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Expert Review of Clinical Immunology Volume 7, 2011 - Issue 4
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Drug Profile

Mepolizumab in eosinophilic disorders

J Pablo Abonia Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, ML2010, Cincinnati, OH 45229-3039, USA; Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, ML2010, Cincinnati, OH 45229-3039, USA
&
Philip E Putnam Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, ML2010, Cincinnati, OH 45229-3039, USA. [email protected]; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, ML2010, Cincinnati, OH 45229-3039, USA. [email protected]
Pages 411-417 | Published online: 10 Jan 2014

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Carlo Cavaliere, Franco Frati, Erminia Ridolo, Antonio Greco, Marco de Vincentiis, Simonetta Masieri, Eleni Makri & Cristoforo Incorvaia. (2019) The spectrum of therapeutic activity of mepolizumab. Expert Review of Clinical Immunology 15:9, pages 959-967.
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Ana Brotons-Canto, Nekane Martín-Arbella, Carlos Gamazo & Juan M. Irache. (2018) New pharmaceutical approaches for the treatment of food allergies. Expert Opinion on Drug Delivery 15:7, pages 675-686.
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Corrado Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Rosa Terracciano, Rocco Savino & Girolamo Pelaia. (2017) Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab. Drug Design, Development and Therapy 11, pages 3137-3144.
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Susan Hua, Dane Cook, Marjorie M. Walker & Nicholas J. Talley. (2016) Pharmacological treatment of eosinophilic gastrointestinal disorders. Expert Review of Clinical Pharmacology 9:9, pages 1195-1209.
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Gina V. Bustamante-Guevara, Ignacio Iglesias-Serrano & Jessica Camacho Soriano. (2023) Refractory Inflammatory Plastic Bronchitis in Children and the Use of Mepolizumab as a Treatment. Archivos de Bronconeumología 59:12, pages 829-830.
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Sivakumar S. Moni & Asmaa Al Basheer. (2022) Molecular targets for cystic fibrosis and therapeutic potential of monoclonal antibodies. Saudi Pharmaceutical Journal 30:12, pages 1736-1747.
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Amina Hamed Alobaidi, Abdulghani Mohamed Alsamarai & Mohamed Almoustafa Alsamarai. (2021) Inflammation in Asthma Pathogenesis: Role of T Cells, Macrophages, Epithelial Cells and Type 2 Inflammation. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 20:4, pages 317-332.
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Alastair K. Williams, Carol Dou & Luke Y. C. Chen. (2021) Treatment of lymphocyte‐variant hypereosinophilic syndrome (L‐HES): what to consider after confirming the elusive diagnosis. British Journal of Haematology 195:5, pages 669-680.
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C. Landi, L. Vantaggiato, E. Shaba, P. Cameli, A. Carleo, M. d’Alessandro, L. Bergantini, E. Bargagli & L. Bini. (2021) Differential redox proteomic profiles of serum from severe asthma patients after one month of benralizumab and mepolizumab treatment. Pulmonary Pharmacology & Therapeutics 70, pages 102060.
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Hannah Martin, Nora Amanda Barrett & Tanya Laidlaw. (2021) Mepolizumab does not prevent all aspirin-induced reactions in patients with aspirin-exacerbated respiratory disease: A case series. The Journal of Allergy and Clinical Immunology: In Practice 9:3, pages 1384-1385.
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Claudia Landi, Paolo Cameli, Lorenza Vantaggiato, Laura Bergantini, Miriana d'Alessandro, Marco Perruzza, Alfonso Carleo, Enxhi Shaba, Fabrizio Di Giuseppe, Stefania Angelucci, Elena Bargagli & Luca Bini. (2021) Ceruloplasmin and oxidative stress in severe eosinophilic asthma patients treated with Mepolizumab and Benralizumab. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1869:2, pages 140563.
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Lijia Zhang, Larry Borish, Anna Smith, Lindsay Somerville & Dana Albon. (2020) Use of mepolizumab in adult patients with cystic fibrosis and an eosinophilic phenotype: case series. Allergy, Asthma & Clinical Immunology 16:1.
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Matthew Mavissakalian & Sean Brady. (2020) The Current State of Biologic Therapies for Treatment of Refractory Asthma. Clinical Reviews in Allergy & Immunology 59:2, pages 195-207.
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Aasha Harish & Stanley A. Schwartz. (2020) Targeted Anti-IL-5 Therapies and Future Therapeutics for Hypereosinophilic Syndrome and Rare Eosinophilic Conditions. Clinical Reviews in Allergy & Immunology 59:2, pages 231-247.
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Usir S. Younis, Ernest Vallorz, Kenneth J. Addison, Julie G. Ledford & Paul B. Myrdal. (2019) Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma. AAPS PharmSciTech 20:5.
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Nicolas M. Zahn, Alec T. Huber, Brandon N. Mikulsky, Mae E. Stepanski, Alexander S. Kehoe, Guanguan Li, Melissa Schussman, Mohammed S. Rashid Roni, Revathi Kodali, James M. Cook, Douglas C. Stafford, Douglas A. Steeber & Leggy A. Arnold. (2019) MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA A receptors without causing systemic immune suppression . Basic & Clinical Pharmacology & Toxicology 125:1, pages 75-84.
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Hyungjun Youn, Jin Her, Jihyun Mok, Bareum Kil, Eunseon Kim, Haesim Park & Changill Ban. (2018) A Novel Eosinophilia Diagnostics Using Label‐free Impedimetric Aptasensor for Soluble Interleukin‐5 Receptor Alpha. Electroanalysis 30:11, pages 2597-2603.
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Carsten Schwarz, Thilo Müller, Susanne Lau, Kirn Parasher, Doris Staab & Ulrich Wahn. (2017) Mepolizumab—a novel option for the treatment of hypereosinophilic syndrome in childhood. Pediatric Allergy and Immunology 29:1, pages 28-33.
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Marco Caminati, Duy Le Pham, Diego Bagnasco & Giorgio Walter Canonica. (2018) Type 2 immunity in asthma. World Allergy Organization Journal 11, pages 13.
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Christian Domingo. (2017) Overlapping Effects of New Monoclonal Antibodies for Severe Asthma. Drugs 77:16, pages 1769-1787.
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Maithili Chitnavis, Daniel J. Stein, Scott Commins, Alex J. Schuyler & Brian Behm. (2017) First-dose anaphylaxis to infliximab: a case of mammalian meat allergy. The Journal of Allergy and Clinical Immunology: In Practice 5:5, pages 1425-1426.
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Diego Bagnasco, Matteo Ferrando, Gilda Varricchi, Francesca Puggioni, Giovanni Passalacqua & Giorgio Walter Canonica. (2017) Anti-Interleukin 5 (IL-5) and IL-5Ra Biological Drugs: Efficacy, Safety, and Future Perspectives in Severe Eosinophilic Asthma. Frontiers in Medicine 4.
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Lynne A Murray, Chris Grainge, Peter A Wark & Darryl A Knight. (2017) Use of biologics to treat acute exacerbations and manage disease in asthma, COPD and IPF. Pharmacology & Therapeutics 169, pages 1-12.
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Francesco Menzella, Mirco Lusuardi, Carla Galeone, Sofia Taddei, Nicola Facciolongo & Luigi Zucchi. (2016) Mepolizumab for severe refractory eosinophilic asthma: evidence to date and clinical potential. Therapeutic Advances in Chronic Disease 7:6, pages 260-277.
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