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Expert Review of Hematology Volume 2, 2009 - Issue 2
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Editorial

Hyperhemolysis syndrome in sickle cell disease

Nay Win Consultant Haematologist, National Blood Service Tooting Centre, 75 Cranmer Terrace, Tooting, London, SW17 0RB, UK. [email protected]
Pages 111-115 | Published online: 10 Jan 2014

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Jennifer Light, Maria Boucher, Jacquelyn Baskin-Miller & Mike Winstead. (2023) Managing the Cerebrovascular Complications of Sickle Cell Disease: Current Perspectives. Journal of Blood Medicine 14, pages 279-293.
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Efthymia Vlachaki, Eleni Gavriilaki, Katerina Kafantari, Despoina Adamidou, Dimitris Tsitsikas, Eleni Chasapopoulou, Achilles Anagnostopoulos & Apostolos Tsapas. (2018) Successful Outcome of Hyperhemolysis in Sickle Cell Disease following Multiple Lines of Treatment: The Role of Complement Inhibition. Hemoglobin 42:5-6, pages 339-341.
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Matthew Yan, Jeannie Callum & Yulia Lin. (2015) Hyperhemolysis associated with marginal zone lymphoma. Leukemia & Lymphoma 56:3, pages 829-831.
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Articles from other publishers (64)

Naeem Desai, Jayne Peters, Elizabeth Davies & Joseph Sharif. (2023) The role of tocilizumab in the treatment of post‐transfusion hyperhaemolysis. eJHaem 4:4, pages 1096-1099.
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Danish Alam, Farha Naaz, Asimul Islam, Meryam Sardar & Tokeer Ahmad. (2023) Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation. Journal of Molecular Liquids 386, pages 122479.
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Allen Green, Heather Jones, Alecia Nero, Ibrahim F. Ibrahim, Ravi Sarode, Lisa M. Scheid, Christopher B. Webb, Brian D. Adkins & Sean G. Yates. (2023) A case of hyperhemolysis syndrome in sickle cell disease and concomitant COVID-19. Transfusion and Apheresis Science 62:4, pages 103712.
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Jeremy W. Jacobs, Laura D. Stephens, Elizabeth S. Allen, Thomas C. Binns, Garrett S. Booth, Jeanne E. Hendrickson, Matthew S. Karafin, Christopher A. Tormey, Jennifer S. Woo & Brian D. Adkins. (2023) Epidemiological and clinical features, therapeutic strategies and outcomes in patients with hyperhaemolysis: A systematic review. British Journal of Haematology 201:6, pages 1025-1032.
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Adir Shaulov, Deborah Rund, Dvora Filon, Boaz Nachmias, Aliaa Khalili, Noga Manny & Orly Zelig. (2023) Successful treatment with plasma exchange in life‐threatening hyperhemolytic syndrome unrelated to sickle cell disease. Transfusion 63:5, pages 1100-1106.
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SagirG Ahmed & UmmaA Ibrahim. (2023) Pathophysiologic basis of haemolysis in patients with sickle cell disease in steady state and in hyperhaemolytic states: Aetiopathogenesis, management, and mitigation. Nigerian Journal of Basic and Clinical Sciences 20:1, pages 10.
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Amal M. El Afifi, Alia M. Saeed, Gihad H. Fekry, Mariam A. Mostafa, Reham A. Elmetwally, Inas M. Hamed, Aliaa N. Hussein & Gomaa M. Hasanien. (2023) Successful Management of Severe Hyperhaemolysis with Combined Tocilizumab and Rituximab in Non-Transfusion-Dependent Thalassaemia: A Case Report. Transfusion Medicine and Hemotherapy 50:1, pages 66-70.
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Claire Falguière, Slimane Allali, Bassem Khazem, Annie Kamdem, Cécile Arnaud, Marie Belloy, Corinne Guitton, Marie-Hélène Odièvre, Sophie Pertuisel, Cecile Dumesnil, Cécile Guillaumat, Nathalie Garrec, Alexandra Gauthier, Perrine Mahe, Valerie Soussan-Banini, Laure Le-Carrer, Etienne Merlin, Audrey David, Beatrice Pellegrino, Catherine Paillard, Jean-Francois Brasme, Marie Lagarde, France Pirenne & Corinne Pondarre. (2022) Delayed hemolytic transfusion reaction in children with sickle cell disease: first 5-year retrospective study in mainland France. Haematologica 108:3, pages 889-894.
