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Expert Review of Molecular Diagnostics Volume 12, 2012 - Issue 6
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How many molecular subtypes? Implications of the unique tumor principle in personalized medicine

Shuji Ogino Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, USA. [email protected]; Department of Medical Oncology, and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, USA. [email protected]; Department of Medical Oncology, and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
,
Charles S Fuchs Department of Medical Oncology, and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Medical Oncology, and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
&
Edward Giovannucci Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Pages 621-628 | Published online: 09 Jan 2014

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Crossref
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Crossref
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Crossref
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Mohammad Azhar Aziz, Zeyad Yousef, Ayman M. Saleh, Sameer Mohammad & Bandar Al Knawy. (2017) Towards personalized medicine of colorectal cancer. Critical Reviews in Oncology/Hematology 118, pages 70-78.
Crossref
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Crossref
Weiwei Zhang, Hao Feng, Hao Wu & Xiaoqi Zheng. (2017) Accounting for tumor purity improves cancer subtype classification from DNA methylation data. Bioinformatics 33:17, pages 2651-2657.
Crossref
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Crossref
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Crossref
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Crossref
NN Brahme & E Szabo. (2017) Cancer Prevention in the Era of Precision Oncology. Clinical Pharmacology & Therapeutics 101:5, pages 575-577.
Crossref
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Crossref
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Crossref
Angelo Wilson. (2017) The Molecular Connections between Lung and Pancreatic Cancer Metastases: are we not seeing the Forest for the Trees?. Journal of Cancer Prevention & Current Research 7:4.
Crossref
Sebastian Schee genannt Halfmann, Nikolaos Evangelatos, Peter Schröder-Bäck & Angela Brand. (2017) European healthcare systems readiness to shift from ‘one-size fits all’ to personalized medicine. Personalized Medicine 14:1, pages 63-74.
Crossref
Wensheng Zhang, Andrea Edwards, Erik K Flemington & Kun Zhang. (2017) Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers . Cancer Informatics 16, pages 117693511769126.
Crossref
Laura  Mählmann, Sebastian Schee gen. Halfmann, Agnes von Wyl & Angela Brand. (2017) Attitudes towards Personal Genomics and Sharing of Genetic Data among Older Swiss Adults: A Qualitative Study. Public Health Genomics 20:5, pages 293-306.
Crossref
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Kjetil Søreide & Dordi Lea. 2017. Coloproctology. Coloproctology 261 285 .
Wenbin Zhang, Jian Tang & Nuo Wang. (2016) Using the machine learning approach to predict patient survival from high-dimensional survival data. Using the machine learning approach to predict patient survival from high-dimensional survival data.
Ivette A.G. Deckers, Manon van Engeland, Piet A. van den Brandt, Leander Van Neste, Patricia M.M.B. Soetekouw, Maureen J.B. Aarts, Marcella M.L.L. Baldewijns, András P. Keszei & Leo J. Schouten. (2016) Promoter CpG island methylation in ion transport mechanisms and associated dietary intakes jointly influence the risk of clear-cell renal cell cancer. International Journal of Epidemiology, pages dyw266.
Crossref
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Crossref
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Crossref
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Crossref
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Akiko Hanyuda, Sun A. Kim, Alejandro Martinez-Fernandez, Zhi Rong Qian, Mai Yamauchi, Reiko Nishihara, Teppei Morikawa, Xiaoyun Liao, Kentaro Inamura, Kosuke Mima, Yin Cao, Xuehong Zhang, Kana Wu, Andrew T. Chan, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Charles S. Fuchs, Ramesh A. Shivdasani & Shuji Ogino. (2015) Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. Annals of Surgical Oncology 23:3, pages 908-917.
Crossref
Devashish Kar. 2016. Epizootic Ulcerative Fish Disease Syndrome. Epizootic Ulcerative Fish Disease Syndrome 63 81 .
Dvir Aran, Marina Sirota & Atul J. Butte. (2015) Systematic pan-cancer analysis of tumour purity. Nature Communications 6:1.
Crossref
Qingxuan Song, Sofia D. Merajver & Jun Z. Li. (2015) Cancer classification in the genomic era: five contemporary problems. Human Genomics 9:1.
Crossref
Molin Wang, Aya Kuchiba & Shuji Ogino. (2015) A Meta-Regression Method for Studying Etiological Heterogeneity Across Disease Subtypes Classified by Multiple Biomarkers. American Journal of Epidemiology 182:3, pages 263-270.
