6,149
Views
65
CrossRef citations to date
0
Altmetric
Review

Hydroxycarbamide: a user’s guide for chronic myeloproliferative disorders

&
Pages 403-414 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Richard T Silver & Ghaith Abu-Zeinah. (2023) Polycythemia vera: aspects of its current diagnosis and initial treatment. Expert Review of Hematology 16:4, pages 253-266.
Read now
Paolo Ricchi, Antonella Meloni, Paolo Rigano, Laura Pistoia, Anna Spasiano, Massimo Allò, Giuseppe Messina, Antonella Quarta, Rosamaria Rosso, Alessandra Quota, Aldo Filosa, Aurelio Maggio & Alessia Pepe. (2022) The use of hydroxyurea in the real life of MIOT network: an observational study. Expert Opinion on Drug Safety 21:11, pages 1433-1440.
Read now
Indu Raman, Sant-Rayn Pasricha, H. Miles Prince & Costas K. Yannakou. (2021) Management of hydroxyurea resistant or intolerant polycythemia vera. Leukemia & Lymphoma 62:10, pages 2310-2319.
Read now
Yong-jie Xu, Saman Khan, Adam C. Didier, Michal Wozniak, Yufeng Liu, Amanpreet Singh & Toru M. Nakamura. (2019) A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast. Molecular and Cellular Biology 39:20.
Read now
Mads Emil Bjørn & Hans Carl Hasselbalch. (2017) Minimal residual disease or cure in MPNs? Rationales and perspectives on combination therapy with interferon-alpha2 and ruxolitinib. Expert Review of Hematology 10:5, pages 393-404.
Read now
María Luisa Antelo, Natalia de las Heras, Jose Ramón Gonzalez Porras, Ana Kerguelen & Jose María Raya. (2015) Management of side effects of BCR/ABL-negative chronic myeloproliferative neoplasm therapies. Focus on anagrelide. Expert Review of Hematology 8:6, pages 819-835.
Read now
Hans Carl Hasselbalch & Richard T Silver. (2015) Interferon in polycythemia vera and related neoplasms. Can it become the treatment of choice without a randomized trial?. Expert Review of Hematology 8:4, pages 439-445.
Read now
Marina Kremyanskaya, John Mascarenhas & Ronald Hoffman. (2015) Anagrelide hydrochloride and ruxolitinib for treatment of polycythemia vera. Expert Opinion on Pharmacotherapy 16:8, pages 1185-1194.
Read now
Richard T Silver, Jean-Jacques Kiladjian & Hans Carl Hasselbalch. (2013) Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis. Expert Review of Hematology 6:1, pages 49-58.
Read now
Hans Carl Hasselbalch. (2011) A new era for IFN-α in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Expert Review of Hematology 4:6, pages 637-655.
Read now

Articles from other publishers (52)

Simone Cilio, Giuseppe Fallara, Maria Teresa Lupo Stanghellini, Fabio Ciceri, Francesco Montorsi, Francesca Lunghi & Andrea Salonia. (2024) Impact of Hydroxyurea to Treat Haematological Disorders on Male Fertility: Two Case Reports and a Systematic Review. The World Journal of Men's Health 42.
Crossref
Zhaoheng Lin, Rongfang Li, Zhiwei Han, Yi Liu, Liyang Gao, Suchang Huang, Ying Miao & Rui Miao. (2023) The Universally Conserved Unconventional G Protein YchF Is Critical for Growth and Stress Response. Life 13:4, pages 1058.
Crossref
Rong Wang, Rory M. Shallis, Jessica M. Stempel, Scott F. Huntington, Amer M. Zeidan, Steven D. Gore, Xiaomei Ma & Nikolai A. Podoltsev. (2023) Second malignancies among older patients with classical myeloproliferative neoplasms treated with hydroxyurea. Blood Advances 7:5, pages 734-743.
Crossref
Marc J. B. Dam, Rasmus K. Pedersen, Trine A. Knudsen, Morten Andersen, Christina Ellervik, Morten Kranker Larsen, Lasse Kjær, Vibe Skov, Hans C. Hasselbalch & Johnny T. Ottesen. (2022) A novel integrated biomarker index for the assessment of hematological responses in MPNs during treatment with hydroxyurea and interferon‐alpha2 . Cancer Medicine 12:4, pages 4218-4226.