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Frederick Chen, Catherine Booth, Filipa Barroso, Sarah Bennett, Banu Kaya, Nay Win & Paul Telfer. (2021) Salvage of refractory post‐transfusion hyperhaemolysis by targeting hyperinflammation and macrophage activation with tocilizumab. Transfusion Medicine 32:5, pages 437-440.
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Gregory A. Denomme. 2022. Practical Transfusion Medicine. Practical Transfusion Medicine 11 20 .
Sasmith R. Menakuru, Adelina Priscu, Vijaypal Dhillon & Ahmed Salih. (2022) Acute Hyperhemolysis Syndrome in a Patient with Known Sickle Cell Anemia Refractory to Steroids and IVIG Treated with Tocilizumab and Erythropoietin: A Case Report and Review of Literature. Hematology Reports 14:3, pages 235-239.
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Jenna Spring & Laveena Munshi. (2022) Hematology Emergencies in Critically Ill Adults. Chest 161:5, pages 1285-1296.
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John Meenan, Rhys Hall, Saket Badle, Basabi Chatterjee, Nay Win & Dimitris A. Tsitsikas. (2022) Tocilizumab in the management of posttransfusion hyperhemolysis syndrome in sickle cell disease: The experience so far. Transfusion 62:3, pages 546-550.
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Merline Augustine, Mohandoss Murugesan, Chandran K. Nair, Vineetha Raghavan & Sangeetha K. Nayanar. (2021) Recurrent hyperhemolytic transfusion reaction in myelodysplastic syndrome- A case based approach. Transfusion and Apheresis Science 60:3, pages 103073.
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Ganesh Kasinathan & Jameela Sathar. (2021) Post‐transfusion hyperhemolysis syndrome in a patient with beta thalassemia major. Clinical Case Reports 9:6.
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Rafey Rehman, Saad B Saadat, Deanna H Tran, Sinziana Constantinescu & Yusuf Qamruzzaman. (2021) Recurrent Hyperhemolysis Syndrome in Sickle Cell Disease. Cureus.
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Yasmine O. Hardy, Divine A. Y. Amenuke, Yakubu Abukari, Alexander Oti‐Acheampong, Kojo Hutton‐Mensah, James Amoah‐Dankwah, Samuel Amoabeng Kontoh, Kwabena Asimeng Danso, Patrick Opoku Berchie & Caleb Otu‐Ansah. (2020) Clinical presentations and outcomes of COVID‐19 infection in sickle cell disease patients: Case series from Komfo Anokye teaching hospital, Ghana. Clinical Case Reports 9:2, pages 1018-1023.
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Connie M. ArthurJerry William L. Allen, Hans VerkerkeJustin YooRyan P. JajoskyKathryn Girard-PierceSatheesh Chonat, Patricia Zerra, Cheryl MaierJen RhaRoss Fasano, Cassandra D. Josephson, John D. RobackSean R. Stowell. (2021) Antigen density dictates RBC clearance, but not antigen modulation, following incompatible RBC transfusion in mice. Blood Advances 5:2, pages 527-538.
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Lakshman Vasanthamohan, Sheryl Choo, Tonisha Marshall, Yahui Tammy Symons, Doreen Matsui, Genevieve Eastabrook & Ziad Solh. (2020) Peripartum hyperhemolysis prophylaxis and management in sickle cell disease: A case report and narrative review. Transfusion 60:10, pages 2448-2455.
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Brian D. Adkins, Deva Sharma & Quentin Eichbaum. (2020) Can we better predict delayed hemolytic transfusion reactions and hyperhemolysis in sickle cell disease?. Transfusion and Apheresis Science 59:2, pages 102681.
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D. Romano, H. Craig & D. Katz. (2020) Management of cesarean delivery in a parturient with sickle cell disease. International Journal of Obstetric Anesthesia 41, pages 104-107.
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Lauren E. Lee, Bradley W. Beeler, Brendan C. Graham, Andrew P. Cap, Nay Win & Frederick Chen. (2019) Posttransfusion hyperhemolysis is arrested by targeting macrophage activation with novel use of Tocilizumab. Transfusion 60:1, pages 30-35.
