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Expert Review of Neurotherapeutics Volume 9, 2009 - Issue 11
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Review

MAPK, β-amyloid and synaptic dysfunction: the role of RAGE

Nicola Origlia Institute of Neuroscience, CNR-Pisa, 56100 Pisa, Italy. [email protected]
,
Ottavio Arancio Department of Pathology and Taub Institute, Columbia University, New York, NY 10032, USA. [email protected]
,
Luciano Domenici Institute of Neuroscience, CNR-Pisa, 56100 Pisa and Department of Biological Sciences and Technology (STB), University of L’Aquila, 67010 L’Aquila, Italy. [email protected]
&
Shirley ShiDu Yan Department of Pathology and Surgery, Taub Institute, Columbia University, New York, NY 10032, USA. [email protected]
Pages 1635-1645 | Published online: 09 Jan 2014

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Hui Yang, Sulei Wang, Linjie Yu, Xiaolei Zhu & Yun Xu. (2015) Esculentoside A suppresses Aβ1–42-induced neuroinflammation by down-regulating MAPKs pathways in vivo . Neurological Research 37:10, pages 859-866.
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Wenbin Wan, Huixian Chen & Yaming Li. (2014) The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease. International Journal of Neuroscience 124:2, pages 75-81.
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D.A. Simmons, T. Yang, S.M. Massa & F.M. Longo. 2016. Developing Therapeutics for Alzheimer's Disease. Developing Therapeutics for Alzheimer's Disease 437 458 .
Wenbin Wan, Lan Cao, Lumei Liu, Chunyan Zhang, Bill Kalionis, Xiantao Tai, Yaming Li & Shijin Xia. (2015) Aβ 1-42 oligomer-induced leakage in an in vitro blood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins . Journal of Neurochemistry 134:2, pages 382-393.
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Andrew F. Teich, Russell E. Nicholls, Daniela Puzzo, Jole Fiorito, Rosa Purgatorio, Mauro Fa’ & Ottavio Arancio. (2015) Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach. Neurotherapeutics 12:1, pages 29-41.
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Hongju Zhang, Yongfu Wang, Shijun Yan, Fang Du, Long Wu, Shiqiang Yan & Shirley S Yan. (2014) Genetic deficiency of neuronal RAGE protects against AGE-induced synaptic injury. Cell Death & Disease 5:6, pages e1288-e1288.
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Rosa Resende, Sueli C. F. Marques, Elisabete Ferreiro, Isaura Sim?es, Catarina R. Oliveira & Cl?udia M. F. Pereira. (2013) Effect of ?-Synuclein on Amyloid ?-Induced Toxicity: Relevance to Lewy Body Variant of Alzheimer Disease. Neurochemical Research 38:4, pages 797-806.
Crossref
Jayakumar Rajadas, Wenchao Sun, Hai Li, Mohammed Inayathullah, Damiano Cereghetti, Aaron Tan, Valeria de Mello Coelho, Francis J. Chrest, John W. Kusiak, Wanli Wei Smith, Dennis Taub, Joseph C. Wu & Joseph M. Rifkind. (2013) Enhanced Aβ1–40 Production in Endothelial Cells Stimulated with Fibrillar Aβ1–42. PLoS ONE 8:3, pages e58194.
Crossref
Le Zhao, Jun-li Wang, Yan-rui Wang & Xiu-zhi Fa. (2013) Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model. Brain Research 1492, pages 33-45.
Crossref
Akhlaq A. FarooquiAkhlaq A. Farooqui. 2012. Phytochemicals, Signal Transduction, and Neurological Disorders. Phytochemicals, Signal Transduction, and Neurological Disorders 1 29 .
Honoree Mazargui, Christian Lévêque, Dirk Bartnik, Jacques Fantini, Tiphany Gouget, Mariarosa A. B. Melone, Susanne A. Funke, Dieter Willbold & Lorena Perrone. (2012) A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis. Aging Cell 11:3, pages 530-541.
Crossref
Wei Yang, Qi Wu, Chan Yuan, Junying Gao, Ming Xiao, Minxia Gu, Jiong Ding & Gang Hu. (2012) Aquaporin-4 mediates astrocyte response to β-amyloid. Molecular and Cellular Neuroscience 49:4, pages 406-414.
Crossref
Armando Piccinni, Nicola Origlia, Antonello Veltri, Chiara Vizzaccaro, Donatella Marazziti, Mario Catena-Dell'Osso, Ciro Conversano, Ilenia Moroni, Luciano Domenici & Liliana Dell'Osso. (2012) Plasma ?-amyloid peptides levels: A pilot study in bipolar depressed patients. Journal of Affective Disorders 138:1-2, pages 160-164.
Crossref
Lorena Perrone, Oualid Sbai, Peter P. Nawroth & Angelika Bierhaus. (2012) The Complexity of Sporadic Alzheimer’s Disease Pathogenesis: The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction. International Journal of Alzheimer's Disease 2012, pages 1-13.
Crossref
S. Askarova, X. Yang, W. Sheng, G.Y. Sun & J.C.-M. Lee. (2011) Role of Aβ-receptor for advanced glycation endproducts interaction in oxidative stress and cytosolic phospholipase A2 activation in astrocytes and cerebral endothelial cells. Neuroscience 199, pages 375-385.
Crossref
Elvis Cuevas, Susan M. Lantz, J. C?sar Tob?n-Velasco, Glenn D. Newport, Qiangen Wu, Ashraf Virmani, Syed F. Ali & Abel Santamar?a. (2011) On the in vivo early toxic properties of A?25?35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression. Neurotoxicology and Teratology 33:2, pages 288-296.
Crossref
Donald J. AbrahamAlbert J. Robichaud, Ji‐In Kim & J. Steven Jacobsen. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 329 404 .
Jorge J Palop & Lennart Mucke. (2010) Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nature Neuroscience 13:7, pages 812-818.
Crossref
Hongxing Lei. (2010) Amyloid and Alzheimer’s disease. Protein & Cell 1:4, pages 312-314.
Crossref
Akhlaq A. FarooquiAkhlaq A. Farooqui. 2010. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases 325 382 .

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