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Expert Review of Anticancer Therapy Volume 10, 2010 - Issue 9
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Review

Molecular biology of squamous cell carcinoma of the head and neck: relevance and therapeutic implications

Sandra Schmitz Centre du Cancer, Departments of Medical Oncology and Head and Neck Surgery, Clinique de Cancérologie Cervico–Maxillo–Faciale, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium; Department of Head and Neck Surgery, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. [email protected]; Department of Head and Neck Surgery, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. [email protected]
&
Jean-Pascal Machiels Centre du Cancer, Departments of Medical Oncology and Head and Neck Surgery, Clinique de Cancérologie Cervico–Maxillo–Faciale, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium; Centre du Cancer, Departments of Medical Oncology and Head and Neck Surgery, Clinique de Cancérologie Cervico–Maxillo–Faciale, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
Pages 1471-1484 | Published online: 10 Jan 2014

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Joseph M. Curry, Madalina Tuluc, Diana Whitaker-Menezes, Julie A. Ames, Archana Anantharaman, Aileen Butera, Benjamin Leiby, David Cognetti, Federica Sotgia, Michael P. Lisanti & Ubaldo E. Martinez-Outschoorn. (2013) Cancer metabolism, stemness and tumor recurrence. Cell Cycle 12:9, pages 1371-1384.
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Vikas Kakkar, Vanita Sarin, Arpita Chatterjee, Mridu Manjari & Ishita Chopra. (2021) Expression of Cyclin-D1 and p53 as Prognostic Markers in Treatment of Oral Squamous Cell Carcinoma. Indian Journal of Otolaryngology and Head & Neck Surgery 74:S3, pages 6136-6145.
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Qimin Zhou, Ouyang Yuan, Hongtu Cui, Tao Hu, Gary Guishan Xiao, Jiao Wei, Honglei Zhang & Chengjun Wu. (2022) Bioinformatic analysis identifies HPV-related tumor microenvironment remodeling prognostic biomarkers in head and neck squamous cell carcinoma. Frontiers in Cellular and Infection Microbiology 12.
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Bhamini Patel & Nabil F. Saba. (2021) Current Aspects and Future Considerations of EGFR Inhibition in Locally Advanced and Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck. Cancers 13:14, pages 3545.
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Constanza Saka‐Herrán, Enric Jané‐Salas, Albert Estrugo‐Devesa & José López‐López. (2021) Head and neck cancer and non‐steroidal anti‐inflammatory drugs: Systematic review and meta‐analysis. Head & Neck 43:5, pages 1664-1682.
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Zane Deliu, Ardaman Shergill, Anne Meier, Phyo Thazin Myint, Sarah Khan, Paramjeet Khosla & Lawrence Feldman. 2020. Precision Medicine in Oncology. Precision Medicine in Oncology 99 131 .
Zhao Xiang, Shijie Zhou, Shuang Liang, Gang Zhang & Yinghui Tan. (2020) RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell‐like activity of oral cavity squamous cell carcinoma cells. Journal of Oral Pathology & Medicine 49:8, pages 741-750.
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Tao Wang, Yong-Xin Wang, Yan-Qin Dong, Yan-Li Yu & Ke Ma. (2020) Prolyl 4-hydroxylase subunit alpha 3 presents a cancer promotive function in head and neck squamous cell carcinoma via regulating epithelial-mesenchymal transition. Archives of Oral Biology 113, pages 104711.
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Upul Dissanayake. (2019) Expression and clinical significance of the receptors of the EGF family in oral squamous cell carcinomas. Translational Research in Oral Oncology 4, pages 2057178X1983653.
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Luís Silva Monteiro, Márcio Diniz-Freitas, Saman Warnakulasuriya, Tomás Garcia-Caballero, Jerónimo Forteza & Máximo Fraga. (2018) An immunohistochemical score to predict the outcome for oral squamous cell carcinoma. Journal of Oral Pathology & Medicine 47:4, pages 375-381.
