Advanced search
Publication Cover
Expert Review of Anti-infective Therapy Volume 10, 2012 - Issue 9
Submit an article Journal homepage
499
Views
42
CrossRef citations to date
0
Altmetric
Review

WhiB7, a transcriptional activator that coordinates physiology with intrinsic drug resistance in Mycobacterium tuberculosis

Ján Burian Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; The Centre for Tuberculosis Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; The Centre for Tuberculosis Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
,
Santiago Ramón-García Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; The Centre for Tuberculosis Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; The Centre for Tuberculosis Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
,
Charles G Howes Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
&
Charles J Thompson Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; The Centre for Tuberculosis Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. [email protected]
Pages 1037-1047 | Published online: 10 Jan 2014

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Savannah M. Seely & Matthieu G. Gagnon. (2022) Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective. RNA Biology 19:1, pages 662-677.
Read now
Shasank S. Swain, Divakar Sharma, Tahziba Hussain & Sanghamitra Pati. (2020) Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis. Emerging Microbes & Infections 9:1, pages 1651-1663.
Read now
Liem Nguyen & Michael R Jacobs. (2012) Counterattacking drug-resistant tuberculosis: molecular strategies and future directions. Expert Review of Anti-infective Therapy 10:9, pages 959-961.
Read now

Articles from other publishers (39)

Kelley Hurst-Hess, Charity McManaman, Yong Yang, Shamba Gupta & Pallavi Ghosh. (2023) Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response to antibiotic stress in Mycobacterium abscessus. PLOS Genetics 19:12, pages e1011060.
Crossref
Olabisi Flora Davies-Bolorunduro, Bharkbhoom Jaemsai, Wuthiwat Ruangchai, Worakorn Phumiphanjarphak, Pakorn Aiewsakun & Prasit Palittapongarnpim. (2023) Analysis of whiB7 in Mycobacterium tuberculosis reveals novel AT-hook deletion mutations. Scientific Reports 13:1.
Crossref
Tao Wan, Magdaléna Horová, Vimmy Khetrapal, Shanren Li, Camden Jones, Andrew Schacht, Xinghui Sun & LiMei Zhang. (2023) Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. Journal of Biological Chemistry 299:6, pages 104777.
Crossref
Haoran Li, Jinfeng Yuan, Shujuan Duan & Yu Pang. (2022) Resistance and tolerance of Mycobacterium tuberculosis to antimicrobial agents—How M . tuberculosis can escape antibiotics . WIREs Mechanisms of Disease 14:6.
Crossref
Paolo Miotto, Rita Sorrentino, Stefano De Giorgi, Roberta Provvedi, Daniela Maria Cirillo & Riccardo Manganelli. (2022) Transcriptional regulation and drug resistance in Mycobacterium tuberculosis. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Luiz Pedro Sório de Carvalho. (2022) Gene–drug potency screening in M. tuberculosis. Nature Microbiology 7:6, pages 743-744.
Crossref
Jaycee Cushman, Emma Freeman, Sarah McCallister, Anna Schumann, Keith W. Hutchison & Sally D. Molloy. (2021) Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages. BMC Microbiology 21:1.
Crossref
Mehak Zahoor Khan, Biplab Singha, Mohammad Farhan Ali, Khushman Taunk, Srikanth Rapole, Samudrala Gourinath & Vinay Kumar Nandicoori. (2021) Redox homeostasis in Mycobacterium tuberculosis is modulated by a novel actinomycete‐specific transcription factor . The EMBO Journal 40:14.
