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Review

Biomarkers as predictors of outcome after cardiac arrest

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Pages 687-699 | Published online: 10 Jan 2014

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Eric Mercier, Pier-Alexandre Tardif, Peter A. Cameron, Marcel Émond, Lynne Moore, Biswadev Mitra, Marie-Christine Ouellet, Jérôme Frenette, Elaine de Guise & Natalie Le Sage. (2018) Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review. Brain Injury 32:1, pages 29-40.
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Junhwan Kim, Tai Yin, Koichiro Shinozaki, Joshua W. Lampe & Lance B. Becker. (2017) Potential of lysophosphatidylinositol as a prognostic indicator of cardiac arrest using a rat model. Biomarkers 22:8, pages 755-763.
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Articles from other publishers (47)

Andrew M. Nguyen, Vishal Saini & H. E. Hinson. (2023) Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury. Seminars in Neurology 43:05, pages 689-698.
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Heejin Hong, Jihyun Kim, Hana Min, Yong Kim & Tae-Youn Kim. (2023) Association of B-Type Natriuretic Peptide Level with Clinical Outcome in Out-of-Hospital Cardiac Arrest in Emergency Department Patients. Diagnostics 13:15, pages 2522.
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Ju Hee Yoon, Woo Sung Choi, Yong Su Lim & Jae Ho Jang. (2023) Comparison of Prognostic Performance between Procalcitonin and Procalcitonin-to-Albumin Ratio in Post Cardiac Arrest Syndrome. Journal of Clinical Medicine 12:14, pages 4568.
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Piotr Fehler, Marzena Zielińska, Bartosz Uchmanowicz, Raúl Juárez-Vela, Łukasz Lewandowski, Stanisław Zieliński & Michał Czapla. (2023) Do Body Mass Index and Nutritional Risk Score 2002 Influence the In-Hospital Mortality of Patients Following Cardiac Arrest?. Nutrients 15:2, pages 436.
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Shuhang Yu, Chenghao Wu, Ying Zhu, Mengyuan Diao & Wei Hu. (2023) Rat model of asphyxia-induced cardiac arrest and resuscitation. Frontiers in Neuroscience 16.
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Alexander Supady, Timm Zahn, Moritz Kuhl, Sven Maier, Christoph Benk, Klaus Kaier, Bernd W. Böttiger, Christoph Bode, Achim Lother, Dawid L. Staudacher, Tobias Wengenmayer & Daniel Duerschmied. (2022) Cytokine adsorption in patients with post-cardiac arrest syndrome after extracorporeal cardiopulmonary resuscitation (CYTER) – A single-centre, open-label, randomised, controlled trial. Resuscitation 173, pages 169-178.
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Alexander Supady, Timm Zahn, Marina Rieder, Christoph Benk, Achim Lother, Christoph Bode, Tobias Wengenmayer, Dawid Staudacher, John A. Kellum & Daniel Duerschmied. (2021) Effect of Cytokine Adsorption on Survival and Circulatory Stabilization in Patients Receiving Extracorporeal Cardiopulmonary Resuscitation. ASAIO Journal 68:1, pages 64-72.
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Fabio S. Taccone, Jerry P. Nolan & Cornelia W. E. Hoedemaekers. (2020) Neurofilament to predict post-anoxic neurological outcome: are we ready for the prime time?. Intensive Care Medicine 47:1, pages 77-79.
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Sümeyye Cakmak, Ozgur Sogut, Levent Albayrak & Ayla Yildiz. (2020) Serum Copeptin Levels Predict the Return of Spontaneous Circulation and the Short-Term Prognosis of Patients with Out-of-Hospital Cardiac Arrest: A Randomized Control Study. Prehospital and Disaster Medicine 35:2, pages 120-127.
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Abubakar Musa Mayaki, Intan Shameha Abdul Razak, Mohd Adzahan Noraniza, Mazlan Mazlina & Abdullah Rasedee. (2020) Biofluid Markers of Equine Neurological Disorders Reviewed From Human Perspectives. Journal of Equine Veterinary Science 86, pages 102907.
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Tongyi Hu, Jianjie Wang, Shuangwei Wang, Jingru Li, Bihua Chen, Feng Zuo, Lei Zhang, Yuanyuan Huang & Yongqin Li. (2019) Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model. Scientific Reports 9:1.
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Gang Chen, Jingru Li, Jianjie Wang, Bihua Chen & Yongqin Li. (2019) Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model. BioMed Research International 2019, pages 1-8.
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Raluca M. Tat, Adela Golea, Ştefan C. Vesa & Daniela Ionescu. (2019) Determination of Cut-off Serum Values for Resistin and S100B Protein in Patients Who Survived a Cardiac Arrest. The Journal of Critical Care Medicine 5:3, pages 97-102.
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Chenxi Dai, Gang Chen, Bihua Chen, Juan Wang, Changlin Yin, Jianjie Wang, Yushun Gong, Liang Wei, Yuanyuan Huang & Yongqin Li. (2019) Repetitive anodal transcranial direct current stimulation improves neurological outcome and survival in a ventricular fibrillation cardiac arrest rat model. Brain Stimulation 12:3, pages 659-667.
