Advanced search
Publication Cover
Expert Review of Clinical Pharmacology Volume 4, 2011 - Issue 1
Submit an article Journal homepage
269
Views
72
CrossRef citations to date
0
Altmetric
Review

Therapeutic potential of new hydrogen sulfide-releasing hybrids

Anna Sparatore Department of Pharmaceutical Science “Pietro Pratesi”, Università degli Studi di Milano, Via Mangiagalli, 25–20133 Milano, Italy. [email protected]; Department of Pharmaceutical Science “Pietro Pratesi”, Università degli Studi di Milano, Via Mangiagalli, 25–20133 Milano, Italy. [email protected]
,
Giancarlo Santus CTG Pharma, Viale Gran Sasso 17, Milano, Italy; CTG Pharma, Viale Gran Sasso 17, Milano, Italy
,
Daniela Giustarini Department of Evolutionary Biology, Laboratory of Pharmacology and Toxicology, University of Siena, Siena, Italy; Department of Evolutionary Biology, Laboratory of Pharmacology and Toxicology, University of Siena, Siena, Italy
,
Ranieri Rossi Department of Evolutionary Biology, Laboratory of Pharmacology and Toxicology, University of Siena, Siena, Italy; Department of Evolutionary Biology, Laboratory of Pharmacology and Toxicology, University of Siena, Siena, Italy
&
Piero Del Soldato CTG Pharma, Viale Gran Sasso 17, Milano, Italy; CTG Pharma, Viale Gran Sasso 17, Milano, Italy
Pages 109-121 | Published online: 10 Jan 2014

Citations (72)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Daniela Giustarini, Valerio Tazzari, Ivan Bassanini, Ranieri Rossi & Anna Sparatore. (2018) The new H2S-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1392-1404.
Read now
Doina Popov. (2013) An outlook on vascular hydrogen sulphide effects, signalling, and therapeutic potential. Archives of Physiology and Biochemistry 119:5, pages 189-194.
Read now

Articles from other publishers (70)

Valentina Citi, Elisabetta Barresi, Eugenia Piragine, Jacopo Spezzini, Lara Testai, Federico Da Settimo, Alma Martelli, Sabrina Taliani & Vincenzo Calderone. (2023) Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate H2S Donor Moiety, in Different Cancer Cell Lines. International Journal of Molecular Sciences 24:22, pages 16131.
Crossref
Shi Xu, Meg Shieh, Bindu D. Paul & Ming Xian. (2023) Hydrogen sulfide: Recent development of its dual donors and hybrid drugs. British Journal of Pharmacology.
Crossref
Ruofei Wang, Xia-Xiao Wu, Zhenming Tian, Tian Hu, Chaoyang Cai, Guan-Ping Wu, Gang-Biao Jiang & Bin Liu. (2023) Sustained release of hydrogen sulfide from anisotropic ferrofluid hydrogel for the repair of spinal cord injury. Bioactive Materials 23, pages 118-128.
Crossref
Szilvia Török, Nikoletta Almási, Médea Veszelka, Denise Börzsei, Renáta Szabó & Csaba Varga. (2023) Protective Effects of H2S Donor Treatment in Experimental Colitis: A Focus on Antioxidants. Antioxidants 12:5, pages 1025.
Crossref
Zi‐Long Song, Lanning Zhao, Tao Ma, Alsiddig Osama, Tong Shen, Yilin He & Jianguo Fang. (2022) Progress and perspective on hydrogen sulfide donors and their biomedical applications. Medicinal Research Reviews 42:5, pages 1930-1977.
Crossref
Trong-Nghia Le, Huang Ru, Cheng-Kang Lee & N. Vijayakameswara Rao. (2022) Polynorbornene-derived block copolymer micelles via ring‐opening metathesis polymerization with capacity of hydrogen sulfide generation. European Polymer Journal 173, pages 111294.
Crossref
S. N. Fedorov, A. S. Kuzmich, I. G. Agafonova, Yu. E. Sabutskii, A. G. Guzii, R. S. Popov, V. A. Ogurtsov, O. A. Rakitin & S. G. Polonik. (2022) Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo. Russian Chemical Bulletin 71:3, pages 489-495.
