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Expert Review of Hematology Volume 2, 2009 - Issue 6
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Review

Acute myeloid leukemia stem cells: seek and destroy

Gail J Roboz Director, Leukemia Program, Associate Professor of Medicine, Weill Medical College of Cornell University, The New York Presbyterian Hospital, 520 East 70th Street, Starr 340A, New York, NY 10021, USA. [email protected]
&
Monica Guzman Assistant Professor of Pharmacology in Medicine, Weill Medical College of Cornell University and The New York Presbyterian Hospital, New York, NY, USA. [email protected]
Pages 663-672 | Published online: 10 Jan 2014

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Samuel S. Y. Wang. (2022) Relationship between leukaemic stem cells and hematopoietic stem cells and their clinical application. Leukemia & Lymphoma 63:7, pages 1524-1533.
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Mahnaz Mohammadi Kian, Mahdieh Salemi, Mohammad Bahadoran, Atousa Haghi, Nasrin Dashti, Saeed Mohammadi, Shahrbano Rostami, Bahram Chahardouli, Davood Babakhani & Mohsen Nikbakht. (2020) Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines. Drug Design, Development and Therapy 14, pages 185-194.
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Hao Qian, Lijuan Xia, Peixue Ling, Samuel Waxman & Yongkui Jing. (2012) CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts. Cancer Biology & Therapy 13:13, pages 1276-1283.
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Felicetto Ferrara. (2012) New agents for acute myeloid leukemia: is it time for targeted therapies?. Expert Opinion on Investigational Drugs 21:2, pages 179-189.
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Andrew Henry Lewis, Cory Seth Bridges, David Neal Moorshead, Taylor J Chen, Wa Du, Barry Zorman, Pavel Sumazin, Monica Puppi & H Daniel Lacorazza. (2022) Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia. Stem Cells 40:8, pages 736-750.
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Igor Valentim Barreto, Flávia Melo Cunha de Pinho Pessoa, Caio Bezerra Machado, Laudreísa da Costa Pantoja, Rodrigo Monteiro Ribeiro, Germison Silva Lopes, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes Filho, Lucas Eduardo Botelho de Souza, Rommel Mário Rodriguez Burbano, André Salim Khayat & Caroline Aquino Moreira-Nunes. (2022) Leukemic Stem Cell: A Mini-Review on Clinical Perspectives. Frontiers in Oncology 12.
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Shilpa Paul & Nicholas J. Short. (2022) Central Nervous System Involvement in Adults with Acute Leukemia: Diagnosis, Prevention, and Management. Current Oncology Reports 24:4, pages 427-436.
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Sophia Khaldoyanidi, Dirk Nagorsen, Anthony Stein, Gerrit Ossenkoppele & Marion Subklewe. (2021) Immune Biology of Acute Myeloid Leukemia: Implications for Immunotherapy. Journal of Clinical Oncology 39:5, pages 419-432.
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Laura M. BystromDaniel P. BezerraHsiao-Ting HsuHongliang ZongLuis A. Lara-MartínezJeanne P. De LeonMegan EmmanuelDavid MérySara GardenghiDuane Hassane, Catherine C. NetoSusanna Cunningham-RundlesMichael W. Becker, Stefano Rivella & Monica L. Guzman. (2019) Cranberry A-type proanthocyanidins selectively target acute myeloid leukemia cells. Blood Advances 3:21, pages 3261-3265.
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Bing Liu, Hongye Ma, Qianqian Liu, Yang Xiao, Shimeng Pan, Huimin Zhou & Li Jia. (2019) MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia. Journal of Experimental & Clinical Cancer Research 38:1.
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Dan-dan Xu, Ying Wang, Peng-jun Zhou, Shu-rong Qin, Rong Zhang, Yi Zhang, Xue Xue, Jianping Wang, Xia Wang, Hong-ce Chen, Xiao Wang, Yu-wei Pan, Li Zhang, Hai-zhao Yan, Qiu-ying Liu, Zhong Liu, Su-hong Chen, Hong-yuan Chen & Yi-fei Wang. (2018) The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells. Frontiers in Pharmacology 9.
