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Expert Review of Hematology Volume 4, 2011 - Issue 3
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Drug Profile

Clinical development of panobinostat in classical Hodgkin’s lymphoma

Yasuhiro Oki Department of Lymphoma/Myeloma, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Lymphoma/Myeloma, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
,
Amanda Copeland Department of Lymphoma/Myeloma, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Lymphoma/Myeloma, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
&
Anas Younes Department of Lymphoma/Myeloma, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA;[email protected]
Pages 245-252 | Published online: 10 Jan 2014

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Read on this site (3)

Nuggehally R. Srinivas. (2017) Clinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives. Xenobiotica 47:4, pages 354-368.
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Minal Surati, Kelly Valla, Katherine Sanvidge Shah, Elyse Hall Panjic & Sagar Lonial. (2015) Panobinostat for the treatment of multiple myeloma. Expert Opinion on Orphan Drugs 3:2, pages 229-238.
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Syed F Zafar, Ganji Purnachandra Nagaraju & Bassel El-Rayes. (2012) Developing histone deacetylase inhibitors in the therapeutic armamentarium of pancreatic adenocarcinoma. Expert Opinion on Therapeutic Targets 16:7, pages 707-718.
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Articles from other publishers (12)

Zsuzsanna Gaál. (2022) Targeted Epigenetic Interventions in Cancer with an Emphasis on Pediatric Malignancies. Biomolecules 13:1, pages 61.
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Louis H. Junker, Biaoru Li, Xingguo Zhu, Sivanagireddy Koti, Ryan E. Cerbone, Clifford L. Hendrick, Jose Sangerman, Susan Perrine & Betty S. Pace. (2022) Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects. Blood Cells, Molecules, and Diseases 93, pages 102626.
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Damir Simic & Nianli Sang. (2019) Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation. Experimental Hematology 72, pages 36-46.
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David A Pride & Alyssa R Summers. (2018) The emergence of specific HDAC inhibitors and their clinical efficacy in the treatment of hematologic malignancies and breast cancer. International Journal of Molecular Biology 3:5.
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Tatjana Maria Swerev, Thomas Wirth & Alexey Ushmorov. (2017) Activation of oncogenic pathways in classical Hodgkin lymphoma by decitabine: A rationale for combination with small molecular weight inhibitors. International Journal of Oncology 50:2, pages 555-566.
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Marije Slingerland, Dagmar Hess, Sally Clive, Sunil Sharma, Per Sandstrom, Niklas Loman, Maria G. Porro, Song Mu, Edward Waldron, Sue-zette Valera & Hans Gelderblom. (2014) A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and various degrees of hepatic function. Cancer Chemotherapy and Pharmacology 74:5, pages 1089-1098.
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Mariano Provencio, Antonio Sánchez & Margarita Sánchez-Beato. (2014) New drugs and targeted treatments in Hodgkin’s lymphoma. Cancer Treatment Reviews 40:3, pages 457-464.
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Maureen M. O’Brien, Michael J. Absalon, Thomas G. Gross & Kara M. Kelly. 2014. Hematopoietic Cell Transplantation in Children with Cancer. Hematopoietic Cell Transplantation in Children with Cancer 251 301 .
Yasuhiro Oki, Daniela Buglio, Michelle Fanale, Luis Fayad, Amanda Copeland, Jorge Romaguera, Larry W. Kwak, Barbara Pro, Silvana de Castro Faria, Sattva Neelapu, Nathan Fowler, Fredrick Hagemeister, Jiexin Zhang, Shouhao Zhou, Lei Feng & Anas Younes. (2013) Phase I Study of Panobinostat plus Everolimus in Patients with Relapsed or Refractory Lymphoma. Clinical Cancer Research 19:24, pages 6882-6890.
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Mariateresa PuglieseNicoletta FortunatiAntonina GermanoSofia AsioliFrancesca MaranoNicola PalestiniRoberto FrairiaGiuseppe BoccuzziMaria Graziella Catalano. (2013) Histone Deacetylase Inhibition Affects Sodium Iodide Symporter Expression and Induces 131 I Cytotoxicity in Anaplastic Thyroid Cancer Cells . Thyroid 23:7, pages 838-846.
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Irene M. GhobrialFederico CampigottoTimothy J. Murphy, Erica N. BoswellRanjit BanwaitFeda AzabStacey ChumaJanet KunsmanAmanda DonovanFarzana MasoodDiane WarrenScott Rodig, Kenneth C. AndersonPaul G. RichardsonEdie WellerJeffrey Matous. (2013) Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia. Blood 121:8, pages 1296-1303.
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Camelia Iancu-Rubin, David Gajzer, Goar Mosoyan, Faye Feller, John Mascarenhas & Ronald Hoffman. (2012) Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation. Experimental Hematology 40:7, pages 564-574.
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