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Luís Silva Monteiro, Márcio Diniz-Freitas, Saman Warnakulasuriya, Tomás Garcia-Caballero, Jerónimo Forteza-Vila & Máximo Fraga. (2018) Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas . Analytical Cellular Pathology 2018, pages 1-10.
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Daniela Fortunato Rêgo, Silvia Taveira Elias, AngéLica Amorim Amato, Graziela De Luca Canto & Eliete Neves Silva Guerra. (2017) Anti-tumor effects of metformin on head and neck carcinoma cell lines: A systematic review. Oncology Letters 13:2, pages 554-566.
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LS Monteiro, ML Delgado, S Ricardo, B do Amaral, F Salazar, JJ Pacheco, CA Lopes, H Bousbaa & S Warnakulasuryia. (2016) Prognostic significance of CD44v6, p63, podoplanin and MMP-9 in oral squamous cell carcinomas. Oral Diseases 22:4, pages 303-312.
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Nirbhay S. Jain, Ulrich H.N. Dürr & Ayyalusamy Ramamoorthy. (2015) Bioanalytical methods for metabolomic profiling: Detection of head and neck cancer, including oral cancer. Chinese Chemical Letters 26:4, pages 407-415.
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Débora Lima Pereira, Ana Carolina dos Santos Ferreira, Giselle Pinto de Faria & Jolie Kiemlian Kwee. (2014) Autophagy Interplays with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Trisenox in HEP-2, a Laryngeal Squamous Cancer. Pathology & Oncology Research 21:1, pages 103-111.
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LS Monteiro, S Ricardo, ML Delgado, F Garcez, B do Amaral & C Lopes. (2014) Phosphorylated EGFR at tyrosine 1173 correlates with poor prognosis in oral squamous cell carcinomas. Oral Diseases 20:2, pages 178-185.
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Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour & Salem Chouaib. (2013) Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+T cells. BMC Cancer 13:1.
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Yiru Xu & Gary Fisher. (2013) Role of Met Axis in Head and Neck Cancer. Cancers 5:4, pages 1601-1618.
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Luís Silva Monteiro, Maria Leonor Delgado, Sara Ricardo, Fernanda Garcez, Barbas do Amaral, Saman Warnakulasuriya & Carlos Lopes. (2013) Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 115:5, pages 638-645.
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Sven Gunia, Andreas Erbersdobler, Oliver W. Hakenberg, Stefan Koch & Matthias May. (2013) C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival. Pathology - Research and Practice 209:4, pages 215-220.
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Pratima Tripathi, Pachiyappan Kamarajan, Bagganahalli S. Somashekar, Neil MacKinnon, Arul M. Chinnaiyan, Yvonne L. Kapila, Thekkelnaycke M. Rajendiran & Ayyalusamy Ramamoorthy. (2012) Delineating metabolic signatures of head and neck squamous cell carcinoma: Phospholipase A2, a potential therapeutic target. The International Journal of Biochemistry & Cell Biology 44:11, pages 1852-1861.
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Nancy P. Judd, Clint T. Allen, Ashley E. Winkler & Ravindra Uppaluri. (2012) Comparative Analysis of Tumor‐Infiltrating Lymphocytes in a Syngeneic Mouse Model of Oral Cancer. Otolaryngology–Head and Neck Surgery 147:3, pages 493-500.
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Luís Silva Monteiro, Márcio Diniz‐Freitas, Tomás Garcia‐Caballero, Saman Warnakulasuriya, Jerónimo Forteza & Máximo Fraga. (2012) Combined cytoplasmic and membranous EGFR and p53 overexpression is a poor prognostic marker in early stage oral squamous cell carcinoma. Journal of Oral Pathology & Medicine 41:7, pages 559-567.
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Bagganahalli S. Somashekar, Pachiyappan Kamarajan, Theodora Danciu, Yvonne L. Kapila, Arul M. Chinnaiyan, Thekkelnaycke M. Rajendiran & Ayyalusamy Ramamoorthy. (2011) Magic Angle Spinning NMR-Based Metabolic Profiling of Head and Neck Squamous Cell Carcinoma Tissues. Journal of Proteome Research 10:11, pages 5232-5241.
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