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Expert Review of Molecular Diagnostics Volume 10, 2010 - Issue 1
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Novel clinico–genome network modeling for revolutionizing genotype–phenotype-based personalized cancer care

Dimitrios H Roukos Personalized Cancer Medicine, Biobank, Ioannina University School of Medicine, Ioannina, 45110 Greece. [email protected]
Pages 33-48 | Published online: 09 Jan 2014

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Ping Zhang & Vladimir Brusic. (2014) Mathematical modeling for novel cancer drug discovery and development. Expert Opinion on Drug Discovery 9:10, pages 1133-1150.
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Shuji Ogino, Charles S Fuchs & Edward Giovannucci. (2012) How many molecular subtypes? Implications of the unique tumor principle in personalized medicine. Expert Review of Molecular Diagnostics 12:6, pages 621-628.
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Niccola Funel, Elisa Giovannetti, Luca E Pollina, Marco del Chiaro, Franco Mosca, Ugo Boggi & Daniela Campani. (2011) Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer. Expert Review of Molecular Diagnostics 11:7, pages 695-701.
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Dimitrios H Roukos. (2011) Innovation versus evidence: to trust direct-to-consumer personal genomic tests?. Expert Review of Molecular Diagnostics 11:1, pages 1-4.
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Christos Katsios, Dimosthenis E Ziogas & Dimitrios H Roukos. (2011) New molecular oncology-changing era: prospects and challenges of cancer genome and integrative systems biology. Expert Review of Anticancer Therapy 11:1, pages 5-8.
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Dimitrios H Roukos. (2010) Next-generation sequencing and epigenome technologies: potential medical applications. Expert Review of Medical Devices 7:6, pages 723-726.
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Christos Katsios, Dimosthenis E Ziogas & Dimitrios H Roukos. (2010) Colorectal cancer: cetuximab, KRAS, BRAF, PIK3CA mutations and beyond. Expert Review of Gastroenterology & Hepatology 4:5, pages 525-529.
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Dimitrios H Roukos, Dimosthenis E Ziogas & Christos Katsios. (2010) Multigene assays and isolated tumor cells for early breast cancer treatment: time for bionetworks. Expert Review of Anticancer Therapy 10:8, pages 1187-1195.
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Dimitrios H Roukos, Christos Katsios & Theodore Liakakos. (2010) Genotype–phenotype map and molecular networks: a promising solution in overcoming colorectal cancer resistance to targeted treatment. Expert Review of Molecular Diagnostics 10:5, pages 541-545.
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Dimitrios H Roukos. (2010) Bionetworks-based personalized medicine versus comparative-effectiveness research or harmonization of both in cancer management?. Expert Review of Molecular Diagnostics 10:3, pages 247-250.
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Dimitrios H Roukos & Dimosthenis Ziogas. (2010) From tumor size and HER2 status to systems oncology for very early breast cancer treatment. Expert Review of Anticancer Therapy 10:2, pages 123-128.
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Articles from other publishers (82)

Demosthenes E. Ziogas, Ioannis D. Kyrochristos & Dimitrios H. Roukos. (2018) Discovering novel valid biomarkers and drugs in patient-centric genomic trials: the new epoch of precision surgical oncology. Drug Discovery Today 23:11, pages 1848-1872.
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Dharmesh R. Chejara, Ravindra V. Badhe, Pradeep Kumar, Yahya E. Choonara, Lomas K. Tomar, Charu Tyagi & Viness Pillay. 2018. Genomics-Driven Healthcare. Genomics-Driven Healthcare 1 17 .
Zoi Anastasiadi, Georgios D. Lianos, Eleftheria Ignatiadou, Haralampos V. Harissis & Michail Mitsis. (2017) Breast cancer in young women: an overview. Updates in Surgery 69:3, pages 313-317.
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Jichun Zhou, Jianguo Shen, Benjamin J. Seifer, Shaojie Jiang, Ji Wang, Hanchu Xiong, Lingmin Xie, Linbo Wang & Xinbing Sui. (2016) Approaches and genetic determinants in predicting response to neoadjuvant chemotherapy in locally advanced gastric cancer. Oncotarget 8:18, pages 30477-30494.
