Advanced search
Publication Cover
Expert Review of Anti-infective Therapy Volume 10, 2012 - Issue 12
Submit an article Journal homepage
462
Views
67
CrossRef citations to date
0
Altmetric
Review

Treatment of Rickettsia spp. infections: a review

Elisabeth Botelho-Nevers Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, Aix-Marseille Université, UMR CNRS 7278, IRD 198, INSERM U1095, Faculté de Médecine, Marseille, France
,
Cristina Socolovschi Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, Aix-Marseille Université, UMR CNRS 7278, IRD 198, INSERM U1095, Faculté de Médecine, Marseille, France
,
Didier Raoult Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, Aix-Marseille Université, UMR CNRS 7278, IRD 198, INSERM U1095, Faculté de Médecine, Marseille, France
&
Philippe Parola Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, Aix-Marseille Université, UMR CNRS 7278, IRD 198, INSERM U1095, Faculté de Médecine, Marseille, France. [email protected]
Pages 1425-1437 | Published online: 10 Jan 2014

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Korakrit Imwattana, Daniel R. Knight, Brian Kullin, Deirdre A. Collins, Papanin Putsathit, Pattarachai Kiratisin & Thomas V. Riley. (2020) Antimicrobial resistance in Clostridium difficile ribotype 017. Expert Review of Anti-infective Therapy 18:1, pages 17-25.
Read now

Articles from other publishers (66)

Yuan-Ping Deng, Yi-Tian Fu, Chaoqun Yao, Renfu Shao, Xue-Ling Zhang, De-Yong Duan & Guo-Hua Liu. (2023) Emerging bacterial infectious diseases/pathogens vectored by human lice. Travel Medicine and Infectious Disease 55, pages 102630.
Crossref
Alhumaidi B. Alabbas. (2023) Identification of promising methionine aminopeptidase enzyme inhibitors: A combine study of comprehensive virtual screening and dynamics simulation study. Saudi Pharmaceutical Journal 31:9, pages 101745.
Crossref
Márton Papp, Adrienn Gréta Tóth, Gábor Valcz, László Makrai, Sára Ágnes Nagy, Róbert Farkas & Norbert Solymosi. (2023) Antimicrobial resistance gene lack in tick-borne pathogenic bacteria. Scientific Reports 13:1.
Crossref
Lucas G. Huggins, Anson V. Koehler, Robin B. Gasser & Rebecca J. Traub. 2023. 1 85 .
Anil Kumar Nehra, Ansu Kumari, Aman Dev Moudgil & Sukhdeep Vohra. 2023. Organ-Specific Parasitic Diseases of Dogs and Cats. Organ-Specific Parasitic Diseases of Dogs and Cats 53 88 .
Gregory A. Dasch & Marina E. Eremeeva. 2023. Principles and Practice of Pediatric Infectious Diseases. Principles and Practice of Pediatric Infectious Diseases 976 984.e8 .
Lluís Valerio Sallent, Laura Soldevila Langa, Silvia Roure Díez, Andrés Martínez Arias & Xavier Vallès Casanova. (2022) Enfermedades transmitidas por picadura de garrapatas. FMC - Formación Médica Continuada en Atención Primaria 29:8, pages 422-429.
Crossref
Faranak Abdoli, Ehsan Mostafavi, Saber Esmaeili & Mahdi Rohani. (2022) Molecular detection and identification of Rickettsia spp. in collected ticks from domestic animals in Southeastern of Iran. Comparative Immunology, Microbiology and Infectious Diseases 85, pages 101798.
Crossref
Dominika Hromníková, Daniel Furka, Samuel Furka, Julio Ariel Dueñas Santana, Táňa Ravingerová, Vanda Klöcklerová & Dušan Žitňan. (2022) Prevention of tick-borne diseases: challenge to recent medicine. Biologia 77:6, pages 1533-1554.
Crossref
Woonji Lee, Hye Seong, Jung Ho Kim, Heun Choi, Jun Hyoung Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Choon-Mee Kim, Dong-Min Kim & Joon-sup Yeom. (2022) A Case of African Tick-Bite Fever in a Returning Traveler from Southern Africa. Infection & Chemotherapy 54:1, pages 202.
