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Editorial

What lessons can be learned from failed Alzheimer’s disease trials?

Keep up to date with the latest research on this topic with citation updates for this article.

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Francesco Panza, Davide Seripa, Madia Lozupone, Vincenzo Solfrizzi, Bruno P. Imbimbo, Maria Rosaria Barulli, Rosanna Tortelli, Rosa Capozzo, Paola Bisceglia, Andrea Dimitri, Roberta Stallone, Vittorio Dibello, Nicola Quaranta, Antonio Daniele, Antonello Bellomo, Antonio Greco & Giancarlo Logroscino. (2018) The potential of solanezumab and gantenerumab to prevent Alzheimer’s disease in people with inherited mutations that cause its early onset. Expert Opinion on Biological Therapy 18:1, pages 25-35.
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Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Madia Lozupone, Antonio Leo, Rodolfo Sardone, Gaetano Gagliardi, Lucia Lofano, Bianca C. Creanza, Paola Bisceglia, Antonio Daniele, Antonello Bellomo, Antonio Greco & Giancarlo Logroscino. (2016) Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer’s disease patients. Expert Opinion on Emerging Drugs 21:4, pages 377-391.
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Fahad Saad Alhodieb, Mohammad Akhlaquer Rahman, Muhammad Abul Barkat, Abdulkareem A Alanezi, Harshita Abul Barkat, Hazrina Ab Hadi, Ranjit K Harwansh & Vineet Mittal. (2023) Nanomedicine-driven therapeutic interventions of autophagy and stem cells in the management of Alzheimer's disease. Nanomedicine 18:2, pages 145-168.
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Dong-Hun Lee, Ji Young Lee, Dong-Yong Hong, Eun Chae Lee, Sang-Won Park, Yu Na Jo, Yu Jin Park, Jae Young Cho, Yoo Jin Cho, Su Hyun Chae, Man Ryul Lee & Jae Sang Oh. (2022) ROCK and PDE-5 Inhibitors for the Treatment of Dementia: Literature Review and Meta-Analysis. Biomedicines 10:6, pages 1348.
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Valentina Oliveri & Graziella Vecchio. (2021) Bis(8‐hydroxyquinoline) Ligands: Exploring their Potential as Selective Copper‐Binding Agents for Alzheimer's Disease. European Journal of Inorganic Chemistry 2021:21, pages 1993-1999.
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James D. Grayson, Matthew P. Baumgartner, Cleide Dos Santos Souza, Samuel J. Dawes, Imane Ghafir El Idrissi, Jennifer C. Louth, Sasha Stimpson, Emma Mead, Charlotte Dunbar, Joanna Wolak, Gary Sharman, David Evans, Anastasia Zhuravleva, Margarita Segovia Roldan, Nicola Antonio Colabufo, Ke Ning, Claire Garwood, James A. Thomas, Benjamin M. Partridge, Antonio de la Vega de Leon, Valerie J. Gillet, Amélia P. Rauter & Beining Chen. (2021) Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrP C binding and downstream pathways . Chemical Science 12:10, pages 3768-3785.
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Samuel King & Cenk Suphioglu. 2020. Neuroprotection - New Approaches and Prospects. Neuroprotection - New Approaches and Prospects.
Colman Moore, Ryan Wing, Timothy Pham & Jesse V. Jokerst. (2020) Multispectral Nanoparticle Tracking Analysis for the Real-Time and Label-Free Characterization of Amyloid-β Self-Assembly In Vitro. Analytical Chemistry 92:17, pages 11590-11599.
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Stefan M. Ivanov, Mariyana Atanasova, Ivan Dimitrov & Irini A. Doytchinova. (2020) Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease. Scientific Reports 10:1.
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Mirna Swayden, Philippe Soubeyran & Juan Iovanna. (2020) Upcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma. Frontiers in Oncology 9.
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Vadim Keyser & Louis Sarry. 2020. Uncertainty in Pharmacology. Uncertainty in Pharmacology 289 318 .
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David Blokh, Ilia Stambler, Emilia Lubart & Eliyahu H. Mizrahi. (2019) An Information Theory Approach for the Analysis of Individual and Combined Evaluation Parameters of Multiple Age-Related Diseases. Entropy 21:6, pages 572.
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John F. Hodes, Carlee I. Oakley, James H. O'Keefe, Peilin Lu, James E. Galvin, Nabeel Saif, Sonia Bellara, Aneela Rahman, Yakir Kaufman, Hollie Hristov, Tarek K. Rajji, Anne Marie Fosnacht Morgan, Smita Patel, David A. Merrill, Scott Kaiser, Josefina Meléndez-Cabrero, Juan A. Melendez, Robert Krikorian & Richard S. Isaacson. (2019) Alzheimer's “Prevention” vs. “Risk Reduction”: Transcending Semantics for Clinical Practice. Frontiers in Neurology 9.
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Mehmet Murat Koseoglu, Andrés Norambuena, Elizabeth R. Sharlow, John S. Lazo & George S. Bloom. (2019) Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer. Journal of Alzheimer's Disease 67:1, pages 1-11.
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Acharaporn Issuriya, Ekkasit Kumarnsit, Chayaporn Reakkamnuan, Nifareeda Samerphob, Pornchai Sathirapanya & Dania Cheaha. (2019) Dexamethasone induces alterations of slow wave oscillation, rapid eye movement sleep and high-voltage spindle in rats. Acta Neurobiologiae Experimentalis 79:3, pages 252-261.
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Ilia Stambler. 2019. The Transhumanism Handbook. The Transhumanism Handbook 381 396 .