Crossref
Francis J. Barrios. 2018. Sesquiterpene Lactones. Sesquiterpene Lactones 93 117 .
Shao‑Feng Yang, Ran Ma, Li‑Li Pan, Jing Cao & Nan Sheng. (2017) RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells. Oncology Letters.
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Xuefei Wang, Shile Huang & Ji-Long Chen. (2017) Understanding of leukemic stem cells and their clinical implications. Molecular Cancer 16:1.
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Yen‐Hua Lee, Yi‐Jen Liao, Chin‐Han Huang, Fu‐Ling Chang, Ting‐Hsi Fan & Yuh‐Ching Twu. (2017) Branched I antigens on leukemia cells enhanced sensitivity against natural killer–cell cytotoxicity through affecting the target–effector interaction. Transfusion 57:4, pages 1040-1051.
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Dorian Forte, Valentina Salvestrini, Giulia Corradi, Lara Rossi, Lucia Catani, Roberto M. Lemoli, Michele Cavo & Antonio Curti. (2016) The tissue inhibitor of metalloproteinases-1 (TIMP-1) promotes survival and migration of acute myeloid leukemia cells through CD63/PI3K/Akt/p21 signaling. Oncotarget 8:2, pages 2261-2274.
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Dan-dan Xu, Peng-jun Zhou, Ying Wang, Yi Zhang, Rong Zhang, Li Zhang, Su-hong Chen, Wu-yu Fu, Bi-bo Ruan, Hai-peng Xu, Chao-zhi Hu, Lu Tian, Jin-hong Qin, Sheng Wang, Xiao Wang, Qiu-ying Liu, Zhe Ren, Xue-kui Gu, Yao-he Li, Zhong Liu & Yi-fei Wang. (2016) miR-150 Suppresses the Proliferation and Tumorigenicity of Leukemia Stem Cells by Targeting the Nanog Signaling Pathway. Frontiers in Pharmacology 7.
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Saeed Mohammadi, Seyed H. Ghaffari, Mojgan Shaiegan, Mahin Nikougoftar Zarif, Mohsen Nikbakht, Shiva Akbari Birgani, Kamran Alimoghadam & Ardeshir Ghavamzadeh. (2016) Acquired expression of osteopontin selectively promotes enrichment of leukemia stem cells through AKT/mTOR/PTEN/β-catenin pathways in AML cells. Life Sciences 152, pages 190-198.
Crossref
Paola E. Ordóñez, Krishan K. Sharma, Laura M. Bystrom, Maria A. Alas, Raul G. Enriquez, Omar Malagón, Darin E. Jones, Monica L. Guzman & Cesar M. Compadre. (2016) Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa , Demonstrates Cytotoxic Activity against Human Leukemia Cells . Journal of Natural Products 79:4, pages 691-696.
Crossref
Rui Zhang, Jiyuan Yang, Yan Zhou, Paul J. Shami & Jindřich Kopeček. (2016) N -(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia . Macromolecular Bioscience 16:1, pages 121-128.
Crossref
Axel Schulenburg, Katharina Blatt, Sabine Cerny-Reiterer, Irina Sadovnik, Harald Herrmann, Brigitte Marian, Thomas W Grunt, Christoph C Zielinski & Peter Valent. (2015) Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?. Journal of Hematology & Oncology 8:1.
Crossref
Xia Jiang, Cheryl Zi Hui Lim, Zhimei Li, Puay Leng Lee, Siti Maryam J. M. Yatim, Peiyong Guan, Juntao Li, Jianbiao Zhou, Jingxuan Pan, Wee-Joo Chng, Christina L. L. Chai & Qiang Yu. (2015) Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML). PLOS ONE 10:4, pages e0122983.
Crossref
Steven M. Kornblau. 2015. Targeted Therapy of Acute Myeloid Leukemia. Targeted Therapy of Acute Myeloid Leukemia 27 43 .
