Rafael León, Manuela G. López & María Isabel Rodríguez-Franco. (2022) Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. Journal of Medicinal Chemistry 65:6, pages 4727-4751.
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Yuko Kinowaki, Towako Taguchi, Iichiroh Onishi, Susumu Kirimura, Masanobu Kitagawa & Kouhei Yamamoto. (2021) Overview of Ferroptosis and Synthetic Lethality Strategies. International Journal of Molecular Sciences 22:17, pages 9271.
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Rashi Singhal, Sreedhar R. Mitta, Nupur K. Das, Samuel A. Kerk, Peter Sajjakulnukit, Sumeet Solanki, Anthony Andren, Roshan Kumar, Kenneth P. Olive, Ruma Banerjee, Costas A. Lyssiotis & Yatrik M. Shah. (2021) HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. Journal of Clinical Investigation 131:12.
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Robert A. Freeborn & Cheryl E. Rockwell. 2021. Advances in Immunopharmacology. Advances in Immunopharmacology 61 110 .
Mahmood Hachim, Noha Elemam & Azzam Maghazachi. (2019) The Beneficial and Debilitating Effects of Environmental and Microbial Toxins, Drugs, Organic Solvents and Heavy Metals on the Onset and Progression of Multiple Sclerosis. Toxins 11:3, pages 147.
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Xingguo Zhu, Aluya R Oseghale, Lopez H Nicole, Biaoru Li & Betty S Pace. (2019) Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease. Experimental Biology and Medicine 244:2, pages 171-182.
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Rehab S. Abdelrahman & Noha Abdel-Rahman. (2019) Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2/HO-1 pathway. Life Sciences 217, pages 251-260.
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Chander K. Negi & Gopabandhu Jena. (2019) Nrf2, a novel molecular target to reduce type 1 diabetes associated secondary complications: The basic considerations. European Journal of Pharmacology 843, pages 12-26.
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Imam Pasha S, Murali Balaram Varanasi & Ibrahim Mohammed. (2017) Bioanalysis of monomethyl fumarate in human plasma by a sensitive and rapid LC–MS/MS method and its pharmacokinetic application. Journal of Pharmaceutical and Biomedical Analysis 146, pages 109-116.
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Diana L Vargas & William R Tyor. (2023) Update on Disease-Modifying Therapies for Multiple Sclerosis. Journal of Investigative Medicine 65:5, pages 883-891.
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Jun Wei, Hongyan Zhu, Gabriel Lord, Mitra Bhattachayya, Brielle M. Jones, Graham Allaway, Shyam S. Biswal, Benjamin Korman, Roberta G. Marangoni, Warren G. Tourtellotte & John Varga. (2017) Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative. Translational Research 183, pages 71-86.e1.
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Hiroshi Yukitake, Masayuki Takizawa & Haruhide Kimura. (2017) Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System. Oxidative Medicine and Cellular Longevity 2017, pages 1-6.
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Zaidoon Al-Jaderi & Azzam A. Maghazachi. (2016) Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases. Frontiers in Immunology 7.
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David A. Provenzano, Joseph R. Williams, Gaye Jarzabek, Leonard A. DeRiggi & Thomas F. Scott. (2016) Treatment of Neuropathic Pain and Functional Limitations Associated With Multiple Sclerosis Using an MRI-Compatible Spinal Cord Stimulator: A Case Report With Two Year Follow-Up and Literature Review. Neuromodulation: Technology at the Neural Interface 19:4, pages 406-413.
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Michael J. Van Kanegan, Denise E. Dunn, Linda S. Kaltenbach, Bijal Shah, Dong Ning He, Daniel D. McCoy, Peiying Yang, Jiangnan Peng, Li Shen, Lin Du, Robert H. Cichewicz, Robert A. Newman & Donald C. Lo. (2016) Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Scientific Reports 6:1.
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Alona Goldstein, Yoram Soroka, Marina Frušić-Zlotkin, Aaron Lewis & Ron Kohen. (2016) The bright side of plasmonic gold nanoparticles; activation of Nrf2, the cellular protective pathway. Nanoscale 8:22, pages 11748-11759.
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Ciric To, Carol S. Ringelberg, Darlene B. Royce, Charlotte R. Williams, Renee Risingsong, Michael B. Sporn & Karen T. Liby. (2015) Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis. Carcinogenesis 36:7, pages 769-781.
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B. M. Hybertson & B. Gao. (2014) Role of the Nrf2 signaling system in health and disease. Clinical Genetics 86:5, pages 447-452.
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Pooja Gopal & Thomas Dick. (2014) Reactive dirty fragments: implications for tuberculosis drug discovery. Current Opinion in Microbiology 21, pages 7-12.
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Oscar Fernandez. (2014) BG-12 (dimethyl fumarate) in the treatment of multiple sclerosis. Clinical Investigation 4:5, pages 441-451.
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Rafal M. Kaminski, Michael A. Rogawski & Henrik Klitgaard. (2014) The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments. Neurotherapeutics 11:2, pages 385-400.
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Michael Brenner & Albee Messing. 2014. Pathological Potential of Neuroglia. Pathological Potential of Neuroglia 89 105 .

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