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Expert Review of Endocrinology & Metabolism Volume 5, 2010 - Issue 5
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Drug Profile

Metoclopramide in the treatment of diabetic gastroparesis

Allen Lee Tufts Medical Center, Boston, MA, USA; Tufts Medical Center, Boston, MA, USA
&
Braden Kuo Massachusetts General Hospital, Blake 4, 55 Fruit St, Boston, MA 02114, USA. [email protected]; Massachusetts General Hospital, Blake 4, 55 Fruit St, Boston, MA 02114, USA. [email protected]
Pages 653-662 | Published online: 10 Jan 2014

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Saeed A. S. Al-Zuhairy, Mahmoud H. Teaima, Nabil A. Shoman, Mohamed Elasaly, Mohamed A. El-Nabarawi & Hossam S. El-Sawy. (2023) PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide. Drug Delivery 30:1.
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Laura Kreckler, Mark Osinski, Scott Williams & Roger Whiting. (2022) Non-Clinical Safety Pharmacology Evaluations of Trazpiroben (TAK-906), a Novel Dopamine D2/D3 Selective Receptor Antagonist for the Management of Gastroparesis. Journal of Experimental Pharmacology 14, pages 43-57.
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Chunlin Chen, Wenwen Zhang, Muhammad Bari, Cristina Almansa, Mike Baratta & Maria Rosario. (2021) Evaluation of the Pharmacokinetics of Trazpiroben (TAK-906), a Peripherally Selective D2/D3 Dopamine Receptor Antagonist, in the Presence and Absence of Itraconazole, a Potent CYP 3A4 Inhibitor. Clinical Pharmacology: Advances and Applications 13, pages 145-155.
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Mitsuhiro Nishihara, Diane Ramsden & Suresh K. Balani. (2021) Evaluation of the drug–drug interaction potential for trazpiroben (TAK-906), a D2/D3 receptor antagonist for gastroparesis, towards cytochrome P450s and transporters. Xenobiotica 51:6, pages 668-679.
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Mahesh Gajendran, Irene Sarosiek & Richard McCallum. (2021) Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults. Expert Review of Endocrinology & Metabolism 16:2, pages 25-35.
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Priyadarshini Loganathan, Mahesh Gajendran & Richard McCallum. (2019) Current and future treatment management strategies for gastroparesis. Expert Opinion on Orphan Drugs 7:5, pages 211-221.
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James Langworthy, Henry P Parkman & Ron Schey. (2016) Emerging strategies for the treatment of gastroparesis. Expert Review of Gastroenterology & Hepatology 10:7, pages 817-825.
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Mark Malamood, Henry Parkman & Ron Schey. (2015) Current advances in treatment of gastroparesis. Expert Opinion on Pharmacotherapy 16:13, pages 1997-2008.
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William L Hasler. (2014) Emerging drugs for the treatment of gastroparesis. Expert Opinion on Emerging Drugs 19:2, pages 261-279.
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Articles from other publishers (53)