Crossref
Neha V. Bhilare, Vinayak S. Marulkar, Dileep Kumar, Vivekanand K. Chatap, Kashmira S. Patil & Pramodkumar J. Shirote. (2022) An insight into prodrug strategy for the treatment of Alzheimer’s disease. Medicinal Chemistry Research 31:3, pages 383-399.
Crossref
Chenyu Li, Hongzhao Sun, Yuan Shi, Yan Yu, Xiaofeng Ji, Enguang Li, Xiaofan Zhou, Xiaomeng Liu, Xikang Xue & Haiji Sun. (2022) Effects of Exogenous Hydrogen Sulfide in the Hypothalamic Paraventricular Nucleus on Gastric Function in Rats. Frontiers in Pharmacology 12.
Crossref
Lissette Sanchez-Aranguren, Mandeep Kaur Marwah & Sarah Nadeem. (2021) Neuroprotective effects of mitochondrial-targeted hydrogen sulphide donor, AP39 on H2O2-induced oxidative stress in human neuroblastoma SHSY5Y cell line. Advances in Redox Research 3, pages 100024.
Crossref
Szilvia Török, Nikoletta Almási, Zsuzsanna Valkusz, Anikó Pósa, Csaba Varga & Krisztina Kupai. (2021) Investigation of H2S Donor Treatment on Neutrophil Extracellular Traps in Experimental Colitis. International Journal of Molecular Sciences 22:23, pages 12729.
Crossref
Yanming Hao, Hongzhen Wang, Lingna Fang, Jinsong Bian, Yan Gao & Chong Li. (2021) H2S Donor and Bone Metabolism. Frontiers in Pharmacology 12.
Crossref
Iryna FOMENKO, Iryna LOZYNSKA, Tetyana BONDARCHUK, Natalia DENYSENKO, Roman LESYK & Alexander SKLYAROV. (2021) Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro- and enterotoxicity on the stress model in rats. Minerva Biotechnology and Biomolecular Research 33:2.
Crossref
Haizhou Zhu, Venkateshwara Dronamraju, Wei Xie & Swati S. More. (2021) Sulfur-containing therapeutics in the treatment of Alzheimer’s disease. Medicinal Chemistry Research 30:2, pages 305-352.
Crossref
Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Lissette Sanchez-Aranguren, Irundika HK. Dias, Swati Agrawal, Anna Sparatore, Keqing Wang & Asif Ahmed. (2021) MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment. Redox Biology 38, pages 101768.
Crossref
Yaw Opoku-Damoah, Run Zhang, Hang T. Ta, D. Amilan Jose, Rahul Sakla & Zhi Ping Xu. (2021) Lipid-encapsulated upconversion nanoparticle for near-infrared light-mediated carbon monoxide release for cancer gas therapy. European Journal of Pharmaceutics and Biopharmaceutics 158, pages 211-221.
Crossref
Nam V. Dao, Francesca Ercole, Lisa M. Kaminskas, Thomas P. Davis, Erica K. Sloan, Michael R. Whittaker & John F. Quinn. (2020) Trisulfide-Bearing PEG Brush Polymers Donate Hydrogen Sulfide and Ameliorate Cellular Oxidative Stress. Biomacromolecules 21:12, pages 5292-5305.
Crossref
Gabriel GojonGuillermo A. Morales. (2020) SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs. Antioxidants & Redox Signaling 33:14, pages 1010-1045.
Crossref
R. C. Maurya & J. M. Mir. 2020. Advances in Metallodrugs. Advances in Metallodrugs 157 201 .
Madou-Marilyn Dali, Patrick M. Dansette, Daniel Mansuy & Jean-Luc Boucher. (2020) Comparison of Various Aryl-Dithiolethiones and Aryl-Dithiolones As Hydrogen Sulfide Donors in the Presence of Rat Liver Microsomes. Drug Metabolism and Disposition 48:6, pages 426-431.
Crossref
Ewelina Zaorska, Lenka Tomasova, Dominik Koszelewski, Ryszard Ostaszewski & Marcin Ufnal. (2020) Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors. Biomolecules 10:2, pages 323.