Katharina Blatt, Harald Herrmann, Gregor Hoermann, Michael Willmann, Sabine Cerny-Reiterer, Irina Sadovnik, Susanne Herndlhofer, Berthold Streubel, Werner Rabitsch, Wolfgang R. Sperr, Matthias Mayerhofer, Thomas Rülicke & Peter Valent. (2014) Identification of Campath-1 (CD52) as Novel Drug Target in Neoplastic Stem Cells in 5q-Patients with MDS and AML. Clinical Cancer Research 20:13, pages 3589-3602.
Crossref
J. Felipe Rico, Duane C. Hassane & Monica L. Guzman. (2013) Acute myelogenous leukemia stem cells: From Bench to Bedside. Cancer Letters 338:1, pages 4-9.
Crossref
Karen-Sue B. Carlson & Monica L. Guzman. (2013) Is Minimal Residual Disease Monitoring Clinically Relevant in Adults with Acute Myelogenous Leukemia?. Current Hematologic Malignancy Reports 8:2, pages 109-115.
Crossref
Nico Lachmann, Sebastian Brennig, Ruhi Phaltane, Michael Flasshove, Dagmar Dilloo & Thomas Moritz. (2013) Myeloprotection by Cytidine Deaminase Gene Transfer in Antileukemic Therapy. Neoplasia 15:3, pages 239-248.
Crossref
Felicetto Ferrara & Charles A Schiffer. (2013) Acute myeloid leukaemia in adults. The Lancet 381:9865, pages 484-495.
Crossref
Gail J. Roboz. (2012) Current treatment of acute myeloid leukemia. Current Opinion in Oncology 24:6, pages 711-719.
Crossref
Yousef Mortazavi, Saeid Kaviani, Fatemeh Mirzamohammadi, Kamran Alimoghaddam, Ali Akbar Pourfathollah & Oveis Salehi. (2012) Evaluation of X-Chromosome Inactivation Patterns in Patients with Acute Myeloid Leukemia during Remission. ISRN Hematology 2012, pages 1-7.
Crossref
Mariam Thomas, Mahadeo A. Sukhai & Suzanne Kamel-Reid. (2012) An emerging role for retinoid X receptor α in malignant hematopoiesis. Leukemia Research 36:9, pages 1075-1081.
Crossref
Jia-Dai Zhai, Dongmei Li, Jing Long, Hao-Liang Zhang, Jian-Ping Lin, Chuan-Jiang Qiu, Quan Zhang & Yue Chen. (2012) Biomimetic Semisynthesis of Arglabin from Parthenolide. The Journal of Organic Chemistry 77:16, pages 7103-7107.
Crossref
Rada M. Grubovikj, Asif Alavi, Ahrin Koppel, Mary Territo & Gary J. Schiller. (2012) Minimal Residual Disease as a Predictive Factor for Relapse after Allogeneic Hematopoietic Stem Cell Transplant in Adult Patients with Acute Myeloid Leukemia in First and Second Complete Remission. Cancers 4:2, pages 601-617.
Crossref
Gail J. Roboz. (2011) Novel Approaches to the Treatment of Acute Myeloid Leukemia. Hematology 2011:1, pages 43-50.
Crossref
Eike C. Buss & Anthony D. Ho. (2011) Leukemia stem cells. International Journal of Cancer 129:10, pages 2328-2336.
Crossref
Brian M. Barth, Erhan I. Altinoğlu, Sriram S. Shanmugavelandy, James M. Kaiser, Daniza Crespo-Gonzalez, Nicole A. DiVittore, Christopher McGovern, Trevor M. Goff, Nicole R. Keasey, James H. Adair, Thomas P. LoughranJr.Jr., David F. Claxton & Mark Kester. (2011) Targeted Indocyanine-Green-Loaded Calcium Phosphosilicate Nanoparticles for In Vivo Photodynamic Therapy of Leukemia . ACS Nano 5:7, pages 5325-5337.
Crossref
Jessica K. Altman, Antonella Sassano & Leonidas C. Platanias. (2011) Targeting mTOR for the treatment of AML. New agents and new directions. Oncotarget 2:6, pages 510-517.
Crossref

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