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Expert Review of Clinical Pharmacology Volume 9, 2016 - Issue 1
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Drug Profiles

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy

Cristina Adelia MeehanDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USACorrespondence[email protected]
,
Elaine CochranDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
,
Andrea KassaiDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
,
Rebecca J. BrownDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
&
Phillip GordenDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Pages 59-68 | Published online: 14 Oct 2015

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Valeria Calcaterra, Vittoria Carlotta Magenes, Virginia Rossi, Valentina Fabiano, Chiara Mameli & Gianvincenzo Zuccotti. (2023) Lipodystrophies in non-insulin-dependent children: Treatment options and results from recombinant human leptin therapy. Pharmacological Research 187, pages 106629.
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Sara Costa, Lurdes Sampaio, Ana Berta Sousa, Chao Xing, Anil K Agarwal & Abhimanyu Garg. (2022) Face-sparing Congenital Generalized Lipodystrophy Type 1 Associated With Nonclassical Congenital Adrenal Hyperplasia. The Journal of Clinical Endocrinology & Metabolism 107:9, pages 2433-2438.
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Marinna C Okawa, Elaine Cochran, Marissa Lightbourne & Rebecca J Brown. (2022) Long-Term Effects of Metreleptin in Rabson-Mendenhall Syndrome on Glycemia, Growth, and Kidney Function. The Journal of Clinical Endocrinology & Metabolism 107:3, pages e1032-e1046.
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Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He, Natalia Nowik, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jörg Matysik, A. Alia & Herman P. Spaink. (2021) Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways. Cell & Bioscience 11:1.
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Giovanni Ceccarini, Silvia Magno, Donatella Gilio, Caterina Pelosini & Ferruccio Santini. (2021) Autoimmunity in lipodystrophy syndromes. La Presse Médicale 50:3, pages 104073.
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Yen-Hua Huang, Tzu-Chien Su, Chung-Hsing Wang, Siew-Lee Wong, Yin-Hsiu Chien, Yu-Tai Wang, Wuh-Liang Hwu & Ni-Chung Lee. (2021) RNA-seq of peripheral blood mononuclear cells of congenital generalized lipodystrophy type 2 patients. Scientific Data 8:1.
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Hany Akeel Al-hussaniy, Ali Hikmate Alburghaif & Meena Akeel Naji. (2021) Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions. Journal of Medicine and Life 14:5, pages 600-605.
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Young Jin Tak & Sang Yeoup Lee. (2021) Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?. Current Obesity Reports 10:1, pages 14-30.
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Pengcheng Zhang, Daniels Konja & Yu Wang. (2020) Adipose tissue secretory profile and cardiometabolic risk in obesity. Endocrine and Metabolic Science 1:3-4, pages 100061.
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Antonio Pérez-Pérez, Flora Sánchez-Jiménez, Teresa Vilariño-García & Víctor Sánchez-Margalet. (2020) Role of Leptin in Inflammation and Vice Versa. International Journal of Molecular Sciences 21:16, pages 5887.
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David M. Williams, Asif Nawaz & Marc Evans. (2020) Drug Therapy in Obesity: A Review of Current and Emerging Treatments. Diabetes Therapy 11:6, pages 1199-1216.
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Shivraj Grewal, Sriram Gubbi, Andin Fosam, Caroline Sedmak, Shanaz Sikder, Harsha Talluru, Rebecca J Brown & Ranganath Muniyappa. (2020) Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy. Journal of the Endocrine Society 4:1.
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Elif A. Oral, Phillip Gorden, Elaine Cochran, David Araújo-Vilar, David B. Savage, Alison Long, Gregory Fine, Taylor Salinardi & Rebecca J. Brown. (2019) Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy. Endocrine 64:3, pages 500-511.
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Johannes Hebebrand, Gabriella Milos, Martin Wabitsch, Martin Teufel, Dagmar Führer, Judith Bühlmeier, Lars Libuda, Christine Ludwig & Jochen Antel. (2019) Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin. Frontiers in Psychology 10.
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Hernan Yupanqui-Lozno, Raul A. Bastarrachea, Maria E. Yupanqui-Velazco, Monica Alvarez-Jaramillo, Esteban Medina-Méndez, Aida P. Giraldo-Peña, Alexandra Arias-Serrano, Carolina Torres-Forero, Angelica M. Garcia-Ordoñez, Claudio A. Mastronardi, Carlos M. Restrepo, Ernesto Rodriguez-Ayala, Edna J. Nava-Gonzalez, Mauricio Arcos-Burgos, Jack W. KentJr.Jr., Shelley A. Cole, Julio Licinio & Luis G. Celis-Regalado. (2019) Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity. Genes 10:5, pages 342.
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Emma Deeks. (2019) Metreleptin in lipodystrophy: a profile of its use. Drugs & Therapy Perspectives 35:5, pages 201-208.
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Miwako Maeda, Tomoki Maeda, Ken Ebihara & Kenji Ihara. (2019) The long-term management of congenital generalized lipodystrophy (Berardinelli-Seip syndrome): the clinical manifestations of Japanese siblings for approximately 20 years. Clinical Pediatric Endocrinology 28:4, pages 139-145.
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Rai-Hseng Hsu, Wei-De Lin, Mei-Chyn Chao, Hui-Pin Hsiao, Siew-Lee Wong, Pao-Chin Chiu, Shao-Yin Chu, Yu-Yuan Ke, Beng-Huat Lau, Yin-Hsiu Chien, Wuh-Liang Hwu, Fuu-Jen Tsai, Chung-Hsing Wang & Ni-Chung Lee. (2019) Congenital generalized lipodystrophy in Taiwan. Journal of the Formosan Medical Association 118:1, pages 142-147.
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Rebecca J. Brown, Elif A. Oral, Elaine Cochran, David Araújo-Vilar, David B. Savage, Alison Long, Gregory Fine, Taylor Salinardi & Phillip Gorden. (2018) Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy. Endocrine 60:3, pages 479-489.
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Laura Papendieck & María B. Araujo. (2018) Clinical outcome in a series of pediatric patients with congenital generalized lipodystrophies treated with dietary therapy. Journal of Pediatric Endocrinology and Metabolism 31:1, pages 77-83.
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Rachel C. Morgan & Robert V. Considine. 2018. Encyclopedia of Endocrine Diseases. Encyclopedia of Endocrine Diseases 420 427 .
Lanhui Huang, Hong Shi & Xinli Zhou. (2017) Mechanistic Insights into Osteoporosis in Patients with Lipodystrophy and Review of the Literature. Endocrine Practice 23:7, pages 857-862.
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Rebecca J. Brown, Cristina Adelia Meehan, Elaine Cochran, Kristina I. Rother, David E. Kleiner, Mary Walter & Phillip Gorden. (2017) Effects of Metreleptin in Pediatric Patients With Lipodystrophy. The Journal of Clinical Endocrinology & Metabolism 102:5, pages 1511-1519.
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Nelson Purizaca-Rosillo, Takayasu Mori, Yamali Benites-Cóndor, Fuki M. Hisama, George M. Martin & Junko Oshima. (2017) High incidence of BSCL2 intragenic recombinational mutation in Peruvian type 2 Berardinelli-Seip syndrome . American Journal of Medical Genetics Part A 173:2, pages 471-478.
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Fabrizio Barbetti, Carlo Colombo, Leena Haataja, Corentin Cras-Méneur, Sergio Bernardini & Peter Arvan. (2016) Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?. Clinical Diabetes and Endocrinology 2:1.
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