Crossref
Zhengchen Su, Thomas R. Shelite, Yuan Qiu, Qing Chang, Maki Wakamiya, Jiani Bei, Xi He, Changcheng Zhou, Yakun Liu, Emmanuel Nyong, Yuejin Liang, Angelo Gaitas, Tais B. Saito & Bin Gong. (2021) Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation. Pathogens 10:10, pages 1307.
Crossref
Nikolaos Spernovasilis, Ioulia Markaki, Michail Papadakis, Nikolaos Mazonakis & Despo Ierodiakonou. (2021) Mediterranean Spotted Fever: Current Knowledge and Recent Advances. Tropical Medicine and Infectious Disease 6:4, pages 172.
Crossref
Carlos Ramiro Silva-Ramos, Marylin Hidalgo & Álvaro A. Faccini-Martínez. (2021) Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review. Ticks and Tick-borne Diseases 12:4, pages 101734.
Crossref
Yakun Liu, Changcheng Zhou, Zhengchen Su, Qing Chang, Yuan Qiu, Jiani Bei, Angelo Gaitas, Jie Xiao, Alexandra Drelich, Kamil Khanipov, Yang Jin, Georgiy Golovko, Tais B. Saito & Bin Gong. (2021) Endothelial Exosome Plays a Functional Role during Rickettsial Infection. mBio 12:3.
Crossref
Sophia G de Vries, Louise E van Eekeren, Hans van der Linden, Benjamin J Visser, Martin P Grobusch, Jiri F P Wagenaar, Marga G A Goris & Abraham Goorhuis. (2021) Searching and Finding the Hidden Treasure: A Retrospective Analysis of Rickettsial Disease Among Dutch International Travelers. Clinical Infectious Diseases 72:7, pages 1171-1178.
Crossref
Natalie Skopicki, Audrey H. Nguyen, Yelena Dokic, Eleanor Johnson, Divya R. Bhamidipati & Harrison P. Nguyen. 2021. Overcoming Antimicrobial Resistance of the Skin. Overcoming Antimicrobial Resistance of the Skin 39 53 .
Mariusz Piotrowski & Anna Rymaszewska. (2020) Expansion of Tick-Borne Rickettsioses in the World. Microorganisms 8:12, pages 1906.
Crossref
Ashwani K Sood & Amit Sachdeva. (2020) Rickettsioses in Children – A Review. The Indian Journal of Pediatrics 87:11, pages 930-936.
Crossref
Wei WeiJie LiYa-Wei WangBao-Gui JiangHong-Bo LiuRan WeiRui-Ruo JiangXiao-Ming CuiLian-Feng LiTing-Ting YuanQian WangLin ZhaoLuo-Yuan XiaJia-Fu JiangYe-Feng QiuNa JiaWu-Chun CaoYan-Ling Hu. (2020) Anaplasma platys -Like Infection in Goats, Beijing, China . Vector-Borne and Zoonotic Diseases 20:10, pages 755-762.
Crossref
Betty A. Situ, Susan J. Streit, Timothy C. Tran, Jim H. Nomura, Simon R. Bababeygy & Damien C. Rodger. (2020) Two cases of uveitis associated with severe transaminitis during a Rickettsia typhi outbreak in Los Angeles County. American Journal of Ophthalmology Case Reports 19, pages 100813.
Crossref
Yakun Liu, Jie Xiao, Ben Zhang, Thomas R. Shelite, Zhengchen Su, Qing Chang, Barbara Judy, Xiang Li, Aleksandra Drelich, Jiani Bei, Yixuan Zhou, Junying Zheng, Yang Jin, Shannan L. Rossi, Shao-Jun Tang, Maki Wakamiya, Tais Saito, Thomas Ksiazek, Bhupendra Kaphalia & Bin Gong. (2020) Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections. Laboratory Investigation 100:8, pages 1030-1041.
Crossref
Zhengchen Su, Qing Chang, Aleksandra Drelich, Thomas Shelite, Barbara Judy, Yakun Liu, Jie Xiao, Changchen Zhou, Xi He, Yang Jin, Tais Saito, Shaojun Tang, Lynn Soong, Maki Wakamiya, Xiang Fang, Alexander Bukreyev, Thomas Ksiazek, William K. Russell & Bin Gong. (2020) Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections. PLOS Neglected Tropical Diseases 14:7, pages e0007960.