Crossref
Ju-Hyung Lee, Ji-Sun Yoo, Yeonbum Kim, Jong-Seo Kim, Eun-Jin Lee & Jung-Hye Roe. (2020) The WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition. mBio 11:2.
Crossref
Matthias Richard, Ana Victoria Gutiérrez & Laurent Kremer. (2020) Dissecting erm (41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus . Antimicrobial Agents and Chemotherapy 64:2.
Crossref
Paulami RudraKelley R. Hurst-HessKatherine L. CottenAndrea Partida-MirandaPallavi Ghosh. (2019) Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance. Proceedings of the National Academy of Sciences 117:1, pages 629-634.
Crossref
Jakob J. Malin, Sandra Winter, Edeltraud van Gumpel, Georg Plum & Jan Rybniker. (2019) Extremely Low Hit Rate in a Diverse Chemical Drug Screen Targeting Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy 63:11.
Crossref
Alan Hibbitts, Ainhoa Lucía, Inés Serrano-Sevilla, Laura De Matteis, Michael McArthur, Jesús M. de la Fuente, José A. Aínsa & Fabrice Navarro. (2019) Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA). PLOS ONE 14:9, pages e0220684.
Crossref
Xue Li, Ping Li, Cao Ruan, Long xiang Xie, Yinzhong Gu, Jiang Li, Qin Yi, Xi Lv & Jianping Xie. (2019) Mycobacterium tuberculosis Rv0191 is an efflux pump of major facilitator superfamily transporter regulated by Rv1353c. Archives of Biochemistry and Biophysics 667, pages 59-66.
Crossref
Sandra Ortega Ugalde, Maikel Boot, Jan N. M. Commandeur, Paul Jennings, Wilbert Bitter & J. Chris Vos. (2019) Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?. Applied Microbiology and Biotechnology 103:9, pages 3597-3614.
Crossref
Rose Lopeman, James Harrison, Maya Desai & Jonathan Cox. (2019) Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare. Microorganisms 7:3, pages 90.
Crossref
Julien Briffotaux, Shengyuan Liu & Brigitte Gicquel. (2019) Genome-Wide Transcriptional Responses of Mycobacterium to Antibiotics. Frontiers in Microbiology 10.
Crossref
Wei Duan, Xue Li, Yan Ge, Zhaoxiao Yu, Ping Li, Jiang Li, Lianhua Qin & Jianping Xie. (2019) Mycobacterium tuberculosis Rv1473 is a novel macrolides ABC Efflux Pump regulated by WhiB7 . Future Microbiology 14:1, pages 47-59.
Crossref
Jason C. CrackNick E. Le Brun. (2018) Redox-Sensing Iron–Sulfur Cluster Regulators. Antioxidants & Redox Signaling 29:18, pages 1809-1829.
Crossref
Xin Sui, Qi Wu, Wei Chang, Xiaoxu Fan & Fuqiang Song. (2018) Proteomic analysis of the response of Funnelifor mismosseae/Medicago sativa to atrazine stress. BMC Plant Biology 18:1.
Crossref
Manbeena Chawla, Saurabh Mishra, Kushi Anand, Pankti Parikh, Mansi Mehta, Manika Vij, Taru Verma, Parul Singh, Kishor Jakkala, H.N. Verma, Parthasarathi AjitKumar, Munia Ganguli, Aswin Sai Narain Seshasayee & Amit Singh. (2018) Redox-dependent condensation of the mycobacterial nucleoid by WhiB4. Redox Biology 19, pages 116-133.
Crossref
Sakshi Luthra, Anna Rominski & Peter Sander. (2018) The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance. Frontiers in Microbiology 9.
Crossref
Ján Burian & Charles J. Thompson. (2018) Regulatory genes coordinating antibiotic-induced changes in promoter activity and early transcriptional termination of the mycobacterial intrinsic resistance gene whiB7 . Molecular Microbiology 107:3, pages 402-415.
Crossref
Jason C. CrackNick E Le Brun. (2017) Redox-sensing iron-sulfur cluster regulators. Antioxidants & Redox Signaling.
Crossref