Alexander Reddy, C. Prakash Gyawali & Amit Patel. (2023) The Impact of Gastroparesis on Medical Therapy for Gastroesophageal Reflux Disease (GERD). Foregut: The Journal of the American Foregut Society.
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M Ammar Kalas, Bhavi Trivedi, Mutaz Kalas, Luis O. Chavez & Richard W. McCallum. (2023) Metoclopramide in Gastroparesis: Its Mechanism of Action and Safety Profile. Gastrointestinal Disorders 5:3, pages 317-328.
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Mohammed S. O. Ahmed, Hannah Forde & Diarmuid Smith. (2022) Diabetic gastroparesis: clinical features, diagnosis and management. Irish Journal of Medical Science (1971 -) 192:4, pages 1687-1694.
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Dharmesh J Patel, Kamlesh Chaudhari, Deepti Shrivastava, Apoorva Dave, Akruti Shinde & Harshith Gowda. (2023) Unveiling the Unprecedented: An Astonishing Rarity of Metoclopramide Hydrochloride-Triggered Nystagmus in a Pregnant Woman. Cureus.
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Sarvee Moosavi, Yang Won Min, Melissa Wong & Ali Rezaie. (2023) Gastroparesis in pregnancy. American Journal of Obstetrics and Gynecology 228:4, pages 382-394.
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Viola Bäuerlein, Ingrid Vervuert & Monica Venner. (2023) Chronische Magendilatation beim Pferd – Diagnostik und kombinierter Behandlungsansatz. pferde spiegel 26:01, pages 4-7.
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Jennifer Connell, Mark Oldham, Pratik Pandharipande, Robert S Dittus, Amanda Wilson, Matthew Mart, Stephan Heckers, E. Wes Ely & Jo Ellen Wilson. (2022) Malignant Catatonia: A Review for the Intensivist. Journal of Intensive Care Medicine 38:2, pages 137-150.
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Ranil Jayawardena, Shahana Majeed, Piumika Sooriyaarachchi, Udara Abeywarne & Probhodana Ranaweera. (2023) The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics 308:4, pages 1075-1084.
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Karen L. Jones, Chinmay S. Marathe, Tongzhi Wu, Christopher K. Rayner & Michael Horowitz. 2023. Diabetic Neuropathy. Diabetic Neuropathy 471 490 .
Andrew Lofts, Fahed Abu-Hijleh, Nicolette Rigg, Ram K. Mishra & Todd Hoare. (2022) Using the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs. CNS Drugs 36:7, pages 739-770.
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Jatinder K. Mukker, George Dukes, Max Tolkoff, Lisi Wang, Cristina Almansa, Susanna Y. Huh, Mitsuhiro Nishihara, Diane Ramsden & Chunlin Chen. (2022) The pharmacokinetics of oral trazpiroben ( TAK ‐906) after organic anion transporting polypeptide 1B1 / 1B3 inhibition: A phase I, randomized study . Clinical and Translational Science 15:6, pages 1532-1543.
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Jeongkuk Seo & Kee Wook Jung. (2021) The Advantages and Disadvantages of Prokinetics. The Korean Journal of Medicine 96:6, pages 478-483.
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Roger L. Whiting, Agnes Choppin, Gary Luehr & Jeffrey R. Jasper. (2021) Preclinical Evaluation of the Effects of Trazpiroben (TAK-906), a Novel, Potent Dopamine D 2 /D 3 Receptor Antagonist for the Management of Gastroparesis . Journal of Pharmacology and Experimental Therapeutics 379:1, pages 85-95.
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R.J. Jalleh, C.S. Marathe, K.L. Jones, M. Horowitz & C.K. Rayner. (2021) Digesting the pathogenesis of diabetic gastroparesis. Journal of Diabetes and its Complications 35:10, pages 107992.
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Alireza Rahat-Dahmardeh, Sara Saneie-Moghadam & Masoum Khosh-Fetrat. (2021) Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized Clinical Trial. BioMed Research International 2021, pages 1-7.
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Braden Kuo, Cecilia Scimia, George Dukes, Wenwen Zhang, Saurabh Gupta, Chunlin Chen, Emil Chuang & Michael Camilleri. (2021) Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK‐906), a dopamine D 2 /D 3 receptor antagonist, in patients with gastroparesis . Alimentary Pharmacology & Therapeutics 54:3, pages 267-280.
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John M. Wo, Richard W. McCallum & Zorisadday Gonzalez. 2021. Gastroparesis. Gastroparesis 341 359 .
Christopher David Vélez & Braden Kuo. 2021. Gastroparesis. Gastroparesis 95 107 .
Marine Aussedat, Annie Lavoie, Jean-François Bussières & Niina Kleiber. (2020) Suspected Overlap Between Serotonin Syndrome and Neuroleptic Malignant Syndrome in a Child Treated With Metoclopramide?. The Journal of Pediatric Pharmacology and Therapeutics 25:6, pages 552-558.
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Michael Camilleri, Anthony Lembo, Richard McCallum, Stavros Tourkodimitris, Lara Kemps, Matthew B. Miller, Kirk Bertelsen & Alexandru Iacob. (2020) Overall safety of relamorelin in adults with diabetic gastroparesis: Analysis of phase 2a and 2b trial data. Alimentary Pharmacology & Therapeutics 51:11, pages 1139-1148.
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Lokesh Agrawal, Mustafa Korkutata, Sunil Kumar Vimal, Manoj Kumar Yadav, Sanjib Bhattacharyya & Takashi Shiga. (2020) Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut. Neuropharmacology 166, pages 107969.
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Bastien Ribot, Jérome Aupy, Marie Vidailhet, Joachim Mazère, Antonio Pisani, Erwan Bezard, Dominique Guehl & Pierre Burbaud. (2019) Dystonia and dopamine: From phenomenology to pathophysiology. Progress in Neurobiology 182, pages 101678.
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Imke Masuy, Lukas Van Oudenhove & Jan Tack. (2019) Review article: treatment options for functional dyspepsia. Alimentary Pharmacology & Therapeutics 49:9, pages 1134-1172.
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Chara Litou, Angela Effinger, Edmund S Kostewicz, Karl J Box, Nikoletta Fotaki & Jennifer B Dressman. (2019) Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review. Journal of Pharmacy and Pharmacology 71:4, pages 643-673.
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Hamidreza T Masoumi, Molouk Hadjibabaie, Morvarid Zarif-Yeganeh, Behrouz Khajeh & Ardeshir Ghavamzadeh. (2017) Treatment of vincristine-induced ileus with metoclopramide: A case report. Journal of Oncology Pharmacy Practice 25:2, pages 507-511.
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Chien-Hsu Lai, Yi-Chun Yeh & Yen-Yu Chen. (2019) Metoclopramide as a prokinetic agent for diabetic gastroparesis: revisiting the risk of Parkinsonism. Therapeutic Advances in Drug Safety 10, pages 204209861985400.
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Bertrand Behm, Carlos Fernandez & Mellar P. Davis. 2019. Textbook of Palliative Care. Textbook of Palliative Care 239 257 .
Huichuan Wang, Zengbing Lu, Yuen Hang Liu, Yayi Sun, Longlong Tu, Man P. Ngan, Chi-Kong Yeung & John A. Rudd. (2018) Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems. Experimental Physiology 103:6, pages 827-837.
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Kristian Svendsen, Mollie Wood, Erika Olsson & Hedvig Nordeng. (2017) Reported time to onset of neurological adverse drug reactions among different age and gender groups using metoclopramide: an analysis of the global database Vigibase®.. European Journal of Clinical Pharmacology 74:5, pages 627-636.
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Yuda Prasetya Nugraha & Hidehiro Uekusa. (2018) Suppressed hydration in metoclopramide hydrochloride by salt cocrystallisation. CrystEngComm 20:19, pages 2653-2662.
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Allen A. Lee & William L. Hasler. (2017) Diabetes and the Stomach. Current Treatment Options in Gastroenterology 15:4, pages 441-459.
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