Crossref
Hans Hasselbalch, Vibe Skov, Lasse Kjær, Morten Kranker Larsen, Trine A. Knudsen, Marko Lucijanić & Rajko Kusec. (2022) Recombinant Interferon-β in the Treatment of Polycythemia Vera and Related Neoplasms: Rationales and Perspectives. Cancers 14:22, pages 5495.
Crossref
Abhinav Mathur, Joakim Edman, Livia Liang, Neil W. Scott & Henry G. Watson. (2022) Skin cancer in essential thrombocythaemia and polycythaemia vera patients treated with hydroxycarbamide. eJHaem 3:4, pages 1305-1309.
Crossref
Roberta Listro, Giacomo Rossino, Federica Piaggi, Falilat Folasade Sonekan, Daniela Rossi, Pasquale Linciano & Simona Collina. (2022) Urea-based anticancer agents. Exploring 100-years of research with an eye to the future. Frontiers in Chemistry 10.
Crossref
Mashael Y Alyahya, Saman Khan, Sankhadip Bhadra, Rittu E Samuel & Yong-jie Xu. (2022) Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast. FEMS Yeast Research 22:1.
Crossref
Sadegh Kaviani & Mohammad Izadyar. (2022) First-principles study of the binding affinity of monolayer BC6N nanosheet: Implications for drug delivery. Materials Chemistry and Physics 276, pages 125375.
Crossref
Marc J. B. Dam, Rasmus K. Pedersen, Trine A. Knudsen, Morten Andersen, Vibe Skov, Lasse Kjær, Hans C. Hasselbalch & Johnny T. Ottesen. (2021) Data‐driven analysis of the kinetics of the JAK2V617F allele burden and blood cell counts during hydroxyurea treatment of patients with polycythemia vera, essential thrombocythemia, and primary myelofibrosis . European Journal of Haematology 107:6, pages 624-633.
Crossref
Hans C. Hasselbalch & Richard T. Silver. (2021) New Perspectives of Interferon-alpha2 and Inflammation in Treating Philadelphia-negative Chronic Myeloproliferative Neoplasms. HemaSphere 5:12, pages e645.
Crossref
Divya R Gavini, Dhairya J Salvi, Prutha H Shah, Davuluri Uma, Jun Hee Lee & Pousette Hamid. (2021) Non-melanoma Skin Cancers in Patients on Hydroxyurea for Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Systematic Review. Cureus.
Crossref
H.C. Hasselbalch, V. Skov, L. Kjær, C. Ellervik, A. Poulsen, T.D. Poulsen & C.H. Nielsen. (2021) COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon. Cytokine & Growth Factor Reviews 60, pages 28-45.
Crossref
Marcelina W. Musiałek & Dorota Rybaczek. (2021) Hydroxyurea—The Good, the Bad and the Ugly. Genes 12:7, pages 1096.
Crossref
Hatim Abid. (2021) Hydroxyurea-induced Amyopathic Dermatomyositis. Journal of Clinical and Medical Research.
Crossref
Gang Cheng, Micael Hardy, Paytsar Topchyan, Ryan Zander, Peter Volberding, Weiguo Cui & Balaraman Kalyanaraman. (2021) Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects. iScience 24:6, pages 102673.
Crossref
Victoria Landwehr, Martin Milanov, Larissa Angebauer, Jiang Hong, Gabriela Jüngert, Anna Hiersemenzel, Ariane Siebler, Fränk Schmit, Yavuz Öztürk, Stefan Dannenmaier, Friedel Drepper, Bettina Warscheid & Hans-Georg Koch. (2021) The Universally Conserved ATPase YchF Regulates Translation of Leaderless mRNA in Response to Stress Conditions. Frontiers in Molecular Biosciences 8.
Crossref
Mark R. Garren, Morgan Ashcraft, Yun Qian, Megan Douglass, Elizabeth J. Brisbois & Hitesh Handa. (2021) Nitric oxide and viral infection: Recent developments in antiviral therapies and platforms. Applied Materials Today 22, pages 100887.
Crossref
Nicole Kucine, Shayla Bergmann, Spencer Krichevsky, Devin Jones, Michael Rytting, Juhi Jain, Carolyn M. Bennett, Linda M.S. Resar, John Mascarenhas, Srdan Verstovsek & Ronald Hoffman. (2020) Use of pegylated interferon in young patients with polycythemia vera and essential thrombocythemia. Pediatric Blood & Cancer 68:3.
Crossref
Vibe Skov. (2020) Next Generation Sequencing in MPNs. Lessons from the Past and Prospects for Use as Predictors of Prognosis and Treatment Responses. Cancers 12:8, pages 2194.