Crossref
Martin Richard Späth, Felix Carlo Koehler, Karla Johanna Ruth Hoyer-Allo, Franziska Grundmann, Volker Burst & Roman-Ulrich Müller. (2020) Preconditioning strategies to prevent acute kidney injury. F1000Research 9, pages 237.
Crossref
Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang & Qing Yang. (2019) H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy & Jean-Luc Boucher. (2019) Mechanism of H 2 S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes . Drug Metabolism and Disposition 47:10, pages 1061-1065.
Crossref
Sul Hwa Yu, Lars Esser, Song Yang Khor, Danielle Senyschyn, Nicholas A. Veldhuis, Michael R. Whittaker, Francesca Ercole, Thomas P. Davis & John F. Quinn. (2019) Development of a shape‐controlled H 2 S delivery system using epoxide‐functional nanoparticles . Journal of Polymer Science Part A: Polymer Chemistry 57:18, pages 1982-1993.
Crossref
Rafat Ali, Hilal Ahmad Pal, Rohil Hameed, Aamir Nazir & Sandeep Verma. (2019) Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans . Chemical Communications 55:68, pages 10142-10145.
Crossref
Ewelina Zaorska, Tomasz Hutsch, Marta Gawryś-Kopczyńska, Ryszard Ostaszewski, Marcin Ufnal & Dominik Koszelewski. (2019) Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure. Bioorganic Chemistry 88, pages 102941.
Crossref
Dominique Detaille, Philippe Pasdois, Audrey Sémont, Pierre Dos Santos & Philippe Diolez. (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLOS ONE 14:5, pages e0216385.
Crossref
Martin Dulac, Amor Sassi, Citra Nagarathinan, Marie-Odile Christen, Patrick M. Dansette, Daniel Mansuy & Jean-Luc Boucher. (2018) Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O -Demethylation and S -Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways . Drug Metabolism and Disposition 46:10, pages 1390-1395.
Crossref
Enrico Gugliandolo, Roberta Fusco, Ramona D’Amico, Angela Militi, Giacomo Oteri, John L. Wallace, Rosanna Di Paola & Salvatore Cuzzocrea. (2018) Anti-inflammatory effect of ATB-352, a H2S −releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. Pharmacological Research 132, pages 220-231.
Crossref
Krisztina Kupai, Nikoletta Almási, Magdolna Kósa, János Nemcsók, Zsolt Murlasits, Szilvia Török, Amin Al-awar, Zoltán Baráth, Anikó Pósa & Csaba Varga. (2017) H2S confers colonoprotection against TNBS-induced colitis by HO-1 upregulation in rats. Inflammopharmacology 26:2, pages 479-489.
Crossref
Khosrow Kashfi. (2018) The dichotomous role of H2S in cancer cell biology? Déjà vu all over again. Biochemical Pharmacology 149, pages 205-223.
Crossref
Milos R. Filipovic, Jasmina Zivanovic, Beatriz Alvarez & Ruma Banerjee. (2017) Chemical Biology of H 2 S Signaling through Persulfidation . Chemical Reviews 118:3, pages 1253-1337.
Crossref
Prerona Bora, Preeti Chauhan, Kundansingh A. Pardeshi & Harinath Chakrapani. (2018) Small molecule generators of biologically reactive sulfur species. RSC Advances 8:48, pages 27359-27374.
Crossref
Yu Zhao, Hillary A. Henthorn & Michael D. Pluth. (2017) Kinetic Insights into Hydrogen Sulfide Delivery from Caged-Carbonyl Sulfide Isomeric Donor Platforms. Journal of the American Chemical Society 139:45, pages 16365-16376.
Crossref
Yulia Sklyarova, Iryna Fomenko, Iryna Lozynska, Andrii Lozynskyi, Roman Lesyk & Alexandr Sklyarov. (2017) Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy. Scientia Pharmaceutica 85:4, pages 35.
Crossref
Gaganpreet Kaur & Om Silakari. (2017) Multiple target-centric strategy to tame inflammation. Future Medicinal Chemistry 9:12, pages 1361-1376.