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Wanjun Zhu, Xiao-Yan Zhang, Sadie L. Marjani, Jialing Zhang, Wengeng Zhang, Shixiu Wu & Xinghua Pan. (2016) Next-generation molecular diagnosis: single-cell sequencing from bench to bedside. Cellular and Molecular Life Sciences 74:5, pages 869-880.
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M.A. Aziz. 2017. Introduction to Cancer Metastasis. Introduction to Cancer Metastasis 95 116 .
Bisakha Ray, Elodie Ghedin & Rumi Chunara. (2016) Network inference from multimodal data: A review of approaches from infectious disease transmission. Journal of Biomedical Informatics 64, pages 44-54.
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Chun Gao. (2016) Molecular pathological epidemiology in diabetes mellitus and risk of hepatocellular carcinoma. World Journal of Hepatology 8:27, pages 1119.
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K. Tryfonidis, D. Zardavas & F. Cardoso. (2014) Small breast cancers: When and how to treat. Cancer Treatment Reviews 40:10, pages 1129-1136.
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Ginny F. Bao, Philip A. Philip & Asfar S. Azmi. 2014. Molecular Diagnostics and Treatment of Pancreatic Cancer. Molecular Diagnostics and Treatment of Pancreatic Cancer 297 322 .
Xiaodan Wu, Xiaocong Fang, Zhitu Zhu & Xiangdong Wang. 2014. Genomics and Proteomics for Clinical Discovery and Development. Genomics and Proteomics for Clinical Discovery and Development 175 191 .
Gerardo Ferrara, Cosimo Misciali, Thomas Brenn, Lorenzo Cerroni, Dmitry W. Kazakov, Antonio Perasole, Rosa Russo, Roberto Ricci, Giuliana Crisman, Pier Alessandro Fanti, Beatrice Passarini & Annalisa Patrizi. (2013) The Impact of Molecular Morphology Techniques on the Expert Diagnosis in Melanocytic Skin Neoplasms. International Journal of Surgical Pathology 21:5, pages 483-492.
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Julian Hamfjord, Astrid M. Stangeland, Timothy Hughes, Martina L. Skrede, Kjell M. Tveit, Tone Ikdahl & Elin H. Kure. (2012) Differential Expression of miRNAs in Colorectal Cancer: Comparison of Paired Tumor Tissue and Adjacent Normal Mucosa Using High-Throughput Sequencing. PLoS ONE 7:4, pages e34150.
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Christos Katsios, Dimosthenis E. Ziogas, Theodore Liakakos, Odysseas Zoras & Dimitrios H. Roukos. (2012) Translating Cancer Genomes Sequencing Revolution into Surgical Oncology Practice. Journal of Surgical Research 173:2, pages 365-369.
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John Cijiang He, Peter Y. Chuang, Avi Ma'Ayan & Ravi Iyengar. (2012) Systems biology of kidney diseases. Kidney International 81:1, pages 22-39.
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Ernst Hanisch & Charalambos Batsis. (2011) Sentinel node biopsy in laparoscopic surgical oncology. Surgical Endoscopy 25:11, pages 3713-3714.
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Theodore Liakakos. (2011) Totally laparoscopic total gastrectomy and the challenge of esophagojejunostomy. Surgical Endoscopy 25:10, pages 3468-3469.
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Theodore Liakakos. (2011) Thoracolaparoscopic esophagectomy: further improvement in the multimodal treatment of esophageal cancer. Surgical Endoscopy 25:10, pages 3466-3467.
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Nataša Todorović-Raković. (2011) Genome-based versus gene-based theory of cancer: Possibleimplications for clinical practice. Journal of Biosciences 36:4, pages 719-724.
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Ajay M Shah & Douglas L Mann. (2011) In search of new therapeutic targets and strategies for heart failure: recent advances in basic science. The Lancet 378:9792, pages 704-712.
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Eugenia Halkia & Nikolaos Kalinoglou. (2011) Challenges with identification of angiogenesis biomarkers in cancer. Surgical Endoscopy 25:8, pages 2769-2770.
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John Spiliotis & Odysseas Zoras. (2011) Linking epidermal growth factor plasma levels with the prognosis and treatment response of colorectal cancer patients treated with a minimally invasive approach: does it have clinical utility?. Surgical Endoscopy 25:8, pages 2766-2767.
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Christof Hottenrott. (2011) Single-incision laparoscopic surgery for colorectal cancer. Surgical Endoscopy 25:8, pages 2764-2765.