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C. Storm. (2019) Biomarker nach ReanimationBiomarkers after resuscitation. Medizinische Klinik - Intensivmedizin und Notfallmedizin 114:4, pages 313-318.
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Vishal H Patel, Philip Vendittelli, Rajat Garg, Susan Szpunar, Thomas LaLonde, John Lee, Howard Rosman, Rajendra H Mehta & Hussein Othman. (2019) Neutrophil-lymphocyte ratio: A prognostic tool in patients with in-hospital cardiac arrest. World Journal of Critical Care Medicine 8:2, pages 9-17.
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Raluca Mihaela Tat, Adela Golea, Ştefan Cristian Vesa & Daniela Ionescu. (2019) Resistin—Can it be a new early marker for prognosis in patients who survive after a cardiac arrest? A pilot study. PLOS ONE 14:1, pages e0210666.
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Gang Chen, Bihua Chen, Chenxi Dai, Jianjie Wang, Juan Wang, Yuanyuan Huang & Yongqin Li. (2018) Hydrogen Inhalation is Superior to Mild Hypothermia for Improving Neurological Outcome and Survival in a Cardiac Arrest Model of Spontaneously Hypertensive Rat. Shock 50:6, pages 689-695.
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Fiqry Fadhlillah & Shashank Patil. (2018) The value of neuron-specific enolase in prognostication after cardiac arrest. Resuscitation 124, pages e13.
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Sarah S Gul, Karl Huesgen, Kevin K Wang & Joseph A Tyndall. (2017) MicroRNAs as potential prognosticators of neurological outcome in out-of-hospital cardiac arrest patients. Biomarkers in Medicine 11:12, pages 1113-1123.
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S.S. Gul, K.W. Huesgen, K.K. Wang, K. Mark & J.A. Tyndall. (2017) Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management. Medical Hypotheses 105, pages 34-47.
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Kirsten Helwig, Florian Seeger, Hans Hölschermann, Volker Lischke, Tibo Gerriets, Marion Niessner & Christian Foerch. (2017) Elevated Serum Glial Fibrillary Acidic Protein (GFAP) is Associated with Poor Functional Outcome After Cardiopulmonary Resuscitation. Neurocritical Care 27:1, pages 68-74.
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Wei Wei, Yong Xie, Shi-Chao Lai, Bo-Fu Liu, Ya-Rong He, Hai Hu & Yu Cao. (2017) Benefits of anti-inflammatory therapy in the treatment of ischemia/reperfusion injury in the renal microvascular endothelium of rats with return of spontaneous circulation. Molecular Medicine Reports 15:6, pages 4231-4238.
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Jung Woo Eun, Hee Doo Yang, Soo Hyun Kim, Sungyoup Hong, Kyu Nam Park, Suk Woo Nam & Sikyoung Jeong. (2017) Identification of novel biomarkers for prediction of neurological prognosis following cardiac arrest. Oncotarget 8:10, pages 16144-16157.
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Fabio Silvio Taccone, Ingrid Baar, Cathy De Deyne, Patrick Druwe, Benjamin Legros, Geert Meyfroidt, Michel Ossemann & Nicolas Gaspard. (2017) Neuroprognostication after adult cardiac arrest treated with targeted temperature management: task force for Belgian recommendations. Acta Neurologica Belgica 117:1, pages 3-15.
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Anders Morten Grejs, Jakob Gjedsted, Kristian Thygesen, Jens Flensted Lassen, Bodil Steen Rasmussen, Anni Nørgaard Jeppesen, Christophe Henri Valdemar Duez, Eldar Søreide & Hans Kirkegaard. (2017) The Extent of Myocardial Injury During Prolonged Targeted Temperature Management After Out-of-Hospital Cardiac Arrest. The American Journal of Medicine 130:1, pages 37-46.
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Pei Wang, Liyan Jia, Bihua Chen, Lei Zhang, Jiankang Liu, Jiangang Long & Yongqin Li. (2016) Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock 46:3, pages 312-318.
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Chien-Hua Huang, Min-Shan Tsai, Kuo-Liong Chien, Wei-Tien Chang, Tzung-Dau Wang, Shyr-Chyr Chen, Matthew Huei-Ming Ma, Hsin-Yun Hsu & Wen-Jone Chen. (2016) Predicting the outcomes for out-of-hospital cardiac arrest patients using multiple biomarkers and suspension microarray assays. Scientific Reports 6:1.
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Martin AnnbornFredrik NilssonJosef DankiewiczMalin RundgrenSabine HertelJoachim StruckTobias CronbergNiklas Nielsen. (2016) The Combination of Biomarkers for Prognostication of Long-Term Outcome in Patients Treated with Mild Hypothermia After Out-of-Hospital Cardiac Arrest—A Pilot Study. Therapeutic Hypothermia and Temperature Management 6:2, pages 85-90.
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Michael A. Ferguson, Robert M. Sutton, Michael Karlsson, Fredrik Sjövall, Lance B. Becker, Robert A. Berg, Susan S. Margulies & Todd J. Kilbaugh. (2016) Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. Journal of Bioenergetics and Biomembranes 48:3, pages 269-279.
