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Expert Review of Anticancer Therapy Volume 10, 2010 - Issue 4
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Review

Evolution of systemic therapy for advanced pancreatic cancer

Daniel Renouf Department of Medical Oncology, Princess Margaret Hospital, 5–708, 610 University Avenue, Toronto, ON M5G 2M9 Canada. [email protected]
&
Malcolm Moore Department of Medical Oncology, Princess Margaret Hospital, 5–708, 610 University Avenue, Toronto, ON M5G 2M9 Canada. [email protected]
Pages 529-540 | Published online: 10 Jan 2014

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Maria C. Ramos, Houria Boulaiz, Carmen Griñan-Lison, Juan Antonio Marchal & Francisca Vicente. (2017) What’s new in treatment of pancreatic cancer: a patent review (2010–2017). Expert Opinion on Therapeutic Patents 27:11, pages 1251-1266.
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Diana Behrens, Ulrike Pfohl, Theresia Conrad, Michael Becker, Bernadette Brzezicha, Britta Büttner, Silvia Wagner, Cora Hallas, Rita Lawlor, Vladimir Khazak, Michael Linnebacher, Thomas Wartmann, Iduna Fichtner, Jens Hoffmann, Mathias Dahlmann & Wolfgang Walther. (2023) Establishment and Thorough Characterization of Xenograft (PDX) Models Derived from Patients with Pancreatic Cancer for Molecular Analyses and Chemosensitivity Testing. Cancers 15:24, pages 5753.
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Ping Chen, Ruochen Dong & Qi Chen. (2022) Extracts of the Medicinal Plants Pao Pereira and Rauwolfia vomitoria Inhibit Ovarian Cancer Stem Cells In Vitro . Integrative Cancer Therapies 21, pages 153473542211230.
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Wan-Chi Tsai, Wen-Hung Wang, Bo-Cian Huang, Chiung-Yao Huang & Jyh-Horng Sheu. (2021) 5-epi-Sinuleptolide from Soft Corals of the Genus Sinularia Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity. Molecules 26:22, pages 6932.
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Jessica Pahle, Dennis Kobelt, Jutta Aumann, Diana Behrens, Ole Daberkow, Margarita Mokritzkij, Jörg Piontek, Ulrike Stein & Wolfgang Walther. (2021) Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with Clostridium perfringens Enterotoxin (CPE). Cancers 13:17, pages 4393.
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Maria Mortoglou, Zoey Kathleen Tabin, E. Damla Arisan, Hemant M Kocher & Pinar Uysal-Onganer. (2021) Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy. Translational Oncology 14:7, pages 101090.
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Arkadiusz Gzil, Izabela Zarębska, Wiktor Bursiewicz, Paulina Antosik, Dariusz Grzanka & Łukasz Szylberg. (2019) Markers of pancreatic cancer stem cells and their clinical and therapeutic implications. Molecular Biology Reports 46:6, pages 6629-6645.
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Yan Li, JinWoo Hong, Bo-Kyeong Jung, Eonju Oh & Chae-Ok Yun. (2019) Oncolytic Ad co-expressing decorin and Wnt decoy receptor overcomes chemoresistance of desmoplastic tumor through degradation of ECM and inhibition of EMT. Cancer Letters 459, pages 15-29.
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Ruochen Dong, Ping Chen & Qi Chen. (2018) Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo. Integrative Cancer Therapies 17:4, pages 1204-1215.
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Jeanne A. Drisko, Oscar K. Serrano, Lisa R. Spruce, Qi Chen & Mark Levine. (2018) Treatment of pancreatic cancer with intravenous vitamin C. Anti-Cancer Drugs 29:4, pages 373-379.
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Kishore Polireddy, Ruochen Dong, Gregory Reed, Jun Yu, Ping Chen, Stephen Williamson, Pierre-Christian Violet, Ziyan Pessetto, Andrew K. Godwin, Fang Fan, Mark Levine, Jeanne A. Drisko & Qi Chen. (2017) High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study. Scientific Reports 7:1.
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Kishore Polireddy, Ruochen Dong, Peter R. McDonald, Tao Wang, Brendan Luke, Ping Chen, Melinda Broward, Anuradha Roy & Qi Chen. (2016) Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation. PLOS ONE 11:10, pages e0164811.
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Muralidharan K Chllamma, Natalie Cook, Neesha C Dhani, Kazim Giby, Anna Dodd, Lisa Wang, David W Hedley, Malcolm J Moore & Jennifer J Knox. (2016) FOLFIRINOX for advanced pancreatic cancer: the Princess Margaret Cancer Centre experience. British Journal of Cancer 115:6, pages 649-654.
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JIN LONG, ZHE LIU, XINGDA WU, YUANHONG XU & CHUNLIN GE. (2016) Screening for genes and subnetworks associated with pancreatic cancer based on the gene expression profile. Molecular Medicine Reports 13:5, pages 3779-3786.