Crossref
Samir Asher, Donal P. McLornan & Claire N. Harrison. (2020) Current and future therapies for myelofibrosis. Blood Reviews 42, pages 100715.
Crossref
Walid Saliba, Maria Khudyakova, Elena Mishchenko, Shai Cohen, Gad Rennert & Meir Preis. (2020) Association between myelofibrosis and risk of non-hematologic malignancies: a population-based retrospective cohort study. Annals of Hematology 99:5, pages 1007-1016.
Crossref
Vardan Nersesjan, Kristoffer A. Zervides, Anders L. Sørensen, Lasse Kjær, Vibe Skov & Hans C. Hasselbalch. (2019) The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera. European Journal of Haematology 104:1, pages 46-54.
Crossref
Carmen Cantisani, Norbert Kiss, Ahmad Faiq Naqeshbandi, Giulio Tosti, Sonia Tofani, Claudio Cartoni, Ida Carmosino & Franca Cantoresi. (2019) Nonmelanoma skin cancer associated with Hydroxyurea treatment: Overview of the literature and our own experience. Dermatologic Therapy 32:5.
Crossref
Yu-yang Pang, Yan Li, Gang Kui, Yong Tang, Ming-juan Liao, Yong-ling Wang, Zhen-dong Cao & Qi Zhu. (2018) Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-8.
Crossref
Rebecca Deering Brose, Elin Lehrmann, Yongqing Zhang, Roger H. Reeves, Kirby D. Smith & Mark P. Mattson. (2018) Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease. Neurobiology of Aging 72, pages 121-133.
Crossref
Gunnar Birgegård, Folke Folkvaljon, Hans Garmo, Lars Holmberg, Carlos Besses, Martin Griesshammer, Luigi Gugliotta, Jingyang Wu, Heinrich Achenbach, Jean-Jacques Kiladjian & Claire N. Harrison. (2018) Leukemic transformation and second cancers in 3649 patients with high-risk essential thrombocythemia in the EXELS study. Leukemia Research 74, pages 105-109.
Crossref
Roberta Risoluti & Stefano Materazzi. (2018) MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea. Frontiers in Chemistry 6.
Crossref
Jerry L. Spivak. (2018) Polycythemia Vera. Current Treatment Options in Oncology 19:2.
Crossref
Irina Nikolaevna Subortseva, A.L. Melikyan, E.A. Gilyazitdinova, T.I. Kolosheinova, E.I. Pustovaya, E.K. Egorova, A.M. Kovrigina, Sudarikov AB & Abdullaev AO. (2018) Dermatological Toxicity of Hydroxycarbamide. Clinical oncohematology 11:3, pages 252-258.
Crossref
Maliha Khan, Rabbia Siddiqi & Naseema Gangat. (2017) Therapeutic options for leukemic transformation in patients with myeloproliferative neoplasms. Leukemia Research 63, pages 78-84.
Crossref
Amanpreet Singh, Ameeta Agarwal & Yong-jie Xu. (2017) Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections. Antimicrobial Agents and Chemotherapy 61:11.
Crossref
Amanpreet Singh & Yong-jie Xu. (2017) Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea. Journal of Biological Chemistry 292:22, pages 9088-9103.
Crossref
Arisa YANO, Hiroshi SARUTA, Ikko MUTOU, Chika OHATA, Koji NAGAFUJI & Takekuni NAKAMA. (2017) A case of hydroxyurea-associated squamous cell carcinoma and Bowen's disease arising in a recalcitrant leg ulcer. Skin Cancer 32:1, pages 39-43.
Crossref
Iben Onsberg Hansen, Anders Lindholm Sørensen & Hans Carl Hasselbalch. (2017) Second malignancies in hydroxyurea and interferon-treated Philadelphia-negative myeloproliferative neoplasms. European Journal of Haematology 98:1, pages 75-84.
Crossref
M A Sokolova, A G Turkina, A L Melikian, A B Sudarikov, S A Treglazova, O A Shukhov, E G Gemdzhian, A О Abdullaev, A M Kovrigina, A V Misyurin, Yu V Pliskunova, V L Ivanova & T N Moiseeva. (2016) Efficiency of interferon therapy in patients with essential thrombocythemia or polycythemia vera. Terapevticheskii arkhiv 88:12, pages 69-77.
