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Expert Review of Cardiovascular Therapy Volume 9, 2011 - Issue 8
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Theme: General - Review

Aging is a primary risk factor for cardiac arrhythmias: disruption of intracellular Ca2+ regulation as a key suspect

Fiona Hatch Biological Sciences and HYMS, University of Hull, Kingston-Upon-Hull, HU6 7RX, UK; Biological Sciences and HYMS, University of Hull, Kingston-Upon-Hull, HU6 7RX, UK
,
Matthew K Lancaster Faculty of Biological Sciences, University of Leeds, LS2 9JT, UK; Faculty of Biological Sciences, University of Leeds, LS2 9JT, UK
&
Sandra A Jones Biological Sciences and HYMS, University of Hull, Kingston-Upon-Hull, HU6 7RX, UK;[email protected]
Pages 1059-1067 | Published online: 10 Jan 2014

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Sajad Khiali, Afra Rezagholizadeh, Hossein Behzad, Hossein Bannazadeh Baghi & Taher Entezari-Maleki. (2023) Current evidence of COVID-19 vaccination-related cardiovascular events. Postgraduate Medicine 135:2, pages 102-120.
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Hua-Qian Yang, Ekaterina Subbotina, Ravichandran Ramasamy & William A. Coetzee. (2016) Cardiovascular KATP channels and advanced aging. Pathobiology of Aging & Age-related Diseases 6:1.
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Julia Stowe, Heather J. Whitaker, Nick J. Andrews & Elizabeth Miller FMedSci. (2023) Risk of cardiac arrhythmia and cardiac arrest after primary and booster COVID-19 vaccination in England: A self-controlled case series analysis. Vaccine: X 15, pages 100418.
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Rafael Romero-Becerra, Francisco M. Cruz, Alfonso Mora, Juan Antonio Lopez, Daniela Ponce-Balbuena, Andrew Allan, Roberto Ramos-Mondragón, Bárbara González-Terán, Marta León, Maria Elena Rodríguez, Luis Leiva-Vega, Guadalupe Guerrero-Serna, Eric N. Jimenez-Vazquez, David Filgueiras-Rama, Jesús Vázquez, José Jalife & Guadalupe Sabio. (2023) p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia. Nature Cardiovascular Research 2:12, pages 1204-1220.
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Joshua A. Keefe & Xander H. T. Wehrens. (2023) Blocking p38γ/δ, a molecular cardiac defibrillator. Nature Cardiovascular Research 2:12, pages 1104-1106.
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Safa Hüseyin Küçük, Ali Batur, Nalan Metin Aksu & Meltem Akkaş. (2023) The effect of serum calcium level on the success of diltiazem treatment: A retrospective cohort study. The American Journal of Emergency Medicine 71, pages 59-62.
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Francesca Graziano, Giulio Mastella, Bela Merkely, Hajnalka Vago, Domenico Corrado & Alessandro Zorzi. (2023) Ventricular arrhythmias recorded on 12-lead ambulatory electrocardiogram monitoring in healthy volunteer athletes and controls: what is common and what is not. Europace 25:9.
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Shubham Banga, Manish Mishra, Stefan D. Heinze-Milne, Hailey J. Jansen, Robert A. Rose & Susan E. Howlett. (2023) Chronic testosterone deficiency increases late inward sodium current and promotes triggered activity in ventricular myocytes from aging male mice. American Journal of Physiology-Heart and Circulatory Physiology 325:2, pages H264-H277.
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Kenichi Hashimoto, Naomi Harada, Motohiro Kimata, Yusuke Kawamura, Naoya Fujita, Akinori Sekizawa, Yosuke Ono, Yasuhiro Obuchi, Tadateru Takayama, Yuji Kasamaki & Yuji Tanaka. (2023) Age-related reference intervals for ambulatory electrocardiographic parameters in healthy individuals. Frontiers in Cardiovascular Medicine 10.
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Laura García-Mendívil, María Pérez-Zabalza, Antoni Oliver-Gelabert, José María Vallejo-GilJavier Fañanás-MastralManuel Vázquez-SanchoJavier André Bellido-MoralesAlexánder Sebastián Vaca-NúñezCarlos Ballester-CuencaEmiliano Diez, Laura Ordovás & Esther Pueyo. (2023) Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk. Research 6.
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Daniel W. T. Wundersitz, Bradley J. Wright, Brett A. Gordon, Stephanie Pompei, Carl J. Lavie, Voltaire Nadurata, Kimberly Nolan & Michael I. C. Kingsley. (2022) Sympathovagal Balance Is a Strong Predictor of Post High-Volume Endurance Exercise Cardiac Arrhythmia. Frontiers in Physiology 13.