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Sean Thoms, Matthew Cooke & James Crawford. (2016) Cardiovascular Collapse Associated With Irreversible Cardiomyopathy, Chronic Renal Failure, and Hypertension During Routine Dental Care. Anesthesia Progress 63:1, pages 34-41.
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Yvan Devaux, Pascal Stammet, Hans Friberg, Christian Hassager, Michael A Kuiper, Matt P Wise & Niklas Nielsen. (2015) MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?. Critical Care 19:1.
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Bob Smit, Angelique ME Spoelstra-de Man, Armand RJ Girbes & Monique C de Waard. (2015) NT-proBNP in cardiopulmonary resuscitated patients treated with mild therapeutic hypothermia is not independently associated with mortality: a retrospective observational study. BMC Anesthesiology 15:1.
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Ravi Starzl, Dolores Wolfram, Ruben Zamora, Bahiyyah Jefferson, Derek Barclay, Chien Ho, Vijay Gorantla, Gerald Brandacher, Stefan Schneeberger, W. P. Andrew Lee, Jaime Carbonell & Yoram Vodovotz. (2015) Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling. Frontiers in Immunology 6.
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Helge Røsjø, Jukka Vaahersalo, Tor-Arne Hagve, Ville Pettilä, Jouni Kurola & Torbjørn Omland. (2014) Prognostic value of high-sensitivity troponin T levels in patients with ventricular arrhythmias and out-of-hospital cardiac arrest: data from the prospective FINNRESUSCI study. Critical Care 18:6.
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Ing-Marie Larsson, Ewa Wallin, Marja-Leena Kristofferzon, Marion Niessner, Henrik Zetterberg & Sten Rubertsson. (2014) Post-cardiac arrest serum levels of glial fibrillary acidic protein for predicting neurological outcome. Resuscitation 85:12, pages 1654-1661.
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Jukka Vaahersalo, Markus B. Skrifvars, Kari Pulkki, Mats Stridsberg, Helge Røsjø, Seppo Hovilehto, Marjaana Tiainen, Tero Varpula, Ville Pettilä & Esko Ruokonen. (2014) Admission interleukin-6 is associated with post resuscitation organ dysfunction and predicts long-term neurological outcome after out-of-hospital ventricular fibrillation. Resuscitation 85:11, pages 1573-1579.
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R. PFEIFER, M. FRANZ & H. R. FIGULLA. (2014) Hypothermia after cardiac arrest does not affect serum levels of neuron‐specific enolase and protein S‐100b. Acta Anaesthesiologica Scandinavica 58:9, pages 1093-1100.
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Chien-Hua Huang, Min-Shan Tsai, Kuo-Liong Chien, Chiung-Yuan Hsu, Wei-Tien Chang, Tzung-Dau Wang, Shyr-Chyr Chen, Matthew Huei-Ming Ma & Wen-Jone Chen. (2014) Prognostic relevance of plasma heart-type fatty acid binding protein after out-of-hospital cardiac arrest. Clinica Chimica Acta 435, pages 7-13.
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Antonio Maria Dell’anna, Julia Bini Viotti, Marjorie Beumier, Diego Orbegozo-Cortes, Katia Donadello, Sabino Scolletta, Jean-Louis Vincent & Fabio Silvio Taccone. (2014) C-reactive protein levels after cardiac arrest in patients treated with therapeutic hypothermia. Resuscitation 85:7, pages 932-938.
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Janneke Horn, Tobias Cronberg & Fabio S. Taccone. (2014) Prognostication after cardiac arrest. Current Opinion in Critical Care 20:3, pages 280-286.
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M. ANNBORN, J. DANKIEWICZ, N. NIELSEN, M. RUNDGREN, J. G. SMITH, S. HERTEL, J. STRUCK & H. FRIBERG. (2014) CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome. Acta Anaesthesiologica Scandinavica 58:4, pages 428-436.
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Seongtak KimJinseong ChoYongsu LimJinjoo KimHyukjun YangGun Lee. (2014) Change in Red Cell Distribution Width as Predictor of Death and Neurologic Outcome in Patients Treated with Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest. Korean Journal of Critical Care Medicine 29:4, pages 313.
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Patrik Gilje, Olof Gidlöf, Malin Rundgren, Tobias Cronberg, Mariam Al-Mashat, Björn Olde, Hans Friberg & David Erlinge. (2014) The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest. Critical Care 18:2, pages R40.
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Fabio Taccone, Tobias Cronberg, Hans Friberg, David Greer, Janneke Horn, Mauro Oddo, Sabino Scolletta & Jean-Louis Vincent. (2014) How to assess prognosis after cardiac arrest and therapeutic hypothermia. Critical Care 18:1, pages 202.
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Hans Friberg & Tobias Cronberg. (2013) Prognostication after cardiac arrest. Best Practice & Research Clinical Anaesthesiology 27:3, pages 359-372.
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Hans Friberg, Erik Westhall, Ingmar Rosén, Malin Rundgren, Niklas Nielsen & Tobias Cronberg. (2013) Clinical review: Continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest. Critical Care 17:4, pages 233.
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