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Review

The hedgehog/Gli signaling paradigm in prostate cancer

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Pages 453-467 | Published online: 10 Jan 2014

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Miaomiao Ge, Lu Zhang, Lina Cao, Chunfeng Xie, Xiaoting Li, Yuan Li, Yu Meng, Yue Chen, Xiaoqian Wang, Jiaqi Chen, Qi Zhang, Jihong Shao & Caiyun Zhong. (2019) Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway. International Journal of Food Sciences and Nutrition 70:5, pages 570-578.
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Alison D. Clark, Marieke Oldenbroek & Thomas G. Boyer. (2015) Mediator kinase module and human tumorigenesis. Critical Reviews in Biochemistry and Molecular Biology 50:5, pages 393-426.
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Gail P Risbridger. (2011) Contemporary approaches to prostate cancer research. Expert Review of Endocrinology & Metabolism 6:3, pages 299-300.
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Articles from other publishers (33)

Andrew G. Wagner, Robert T. Stagnitta, Zihan Xu, John L. Pezzullo, Nabin Kandel, José-Luis Giner, Douglas F. Covey, Chunyu Wang & Brian P. Callahan. (2021) Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the “Irreversibility Rule” for Protein Autoprocessing Inhibition. Biochemistry 61:11, pages 1022-1028.
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Cristian Gonzalez, Shivani Akula & Marieke Burleson. (2022) The role of mediator subunit 12 in tumorigenesis and cancer therapeutics (Review). Oncology Letters 23:3.
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Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, Lu-Zhe Sun & Thomas G. Boyer. (2022) GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer. Molecular Cancer Research 20:1, pages 62-76.
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Diana Trnski, Maja Sabol, Sanja Tomić, Ivan Štefanac, Milanka Mrčela, Vesna Musani, Nikolina Rinčić, Matea Kurtović, Tina Petrić, Sonja Levanat & Petar Ozretić. (2021) SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells. Scientific Reports 11:1.
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Abhishek Shah, Aarti Abhishek Shah, Nandakumar K & Richard Lobo. (2021) Mechanistic targets for BPH and prostate cancer–a review. Reviews on Environmental Health 36:2, pages 261-270.
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Santosh Kumar Singh, Jennifer B. Gordetsky, Sejong Bae, Edward P. Acosta, James W. LillardJr.Jr. & Rajesh Singh. (2020) Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer. Cells 9:9, pages 1976.
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Gianluca Civenni, Domenico Albino, Dheeraj Shinde, Ramiro Vázquez, Jessica Merulla, Aleksandra Kokanovic, Sarah N. Mapelli, Giuseppina M. Carbone & Carlo V. Catapano. (2019) Transcriptional Reprogramming and Novel Therapeutic Approaches for Targeting Prostate Cancer Stem Cells. Frontiers in Oncology 9.
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Qianjin Li, Omar A. Alsaidan, Sumit Rai, Meng Wu, Huifeng Shen, Zanna Beharry, Luciana L. Almada, Martin E. Fernandez-Zapico, Lianchun Wang & Houjian Cai. (2018) Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells. Journal of Biological Chemistry 293:27, pages 10547-10560.
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Linqi Guo, Yu Zhou, Ying Chen, Huawei Sun, Yue Wang & Yikun Qu. (2018) LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway. Biomedicine & Pharmacotherapy 103, pages 167-173.
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Hong Yang, Libing Hu, Zhimin Liu, Yang Qin, Ruiqian Li, Guoying Zhang, Bin Zhao, Chengwei Bi, Yonghong Lei & Yu Bai. (2017) Inhibition of Gli1‑mediated prostate cancer cell proliferation by inhibiting the mTOR/S6K1 signaling pathway. Oncology Letters.
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Gurdeep Marwarha, Shaneabbas Raza, Kimberly Hammer & Othman Ghribi. (2017) 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. Chemistry and Physics of Lipids 207, pages 108-126.
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Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Nibedita Pradhan & Samir Kumar Patra. (2017) SOX2 function and Hedgehog signaling pathway are co-conspirators in promoting androgen independent prostate cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:1, pages 253-265.
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Lan G. Coffman, Yun-Jung Choi, Karen McLean, Benjamin L. Allen, Marina Pasca di Magliano & Ronald J. Buckanovich. (2016) Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop . Oncotarget 7:6, pages 6916-6932.
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Hui Lin, Glenn A. Jackson, Yuan Lu, Sara K. Drenkhahn, Korey J. Brownstein, Nicholas J. Starkey, William R. Lamberson, Kevin L. Fritsche, Valeri V. Mossine, Cynthia L. Besch-Williford, William R. Folk, Yong Zhang & Dennis B. Lubahn. (2016) Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract . Cell Biology International 40:2, pages 131-142.