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Ahmed Yassin, Khalid El-Salem, Basheer Y. Khassawneh, Abdel-Hameed Al-Mistarehi, Mohamad Jarrah, Anas M. Zein Alaabdin, Sumayyah K. Abumurad, Mohammad G. Qasaimeh, Salma Y. Bashayreh, Raid M. Kofahi, Kefah A. Alhayk, Duha Alshorafat & Majdi Al Qawasmeh. (2021) Diagnostic value of electrocardiogram during routine electroencephalogram. Seizure 89, pages 19-23.
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Maartje Westhoff & Rose E. Dixon. (2021) Mechanisms and Regulation of Cardiac CaV1.2 Trafficking. International Journal of Molecular Sciences 22:11, pages 5927.
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ZengDing Liu, Bin Zhou, Ye Li, Min Tang & Fen Miao. (2020) Continuous Blood Pressure Estimation From Electrocardiogram and Photoplethysmogram During Arrhythmias. Frontiers in Physiology 11.
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Arsenii Dokuchaev, Svyatoslav Khamzin & Olga Solovyova. (2020) In-silico study of age-related ionic remodeling in human ventricular cardiomyocytes. BIO Web of Conferences 22, pages 01024.
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D. Wundersitz, Jacqui Williamson, Voltaire Nadurata, Kimberly Nolan, Carl Lavie & M. Kingsley. (2019) The impact of a 21-day ultra-endurance ride on the heart in young, adult and older adult recreational cyclists. International Journal of Cardiology 286, pages 137-142.
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Lorenzo Porta, Meng-tse Gabriel Lee, Wan-Ting Hsu, Tzu-Chun Hsu, Tou-Yuan Tsai & Chien-Chang Lee. (2019) Fluoroquinolone use and serious arrhythmias: A nationwide case-crossover study. Resuscitation 139, pages 262-268.
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Alessandro Zorzi, Giulio Mastella, Alberto Cipriani, Giampaolo Berton, Alvise Del Monte, Beatrice Gusella, Alberto Nese, Leonardo Portolan, Federico Sciacca, Suada Tikvina, Saverio Tollot, Domenico Trovato, Sabino Iliceto, Maurizio Schiavon & Domenico Corrado. (2018) Burden of ventricular arrhythmias at 12-lead 24-hour ambulatory ECG monitoring in middle-aged endurance athletes versus sedentary controls. European Journal of Preventive Cardiology 25:18, pages 2003-2011.
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Haseeb Valli, Shiraz Ahmad, James A. Fraser, Kamalan Jeevaratnam & Christopher L.-H. Huang. (2017) Pro-arrhythmic atrial phenotypes in incrementally paced murine Pgc1β −/− hearts: effects of age . Experimental Physiology 102:12, pages 1619-1634.
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Shiraz Ahmad, Haseeb Valli, Charlotte E. Edling, Andrew A. Grace, Kamalan Jeevaratnam & Christopher L-H Huang. (2017) Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β −/− hearts. Pflügers Archiv - European Journal of Physiology 469:12, pages 1579-1590.
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Florian Stöckigt, Thomas Beiert, Vincent Knappe, Olivier R. Baris, Rudolf J. Wiesner, Christoph S. Clemen, Georg Nickenig, René P. Andrié & Jan W. Schrickel. (2017) Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction. Biochemical and Biophysical Research Communications 493:1, pages 604-610.
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Nages Nagaratnam, Kujan Nagaratnam & Gary CheukNages Nagaratnam, Kujan Nagaratnam & Gary Cheuk. 2016. Diseases in the Elderly. Diseases in the Elderly 1 37 .
Kai-Chien YangJohn W. KyleJonathan C. MakielskiSamuel C. DudleyJrJr. (2015) Mechanisms of Sudden Cardiac Death. Circulation Research 116:12, pages 1937-1955.
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Olivier R. Baris, Stefan Ederer, Johannes F.G. Neuhaus, Jürgen-Christoph von Kleist-Retzow, Claudia M. Wunderlich, Martin Pal, F. Thomas Wunderlich, Viktoriya Peeva, Gabor Zsurka, Wolfram S. Kunz, Tilman Hickethier, Alexander C. Bunck, Florian Stöckigt, Jan W. Schrickel & Rudolf J. Wiesner. (2015) Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging. Cell Metabolism 21:5, pages 667-677.
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K. M. Rice, J. C. Fannin, C. Gillette & E. R. Blough. (2014) Efficacy of Female Rat Models in Translational Cardiovascular Aging Research. Journal of Aging Research 2014, pages 1-14.
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