Crossref
Manisha Biswal, Sivanantham Krishnamoorthi, Kamlesh Bisht, Amit Sehgal, Jasleen Kaur, Navneet Sharma, Vikas Suri & Sunil Sethi. (2020) Rickettsial Diseases: Not Uncommon Causes of Acute Febrile Illness in India. Tropical Medicine and Infectious Disease 5:2, pages 59.
Crossref
G. Grouteau, O. Lancelot, A. Bertolotti, P. Poubeau, R. Manaquin, A. Foucher, J. Jaubert, P. Parola, F. Pagès & G. Camuset. (2020) Emergence of murine typhus in La Réunion, France, 2012–2017. Médecine et Maladies Infectieuses 50:1, pages 22-27.
Crossref
Achilleas Gikas & Meropi Gkika. 2020. Hunter's Tropical Medicine and Emerging Infectious Diseases. Hunter's Tropical Medicine and Emerging Infectious Diseases 580 582 .
Stephen J. Lockwood, Arturo Saavedra & David Rosmarin. 2020. Hunter's Tropical Medicine and Emerging Infectious Diseases. Hunter's Tropical Medicine and Emerging Infectious Diseases 69 77 .
Ryan O. M. Rego, Jos J. A. Trentelman, Juan Anguita, Ard M. Nijhof, Hein Sprong, Boris Klempa, Ondrej Hajdusek, Julen Tomás-Cortázar, Tal Azagi, Martin Strnad, Sarah Knorr, Radek Sima, Marie Jalovecka, Sabína Fumačová Havlíková, Martina Ličková, Monika Sláviková, Petr Kopacek, Libor Grubhoffer & Joppe W. Hovius. (2019) Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission. Parasites & Vectors 12:1.
Crossref
Zhihui Dong, Yicheng Yang, Qian Wang, Songsong Xie, Shanshan Zhao, Wenbo Tan, Wumei Yuan & Yuanzhi Wang. (2019) A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. BMC Infectious Diseases 19:1.
Crossref
Xi He, Weiwei Zhang, Qing Chang, Zhengchen Su, Dejun Gong, Yixuan Zhou, Jie Xiao, Aleksandra Drelich, Yakun Liu, Vsevolod Popov, Xin Zhao, Maki Wakamiya, Angelo Gaitas, Fangling Lu & Bin Gong. (2019) A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study. Laboratory Investigation 99:11, pages 1650-1660.
Crossref
Yi-Chin Chang, Kuang-Che Kuo, Wu Sun, Jiun-Nong Lin, Chung-Hsu Lai & Chen-Hsiang Lee. (2019) Clinicoepidemiologic characteristics of scrub typhus and murine typhus: A multi-center study in southern Taiwan. Journal of Microbiology, Immunology and Infection 52:5, pages 769-778.
Crossref
Marie Hocquart, Hortense Drouet, Paul Levet, Didier Raoult, Philippe Parola & Carole Eldin. (2019) Cellulitis of the face associated with SENLAT caused by Rickettsia slovaca detected by qPCR on scalp eschar swab sample: An unusual case report and review of literature. Ticks and Tick-borne Diseases 10:5, pages 1142-1145.
Crossref
Wook-Jin Chae & Alfred L.M. Bothwell. (2019) Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation. Differentiation 108, pages 33-39.
Crossref
Elena Espejo, Marta Andrés, Maria-Consol Garcia, Anna Fajardo, Marta Mauri, Josefa Pérez & Feliu Bella. (2019) Mediterranean spotted fever in the elderly: a prospective cohort study. European Journal of Clinical Microbiology & Infectious Diseases 38:7, pages 1333-1337.
Crossref
Evgeny RogozinTsilia LazarovitchMiriam Weinberger. (2019) High Morbidity Due to Murine Typhus Upsurge in Urban Neighborhoods in Central Israel. The American Journal of Tropical Medicine and Hygiene 100:4, pages 952-956.
Crossref
Paul N Newton, Valy Keolouangkhot, Sue J Lee, Khamla Choumlivong, Siho Sisouphone, Khamloune Choumlivong, Manivanh Vongsouvath, Mayfong Mayxay, Vilada Chansamouth, Viengmon Davong, Koukeo Phommasone, Joy Sirisouk, Stuart D Blacksell, Pruksa Nawtaisong, Catrin E Moore, Josée Castonguay-Vanier, Sabine Dittrich, Sayaphet Rattanavong, Ko Chang, Chirapha Darasavath, Oudayvone Rattanavong, Daniel H Paris & Rattanaphone Phetsouvanh. (2019) A Prospective, Open-label, Randomized Trial of Doxycycline Versus Azithromycin for the Treatment of Uncomplicated Murine Typhus. Clinical Infectious Diseases 68:5, pages 738-747.