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Samuel A. Merrill, Robert A. Brodsky, Sophie M. Lanzkron & Rakhi Naik. (2019) A case‐control analysis of hyperhemolysis syndrome in adults and laboratory correlates of complement involvement. Transfusion 59:10, pages 3129-3139.
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Stacy S. Epstein & Terence J. Hadley. (2019) Successful management of the potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure. Journal of Clinical Pharmacy and Therapeutics 44:5, pages 815-818.
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Suthesh Sivapalaratnam, Lisa Linpower, Bala Sirigireddy, Alexandra Agapidou, Susan Jain, Nay Win & Dimitris A. Tsitsikas. (2019) Treatment of post‐transfusion hyperhaemolysis syndrome in Sickle Cell Disease with the anti‐IL6R humanised monoclonal antibody Tocilizumab. British Journal of Haematology 186:6.
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Sandhya R. PanchCelina Montemayor-GarciaHarvey G. Klein. (2019) Hemolytic Transfusion Reactions. New England Journal of Medicine 381:2, pages 150-162.
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Sarita Coleman, Connie M. Westhoff, David F. Friedman & Stella T. Chou. (2019) Alloimmunization in patients with sickle cell disease and underrecognition of accompanying delayed hemolytic transfusion reactions. Transfusion 59:7, pages 2282-2291.
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Lilian Antwi Boateng, Alain Mayindu Ngoma, Imelda Bates & Henk Schonewille. (2019) Red Blood Cell Alloimmunization in Transfused Patients With Sickle Cell Disease in Sub-Saharan Africa; a Systematic Review and Meta-Analysis. Transfusion Medicine Reviews 33:3, pages 162-169.
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D. J. Roberts & M. Delaney. (2019) Immunohaematology: the core of laboratory transfusion practice. Transfusion Medicine 29:3, pages 143-145.
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L. Aiken, L. Linpower, D. A. Tsitsikas & N. Win. (2019) Hyperhaemolysis in a pregnant patient with HbH disease. Transfusion Medicine 29:3, pages 217-218.
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Satheesh Chonat, Connie M. Arthur, Patricia E. Zerra, Cheryl L. Maier, Ryan P. Jajosky, Marianne E.M. Yee, Maureen J. Miller, Cassandra D. Josephson, John D. Roback, Ross Fasano & Sean R. Stowell. (2019) Challenges in preventing and treating hemolytic complications associated with red blood cell transfusion. Transfusion Clinique et Biologique 26:2, pages 130-134.
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Aditya Srinivasan & Anand Gourishankar. (2019) A Differential Approach to an Uncommon Case of Acute Anemia in a Child With Sickle Cell Disease. Global Pediatric Health 6, pages 2333794X1984867.
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Mara Banks & James Shikle. (2018) Hyperhemolysis Syndrome in Patients With Sickle Cell Disease. Archives of Pathology & Laboratory Medicine 142:11, pages 1425-1427.
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Elizabeth Biller, Yong Zhao, Mary Berg, Lisa Boggio, Kelley E. Capocelli, Deanna C. Fang, Scott Koepsell, Lejla Music-Aplenc, Huy P. Pham, Angela Treml, John Weiss, Geoffrey Wool & Beverly W. Baron. (2018) Red blood cell exchange in patients with sickle cell disease-indications and management: a review and consensus report by the therapeutic apheresis subsection of the AABB. Transfusion 58:8, pages 1965-1972.
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Nay Win, Malcolm Needs, Nicole Thornton, Robert Webster & Cherry Chang. (2018) Transfusions of least‐incompatible blood with intravenous immunoglobulin plus steroids cover in two patients with rare antibody. Transfusion 58:7, pages 1626-1630.
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С. В. Видиборець, С. М. Гайдукова, О. В. Кучер & Г. І. Мороз. (2018) Hyperhemolysis syndrome: theory and practice. Family medicine:2, pages 64-66.
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Sara Chinchilla Langeber, Marta Pilar Osuna Marco, María Benedit & Áurea Cervera Bravo. (2018) When a transfusion in an emergency service is not really urgent: hyperhaemolysis syndrome in a child with sickle cell disease. BMJ Case Reports, pages bcr-2017-223209.