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Charalambos Batsis. (2011) Proximal gastric cancer: advances of laparoscopic surgery. Surgical Endoscopy 25:8, pages 2761-2763.
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Charalambos Batsis. (2011) Mediastinal lymphadenopathy: assessing clinical utility of EUS-FNA. Surgical Endoscopy 25:8, pages 2756-2757.
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Christof Hottenrott. (2011) Laparoscopic and robotic-assisted D2 surgery for gastric cancer: a reality in Europe?. Surgical Endoscopy 25:7, pages 2414-2416.
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Mark Murphy & Britta Stordal. (2011) Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review. Drug Resistance Updates 14:3, pages 177-190.
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Odysseas Zoras & John Spiliotis. (2010) Nonepithelial, submucosal gastric tumors: is laparoscopic wedge resection the optimal treatment?. Surgical Endoscopy 25:6, pages 2052-2053.
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Ernst Hanisch & Dimosthenis E. Ziogas. (2010) Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis and impact of anti-tumor necrosis factor on postoperative outcomes. Surgical Endoscopy 25:6, pages 2057-2058.
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John Spiliotis. (2010) Exploring indications for laparoscopic primary tumor resection in metastatic colorectal cancer. Surgical Endoscopy 25:5, pages 1706-1707.
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Christos Katsios & Georgios Baltogiannis. (2010) Advances and high demands in totally robotic surgery for rectal cancer. Surgical Endoscopy 25:5, pages 1691-1692.
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M M Chaturvedi, B Sung, V R Yadav, R Kannappan & B B Aggarwal. (2010) NF-κB addiction and its role in cancer: ‘one size does not fit all’. Oncogene 30:14, pages 1615-1630.
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D H Roukos. (2010) Trastuzumab and beyond: sequencing cancer genomes and predicting molecular networks. The Pharmacogenomics Journal 11:2, pages 81-92.
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Charalambos Batsis & Ioannis Makris. (2010) Optimizing locoregional staging in the preoperative setting of resectable esophageal cancer. Surgical Endoscopy 25:4, pages 1344-1345.
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George C Zografos & Dimitrios H Roukos. (2011) Innovative biomarker development for personalized medicine in breast cancer care. Biomarkers in Medicine 5:1, pages 73-78.
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E. Hanisch, D. Ziogas & C. Katsios. (2010) Quality Control in Laparoscopic Gastrectomy for Gastric Cancer—Measurement of Nodes Harvested?. Annals of Surgical Oncology 18:1, pages 289-290.
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Christos Katsios, Odysseas Zoras & Dimitrios H Roukos. (2010) Cancer genome sequencing and potential application in oncology. Future Oncology 6:10, pages 1527-1531.
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T. Werner. (2010) Next generation sequencing in functional genomics. Briefings in Bioinformatics 11:5, pages 499-511.
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Odysseas Zoras & John Spiliotis. (2010) Monitoring and assessing the intraabdominal therapeutic response for gastric cancer: is second-look laparoscopy the solution?. Surgical Endoscopy 24:9, pages 2351-2353.
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Georgios Baltogiannis & Christos Katsios. (2010) Predictive Factors for Improving Survival after Gastrectomy in Gastric Cancer Patients with Peritoneal Carcinomatosis. World Journal of Surgery 34:9, pages 2267-2268.
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Dimitrios H Roukos. (2010) Complete genome sequencing and network modeling to overcome trastuzumab resistance. Pharmacogenomics 11:8, pages 1039-1043.
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K. Kalogerakos. (2010) Letter: The Importance of Complete Pathologic Response after Neoadjuvant Systemic Treatment in Breast Cancer Research and Practice. World Journal of Surgery 34:8, pages 1984-1985.
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Christof Hottenrott. (2010) Moving from Lymph Nodes Measurement to Standardizing Colon Cancer Surgery: Letter to the Editor. World Journal of Surgery 34:7, pages 1732-1733.
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E. Fatourou, D. Ziogas & G. Baltogiannis. (2010) Moving from Lymph Node Metastasis in Gastric Cancer to Biological Markers. World Journal of Surgery 34:5, pages 1140-1141.
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Dimitrios H Roukos. (2010) Systems medicine: a real approach for future personalized oncology?. Pharmacogenomics 11:3, pages 283-287.
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