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Novel therapeutic options for multiple sclerosis

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François Curtin, Hervé Perron, Arno Kromminga, Hervé Porchet & Alois B Lang. (2015) Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein. mAbs 7:1, pages 265-275.
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Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan & Pierre‐Antoine Gourraud. (2022) Multiple sclerosis clinical decision support system based on projection to reference datasets. Annals of Clinical and Translational Neurology 9:12, pages 1863-1873.
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Shayan Ali Irfan, Minha Murtaza, Ali Ahmed, Hina Altaf, Abid Anwar Ali, Naqiha Shabbir & Mirza Mehmood Ali Baig. (2022) Promising role of temelimab in multiple sclerosis treatment. Multiple Sclerosis and Related Disorders 61, pages 103743.
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Gabrielle Kornmann & François Curtin. (2020) Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Development Safety Review. Drug Safety 43:12, pages 1287-1296.
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Lu Wang, Hanyu Yang, Caixia Zang, Yi Dong, Junmei Shang, Jiajing Chen, Yue Wang, Hui Liu, Zihong Zhang, Heng Xu, Xiuqi Bao & Dan Zhang. (2020) CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis. Neurobiology of Disease 134, pages 104630.
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Mark S. Freedman, Daniel Selchen, Alexandre Prat & Paul S. Giacomini. (2018) Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45:5, pages 489-503.
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Ilona Shapira, Nina Fainstein, Maria Tsirlin, Ilana Stav, Evgenia Volinsky, Claudia Moresi, Tamir Ben-Hur & Raphael Gorodetsky. (2017) Placental Stromal Cell Therapy for Experimental Autoimmune Encephalomyelitis: The Role of Route of Cell Delivery. Stem Cells Translational Medicine 6:4, pages 1286-1294.
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Francois Curtin, Herve Porchet, Robert Glanzman, Hans Martin Schneble, Virginie Vidal, Marie-Laure Audoli-Inthavong, Estelle Lambert & Hans Peter Hartung. (2016) A placebo randomized controlled study to test the efficacy and safety of GNbAC1, a monoclonal antibody for the treatment of multiple sclerosis – Rationale and design. Multiple Sclerosis and Related Disorders 9, pages 95-100.
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Janos Groh, Hana C. Friedman, Nadiya Orel, Chi Wang Ip, Stefan Fischer, Irene Spahn, Erik Schäffner, Michaela Hörner, David Stadler, Mathias Buttmann, Csanad Varallyay, László Solymosi, Michael Sendtner, Alan C. Peterson & Rudolf Martini. (2016) Pathogenic inflammation in the CNS of mice carrying human PLP1 mutations . Human Molecular Genetics, pages ddw296.
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Bruce A.C. Cree & Hans-Peter Hartung. (2016) Steering through complexity. Current Opinion in Neurology 29:3, pages 263-271.
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Alexandra Madeira, Ingrid Burgelin, Hervé Perron, Francois Curtin, Alois B. Lang & Raphael Faucard. (2016) MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment. Journal of Neuroimmunology 291, pages 29-38.
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. (2015) MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—establishing disease prognosis and monitoring patients. Nature Reviews Neurology 11:10, pages 597-606.
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Beatrice Macchi, Francesca Marino-Merlo, Ugo Nocentini, Valerio Pisani, Salvatore Cuzzocrea, Sandro Grelli & Antonio Mastino. (2015) Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system. Journal of Neuroimmunology 287, pages 80-87.
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François Curtin, Hervé Perron, Raphael Faucard, Hervé Porchet & Alois B. Lang. (2015) Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis. Molecular Diagnosis & Therapy 19:5, pages 255-265.
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L Mestre, M Redondo, F J Carrillo-Salinas, J A Morales-García, S Alonso-Gil, A Pérez-Castillo, C Gil, A Martínez & C Guaza. (2015) PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis. British Journal of Pharmacology 172:17, pages 4277-4290.
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Robert Patejdl, Saskia Krohn, Hugo Murua Escobar & Uwe K. Zettl. (2015) Fatal Acute Myeloid Leukemia With 11q23 MLL Gene Rearrangement Following Mitoxantrone Treatment in a Case of Childhood-onset Multiple Sclerosis. Journal of Pediatric Hematology/Oncology 37:5, pages 413-414.
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Tobias Derfuss, François Curtin, Claudia Guebelin, Claire Bridel, Maria Rasenack, Alain Matthey, Renaud Du Pasquier, Myriam Schluep, Jules Desmeules, Alois B Lang, Hervé Perron, Raphael Faucard, Hervé Porchet, Hans-Peter Hartung, Ludwig Kappos & Patrice H Lalive. (2014) A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients. Multiple Sclerosis Journal 21:7, pages 885-893.
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Caroline Bruun Helland, Trygve Holmøy & Pål Gulbrandsen. (2015) Barriers and Facilitators Related to Rehabilitation Stays in Multiple Sclerosis. International Journal of MS Care 17:3, pages 122-129.
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Jaime Toro, Lisseth Estefania Burbano, Adrián Zamora & Erica Jones. (2015) Teaching case: A man with a progressive gait impairment and visual compromise. Multiple Sclerosis and Related Disorders 4:2, pages 176-179.
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Hans-Peter Hartung & Bernd C. Kieseier. (2014) The new therapeutic landscape in multiple sclerosis. Current Opinion in Neurology 27:3, pages 243-245.
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