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Review

A new era for IFN-α in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms

Pages 637-655 | Published online: 10 Jan 2014

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Niccolò Bartalucci, Paola Guglielmelli & Alessandro M. Vannucchi. (2020) Polycythemia vera: the current status of preclinical models and therapeutic targets. Expert Opinion on Therapeutic Targets 24:7, pages 615-628.
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Vibe Skov, Caroline Hasselbalch Riley, Mads Thomassen, Lasse Kjær, Thomas Stauffer Larsen, Ole Weis Bjerrum, Torben A Kruse & Hans Carl Hasselbalch. (2017) The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms. Leukemia & Lymphoma 58:8, pages 1914-1921.
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Mads Emil Bjørn & Hans Carl Hasselbalch. (2017) Minimal residual disease or cure in MPNs? Rationales and perspectives on combination therapy with interferon-alpha2 and ruxolitinib. Expert Review of Hematology 10:5, pages 393-404.
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Kris Vaddi, Srdan Verstovsek & Jean-Jacques Kiladjian. (2016) Ruxolitinib: a targeted treatment option for patients with polycythemia vera. Blood and Lymphatic Cancer: Targets and Therapy 6, pages 7-19.
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Cecilie Utke Rank, Ole Weis Bjerrum, Thomas Stauffer Larsen, Lasse Kjær, Karin de Stricker, Caroline Hasselbalch Riley & Hans Carl Hasselbalch. (2016) Minimal residual disease after long-term interferon-alpha2 treatment: a report on hematological, molecular and histomorphological response patterns in 10 patients with essential thrombocythemia and polycythemia vera. Leukemia & Lymphoma 57:2, pages 348-354.
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María Luisa Antelo, Natalia de las Heras, Jose Ramón Gonzalez Porras, Ana Kerguelen & Jose María Raya. (2015) Management of side effects of BCR/ABL-negative chronic myeloproliferative neoplasm therapies. Focus on anagrelide. Expert Review of Hematology 8:6, pages 819-835.
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Jean-Jacques Kiladjian, Elliott F Winton, Moshe Talpaz & Srdan Verstovsek. (2015) Ruxolitinib for the treatment of patients with polycythemia vera. Expert Review of Hematology 8:4, pages 391-401.
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Marina Kremyanskaya, John Mascarenhas & Ronald Hoffman. (2015) Anagrelide hydrochloride and ruxolitinib for treatment of polycythemia vera. Expert Opinion on Pharmacotherapy 16:8, pages 1185-1194.
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Srdan Verstovsek & Rami S Komrokji. (2015) Novel and emerging therapies for the treatment of polycythemia vera. Expert Review of Hematology 8:1, pages 101-113.
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Carles Besses. (2013) Anagrelide hydrochloride for essential thrombocythemia. Expert Opinion on Orphan Drugs 1:12, pages 1049-1062.
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Vibe Skov, Caroline Hasselbalch Riley, Mads Thomassen, Thomas Stauffer Larsen, Morten K. Jensen, Ole Weis Bjerrum, Torben A. Kruse & Hans Carl Hasselbalch. (2013) Whole blood transcriptional profiling reveals significant down-regulation of human leukocyte antigen class I and II genes in essential thrombocythemia, polycythemia vera and myelofibrosis. Leukemia & Lymphoma 54:10, pages 2269-2273.
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Brady L. Stein, Santosh Saraf, Urszula Sobol, Anna Halpern, Jamile Shammo, Damiano Rondelli, Laura Michaelis, Olatoyosi Odenike, Alfred Rademaker, Anaadriana Zakarija, Brandon McMahon, Jerry L. Spivak & Alison R. Moliterno. (2013) Age-related differences in disease characteristics and clinical outcomes in polycythemia vera. Leukemia & Lymphoma 54:9, pages 1989-1995.
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Richard T Silver, Jean-Jacques Kiladjian & Hans Carl Hasselbalch. (2013) Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis. Expert Review of Hematology 6:1, pages 49-58.
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Helen O. Ajufo, Julian A. Waksal, John O. Mascarenhas & Raajit K. Rampal. (2023) Treating accelerated and blast phase myeloproliferative neoplasms: progress and challenges. Therapeutic Advances in Hematology 14.
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Hans Hasselbalch, Vibe Skov, Lasse Kjær, Morten Kranker Larsen, Trine A. Knudsen, Marko Lucijanić & Rajko Kusec. (2022) Recombinant Interferon-β in the Treatment of Polycythemia Vera and Related Neoplasms: Rationales and Perspectives. Cancers 14:22, pages 5495.
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Cosimo Cumbo, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Francesco Tarantini, Giorgina Specchia, Pellegrino Musto & Francesco Albano. (2022) Second Cancer Onset in Myeloproliferative Neoplasms: What, When, Why?. International Journal of Molecular Sciences 23:6, pages 3177.
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Hans Carl Hasselbalch & Morten Orebo Holmström. (2018) Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure?. Seminars in Immunopathology 41:1, pages 5-19.
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Rasmus Tolstrup Larsen, Lars H. Tang, Nana Brochmann, Esben Meulengracht Flachs, Anne Illemann Christensen, Hans C. Hasselbalch & Ann‐Dorthe Zwisler. (2018) Associations between fatigue, physical activity, and QoL in patients with myeloproliferative neoplasms. European Journal of Haematology 100:6, pages 550-559.
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Kim-Hien T. Dao, Jeffrey W. Tyner & Jason Gotlib. (2017) Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. Current Hematologic Malignancy Reports 12:5, pages 432-441.