Kelley Hurst-Hess, Paulami Rudra & Pallavi Ghosh. (2017) Mycobacterium abscessus WhiB7 Regulates a Species-Specific Repertoire of Genes To Confer Extreme Antibiotic Resistance. Antimicrobial Agents and Chemotherapy 61:11.
Crossref
Ji-Sun Yoo, Gyeong-Seok Oh, Sungweon Ryoo & Jung-Hye Roe. (2016) Induction of a stable sigma factor SigR by translation-inhibiting antibiotics confers resistance to antibiotics. Scientific Reports 6:1.
Crossref
Kelly Flentie, Ashley L. Garner & Christina L. Stallings. (2016) Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks. Journal of Bacteriology 198:9, pages 1360-1373.
Crossref
Beatriz E. Ferro, Joseph Meletiadis, Melanie Wattenberg, Arjan de Jong, Dick van Soolingen, Johan W. Mouton & Jakko van Ingen. (2016) Clofazimine Prevents the Regrowth of Mycobacterium abscessus and Mycobacterium avium Type Strains Exposed to Amikacin and Clarithromycin. Antimicrobial Agents and Chemotherapy 60:2, pages 1097-1105.
Crossref
Simerpreet Kaur, Vibhuti Rana, Pooja Singh, Garima Trivedi, Shashi Anand, Amanpreet Kaur, Pawan Gupta, Amita Jain & Charu Sharma. (2016) Novel mutations conferring resistance to kanamycin in Mycobacterium tuberculosis clinical isolates from Northern India. Tuberculosis 96, pages 96-101.
Crossref
Pedro Eduardo Almeida da Silva, Diana Machado, Daniela Ramos, Isabel Couto, Andrea Von Groll & Miguel Viveiros. 2016. Efflux-Mediated Antimicrobial Resistance in Bacteria. Efflux-Mediated Antimicrobial Resistance in Bacteria 527 559 .
Matthew J. Bush, Natalia Tschowri, Susan Schlimpert, Klas Flärdh & Mark J. Buttner. (2015) c-di-GMP signalling and the regulation of developmental transitions in streptomycetes. Nature Reviews Microbiology 13:12, pages 749-760.
Crossref
Yangbo Hu, Zakia Morichaud, Ayyappasamy Sudalaiyadum Perumal, Françoise Roquet-Baneres & Konstantin Brodolin. (2014) Mycobacterium RbpA cooperates with the stress-response σB subunit of RNA polymerase in promoter DNA unwinding. Nucleic Acids Research 42:16, pages 10399-10408.
Crossref
Bridgette M. Cumming, Dirk A. Lamprecht, Ryan M. Wells, Vikram Saini, James H. Mazorodze & Adrie J. C. Steyn. 2014. Molecular Genetics of Mycobacteria. Molecular Genetics of Mycobacteria 297 322 .
A. A. Prozorov, I. A. Fedorova, O. B. Bekker & V. N. Danilenko. (2014) The virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions. Russian Journal of Genetics 50:8, pages 775-797.
Crossref
Bridgette M. Cumming, Dirk A. Lamprecht, Ryan M. Wells, Vikram Saini, James H. Mazorodze & Adrie J. C. Steyn. (2014) The Physiology and Genetics of Oxidative Stress in Mycobacteria. Microbiology Spectrum 2:3.
Crossref
Philippa A. Black, Robin M. Warren, Gail E. Louw, Paul D. van Helden, Thomas C. Victor & Bavesh D. Kana. (2014) Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 58:5, pages 2491-2503.
Crossref
Joshua Bowman & Pallavi Ghosh. (2014) A complex regulatory network controlling intrinsic multidrug resistance in Mycobacterium smegmatis . Molecular Microbiology 91:1, pages 121-134.
Crossref
Ján Burian, Grace Yim, Michael Hsing, Peter Axerio-Cilies, Artem Cherkasov, George B. Spiegelman & Charles J. Thompson. (2013) The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV). Nucleic Acids Research 41:22, pages 10062-10076.
Crossref
Santiago Ramón-García, Carol Ng, Pernille R. Jensen, Manisha Dosanjh, Jan Burian, Rowan P. Morris, Marc Folcher, Lindsay D. Eltis, Stephan Grzesiek, Liem Nguyen & Charles J. Thompson. (2013) WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria. Journal of Biological Chemistry 288:48, pages 34514-34528.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.