Crossref
Amanpreet Singh & Yong-Jie Xu. (2016) The Cell Killing Mechanisms of Hydroxyurea. Genes 7:11, pages 99.
Crossref
Yong-jie Xu, Amanpreet Singh & Gerald M Alter. (2016) Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway. Genetics 204:3, pages 959-973.
Crossref
Panagiota Vlachogianni, Maria Volosyraki, Maria Stefanidou, Sabine Krueger-Krasagakis, George Evangelou, Vrettos Haniotis, Diamantis Kofteridis, Sofia Maraki & Konstantin Krasagakis. (2016) Mycobacterium avium Auricular Infection in an Apparent Immunocompetent Patient: A Case Report. Folia Medica 58:2, pages 131-135.
Crossref
Eva Lizarralde Palacios, Alfonso Gutiérrez Macías, Mayte Rámiz Martínez & Mikel Escalante Boleas. (2015) Fiebre por hidroxiurea. Medicina Clínica 145:11, pages 505-506.
Crossref
Eva Lizarralde Palacios, Alfonso Gutiérrez Macías, Mayte Rámiz Martínez & Mikel Escalante Boleas. (2015) Fever induced by hydroxycarbamide. Medicina Clínica (English Edition) 145:11, pages 505-506.
Crossref
C. Doutrelon, E. Lazaro, E. Ribeiro, C. Greib, J.-L. Pellegrin & J.-F. Viallard. (2015) Hyperthermie induite par l’hydroxyurée : à propos de 4 cas et revue de la littérature. La Revue de Médecine Interne 36:2, pages 73-77.
Crossref
Hans Carl Hasselbalch & Mads Emil Bjørn. (2015) MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives. Mediators of Inflammation 2015, pages 1-16.
Crossref
Yuzuru Kanakura, Yoshitaka Miyakawa, Paul Wilde, Jonathan Smith, Heinrich Achenbach & Shinichiro Okamoto. (2014) Phase III, single-arm study investigating the efficacy, safety, and tolerability of anagrelide as a second-line treatment in high-risk Japanese patients with essential thrombocythemia. International Journal of Hematology 100:4, pages 353-360.
Crossref
Magnus Björkholm, Malin Hultcrantz & Åsa Rangert Derolf. (2014) Leukemic transformation in myeloproliferative neoplasms: Therapy-related or unrelated?. Best Practice & Research Clinical Haematology 27:2, pages 141-153.
Crossref
Nicole C. C. Them & Robert Kralovics. (2013) Genetic Basis of MPN: Beyond JAK2-V617F. Current Hematologic Malignancy Reports 8:4, pages 299-306.
Crossref
Filippo Quattrone, Valentina Dini, Sabrina Barbanera, Nicola Zerbinati & Marco Romanelli. (2013) Cutaneous ulcers associated with hydroxyurea therapy. Journal of Tissue Viability 22:4, pages 112-121.
Crossref
Ariel Amaru Calzada, Olga Pedrini, Guido Finazzi, Flavio Leoni, Paolo Mascagni, Martino Introna, Alessandro Rambaldi & Josée Golay. (2013) Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2V617F myeloproliferative neoplasm patients. Experimental Hematology 41:3, pages 253-260.e2.
Crossref
Carlos Besses, Jean-Jacques Kiladjian, Martin Griesshammer, Luigi Gugliotta, Claire Harrison, Ruth Coll, Jonathan Smith, Brihad Abhyankar & Gunnar Birgegård. (2013) Cytoreductive treatment patterns for essential thrombocythemia in Europe. Analysis of 3643 patients in the EXELS study. Leukemia Research 37:2, pages 162-168.
Crossref
Sebastian Francis, David Bareford, Christina Baginott & Jecko Thachil. (2012) Prognostic implications of leg ulcers from hydroxycarbamide therapy in patients with essential thrombocythaemia. Leukemia Research 36:4, pages 488-490.
Crossref
Ivana Vinković Vrček, Davor Šakić, Valerije Vrček, Hendrik Zipse & Mladen Biruš. (2012) Computational study of radicals derived from hydroxyurea and its methylated analogues. Org. Biomol. Chem. 10:6, pages 1196-1206.
Crossref
Sanath R. Wijerathna, Md. Faiz Ahmad, Hai Xu, James W. Fairman, Andrew Zhang, Prem Singh Kaushal, Qun Wan, Jianying Kiser & Chris G. Dealwis. (2011) Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy. Pharmaceuticals 4:10, pages 1328-1354.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.