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Anthony R. Colombo, Asif Zubair, Devi Thiagarajan, Sergey Nuzhdin, Timothy J. Triche & Giridharan Ramsingh. (2017) Suppression of Transposable Elements in Leukemic Stem Cells. Scientific Reports 7:1.
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Hans Carl Hasselbalch. (2017) Molecular profiling as a novel tool to predict response to interferon-α2 in MPNs: The proof of concept in early myelofibrosis. Cancer 123:14, pages 2600-2603.
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Srdan Verstovsek, Claire N. Harrison, Jean-Jacques Kiladjian, Carole Miller, Ahmad B. Naim, Dilan C. Paranagama, Dany Habr & Alessandro M. Vannucchi. (2017) Markers of iron deficiency in patients with polycythemia vera receiving ruxolitinib or best available therapy. Leukemia Research 56, pages 52-59.
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Moshe Talpaz, Jessica Mercer & Rüdiger Hehlmann. 2016. Chronic Myeloid Leukemia. Chronic Myeloid Leukemia 207 230 .
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Katherine Y. King, Katie A. Matatall, Ching-Chieh Shen, Margaret A. Goodell, Sabina I. Swierczek & Josef T. Prchal. (2015) Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells. Experimental Hematology 43:10, pages 912-918.e2.
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Gunnar Birgegård. (2015) Advances and challenges in the management of essential thrombocythemia. Therapeutic Advances in Hematology 6:3, pages 142-156.
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Lorenzo Falchi, Kate J. Newberry & Srdan Verstovsek. (2015) New Therapeutic Approaches in Polycythemia Vera. Clinical Lymphoma Myeloma and Leukemia 15, pages S27-S33.
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Srdan VerstovsekHans Carl Hasselbalch. 2015. Novel Insights into Myelofibrosis Pathophysiology and Treatment. Novel Insights into Myelofibrosis Pathophysiology and Treatment 86 102 .
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Hans Carl Hasselbalch. (2015) Perspectives on the increased risk of second cancer in patients with essential thrombocythemia, polycythemia vera and myelofibrosis. European Journal of Haematology 94:2, pages 96-98.
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Mads Emil Bjørn & Hans Carl Hasselbalch. (2015) The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms. Mediators of Inflammation 2015, pages 1-11.
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Hans Carl Hasselbalch & Mads Emil Bjørn. (2015) MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives. Mediators of Inflammation 2015, pages 1-16.
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Naba R Mainali, Vijaya R Bhatt, Shiksha Kedia, Jairam Krishnamurthy, Laura M Wake & Mojtaba Akhtari. (2013) Reversible bone marrow aplasia induced by pegylated interferon-α-2a therapy in a patient with primary myelofibrosis. Journal of Oncology Pharmacy Practice 20:5, pages 386-392.
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Hans Carl Hasselbalch. (2014) The platelet–cancer loop in myeloproliferative cancer. Is thrombocythemia an enhancer of cancer invasiveness and metastasis in essential thrombocythemia, polycythemia vera and myelofibrosis?. Leukemia Research 38:10, pages 1230-1236.
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Min Lu, Lijuan Xia, Yan Li, Xiaoli Wang & Ronald Hoffman. (2014) The orally bioavailable MDM2 antagonist RG7112 and pegylated interferon α 2a target JAK2V617F-positive progenitor and stem cells. Blood 124:5, pages 771-779.
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John Mascarenhas. (2014) Rationale for combination therapy in myelofibrosis. Best Practice & Research Clinical Haematology 27:2, pages 197-208.
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Zhi-Rong Zhang & Yan-Chao Duan. (2014) Interferon Apha 2b for Treating Patients with JAK2V617F Positive Polycythemia Vera and Essential Thrombocytosis. Asian Pacific Journal of Cancer Prevention 15:4, pages 1681-1684.
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Richard T. SilverWilliam ChowAttilio Orazi, Stephen P. Arles & Stanley J. Goldsmith. (2013) Evaluation of WHO criteria for diagnosis of polycythemia vera: a prospective analysis. Blood 122:11, pages 1881-1886.
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Francesca PalandriNicola Polverelli, Lucia Catani, Michele Cavo & Nicola Vianelli. (2013) Update on the treatment of Ph-negative myeloproliferative neoplasms. International Journal of Hematologic Oncology 2:3, pages 251-262.
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Brady L. SteinRamon V. Tiu. (2013) Biological Rationale and Clinical Use of Interferon in the Classical BCR-ABL-Negative Myeloproliferative Neoplasms. Journal of Interferon & Cytokine Research 33:4, pages 145-153.
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Serge Y. Fuchs. (2013) Hope and Fear for Interferon: The Receptor-Centric Outlook on the Future of Interferon Therapy. Journal of Interferon & Cytokine Research 33:4, pages 211-225.
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Hans C. Hasselbalch. (2013) The role of cytokines in the initiation and progression of myelofibrosis. Cytokine & Growth Factor Reviews 24:2, pages 133-145.
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Hans Carl Hasselbalch. (2013) Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?. Leukemia Research 37:2, pages 214-220.
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Vibe Skov, Thomas Stauffer Larsen, Mads Thomassen, Caroline Hasselbalch Riley, Morten K. Jensen, Ole Weis Bjerrum, Torben A. Kruse & Hans Carl Hasselbalch. (2012) Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance. Leukemia Research 36:11, pages 1387-1392.
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Hans Carl Hasselbalch. (2012) Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?. Blood 119:14, pages 3219-3225.
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