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Ahmed A. Ejaeidi, Barbara S. Craft, Louis V. Puneky, Robert E. Lewis & Julius M. Cruse. (2015) Hormone receptor-independent CXCL10 production is associated with the regulation of cellular factors linked to breast cancer progression and metastasis. Experimental and Molecular Pathology 99:1, pages 163-172.
Crossref
Yang Xu & Chengtao Her. (2015) Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy. Biomolecules 5:3, pages 1652-1670.
Crossref
A H Ree & K R Redalen. (2015) Personalized radiotherapy: concepts, biomarkers and trial design. The British Journal of Radiology 88:1051, pages 20150009.
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Anne Hansen Ree, Kjersti Flatmark, Marie Grøn Saelen, Sigurd Folkvord, Svein Dueland, Jürgen Geisler & Kathrine Røe Redalen. (2015) Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: Opportunities for signaling-adapted therapies. Critical Reviews in Oncology/Hematology 95:1, pages 114-124.
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Shuji Ogino, Peter T. Campbell, Reiko Nishihara, Amanda I. Phipps, Andrew H. Beck, Mark E. Sherman, Andrew T. Chan, Melissa A. Troester, Adam J. Bass, Kathryn C. Fitzgerald, Rafael A. Irizarry, Karl T. Kelsey, Hongmei Nan, Ulrike Peters, Elizabeth M. Poole, Zhi Rong Qian, Rulla M. Tamimi, Eric J. Tchetgen Tchetgen, Shelley S. Tworoger, Xuehong Zhang, Edward L. Giovannucci, Piet A. van den Brandt, Bernard A. Rosner, Molin Wang, Nilanjan Chatterjee & Colin B. Begg. (2015) Proceedings of the second international molecular pathological epidemiology (MPE) meeting. Cancer Causes & Control 26:7, pages 959-972.
Crossref
Moisés Blanco-Calvo, Ángel Concha, Angélica Figueroa, Federico Garrido & Manuel Valladares-Ayerbes. (2015) Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach. International Journal of Molecular Sciences 16:12, pages 13610-13632.
Crossref
Jennifer Liang, Alok A Khorana & Matthew F Kalady. (2015) BRAF -mutated colorectal cancer: clinical implications for a distinct subset of the disease . Colorectal Cancer 4:3, pages 125-133.
Crossref
Gisah Guilgen. (2015) Reviewing the Role of Aspirin in Chemoprevention of Colorectal Cancer. Current Colorectal Cancer Reports 11:3, pages 105-111.
Crossref
Wei WeiYanqin WangXiaoming YuLan YeYuhua JiangYufeng Cheng. (2015) Expression of TP53, BCL-2, and VEGFA Genes in Esophagus Carcinoma and its Biological Significance. Medical Science Monitor 21, pages 3016-3022.
Crossref
Peter Zauber, Stephen Marotta & Marlene Sabbath-Solitare. (2015) Colorectal Cancers with the Uncommon Findings of <b><i>KRAS</i></b> Mutation and Microsatellite Instability. Cytogenetic and Genome Research 146:4, pages 261-267.
Crossref
Paul Lochhead, Andrew T Chan, Reiko Nishihara, Charles S Fuchs, Andrew H Beck, Edward Giovannucci & Shuji Ogino. (2015) Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression. Modern Pathology 28:1, pages 14-29.
Crossref
Akihiro Nishi, Ichiro Kawachi, Karestan C. Koenen, Kana Wu, Reiko Nishihara & Shuji Ogino. (2015) Lifecourse Epidemiology and Molecular Pathological Epidemiology. American Journal of Preventive Medicine 48:1, pages 116-119.
Crossref
Tingting Li, Xiaoyun Liao, Paul Lochhead, Teppei Morikawa, Mai Yamauchi, Reiko Nishihara, Kentaro Inamura, Sun A. Kim, Kosuke Mima, Yasutaka Sukawa, Aya Kuchiba, Yu Imamura, Yoshifumi Baba, Kaori Shima, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino & Zhi Rong Qian. (2014) SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features. Annals of Surgical Oncology 21:13, pages 4164-4173.