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Yuan Lu, Nicholas Starkey, Wei Lei, Jilong Li, Jianlin Cheng, William R. Folk & Dennis B. Lubahn. (2015) Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. PLOS ONE 10:12, pages e0145507.
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Timothy S. Owen, George Ngoje, Travis J. Lageman, Brandon M. Bordeau, Marlene Belfort & Brian P. Callahan. (2015) Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor. Analytical Biochemistry 488, pages 1-5.
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Brian Callahan & Chunyu Wang. (2015) Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling. Cancers 7:4, pages 2037-2053.
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Zizhang Zhou, Xia Yao, Shuang Li, Yue Xiong, Xiaohua Dong, Yun Zhao, Jin Jiang & Qing Zhang. (2015) Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Developmental Cell 34:1, pages 58-72.
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Timothy S. Owen, Xie Jian Xie, Benjamin Laraway, George Ngoje, Chunyu Wang & Brian P. Callahan. (2015) Active Site Targeting of Hedgehog Precursor Protein with Phenylarsine Oxide. ChemBioChem 16:1, pages 55-58.
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Emma Shtivelman, Tomasz M. Beer & Christopher P. Evans. (2014) Molecular pathways and targets in prostate cancer. Oncotarget 5:17, pages 7217-7259.
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Ralitsa Petrova & Alexandra L. Joyner. (2014) Roles for Hedgehog signaling in adult organ homeostasis and repair. Development 141:18, pages 3445-3457.
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Victoria Anastasia Belle, Niamh McDermott, Armelle Meunier & Laure Marignol. (2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nature Reviews Urology 11:9, pages 499-507.
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Jocelyn L. Wozney & Emmanuel S. Antonarakis. (2014) Growth factor and signaling pathways and their relevance to prostate cancer therapeutics. Cancer and Metastasis Reviews 33:2-3, pages 581-594.
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Zaki Shaikhibrahim, Anne Offermann, Martin Braun, Roopika Menon, Isabella Syring, Michael Nowak, Rebecca Halbach, Wenzel Vogel, Christian Ruiz, Tobias Zellweger, Cyrill A Rentsch, Maria Svensson, Ove Andren, Lukas Bubendorf, Saskia Biskup, Stefan Duensing, Jutta Kirfel & Sven Perner. (2014) MED12 overexpression is a frequent event in castration-resistant prostate cancer. Endocrine-Related Cancer 21:4, pages 663-675.
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J. Ranson. (2014) The roles of Hedgehog signalling and NF- B activity in pancreatic cancer and opportunities for treatment. Bioscience Horizons 7:0, pages hzu004-hzu004.
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Monica D. Nye, Luciana L. Almada, Maite G. Fernandez-Barrena, David L. Marks, Sherine F. Elsawa, Anne Vrabel, Ezequiel J. Tolosa, Volker Ellenrieder & Martin E. Fernandez-Zapico. (2014) The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner. Journal of Biological Chemistry 289:22, pages 15495-15506.
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Cheng Bao, Hyeju Namgung, Jaehoo Lee, Hyun-Chang Park, Jiwon Ko, Heejung Moon, Hyuk Wan Ko & Hong Jin Lee. (2014) Daidzein Suppresses Tumor Necrosis Factor-α Induced Migration and Invasion by Inhibiting Hedgehog/Gli1 Signaling in Human Breast Cancer Cells. Journal of Agricultural and Food Chemistry 62:17, pages 3759-3767.
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Trieu N. Trinh, Eileen A. McLaughlin, Christopher P. Gordon & Adam McCluskey. (2014) Hedgehog signalling pathway inhibitors as cancer suppressing agents. Med. Chem. Commun. 5:2, pages 117-133.
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GUODONG ZHU, JIANCHENG ZHOU, WENBIN SONG, DAPENG WU, QIANG DANG, LINLIN ZHANG, LEI LI, XINYANG WANG & DALIN HE. (2013) Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells. Oncology Reports 30:2, pages 904-910.
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Annelies Gonnissen, Sofie Isebaert & Karin Haustermans. (2013) Hedgehog Signaling in Prostate Cancer and Its Therapeutic Implication. International Journal of Molecular Sciences 14:7, pages 13979-14007.
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Swayamsiddha Kar, Moonmoon Deb, Dipta Sengupta, Arunima Shilpi, Sujit Kumar Bhutia & Samir Kumar Patra. (2012) Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis. Experimental Cell Research 318:16, pages 1959-1972.
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Karla C.S. Queiroz, C. Arnold Spek & Maikel P. Peppelenbosch. (2012) Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors. Drug Resistance Updates 15:4, pages 211-222.
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Elina Levina, Mengqian Chen, Richard Carkner, Michael Shtutman & Ralph Buttyan. (2011) Paracrine hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli‐dependent manner. The Prostate 72:8, pages 817-824.
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