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Review

Targeting sigma receptors: novel medication development for drug abuse and addiction

Pages 351-358 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Annadurai Thangaraj, Palsamy Periyasamy, Ming-Lei Guo, Ernest T. Chivero, Shannon Callen & Shilpa Buch. (2020) Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy 16:2, pages 289-312.
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Colin G. Rousseaux & Stephanie F. Greene. (2016) Sigma receptors [σRs]: biology in normal and diseased states. Journal of Receptors and Signal Transduction 36:4, pages 327-388.
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Articles from other publishers (40)

Genís Ona, Ingrid Reverte, Giordano N Rossi, Rafael G dos Santos, Jaime EC Hallak, Maria Teresa Colomina & José Carlos Bouso. (2023) Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview. Journal of Psychopharmacology.
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Edijs Vavers, Liga Zvejniece & Maija Dambrova. (2023) Sigma-1 receptor and seizures. Pharmacological Research 191, pages 106771.
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Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos & José Miguel Vela. (2023) Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids. Acta Pharmaceutica Sinica B 13:1, pages 82-99.
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Lisa L. Wilson, Amy R. Alleyne, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy & Jay P. McLaughlin. (2022) Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain. Molecules 27:11, pages 3617.
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Barinderjit KaurMuthuraman A.Surya P Gautam. (2021) Sigma Receptors Ligands: New insights into the Cardioprotective Potential. Research Journal of Pharmacy and Technology, pages 6753-6760.
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Agnieszka Piechal, Alicja Jakimiuk & Dagmara Mirowska-Guzel. (2021) Sigma receptors and neurological disorders. Pharmacological Reports 73:6, pages 1582-1594.
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Sema G. Quadir, Sean M. Tanino, Christian D. Rohl, James J. Sahn, Emily J. Yao, Luíza dos Reis Cruz, Pietro Cottone, Stephen F. Martin & Valentina Sabino. (2021) The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology 184, pages 108409.
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Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos & Javier Garzón-Niño. (2020) The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception. Molecular Brain 13:1.
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Duc Toan Pham, Yoon Hee Chung, Huynh Nhu Mai, Naveen Sharma, Jaesuk Yun, Hee Jin Kim, Jae Hoon Cheong, Ji Hoon Jeong, Dae‐Joong Kim, Eun‐Joo Shin & Hyoung‐Chun Kim. (2019) Glutathione peroxidase‐1 gene rescues cocaine‐induced conditioned place preference in mice by inhibiting σ ‐1 receptor expression . Clinical and Experimental Pharmacology and Physiology 46:9, pages 791-797.
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Susmita Sil, Fang Niu, Eric Tom, Ke Liao, Palsamy Periyasamy & Shilpa Buch. (2018) Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes. Molecular Neurobiology 56:5, pages 3576-3590.
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Zachery J. Harter, Stuti Agarwal, Pranjali Dalvi, Norbert F. Voelkel & Navneet K. Dhillon. (2018) Drug abuse and HIV-related pulmonary hypertension. AIDS 32:18, pages 2651-2667.
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Simona Collina, Marta Rui, Silvia Stotani, Emanuele Bignardi, Daniela Rossi, Daniela Curti, Fabrizio Giordanetto, Alessio Malacrida, Arianna Scuteri & Guido Cavaletti. (2017) Are sigma receptor modulators a weapon against multiple sclerosis disease?. Future Medicinal Chemistry 9:17, pages 2029-2051.
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Richard J. Gillams, Christian D. Lorenz & Sylvia E. McLain. (2017) On the hydration and conformation of cocaine in solution. Chemical Physics Letters 676, pages 58-64.
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Tzu-Yu Weng, Denise T. Hung, Tsung-Ping Su & Shang-Yi A. Tsai. (2017) Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense. Oxidative Medicine and Cellular Longevity 2017, pages 1-14.
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Cristina Sánchez-Fernández, José Manuel Entrena, José Manuel Baeyens & Enrique José Cobos. 2017. Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Sigma Receptors: Their Role in Disease and as Therapeutic Targets 109 132 .
Satishkumar Gadhiya, Sudharshan Madapa, Thomas Kurtzman, Ian L. Alberts, Steven Ramsey, Nagavara-Kishore Pillarsetty, Teja Kalidindi & Wayne W. Harding. (2016) Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity. Bioorganic & Medicinal Chemistry 24:9, pages 2060-2071.
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Ricardo López-González, Araceli Zárate, David M. Aparicio, Angel Mendoza, Dino Gnecco, Jorge R. Juárez, Nancy Romero-Ceronio, Laura Orea & Joel L. Terán. (2016) Chiral cyclic zwitterionic bipyridinium-4-olates for the diastereoselective synthesis of (R,S)- and (S,R)-trozamicol. Tetrahedron Letters 57:15, pages 1683-1686.
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Sonia Mediouni, Maria Cecilia Garibaldi Marcondes, Courtney Miller, Jay P. McLaughlin & Susana T. Valente. (2015) The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology 6.
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Jeffrey L. Barr, Elena Deliu, G. Cristina Brailoiu, Pingwei Zhao, Guang Yan, Mary E. Abood, Ellen M. Unterwald & Eugen Brailoiu. (2015) Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor–inositol 1,4,5-trisphosphate–transient receptor potential canonical channel pathways. Cell Calcium 58:2, pages 196-207.