Crossref
Panagiotis Apostolou, Maria Toloudi, Eleni Kourtidou, Georgia Mimikakou, Ioanna Vlachou, Marina Chatziioannou & Ioannis Papasotiriou. (2014) Use of the comet assay technique for quick and reliable prediction of in vitro response to chemotherapeutics in breast and colon cancer. Journal of Biological Research-Thessaloniki 21:1.
Crossref
Jing Chen, Fang Guo, Xin Shi, Lihua Zhang, Aifeng Zhang, Hui Jin & Youji He. (2014) BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients. BMC Cancer 14:1.
Crossref
Martin C Boonstra, Floris PR Verbeek, Andrew P Mazar, Hendrica AJM Prevoo, Peter JK Kuppen, Cornelis JH van de Velde, Alexander L Vahrmeijer & Cornelis FM Sier. (2014) Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study. BMC Cancer 14:1.
Crossref
Mukesh Verma. (2014) Molecular profiling and companion diagnostics: where is personalized medicine in cancer heading?. Personalized Medicine 11:8, pages 761-771.
Crossref
Meira Epplein, Roberd M. Bostick, Lina Mu, Shuji Ogino, Dejana Braithwaite & Peter A. Kanetsky. (2014) Challenges and Opportunities in International Molecular Cancer Prevention Research: An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report. Cancer Epidemiology, Biomarkers & Prevention 23:11, pages 2613-2617.
Crossref
Amelie Fassbender, Nilufer Rahmioglu, Allison F. Vitonis, Paola Viganò, Linda C. Giudice, Thomas M. D’Hooghe, Lone Hummelshoj, G. David Adamson, Christian M. Becker, Stacey A. Missmer, Krina T. Zondervan, G.D. Adamson, C. Allaire, R. Anchan, C.M. Becker, M.A. Bedaiwy, G.M. Buck Louis, C. Calhaz-Jorge, K. Chwalisz, T.M. D'Hooghe, A. Fassbender, T. Faustmann, A.T. Fazleabas, I. Flores, A. Forman, I. Fraser, L.C. Giudice, M. Gotte, P. Gregersen, S.-W. Guo, T. Harada, D. Hartwell, A.W. Horne, M.L. Hull, L. Hummelshoj, M.G. Ibrahim, L. Kiesel, M.R. Laufer, K. Machens, S. Mechsner, S.A. Missmer, G.W. Montgomery, A. Nap, M. Nyegaard, K.G. Osteen, C.A. Petta, N. Rahmioglu, S.P. Renner, J. Riedlinger, S. Roehrich, P.A. Rogers, L. Rombauts, A. Salumets, E. Saridogan, T. Seckin, P. Stratton, K.L. Sharpe-Timms, S. Tworoger, P. Vigano, K. Vincent, A.F. Vitonis, U.-H. Wienhues-Thelen, P.P. YeungJr.Jr., P. Yong & K.T. Zondervan. (2014) World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research. Fertility and Sterility 102:5, pages 1244-1253.
Crossref
Paul Lochhead, Andrew T Chan, Edward Giovannucci, Charles S Fuchs, Kana Wu, Reiko Nishihara, Michael O'Brien & Shuji Ogino. (2014) Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions. American Journal of Gastroenterology 109:8, pages 1205-1214.
Crossref
Christine Miaskowski, Bruce A. Cooper, Michelle Melisko, Lee-May Chen, Judy Mastick, Claudia West, Steven M. Paul, Laura B. Dunn, Brian L. Schmidt, Marilyn Hammer, Frances Cartwright, Fay Wright, Dale J. Langford, Kathryn Lee & Bradley E. Aouizerat. (2014) Disease and treatment characteristics do not predict symptom occurrence profiles in oncology outpatients receiving chemotherapy. Cancer 120:15, pages 2371-2378.
Crossref
Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer & Dana Dvorakova. (2014) TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC. Lung Cancer 85:1, pages 25-30.
Crossref
S Ogino, P Lochhead, E Giovannucci, J A Meyerhardt, C S Fuchs & A T Chan. (2013) Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology. Oncogene 33:23, pages 2949-2955.
Crossref
Bernard Leroy, Martha Anderson & Thierry Soussi. (2014) TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade. Human Mutation 35:6, pages 672-688.
Crossref
Melanie Arul, April Camilla Roslani, Colin Leong Liong Ng & Swee Hung Cheah. (2013) Culture of low passage colorectal cancer cells and demonstration of variation in selected tumour marker expression. Cytotechnology 66:3, pages 481-491.
