364
Views
45
CrossRef citations to date
0
Altmetric
Theme: Pharmacogenomic, Proteomic & Metabolomic Applications - Review

Label-free mass spectrometry-based proteomics for biomarker discovery and validation

, , &
Pages 343-359 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jianqiang Wu, Wei Wang, Zhaoran Chen, Fang Xu & Yuehong Zheng. (2021) Proteomics applications in biomarker discovery and pathogenesis for abdominal aortic aneurysm. Expert Review of Proteomics 18:4, pages 305-314.
Read now
Li Zhou, Kui Wang, Qifu Li, Edouard C. Nice, Haiyuan Zhang & Canhua Huang. (2016) Clinical proteomics-driven precision medicine for targeted cancer therapy: current overview and future perspectives. Expert Review of Proteomics 13:4, pages 367-381.
Read now
Kui Wang, Canhua Huang & Edouard Collins Nice. (2014) Proteomics, genomics and transcriptomics: their emerging roles in the discovery and validation of colorectal cancer biomarkers. Expert Review of Proteomics 11:2, pages 179-205.
Read now
Yansheng Liu, Ruth Hüttenhain, Ben Collins & Ruedi Aebersold. (2013) Mass spectrometric protein maps for biomarker discovery and clinical research. Expert Review of Molecular Diagnostics 13:8, pages 811-825.
Read now
Irene V. Bijnsdorp, Albert A. Geldof, Mehrdad Lavaei, Sander R. Piersma, R. Jeroen A. van Moorselaar & Connie R. Jimenez. (2013) Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. Journal of Extracellular Vesicles 2:1.
Read now

Articles from other publishers (40)

Camilla Johansson, Helian Hunt, Mirko Signorelli, Fredrik Edfors, Andreas Hober, Anne-Sophie Svensson, Hanna Tegel, Björn Forstström, Annemieke Aartsma-Rus, Erik Niks, Pietro Spitali, Mathias Uhlén & Cristina Al-Khalili Szigyarto. (2023) Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers. Clinical Proteomics 20:1.
Crossref
Martin Kussmann. (2023) Mass spectrometry as a lens into molecular human nutrition and health. European Journal of Mass Spectrometry 29:5-6, pages 370-379.
Crossref
Martin Kussmann. (2022) Prediction, Discovery, and Characterization of Plant- and Food-Derived Health-Beneficial Bioactive Peptides. Nutrients 14:22, pages 4810.
Crossref
Zhijun Cao & Li-Rong Yu. 2022. Systems Medicine. Systems Medicine 3 17 .
Randa G. Hanna-Sawires, Jorinde H. Schiphuis, Manfred Wuhrer, Hans F. A. Vasen, Monique E. van Leerdam, Bert A. Bonsing, Wilma E. Mesker, Yuri E. M. van der Burgt & Rob A. E. M. Tollenaar. (2021) Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer. International Journal of Molecular Sciences 22:5, pages 2655.
Crossref
Ning Ma, Hengjun Du, Gaoxing Ma, Wenjian Yang, Yanhui Han, Qiuhui Hu & Hang Xiao. (2020) Characterization of the Immunomodulatory Mechanism of a Pleurotus eryngii Protein by Isobaric Tags for Relative and Absolute Quantitation Proteomics . Journal of Agricultural and Food Chemistry 68:46, pages 13189-13199.
Crossref
Lian Xu, Ryan C. Gimple, Wayne Bond Lau, Bonnie Lau, Fan Fei, Qiuhong Shen, Xiaolin Liao, Yichen Li, Wei Wang, Ying He, Min Feng, Hong Bu, Wei Wang & Shengtao Zhou. (2020) THE PRESENT AND FUTURE OF THE MASS SPECTROMETRY‐BASED INVESTIGATION OF THE EXOSOME LANDSCAPE. Mass Spectrometry Reviews 39:5-6, pages 745-762.
Crossref
Min‐Jung Kang, Yunseo Seong, Joyeta Mahmud & Binh Thanh Nguyen. (2020) Obscurin and Clusterin Elevation in Serum of Acute Myocardial Infarction Patients. Bulletin of the Korean Chemical Society 41:3, pages 266-273.
Crossref
Leyla Ayse Erozenci, Franziska Böttger, Irene V. Bijnsdorp & Connie R. Jimenez. (2019) Urinary exosomal proteins as (pan‐)cancer biomarkers: insights from the proteome. FEBS Letters 593:13, pages 1580-1597.