Crossref
M. Abdeljelil, H. Sakly, I. Kooli, W. Marrakchi, A. Aouam, C. Loussaief, A. Toumi, H. Ben Brahim & M. Chakroun. (2019) Mediterranean spotted fever as a cause of septic shock. IDCases 15, pages e00528.
Crossref
Elena Espejo, Marta Andrés, Maria-Consol Garcia, Anna Fajardo, Josefa Pérez & Feliu Bella. (2018) Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. Antimicrobial Agents and Chemotherapy 62:11.
Crossref
Hayet Bouchaib, Carole Eldin, Maureen Laroche, Didier Raoult & Philippe Parola. (2018) Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine. Travel Medicine and Infectious Disease 26, pages 51-57.
Crossref
Louise E. van Eekeren, Sophia G. de Vries, Jiri F.P. Wagenaar, René Spijker, Martin P. Grobusch & Abraham Goorhuis. (2018) Under-diagnosis of rickettsial disease in clinical practice: A systematic review. Travel Medicine and Infectious Disease 26, pages 7-15.
Crossref
Ruaridh Buchanan. (2018) Typhus and the spotted fevers. British Journal of Hospital Medicine 79:10, pages C146-C149.
Crossref
Sara Homem de Melo Marques, Marta Gomes Guerra, Catarina Almeida & Miguel Ribeiro. (2018) Ocular manifestations of rickettsia in children: common but frequently overlooked. BMJ Case Reports, pages bcr-2017-222809.
Crossref
Hao Li, Pan-He Zhang, Yong Huang, Juan Du, Ning Cui, Zhen-Dong Yang, Fang Tang, Fei-Xiang Fu, Xiao-Mei Li, Xiao-Ming Cui, Ya-Di Fan, Bo Xing, Xiao-Kun Li, Yi-Gang Tong, Wu-Chun Cao & Wei Liu. (2018) Isolation and Identification of Rickettsia raoultii in Human Cases: A Surveillance Study in 3 Medical Centers in China. Clinical Infectious Diseases 66:7, pages 1109-1115.
Crossref
Milena Salgado Lynn, Timothy William, Ampai Tanganuchitcharnchai, Suthatip Jintaworn, Janjira Thaipadungpanit, Mei Lee, Cyrlen Jalius, Peter Daszak, Benoît Goossens, Tom Hughes & Stuart Blacksell. (2018) Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. Tropical Medicine and Infectious Disease 3:1, pages 29.
Crossref
Marina E. Eremeeva & Gregory A. Dasch. 2018. Principles and Practice of Pediatric Infectious Diseases. Principles and Practice of Pediatric Infectious Diseases 957 966.e4 .
Bonnie Fergie, James Basha, Michelle McRae & Ian McCrossin. (2017) Queensland tick typhus in rural New South Wales. Australasian Journal of Dermatology 58:3, pages 224-227.
Crossref
Fátima Albízuri Prado, Alba Sánchez, Marta Feito, Ander Mayor, Ana Rodriguez & Raúl de Lucas. (2017) Fever and Multiple Eschars After an African Safari: Report of Three Cases. Pediatric Dermatology 34:4, pages e179-e181.
Crossref
Jorge A. Cortés & Sonia I. Cuervo. (2017) Respuesta a la carta de Faccini et al.. Infectio 21:2.
Crossref
Álvaro A. Faccini-Martínez, Carlos A. Botero-García, Carlos E. Pérez-Díaz & Alfonso J. Rodríguez-Morales. (2017) Algunas consideraciones diagnósticas y terapéuticas del paciente con síndrome febril en Colombia. Infectio 21:2.
Crossref
Narendra Rathi, Atul Kulkarni & Vijay Yewale. (2017) IAP guidelines on rickettsial diseases in children. Indian Pediatrics 54:3, pages 223-229.
Crossref
Nicholas P.J. Day & Paul N. Newton. 2017. Infectious Diseases. Infectious Diseases 1091 1097.e1 .