Crossref
N. I. Tkacheva, S. V. Morozov, B. B. Lomivorotov & I. A. Grigor’ev. (2017) Organic Hydrogen Sulfide Donor Compounds with Cardioprotective Properties (Review). Pharmaceutical Chemistry Journal 51:3, pages 165-174.
Crossref
Yu Zhao, Sarah G. Bolton & Michael D. Pluth. (2017) Light-Activated COS/H 2 S Donation from Photocaged Thiocarbamates . Organic Letters 19:9, pages 2278-2281.
Crossref
Csaba Szabo. (2017) Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications. American Journal of Physiology-Cell Physiology 312:1, pages C3-C15.
Crossref
Francesca Ercole, Michael R. Whittaker, Michelle L. Halls, Ben J. Boyd, Thomas P. Davis & John F. Quinn. (2017) Garlic-inspired trisulfide linkers for thiol-stimulated H 2 S release . Chemical Communications 53:57, pages 8030-8033.
Crossref
Khosrow Kashfi & Mahnoush Esmaili. 2017. Nitric Oxide as a Chemosensitizing Agent. Nitric Oxide as a Chemosensitizing Agent 105 142 .
Christopher Kevil, Miriam M. Cortese-Krott, Péter Nagy, Andreas Papapetropoulos, Martin Feelisch & Csaba Szabo. 2017. Nitric Oxide. Nitric Oxide 57 83 .
Yu Zhao & Michael D. Pluth. (2016) Hydrogen Sulfide Donors Activated by Reactive Oxygen Species. Angewandte Chemie International Edition 55:47, pages 14638-14642.
Crossref
Yu Zhao & Michael D. Pluth. (2016) Hydrogen Sulfide Donors Activated by Reactive Oxygen Species. Angewandte Chemie 128:47, pages 14858-14862.
Crossref
J. Roy, R. Adili, R. Kulmacz, M. Holinstat & A. Das. (2016) Development of Poly Unsaturated Fatty Acid Derivatives of Aspirin for Inhibition of Platelet Function. Journal of Pharmacology and Experimental Therapeutics 359:1, pages 134-141.
Crossref
Yueqin Zheng, Bingchen Yu, Kaili Ji, Zhixiang Pan, Vayou Chittavong & Binghe Wang. (2016) Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide. Angewandte Chemie International Edition 55:14, pages 4514-4518.
Crossref
Yueqin Zheng, Bingchen Yu, Kaili Ji, Zhixiang Pan, Vayou Chittavong & Binghe Wang. (2016) Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide. Angewandte Chemie 128:14, pages 4590-4594.
Crossref
Francesca Ercole, Friederike M. Mansfeld, Maria Kavallaris, Michael R. Whittaker, John F. Quinn, Michelle L. Halls & Thomas P. Davis. (2015) Macromolecular Hydrogen Sulfide Donors Trigger Spatiotemporally Confined Changes in Cell Signaling. Biomacromolecules 17:1, pages 371-383.
Crossref
Beata Olas. 2016. 195 210 .
Yu Zhao, Chuntao Yang, Chelsea Organ, Zhen Li, Shashi Bhushan, Hiro Otsuka, Armando Pacheco, Jianming Kang, Hector C. Aguilar, David J. Lefer & Ming Xian. (2015) Design, Synthesis, and Cardioprotective Effects of N -Mercapto-Based Hydrogen Sulfide Donors . Journal of Medicinal Chemistry 58:18, pages 7501-7511.
Crossref
Yueqin Zheng, Xingyue Ji, Kaili Ji & Binghe Wang. (2015) Hydrogen sulfide prodrugs—a review. Acta Pharmaceutica Sinica B 5:5, pages 367-377.
Crossref
Doreen SchmidlLeopold SchmettererGerhard GarhöferAlina Popa-Cherecheanu. (2015) Pharmacotherapy of Glaucoma. Journal of Ocular Pharmacology and Therapeutics 31:2, pages 63-77.