Crossref
Franziska Böttger, Tieneke B. Schaaij-Visser, Inge de Reus, Sander R. Piersma, Thang V. Pham, Remco Nagel, Ruud H. Brakenhoff, Erik Thunnissen, Egbert F. Smit & Connie R. Jimenez. (2019) Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction. Journal of Proteomics 196, pages 106-119.
Crossref
Marijn F. Stokman, Irene V. Bijnsdorp, Tim Schelfhorst, Thang V. Pham, Sander R. Piersma, Jaco C. Knol, Rachel H. Giles, Ernie M.H.F. Bongers, Nine V.A.M. Knoers, Marc R. Lilien, Connie R. Jiménez & Kirsten Y. Renkema. (2019) Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. Journal of Proteomics 192, pages 27-36.
Crossref
Camila Dias-Lopes, Ana Paiva, Clara Guerra-Duarte, Franck Molina & Liza Felicori. (2018) Venomous Arachnid Diagnostic Assays, Lessons from Past Attempts. Toxins 10:9, pages 365.
Crossref
Birgit Belter, Cathleen Haase-Kohn & Jens Pietzsch. 2017. Cutaneous Melanoma: Etiology and Therapy. Cutaneous Melanoma: Etiology and Therapy 39 56 .
Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri & Carla Rozzo. (2016) Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6. BMC Cancer 16:1.
Crossref
Qing Yu, Xudong Shi, Tyler Greer, Christopher B. Lietz, K. Craig Kent & Lingjun Li. (2016) Evaluation and Application of Dimethylated Amino Acids as Isobaric Tags for Quantitative Proteomics of the TGF-β/Smad3 Signaling Pathway. Journal of Proteome Research 15:9, pages 3420-3431.
Crossref
Jaco C. Knol, Inge de Reus, Tim Schelfhorst, Robin Beekhof, Meike de Wit, Sander R. Piersma, Thang V. Pham, Egbert F. Smit, Henk M.W. Verheul & Connie R. Jiménez. (2016) Peptide-mediated ‘miniprep’ isolation of extracellular vesicles is suitable for high-throughput proteomics. EuPA Open Proteomics 11, pages 11-15.
Crossref
Li Zhou, Qifu Li, Jiandong Wang, Canhua Huang & Edouard C. Nice. (2016) Oncoproteomics: Trials and tribulations. PROTEOMICS - Clinical Applications 10:4, pages 516-531.
Crossref
Y. Melodie Du, Ye Hu, Yu Xia & Zheng Ouyang. (2016) Power Normalization for Mass Spectrometry Data Analysis and Analytical Method Assessment. Analytical Chemistry 88:6, pages 3156-3163.
Crossref
Qian Xiong, Zhuo Chen & Feng Ge. (2016) Proteomic analysis of post translational modifications in cyanobacteria. Journal of Proteomics 134, pages 57-64.
Crossref
Charlotte E. Teunissen, Naura Elias, Marleen J.A. Koel‐Simmelink, Sisi Durieux‐Lu, Arjan Malekzadeh, Thang V. Pham, Sander R. Piersma, Tommaso Beccari, Lieke H.H. Meeter, Elise G.P. Dopper, John C. van Swieten, Connie R. Jimenez & Yolande A.L. Pijnenburg. (2016) Novel diagnostic cerebrospinal fluid biomarkers for pathologic subtypes of frontotemporal dementia identified by proteomics. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2:1, pages 86-94.
Crossref
Connie R Jimenez & Remond J A Fijneman. (2015) Proteomics of Colorectal Cancer in a Genomic Context: First Large-scale Mass Spectrometry–Based Analysis from the Cancer Genome Atlas. Clinical Chemistry 61:9, pages 1126-1128.
Crossref
Simone Nicolardi, Marco R. Bladergroen, André M. Deelder, Rob A. E. M. Tollenaar, Magnus Palmblad, Wilma Mesker & Yuri E. M. van der Burgt. (2014) SPE-MALDI Profiling of Serum Peptides and Proteins by Ultrahigh Resolution FTICR-MS. Chromatographia 78:5-6, pages 445-449.
Crossref
Hanne Haslene-HoxEystein OvelandKathrine Woie, Helga B. Salvesen, Olav TenstadHelge Wiig. (2015) Distribution volumes of macromolecules in human ovarian and endometrial cancers—effects of extracellular matrix structure. American Journal of Physiology-Heart and Circulatory Physiology 308:1, pages H18-H28.
Crossref
Li Wu & Xiaogang Qu. (2015) Cancer biomarker detection: recent achievements and challenges. Chemical Society Reviews 44:10, pages 2963-2997.