Crossref
Nicholas J Shaheen. (2014) Editorial: What Is Behind the Remarkable Increase in Esophageal Adenocarcinoma?. American Journal of Gastroenterology 109:3, pages 345-347.
Crossref
Tyler J. VanderWeele & Mirjam J. Knol. (2014) Interactions and Complexity: Goals and Limitations. Epidemiologic Methods 3:1.
Crossref
Gyula Pekar, Maria Gere, Miklos Tarjan, Dan Hellberg & Tibor Tot. (2014) Molecular phenotype of the foci in multifocal invasive breast carcinomas: Intertumoral heterogeneity is related to shorter survival and may influence the choice of therapy. Cancer 120:1, pages 26-34.
Crossref
Fiorenza Lotti, Awad M. Jarrar, Rish K. Pai, Masahiro Hitomi, Justin Lathia, Adam Mace, Gerald A. GanttJr.Jr., Kumar Sukhdeo, Jennifer DeVecchio, Amit Vasanji, Patrick Leahy, Anita B. Hjelmeland, Matthew F. Kalady & Jeremy N. Rich. (2013) Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. Journal of Experimental Medicine 210:13, pages 2851-2872.
Crossref
Shuji Ogino, Xiaoyun Liao, Yu Imamura, Mai Yamauchi, Nadine J. McCleary, Kimmie Ng, Donna Niedzwiecki, Leonard B. Saltz, Robert J. Mayer, Renaud Whittom, Alexander Hantel, Al B. BensonIIIIII, Rex B. Mowat, Donna Spiegelman, Richard M. Goldberg, Monica M. Bertagnolli, Jeffrey A. Meyerhardt & Charles S. Fuchs. (2013) Predictive and Prognostic Analysis of PIK3CA Mutation in Stage III Colon Cancer Intergroup Trial. JNCI: Journal of the National Cancer Institute 105:23, pages 1789-1798.
Crossref
William B. Coleman. (2013) Breast Cancer Personalized Medicine. The American Journal of Pathology 183:4, pages 1036-1037.
Crossref
Paul Lochhead, Aya Kuchiba, Yu Imamura, Xiaoyun Liao, Mai Yamauchi, Reiko Nishihara, Zhi Rong Qian, Teppei Morikawa, Jeanne Shen, Jeffrey A. Meyerhardt, Charles S. Fuchs & Shuji Ogino. (2013) Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication. JNCI: Journal of the National Cancer Institute 105:15, pages 1151-1156.
Crossref
Reiko Nishihara, Teppei Morikawa, Aya Kuchiba, Paul Lochhead, Mai Yamauchi, Xiaoyun Liao, Yu Imamura, Katsuhiko Nosho, Kaori Shima, Ichiro Kawachi, Zhi Rong Qian, Charles S. Fuchs, Andrew T. Chan, Edward Giovannucci & Shuji Ogino. (2013) A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification. American Journal of Epidemiology 178:1, pages 84-100.
Crossref
Mai Yamauchi, Paul Lochhead, Yu Imamura, Aya Kuchiba, Xiaoyun Liao, Zhi Rong Qian, Reiko Nishihara, Teppei Morikawa, Kaori Shima, Kana Wu, Edward Giovannucci, Jeffrey A. Meyerhardt, Charles S. Fuchs, Andrew T. Chan & Shuji Ogino. (2013) Physical Activity, Tumor PTGS2 Expression, and Survival in Patients with Colorectal Cancer. Cancer Epidemiology, Biomarkers & Prevention 22:6, pages 1142-1152.
Crossref
Christophe Rosty, Joanne P Young, Michael D Walsh, Mark Clendenning, Rhiannon J Walters, Sally Pearson, Erika Pavluk, Belinda Nagler, David Pakenas, Jeremy R Jass, Mark A Jenkins, Aung Ko Win, Melissa C Southey, Susan Parry, John L Hopper, Graham G Giles, Elizabeth Williamson, Dallas R English & Daniel D Buchanan. (2013) Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features. Modern Pathology 26:6, pages 825-834.
Crossref
Lucia Pérez-Cabornero, Mar Infante, Eladio Velasco, Enrique Lastra, Cristina Miner & Mercedes Durán. (2013) Evaluating the Effect of Unclassified Variants Identified in MMR Genes Using Phenotypic Features, Bioinformatics Prediction, and RNA Assays. The Journal of Molecular Diagnostics 15:3, pages 380-390.
