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Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin

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Pages 509-519 | Published online: 09 Jan 2014

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Claudio Annaloro, Lorena Airaghi, Giorgia Saporiti, Francesco Onida, Agostino Cortelezzi & Giorgio Lambertenghi Deliliers. (2012) Metabolic syndrome in patients with hematological diseases. Expert Review of Hematology 5:4, pages 439-458.
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Nikolaos Papanas, Efstratios Maltezos & Dimitri P Mikhailidis. (2010) Metformin and cancer: licence to heal?. Expert Opinion on Investigational Drugs 19:8, pages 913-917.
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Md Sumon Sarkar, Md Misor Mia, Md Al Amin, Md Sojib Hossain & Md Zahidul Islam. (2023) Bioinformatics and network biology approach to identifying type 2 diabetes genes and pathways that influence the progression of breast cancer. Heliyon, pages e16151.
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Martyna Bednarczyk, Małgorzata Muc-Wierzgoń, Sylwia Dzięgielewska-Gęsiak, Edyta Fatyga & Dariusz Waniczek. (2023) Transcription of Autophagy Associated Gene Expression as Possible Predictors of a Colorectal Cancer Prognosis. Biomedicines 11:2, pages 418.
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Shuwen Dong, Zheng Wang, Kunwei Shen & Xiaosong Chen. (2021) Metabolic Syndrome and Breast Cancer: Prevalence, Treatment Response, and Prognosis. Frontiers in Oncology 11.
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Yen-Yun Wang, Amos C. Hung, Steven Lo & Shyng-Shiou F. Yuan. (2021) Adipocytokines visfatin and resistin in breast cancer: Clinical relevance, biological mechanisms, and therapeutic potential. Cancer Letters 498, pages 229-239.
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Ana M. Barbosa & Fátima Martel. (2020) Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds. Cancers 12:1, pages 154.
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J. Faria, G. Negalha, A. Azevedo & F. Martel. (2019) Metformin and Breast Cancer: Molecular Targets. Journal of Mammary Gland Biology and Neoplasia 24:2, pages 111-123.
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Clinton Yam, Francisco J. Esteva, Miral M. Patel, Akshara S. Raghavendra, Naoto T. Ueno, Stacy L. Moulder, Kenneth R. Hess, Girish S. Shroff, Silvia Hodge, Kimberly H. Koenig, Mariana Chavez Mac Gregor, Robin L. Griner, Sai-Ching J. Yeung, Gabriel N. Hortobagyi & Vicente Valero. (2019) Efficacy and safety of the combination of metformin, everolimus and exemestane in overweight and obese postmenopausal patients with metastatic, hormone receptor-positive, HER2-negative breast cancer: a phase II study. Investigational New Drugs 37:2, pages 345-351.
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Yun-Cheol Chae, Ji-Young Kim, Jin Woo Park, Kee-Beom Kim, Hyein Oh, Kyung-Hwa Lee & Sang-Beom Seo. (2019) FOXO1 degradation via G9a-mediated methylation promotes cell proliferation in colon cancer. Nucleic Acids Research 47:4, pages 1692-1705.
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Mohsin HK Roshan, Yan K Shing & Nikolai P Pace. (2019) Metformin as an adjuvant in breast cancer treatment. SAGE Open Medicine 7, pages 205031211986511.
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Prateek Sharma & Sanjeev Kumar. (2018) Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD). Cellular Oncology 41:6, pages 637-650.
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Tuğba Adak, Afshin Samadi, Ayşe Zeynep Ünal & Suna Sabuncuoğlu. (2018) A reappraisal on metformin. Regulatory Toxicology and Pharmacology 92, pages 324-332.
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Leslie H. Clark & Victoria L. Bae-Jump. 2018. Focus on Gynecologic Malignancies. Focus on Gynecologic Malignancies 279 304 .
Jianjun Han, Weiya Z. Wysham, Yan Zhong, Hui Guo, Lu Zhang, Kim M. Malloy, Hallum K. Dickens, Gene Huh, Douglas Lee, Liza Makowski, Chunxiao Zhou & Victoria L. Bae-Jump. (2017) Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice . Oncotarget 8:67, pages 110965-110982.
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Tian Li, Xiangzhou Sun & Xianhan Jiang. (2017) UCA1 involved in the metformin-regulated bladder cancer cell proliferation and glycolysis. Tumor Biology 39:6, pages 101042831771082.
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Ui-Jin Bae, Mi-Ra Oh, Tae-Sung Jung, Soo-Wan Chae & Byung-Hyun Park. (2017) Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet. Journal of Functional Foods 31, pages 208-216.
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Osama A. Arshad, Priyadharshini S. Venkatasubramani, Aniruddha Datta & Jijayanagaram Venkatraj. (2016) Using Boolean Logic Modeling of Gene Regulatory Networks to Exploit the Links Between Cancer and Metabolism for Therapeutic Purposes. IEEE Journal of Biomedical and Health Informatics 20:1, pages 399-407.
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Jin KimYoon Hee LeeJung Han Yoon ParkMi-Kyung Sung. (2015) Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice. Nutrition Research and Practice 9:6, pages 628.