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Savannah Mwesigwa, Joann M. Moulds, Alice Chen, Jonathan Flanagan, Vivien A. Sheehan, Alex George & Neil A. Hanchard. (2018) Whole-exome sequencing of sickle cell disease patients with hyperhemolysis syndrome suggests a role for rare variation in disease predisposition. Transfusion 58:3, pages 726-735.
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Michelle L. Erickson. 2018. Clinical Principles of Transfusion Medicine. Clinical Principles of Transfusion Medicine 53 67 .
Basile Nsimba. (2017) RETRACTED: Delayed Hemolytic Transfusion Reaction and Hyperhemolysis Syndrome without Detectable Alloantibodies or Autoantibodies in a Patient with Sickle Cell Disease: A Fatal Case Report and Literature Review. Transfusion Clinique et Biologique.
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Thida Aung. (2017) Hyperhemolysis with Hemoglobin H Disease. Hematology & Transfusion International Journal 5:3.
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Jaap Jan Zwaginga & S. Marieke Ham. 2017. Practical Transfusion Medicine. Practical Transfusion Medicine 11 19 .
Matthew S. Karafin, Arun Singavi, Susan T. Johnson & Joshua J. Field. (2017) A Fatal Case of Immune Hyperhemolysis with Bone Marrow Necrosis in a Patient with Sickle Cell Disease. Hematology Reports 9:1, pages 8-11.
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Bernard A. Davis, Shubha Allard, Amrana Qureshi, John B. Porter, Shivan Pancham, Nay Win, Gavin Cho & Kate Ryan. (2017) Guidelines on red cell transfusion in sickle cell disease. Part I: principles and laboratory aspects. British Journal of Haematology 176:2, pages 179-191.
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Jose Manuel Vagace, Rocío Cardesa, Antonio Corbacho, Teresa Vázquez, Maria Dolores de la Maya, Fernando Ataulfo Gonzalez, José Bartolomé Nieto, Emilia Urrutia, María Jesus Gómez, Teresa Pascual, Maria Reyes Aguinaco & Guillermo Gervasini. (2016) Etiopathological mechanisms and clinical characteristics of hyperhemolysis syndrome in Spanish patients with thalassemia. Annals of Hematology 95:9, pages 1419-1427.
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Michael Winstead & Elliott Vichinsky. 2016. Nonmalignant Hematology. Nonmalignant Hematology 75 87 .
Robert S. Nickel, John T. Horan, Ross M. Fasano, Erin Meyer, Cassandra D. Josephson, Anne M. Winkler, Marianne E.M. Yee, Leslie S. Kean & Jeanne E. Hendrickson. (2015) Immunophenotypic parameters and RBC alloimmunization in children with sickle cell disease on chronic transfusion. American Journal of Hematology 90:12, pages 1135-1141.
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Anicee Danaee, Baba Inusa, Jo Howard & Susan Robinson. (2015) Hyperhemolysis in Patients With Hemoglobinopathies: A Single-Center Experience and Review of the Literature. Transfusion Medicine Reviews 29:4, pages 220-230.
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Maria Emmerick Gouveia, Natalia Bertges Soares, Mario Sant’Anna Santoro & Flávia Carolina Marques de Azevedo. (2015) Hyperhemolysis syndrome in a patient with sickle cell anemia: case report. Revista Brasileira de Hematologia e Hemoterapia 37:4, pages 266-268.
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Berta Santos, Rodrigo Portugal, Carmen Nogueira & Monique Loureiro. (2015) Hyperhemolysis syndrome in patients with sickle cell anemia: report of three cases. Transfusion 55:6pt2, pages 1394-1398.
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Shruti Gupta, Andrew Fenves, Sandra Taddie Nance, David B. Sykes & Walter “Sunny” Dzik. (2014) Hyperhemolysis syndrome in a patient without a hemoglobinopathy, unresponsive to treatment with eculizumab. Transfusion 55:3, pages 623-628.
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Lauren Anne Eberly, Diaa Osman & Nathaniel Perryman Collins. (2015) Hyperhemolysis Syndrome without Underlying Hematologic Disease. Case Reports in Hematology 2015, pages 1-3.
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