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ANNA M. CZARNECKA, PIOTR KORZEŃ, ANNA NOWAK-DEMENT, WOJCIECH KUKWA, JAN KORNILUK & CEZARY SZCZYLIK. (2016) Prolonged complete response following gemcitabine-erlotinib combined therapy in advanced pancreatic cancer. Oncology Letters 11:2, pages 1101-1104.
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H. Zhao, L. Wang, R. Wei, D. Xiu, M. Tao, J. Ke, Y. Liu, J. Yang & T. Hong. (2014) Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway. Diabetes, Obesity and Metabolism 16:9, pages 850-860.
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D.J. Renouf, P.A. Tang, D. Hedley, E. Chen, S. Kamel-Reid, M.S. Tsao, D. Tran-Thanh, S. Gill, N. Dhani, H.J. Au, L. Wang & M.J. Moore. (2014) A phase II study of erlotinib in gemcitabine refractory advanced pancreatic cancer. European Journal of Cancer 50:11, pages 1909-1915.
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Xiao-ping Tan, Wei-guo Dong, Qing Zhang, Zi-rong Yang, Xiao-fei Lei & Ming-hua Ai. (2014) Potential Effects of Mina53 on Tumor Growth in Human Pancreatic Cancer. Cell Biochemistry and Biophysics 69:3, pages 619-625.
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Jun Yu & Qi Chen. (2014) Antitumor Activities of Rauwolfia vomitoria Extract and Potentiation of Gemcitabine Effects Against Pancreatic Cancer . Integrative Cancer Therapies 13:3, pages 217-225.
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Nadezhda V. Koshkina, Katrina Briggs, Flavio Palalon & Steven A. Curley. (2014) Autophagy and enhanced chemosensitivity in experimental pancreatic cancers induced by noninvasive radiofrequency field treatment. Cancer 120:4, pages 480-491.
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Shu-Kun Hong, Shi-Yong Yang, Shao-Hua Yin & Kun-Xing Yang. (2014) RC-3095, a Gastrin-Releasing Peptide Receptor Antagonist, Synergizes With Gemcitabine to Inhibit the Growth of Human Pancreatic Cancer CFPAC-1 In Vitro and In Vivo. Pancreas 43:1, pages 15-21.
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Giovanni Brandi, Simona Tavolari, Tiziana Guarnieri, Mariacristina Di Marco, Paola Paterini, Marina Macchini, Stefania Di Girolamo, Alessio Papi, Francesco De Rosa & Guido Biasco. (2014) Antiprotease Strategy in Pancreatic Cancer Treatment. Pancreas 43:1, pages 53-63.
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JUN YU, JEANNE DRISKO & QI CHEN. (2013) Inhibition of pancreatic cancer and potentiation of gemcitabine effects by the extract of Pao Pereira. Oncology Reports 30:1, pages 149-156.
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H. M. Gooden & K. J. White. (2013) Pancreatic cancer and supportive care—pancreatic exocrine insufficiency negatively impacts on quality of life. Supportive Care in Cancer 21:7, pages 1835-1841.
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Kun-Chun Chiang, Chi-Chang Yu, Jim-Ray Chen, Yu-Ting Huang, Cheng-Cheng Huang, Chun-Nan Yeh, Chien-Sheng Tsai, Li-Wei Chen, Hsien-Cin Chen, Jun-Te Hsu, Cheng-Hsu Wang & Huang-Yang Chen. (2012) Oncocytic-type intraductal papillary mucinous neoplasm (IPMN)-derived invasive oncocytic pancreatic carcinoma with brain metastasis - a case report. World Journal of Surgical Oncology 10:1.
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Daniel J. Renouf, Patricia A. Tang, Pierre Major, Monika K. Krzyzanowska, Bindi Dhesy-Thind, John R. Goffin, David Hedley, Lisa Wang, L. Doyle & Malcolm J. Moore. (2011) A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer. Investigational New Drugs 30:3, pages 1203-1207.
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Margaret S. Lee. 2012. Drug Repositioning. Drug Repositioning 207 252 .
Adam J. Johnson, Melissa N. Brown & Margaret E. Black. (2011) Evaluation of a UCMK/dCK fusion enzyme for gemcitabine-mediated cytotoxicity. Biochemical and Biophysical Research Communications 416:1-2, pages 199-204.
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Michael Graham Espey, Ping Chen, Brian Chalmers, Jeanne Drisko, Andrew Y. Sun, Mark Levine & Qi Chen. (2011) Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radical Biology and Medicine 50:11, pages 1610-1619.
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Thilo Hackert, Markus W. Büchler & Jens Werner. (2011) Current State of Surgical Management of Pancreatic Cancer. Cancers 3:1, pages 1253-1273.
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Kun-Chun Chiang, Chun-Nan Yeh & Tai C. Chen. (2011) Vitamin D and Pancreatic Cancer—An Update. Cancers 3:1, pages 213-226.
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