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Maarten E.A. Reith, Bruce E. Blough, Weimin C. Hong, Kymry T. Jones, Kyle C. Schmitt, Michael H. Baumann, John S. Partilla, Richard B. Rothman & Jonathan L. Katz. (2015) Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter. Drug and Alcohol Dependence 147, pages 1-19.
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Teruo Hayashi. (2015) Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs. Journal of Pharmacological Sciences 127:1, pages 2-5.
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David R. Compton & Thomas J. Hudzik. 2015. Nonclinical Assessment of Abuse Potential for New Pharmaceuticals. Nonclinical Assessment of Abuse Potential for New Pharmaceuticals 9 48 .
Rajeev I. Desai, David K. Grandy, Carl R. Lupica & Jonathan L. Katz. (2014) Pharmacological Characterization of a Dopamine Transporter Ligand That Functions as a Cocaine Antagonist. Journal of Pharmacology and Experimental Therapeutics 348:1, pages 106-115.
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Rae R. Matsumoto, Linda Nguyen, Nidhi Kaushal & Matthew J. Robson. 2014. Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse. Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse 323 386 .
Takato Hiranita, Paul L. Soto, Gianluigi Tanda, Theresa A. Kopajtic & Jonathan L. Katz. (2013) Stimulants as Specific Inducers of Dopamine-Independent σ Agonist Self-Administration in Rats . Journal of Pharmacology and Experimental Therapeutics 347:1, pages 20-29.
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Lidiya Stavitskaya, Michael J. Seminerio, Jason R. Healy, Bahar Noorbakhsh, Rae R. Matsumoto & Andrew Coop. (2013) Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors. Bioorganic & Medicinal Chemistry 21:17, pages 4923-4927.
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Akula Bala Pramod, James Foster, Lucia Carvelli & L. Keith Henry. (2013) SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Molecular Aspects of Medicine 34:2-3, pages 197-219.
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Takato Hiranita, Maddalena Mereu, Paul L Soto, Gianluigi Tanda & Jonathan L Katz. (2012) Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists. Neuropsychopharmacology 38:4, pages 605-615.
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Samuel D. Banister, Miral Manoli, Munikumar Reddy Doddareddy, David E. Hibbs & Michael Kassiou. (2012) A σ1 receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ols (AHDs). Bioorganic & Medicinal Chemistry Letters 22:19, pages 6053-6058.
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Michiko Fujimoto, Teruo Hayashi, Roman Urfer, Shiro Mita & Tsung-Ping Su. (2012) Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor. Synapse 66:7, pages 630-639.
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Samuel D. Banister, Louis M. Rendina & Michael Kassiou. (2012) 7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands. Bioorganic & Medicinal Chemistry Letters 22:12, pages 4059-4063.
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Yan-Tong Xu, Matthew J. Robson, Wioletta Szeszel-Fedorowicz, Divyen Patel, Robert Rooney, Christopher R. McCurdy & Rae R. Matsumoto. (2012) CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain. Pharmacology Biochemistry and Behavior 101:1, pages 174-180.
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Takato Hiranita, Paul L. Soto, Stephen J. Kohut, Theresa Kopajtic, Jianjing Cao, Amy H. Newman, Gianluigi Tanda & Jonathan L. Katz. (2011) Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors. Journal of Pharmacology and Experimental Therapeutics 339:2, pages 662-677.
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Rae R. Matsumoto, Su-Min Li, Jonathan L. Katz, William E. Fantegrossi & Andrew Coop. (2011) Effects of the selective sigma receptor ligand, 1-(2-phenethyl)piperidine oxalate (AC927), on the behavioral and toxic effects of cocaine. Drug and Alcohol Dependence 118:1, pages 40-47.
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Nidhi Kaushal, Matthew J. Robson, Harsha Vinnakota, Sanju Narayanan, Bonnie A. Avery, Christopher R. McCurdy & Rae R. Matsumoto. (2011) Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents. The AAPS Journal 13:3, pages 336-346.
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Wei Wang, Jinquan Cui, Xiaoxia Lu, Prashanth K. Padakanti, Jinbin Xu, Stanley M. Parsons, Robert R. Luedtke, Nigam P. Rath & Zhude Tu. (2011) Synthesis and in Vitro Biological Evaluation of Carbonyl Group-Containing Analogues for σ 1 Receptors . Journal of Medicinal Chemistry 54:15, pages 5362-5372.
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Jonathan L. Katz, Tsung-Ping Su, Takato Hiranita, Teruo Hayashi, Gianluigi Tanda, Theresa Kopajtic & Shang-Yi Tsai. (2011) A Role for Sigma Receptors in Stimulant Self Administration and Addiction. Pharmaceuticals 4:6, pages 880-914.
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Samuel D. Banister, Iman A. Moussa, William T. Jorgensen, Sook Wern Chua & Michael Kassiou. (2011) Molecular hybridization of 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecane-3-ol with sigma (σ) receptor ligands modulates off-target activity and subtype selectivity. Bioorganic & Medicinal Chemistry Letters 21:12, pages 3622-3626.
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Su-Min Li, Theresa A. Kopajtic, Matthew J. O'Callaghan, Gregory E. Agoston, Jianjing Cao, Amy Hauck Newman & Jonathan L. Katz. (2011) N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects. Journal of Pharmacology and Experimental Therapeutics 336:2, pages 575-585.
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Linda Garcés-Ramírez, Jennifer L. Green, Takato Hiranita, Theresa A. Kopajtic, Maddalena Mereu, Alexandra M. Thomas, Christophe Mesangeau, Sanju Narayanan, Christopher R. McCurdy, Jonathan L. Katz & Gianluigi Tanda. (2011) Sigma Receptor Agonists: Receptor Binding and Effects on Mesolimbic Dopamine Neurotransmission Assessed by Microdialysis. Biological Psychiatry 69:3, pages 208-217.
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