Crossref
Manuel F. Rosario-Alomar, Tatiana Quiñones-Ruiz, Dmitry Kurouski, Valentin Sereda, Eduardo B. Ferreira, Lorraine De Jesús-Kim, Samuel Hernández-Rivera, Dmitri V. Zagorevski, Juan López-Garriga & Igor K. Lednev. (2015) Hydrogen Sulfide Inhibits Amyloid Formation. The Journal of Physical Chemistry B 119:4, pages 1265-1274.
Crossref
T. Spencer Bailey & Michael D. Pluth. 2015. Hydrogen Sulfide in Redox Biology, Part A. Hydrogen Sulfide in Redox Biology, Part A 81 99 .
Yu Zhao, Armando Pacheco & Ming Xian. 2015. Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide. Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide 365 388 .
B. V. Nagpure & Jin-Song Bian. 2015. Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide. Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide 193 215 .
Xingzhou Zhang & Jin-Song Bian. (2014) Hydrogen Sulfide: A Neuromodulator and Neuroprotectant in the Central Nervous System. ACS Chemical Neuroscience 5:10, pages 876-883.
Crossref
Maria Letizia Lo Faro, Bridget Fox, Jacqueline L. Whatmore, Paul G. Winyard & Matthew Whiteman. (2014) Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide 41, pages 38-47.
Crossref
John Toohey & Arthur Cooper. (2014) Thiosulfoxide (Sulfane) Sulfur: New Chemistry and New Regulatory Roles in Biology. Molecules 19:8, pages 12789-12813.
Crossref
Khosrow Kashfi. (2014) Anti-Cancer Activity of New Designer Hydrogen Sulfide-Donating Hybrids. Antioxidants & Redox Signaling 20:5, pages 831-846.
Crossref
Xiaoli Wang, Linna Wang, Xiao Sheng, Zhangjian Huang, Tingting Li, Ming Zhang, Jinyi Xu, Hui Ji, Jian Yin & Yihua Zhang. (2014) Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org. Biomol. Chem. 12:31, pages 5995-6004.
Crossref
Yu Zhao, Tyler D. Biggs & Ming Xian. (2014) Hydrogen sulfide (H 2 S) releasing agents: chemistry and biological applications . Chem. Commun. 50:80, pages 11788-11805.
Crossref
Mitali Chattopadhyay, Niharika Nath, Ravinder Kodela, Tomasz Sobocki, Shalaka Metkar, Zong Yuan Gan & Khosrow Kashfi. (2013) Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression. Leukemia Research 37:10, pages 1302-1308.
Crossref
Li Xie, Li-Fang Hu, Xing Qi Teo, Chi Xin Tiong, Valerio Tazzari, Anna Sparatore, Piero Del Soldato, Gavin Stewart Dawe & Jin-Song Bian. (2013) Therapeutic Effect of Hydrogen Sulfide-Releasing L-Dopa Derivative ACS84 on 6-OHDA-Induced Parkinson’s Disease Rat Model. PLoS ONE 8:4, pages e60200.
Crossref
Ling Li, Mohamed Shirhan Bin Mohamed & Philip K. Moore. 2013. Hydrogen Sulfide and its Therapeutic Applications. Hydrogen Sulfide and its Therapeutic Applications 63 82 .
Dexiao Zhu, Xiao Yu, Jinpeng Sun, Jingxin Li, Xuelian Ma & Wei Yao. (2012) H2S induces catecholamine secretion in rat adrenal chromaffin cells. Toxicology 302:1, pages 40-43.
Crossref
Benjamin Lee PredmoreDavid Joseph LeferGabriel Gojon. (2012) Hydrogen Sulfide in Biochemistry and Medicine. Antioxidants & Redox Signaling 17:1, pages 119-140.
Crossref
Anna Tarantini, Alessandra Faraoni, Francesca Menchini & Paolo Lanzetta. (2012) Bilateral Simultaneous Nonarteritic Anterior Ischemic Optic Neuropathy after Ingestion of Sildenafil for Erectile Dysfunction. Case Reports in Medicine 2012, pages 1-5.
Crossref
Matthew WhitemanSophie Le TrionnaireMohit ChopraBridget FoxJacqueline Whatmore. (2011) Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clinical Science 121:11, pages 459-488.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.