Crossref
Shuji Ogino, Paul Lochhead, Andrew T Chan, Reiko Nishihara, Eunyoung Cho, Brian M Wolpin, Jeffrey A Meyerhardt, Alexander Meissner, Eva S Schernhammer, Charles S Fuchs & Edward Giovannucci. (2013) Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Modern Pathology 26:4, pages 465-484.
Crossref
Teppei Morikawa, Aya Kuchiba, Paul Lochhead, Reiko Nishihara, Mai Yamauchi, Yu Imamura, Xiaoyun Liao, Zhi Rong Qian, Kimmie Ng, Andrew T. Chan, Jeffrey A. Meyerhardt, Edward Giovannucci, Charles S. Fuchs & Shuji Ogino. (2013) Prospective Analysis of Body Mass Index, Physical Activity, and Colorectal Cancer Risk Associated with β-Catenin (CTNNB1) Status. Cancer Research 73:5, pages 1600-1610.
Crossref
Christophe Rosty, David G. Hewett, Ian S. Brown, Barbara A. Leggett & Vicki L. J. Whitehall. (2012) Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. Journal of Gastroenterology 48:3, pages 287-302.
Crossref
Lena Secky, Martin Svoboda, Lukas Klameth, Erika Bajna, Gerhard Hamilton, Robert Zeillinger, Walter Jäger & Theresia Thalhammer. (2013) The Sulfatase Pathway for Estrogen Formation: Targets for the Treatment and Diagnosis of Hormone-Associated Tumors. Journal of Drug Delivery 2013, pages 1-13.
Crossref
Shuji Ogino, Reiko Nishihara, Paul Lochhead, Yu Imamura, Aya Kuchiba, Teppei Morikawa, Mai Yamauchi, Xiaoyun Liao, Zhi Rong Qian, Ruifang Sun, Kaori Sato, Gregory J. Kirkner, Molin Wang, Donna Spiegelman, Jeffrey A. Meyerhardt, Eva S. Schernhammer, Andrew T. Chan, Edward Giovannucci & Charles S. Fuchs. (2013) Prospective Study of Family History and Colorectal Cancer Risk by Tumor LINE-1 Methylation Level. JNCI: Journal of the National Cancer Institute 105:2, pages 130-140.
Crossref
Ka-To Shum, Jiehua Zhou & John J. Rossi. (2013) Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma. Journal of Cancer Therapy 04:04, pages 872-890.
Crossref
K. Stephen Suh, Sreeja Sarojini, Maher Youssif, Kip Nalley, Natasha Milinovikj, Fathi Elloumi, Steven Russell, Andrew Pecora, Elyssa Schecter & Andre Goy. (2013) Tissue Banking, Bioinformatics, and Electronic Medical Records: The Front-End Requirements for Personalized Medicine. Journal of Oncology 2013, pages 1-12.
Crossref
Bradford Hirsch & Amy Abernethy. (2012) Structured Decision-Making: Using Personalized Medicine to Improve the Value of Cancer Care. Journal of Personalized Medicine 3:1, pages 1-13.
Crossref
Xiaoyun Liao, Paul Lochhead, Reiko Nishihara, Teppei Morikawa, Aya Kuchiba, Mai Yamauchi, Yu Imamura, Zhi Rong Qian, Yoshifumi Baba, Kaori Shima, Ruifang Sun, Katsuhiko Nosho, Jeffrey A. Meyerhardt, Edward Giovannucci, Charles S. Fuchs, Andrew T. Chan & Shuji Ogino. (2012) Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival . New England Journal of Medicine 367:17, pages 1596-1606.
Crossref
Yu Imamura, Teppei Morikawa, Xiaoyun Liao, Paul Lochhead, Aya Kuchiba, Mai Yamauchi, Zhi Rong Qian, Reiko Nishihara, Jeffrey A. Meyerhardt, Kevin M. Haigis, Charles S. Fuchs & Shuji Ogino. (2012) Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers . Clinical Cancer Research 18:17, pages 4753-4763.
Crossref
Jianqing Wu & Ping Zha. (2020) Public Health Intervention Framework for Reviving Economy Amid the COVID-19 Pandemic (2): Use of Personalized Mitigation Measures Beyond the Epidemiological Model Limits. SSRN Electronic Journal.
Crossref

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