H. Robert Brashear, Nzeera Ketter, Jennifer Bogert, Jianing Di, Stephen P. Salloway & Reisa Sperling. (2018) Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies. Journal of Alzheimer's Disease 66:4, pages 1409-1424.
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Dario Carradori, Claudia Balducci, Francesca Re, Davide Brambilla, Benjamin Le Droumaguet, Orfeu Flores, Alice Gaudin, Simona Mura, Gianluigi Forloni, Lara Ordoñez-Gutierrez, Francisco Wandosell, Massimo Masserini, Patrick Couvreur, Julien Nicolas & Karine Andrieux. (2018) Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model. Nanomedicine: Nanotechnology, Biology and Medicine 14:2, pages 609-618.
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Steffen E. Storck & Claus U. Pietrzik. (2017) Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease. Pharmaceutical Research 34:12, pages 2637-2651.
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Doreen Osgood, Miles C. Miller, Arthur A. Messier, Liliana Gonzalez & Gerald D. Silverberg. (2017) Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier. Neurobiology of Aging 57, pages 178-185.
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Marina Chemerovski‐Glikman, Moran Frenkel‐Pinter, Ragad Mdah, Amjaad Abu‐Mokh, Ehud Gazit & Daniel Segal. (2017) Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro‐Substituted Analogues. Chemistry – A European Journal 23:40, pages 9618-9624.
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R Derungs, G G Camici, R D Spescha, T Welt, C Tackenberg, C Späni, F Wirth, A Grimm, A Eckert, R M Nitsch & L Kulic. (2016) Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer’s disease. Molecular Psychiatry 22:4, pages 605-614.
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Diane B. Miller & James P. O'Callaghan. (2017) New horizons for focused ultrasound (FUS) – therapeutic applications in neurodegenerative diseases. Metabolism 69, pages S3-S7.
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Nitin Charbe, Paul A McCarron & Murtaza M Tambuwala. (2017) Three-dimensional bio-printing: A new frontier in oncology research. World Journal of Clinical Oncology 8:1, pages 21.
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Ilia Stambler. (2017) Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy. Aging and disease 8:5, pages 583.
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Youmei Wang, Tao Yan, Honghui Lu, Weiming Yin, Bin Lin, Weibin Fan, Xiaoli Zhang & Pedro Fernandez-Funez. (2017) Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target. Neurodegenerative Diseases 17:6, pages 242-250.
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Moran Frenkel-Pinter, Sharon Tal, Roni Scherzer-Attali, Malak Abu-Hussien, Idan Alyagor, Tal Eisenbaum, Ehud Gazit & Daniel Segal. (2017) Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neurodegenerative Diseases 17:2-3, pages 73-82.
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Brinda Tammara, Sangeeta Raje, William McKeand & Joan M. Korth-Bradley. 2017. Translating Molecules into Medicines. Translating Molecules into Medicines 341 372 .
Todd E. Golde. (2016) Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies. Journal of Neurochemistry 139, pages 224-236.
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Carlos J.V. Simões, Zaida L. Almeida, Dora Costa, Catarina S.H. Jesus, Ana L. Cardoso, Maria R. Almeida, Maria J. Saraiva, Teresa M.V. D. Pinho e Melo & Rui M.M. Brito. (2016) A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. European Journal of Medicinal Chemistry 121, pages 823-840.
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Alessandro Sinopoli, Alessandro Giuffrida, Marianna Flora Tomasello, Maria Laura Giuffrida, Marilisa Leone, Francesco Attanasio, Filippo Caraci, Paolo De Bona, Irina Naletova, Michele Saviano, Agata Copani, Giuseppe Pappalardo & Enrico Rizzarelli. (2016) Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity. ChemBioChem 17:16, pages 1541-1549.
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Kenneth Hensley & Petri Kursula. (2016) Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer’s Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. Journal of Alzheimer's Disease 53:1, pages 1-14.
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H. D. Soares, M. Gasior, J. H. Toyn, J.-S. Wang, Q. Hong, F. Berisha, M. T. Furlong, J. Raybon, K. A. Lentz, F. Sweeney, N. Zheng, B. Akinsanya, R. M. Berman, L. A. Thompson, R. E. Olson, J. Morrison, D. M. Drexler, J. E. Macor, C. F. Albright, M. K. Ahlijanian & M. AbuTarif. (2016) The  -Secretase Modulator, BMS-932481, Modulates A  Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers. Journal of Pharmacology and Experimental Therapeutics 358:1, pages 138-150.
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James A. Hendrix, Randall J. Bateman, H. Robert Brashear, Cynthia Duggan, Maria C. Carrillo, Lisa J. Bain, Ronald DeMattos, Russell G. Katz, Susanne Ostrowitzki, Eric Siemers, Reisa Sperling & Ottavio V. Vitolo. (2016) Challenges, solutions, and recommendations for Alzheimer's disease combination therapy. Alzheimer's & Dementia 12:5, pages 623-630.
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Sandeep Kumar, A. Mary Thangakani, R. Nagarajan, Satish K. Singh, D. Velmurugan & M. Michael Gromiha. (2016) Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions. Scientific Reports 6:1.
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