Yan GeHongmei YinYasuko RikihisaWeiqing PanHong Yin. (2016) Molecular Detection of Tick-Borne Rickettsiales in Goats and Sheep from Southeastern China . Vector-Borne and Zoonotic Diseases 16:5, pages 309-316.
Crossref
Esperança Anton, Tomas Muñoz, Francisco Javier Travería, Gemma Navarro, Bernat Font, Isabel Sanfeliu & Ferran Segura. (2016) Randomized Trial of Clarithromycin for Mediterranean Spotted Fever. Antimicrobial Agents and Chemotherapy 60:3, pages 1642-1645.
Crossref
Susana WidjajaMaya WilliamsImelda WinotoArik FarzeliCraig A. StoopsKathryn A. BarbaraAllen L. RichardsPatrick J. Blair. (2016) Geographical Assessment of Rickettsioses in Indonesia. Vector-Borne and Zoonotic Diseases 16:1, pages 20-25.
Crossref
Benjamin L. Makepeace & A. Christina Gill. 2016. Rickettsiales. Rickettsiales 465 512 .
Elsa Balleydier, Guillaume Camuset, Cristina Socolovschi, Marie-Pierre Moiton, Barbara Kuli, Aurélie Foucher, Patrice Poubeau, Gianandrea Borgherini, Guillaume Wartel, Héla Audin, Didier Raoult, Laurent Filleul, Philippe Parola & Fréderic Pagès. (2015) Murine Typhus, Reunion, France, 2011–2013. Emerging Infectious Diseases 21:2, pages 316-319.
Crossref
Laura Gastellier, Fanny Lanternier, Aurélie Renvoisé, Sébastien Rivière, Didier Raoult, Olivier Lortholary & Marc Lecuit. (2015) Noneruptive Fever Revealing Murine Typhus in a Traveler Returning From Tunisia. Journal of Travel Medicine 22:1, pages 67-69.
Crossref
Dongyou Liu. 2015. Molecular Medical Microbiology. Molecular Medical Microbiology 2043 2056 .
Álvaro A. Faccini-Martínez, Lara García-Álvarez, Marylin Hidalgo & José A. Oteo. (2014) Syndromic classification of rickettsioses: an approach for clinical practice. International Journal of Infectious Diseases 28, pages 126-139.
Crossref
Marion Delord, Cristina Socolovschi & Philippe Parola. (2014) Rickettsioses and Q fever in travelers (2004–2013). Travel Medicine and Infectious Disease 12:5, pages 443-458.
Crossref
Julie Solary, Cristina Socolovschi, Camille Aubry, Philippe Brouqui, Didier Raoult & Philippe Parola. (2014) Detection of Rickettsia sibirica mongolitimonae by Using Cutaneous Swab Samples and Quantitative PCR . Emerging Infectious Diseases 20:4, pages 716-718.
Crossref
Alistair C Darby, A Christina Gill, Stuart D Armstrong, Catherine S Hartley, Dong Xia, Jonathan M Wastling & Benjamin L Makepeace. (2013) Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress. The ISME Journal 8:4, pages 925-937.
Crossref
E. Rigal, D. Dorcier, O. Lesens, C. Texier & M. D’Incan. (2014) TIBOLA : une rickettsiose en expansion, cliniquement polymorphe. Annales de Dermatologie et de Vénéréologie 141:3, pages 186-191.
Crossref
E.R. Houpt & W.A. PetriJr.Jr.. 2014. Encyclopedia of the Neurological Sciences. Encyclopedia of the Neurological Sciences 48 52 .
Sanjeev K SahniHema P Narra, Abha Sahni & David H Walker. (2013) Recent molecular insights into rickettsial pathogenesis and immunity. Future Microbiology 8:10, pages 1265-1288.
Crossref
Philippe Parola, Christopher D. Paddock, Cristina Socolovschi, Marcelo B. Labruna, Oleg Mediannikov, Tahar Kernif, Mohammad Yazid Abdad, John Stenos, Idir Bitam, Pierre-Edouard Fournier & Didier Raoult. (2013) Update on Tick-Borne Rickettsioses around the World: a Geographic Approach. Clinical Microbiology Reviews 26:4, pages 657-702.
Crossref
M. Foissac, C. Socolovschi & D. Raoult. (2013) Les nouveautés sur le syndrome SENLAT : Scalp Eschar and Neck LymphAdenopathy after Tick bite. Annales de Dermatologie et de Vénéréologie 140:10, pages 598-609.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.