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Tao Zhang, Xinyang Wang, Dalin He, Xunbo Jin & Peng Guo. (2014) Metformin sensitizes human bladder cancer cells to TRAIL-induced apoptosis through mTOR/S6K1-mediated downregulation of c-FLIP. Anti-Cancer Drugs 25:8, pages 887-897.
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Ruchi Bhandari, George A. Kelley, Tara A. Hartley & Ian R. H. Rockett. (2014) Metabolic Syndrome Is Associated with Increased Breast Cancer Risk: A Systematic Review with Meta-Analysis. International Journal of Breast Cancer 2014, pages 1-13.
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Stephen D. Hursting. 2014. Advances in Nutrition and Cancer. Advances in Nutrition and Cancer 21 33 .
Sarah S. Cohen & Loren Lipworth. 2014. Impact of Energy Balance on Cancer Disparities. Impact of Energy Balance on Cancer Disparities 201 232 .
Tao Zhang, Peng Guo, Yinan Zhang, Hui Xiong, Xiao Yu, Shan Xu, Xinyang Wang, Dalin He & Xunbo Jin. (2013) The Antidiabetic Drug Metformin Inhibits the Proliferation of Bladder Cancer Cells in Vitro and in Vivo. International Journal of Molecular Sciences 14:12, pages 24603-24618.
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Ai Kubo, Michael Blaise Cook, Nicholas J Shaheen, Thomas L Vaughan, David C Whiteman, Liam Murray & Douglas A Corley. (2013) Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium. Gut 62:12, pages 1684-1691.
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Vladimir N. Anisimov & Andrzej Bartke. (2013) The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer. Critical Reviews in Oncology/Hematology 87:3, pages 201-223.
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Jiezhong Chen, Mengna Chi, Chen Chen & Xu Dong Zhang. (2013) Obesity and melanoma: Exploring molecular links. Journal of Cellular Biochemistry 114:9, pages 1955-1961.
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Jen‐Chung Ko, Yu‐Ching Huang, Huang‐Jen Chen, Sheng‐Chieh Tseng, Hsien‐Chun Chiu, Ting‐Yu Wo, Yi‐Jhen Huang, Shao‐Hsing Weng, Robin Y. Y. Chiou & Yun‐Wei Lin. (2013) Metformin Induces Cytotoxicity by Down‐Regulating Thymidine Phosphorylase and Excision Repair Cross‐Complementation 1 Expression in Non‐Small Cell Lung Cancer Cells. Basic & Clinical Pharmacology & Toxicology 113:1, pages 56-65.
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Emmanuel Beck & André J. Scheen. (2013) Quels bénéfices antitumoraux attendre de la metformine ?. Annales d'Endocrinologie 74:2, pages 137-147.
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Christos V. Rizos & Moses S. Elisaf. (2013) Metformin and cancer. European Journal of Pharmacology 705:1-3, pages 96-108.
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Jorge Eduardo Duque, Juliana Velez, Ismael Samudio & Enoch Lai. (2012) Metformin as a Novel Component of Metronomic Chemotherapeutic Use: A Hypothesis. Journal of Experimental & Clinical Medicine 4:3, pages 140-144.
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Rabbie K. Hanna, Chunxiao Zhou, Kimberly M. Malloy, Li Sun, Yan Zhong, Paola A. Gehrig & Victoria L. Bae-Jump. (2012) Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. Gynecologic Oncology 125:2, pages 458-469.
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A V Lavrenko, N L Kutsenko, L A Kutsenko, T V Mamontova & I P Kaĭdashev. (2012) The action of metformin on the production of pro-inflammatory cytokines and insulin resistance (NF-kB signal pathway). Problems of Endocrinology 58:2, pages 25-28.
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Spike D. L. Postnikoff, Mackenzie E. Malo, Berchman Wong & Troy A. A. Harkness. (2012) The Yeast Forkhead Transcription Factors Fkh1 and Fkh2 Regulate Lifespan and Stress Response Together with the Anaphase-Promoting Complex. PLoS Genetics 8:3, pages e1002583.
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Abayomi O AkanjiRobert J Smith. (2012) The Insulin-Like Growth Factor System, Metabolic Syndrome, and Cardiovascular Disease Risk. Metabolic Syndrome and Related Disorders 10:1, pages 3-13.
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Mario I. Ortiz. (2011) Blockade of the antinociception induced by diclofenac, but not of indomethacin, by sulfonylureas and biguanides. Pharmacology Biochemistry and Behavior 99:1, pages 1-6.
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Jesús Pérez-Losada, Andrés Castellanos-Martín & Jian-Hua Mao. (2011) Cancer evolution and individual susceptibility. Integrative Biology 3:4, pages 316.
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Pamela J. Goodwin. (2010) Metabolic Syndrome, Insulin Resistance, and Inflammation in Breast Cancer: Impact on Prognosis and Adjuvant Interventions. Current Breast Cancer Reports 2:4, pages 182-189.
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Vladimir N. Anisimov. (2010) Metformin for aging and cancer prevention. Aging 2:11, pages 760-774.
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Pamela J. Goodwin. (2010) Commentary on: “Effect of obesity on survival in women with breast cancer: systematic review and meta-analysis” (Melinda Protani, Michael Coory, Jennifer H. Martin). Breast Cancer Research and Treatment 123:3, pages 637-640.
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