Crossref
Maria Frantzi, Akshay Bhat & Agnieszka Latosinska. (2014) Clinical proteomic biomarkers: relevant issues on study design & technical considerations in biomarker development. Clinical and Translational Medicine 3:1.
Crossref
Vladimir Gubala, Reinhild Klein, Douglas M. Templeton & Michael Schwenk. (2014) Immunodiagnostics and immunosensor design (IUPAC Technical Report). Pure and Applied Chemistry 86:10, pages 1539-1571.
Crossref
Feng Ge, Weichao Huang, Zhuo Chen, Chunye Zhang, Qian Xiong, Chris Bowler, Juan Yang, Jin Xu & Hanhua Hu. (2014) Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum       . The Plant Cell 26:4, pages 1681-1697.
Crossref
Connie R. JimenezHenk M. W. Verheul. (2014) Mass Spectrometry-Based Proteomics: From Cancer Biology to Protein Biomarkers, Drug Targets, and Clinical Applications. American Society of Clinical Oncology Educational Book:34, pages e504-e510.
Crossref
Meike de Wit, Huub Kant, Sander R. Piersma, Thang V. Pham, Sandra Mongera, Maaike P.A. van Berkel, Epie Boven, Fredrik Pontén, Gerrit A. Meijer, Connie R. Jimenez & Remond J.A. Fijneman. (2014) Colorectal cancer candidate biomarkers identified by tissue secretome proteome profiling. Journal of Proteomics 99, pages 26-39.
Crossref
S.W. Lam, C.R. Jimenez & E. Boven. (2014) Breast cancer classification by proteomic technologies: Current state of knowledge. Cancer Treatment Reviews 40:1, pages 129-138.
Crossref
Bin Zhang, Zi Wang, Bin Deng, Xiaoqiong Wu, Jing Liu & Xueping Feng. (2013) Identification of Enolase 1 and Thrombospondin-1 as serum biomarkers in HBV hepatic fibrosis by proteomics. Proteome Science 11:1.
Crossref
Ning Qing Liu, Lennard J. M. Dekker, Christoph Stingl, Coşkun Güzel, Tommaso De Marchi, John W. M. Martens, John A. Foekens, Theo M. Luider & Arzu Umar. (2013) Quantitative Proteomic Analysis of Microdissected Breast Cancer Tissues: Comparison of Label-Free and SILAC-based Quantification with Shotgun, Directed, and Targeted MS Approaches. Journal of Proteome Research 12:10, pages 4627-4641.
Crossref
J PosthumaDeBoer, S R Piersma, T V Pham, P W van Egmond, J C Knol, A M Cleton-Jansen, M A van Geer, V W van Beusechem, G J L Kaspers, B J van Royen, C R Jiménez & M N Helder. (2013) Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery. British Journal of Cancer 109:8, pages 2142-2154.
Crossref
J. Pesek, Th. Krüger, B. Tautkus & H. Rhode. (2013) Colorful quality control of chromatographic sample preparation. Journal of Chromatography B 934, pages 66-70.
Crossref
Meike de Wit, Remond J.A. Fijneman, Henk M.W. Verheul, Gerrit A. Meijer & Connie R. Jimenez. (2013) Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications. Clinical Biochemistry 46:6, pages 466-479.
Crossref
Harald Mischak, Antonia Vlahou & John P.A. Ioannidis. (2013) Technical aspects and inter-laboratory variability in native peptide profiling: The CE–MS experience. Clinical Biochemistry 46:6, pages 432-443.
Crossref
Nina Kočevar, Petra Hudler & Radovan Komel. (2013) The progress of proteomic approaches in searching for cancer biomarkers. New Biotechnology 30:3, pages 319-326.
Crossref
Cristina C. Clement & Laura Santambrogio. 2013. Immunology of the Lymphatic System. Immunology of the Lymphatic System 65 79 .
Juan Martínez‐Aguilar, Jenny Chik, Judith Nicholson, Crystal Semaan, Matthew J. McKay & Mark P. Molloy. (2013) Quantitative mass spectrometry for colorectal cancer proteomics. PROTEOMICS – Clinical Applications 7:1-2, pages 42-54.
Crossref
Alessandro Tanca, Daniela Pagnozzi, Giovanni P. Burrai, Marta Polinas, Sergio Uzzau, Elisabetta Antuofermo & Maria Filippa Addis. (2012) Comparability of differential proteomics data generated from paired archival fresh-frozen and formalin-fixed samples by GeLC–MS/MS and spectral counting. Journal of Proteomics 77, pages 561-576.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.