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Expert Review of Neurotherapeutics Volume 9, 2009 - Issue 12
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Review

Management of the patient with medically refractory epilepsy

Tiziana Granata Department of Neurology, Cleveland, OH, USA and Department of Child Neurology, Carlo Besta Neurological Institute, Milan, Italy. [email protected]
,
Nicola Marchi Department of Cell Biology and Cerebrovascular Research Cleveland Clinic Foundation, Cleveland, OH, USA. [email protected]
,
Erin Carlton Cerebrovascular Research Cleveland Clinic Foundation, Cleveland, OH, USA. [email protected]
,
Chaitali Ghosh Department of Cell Biology and Cerebrovascular Research Cleveland Clinic Foundation, Cleveland, OH, USA. [email protected]
,
Jorge Gonzalez-Martinez Department of Neurological Surgery, Cleveland, OH, USA. [email protected]
,
Andreas V Alexopoulos Cleveland Clinic Epilepsy Center, 9500 Euclid Ave, S-51, Cleveland, OH 44195, USA. [email protected]
&
Damir Janigro Departments of Neurological Surgery, Molecular Medicine and Cell Biology and the Cerebrovascular Research Cleveland Clinic Foundation, Cleveland, OH, USA. [email protected]
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Pages 1791-1802 | Published online: 09 Jan 2014

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Karan Thakkar, Gauri Billa, Jay Rane, Hiren Chudasama, Sailendra Goswami & Rajen Shah. (2015) The rise and fall of felbamate as a treatment for partial epilepsy – aplastic anemia and hepatic failure to blame?. Expert Review of Neurotherapeutics 15:12, pages 1373-1375.
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Detlev Boison, Susan A Masino & Jonathan D Geiger. (2011) Homeostatic bioenergetic network regulation: a novel concept to avoid pharmacoresistance in epilepsy. Expert Opinion on Drug Discovery 6:7, pages 713-724.
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Articles from other publishers (63)

E.A. Mayer, J. Horn, E.D. Mayer & S. Chen. 2023. Neurobiology of Brain Disorders. Neurobiology of Brain Disorders 913 928 .
Kaleem Imdad, Turki Abualait, Ammara Kanwal, Ziyad Tareq AlGhannam, Shahab Bashir, Anum Farrukh, Sahir Hameed Khattak, Raidah Albaradie & Shahid Bashir. (2022) The Metabolic Role of Ketogenic Diets in Treating Epilepsy. Nutrients 14:23, pages 5074.
Crossref
Rachel J Smith, Mark A Hays, Golnoosh Kamali, Christopher Coogan, Nathan E Crone, Joon Y Kang & Sridevi V Sarma. (2022) Stimulating native seizures with neural resonance: a new approach to localize the seizure onset zone. Brain 145:11, pages 3886-3900.
Crossref
Francesco Brigo, Stanley C Igwe & Nicola Luigi Bragazzi. (2022) Stiripentol add-on therapy for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews 2022:9.
Crossref
Al Mehdi Krami, Chorouk Ratib, Hicham Charoute, Hassan Rouba, Rachida Roky, Abdelhamid Barakat & Halima Nahili. (2022) Association between G2677T/A polymorphism in ABCB1 gene and the risk of drug resistance epilepsy: An updated systematic review and meta-analysis. Epilepsy Research 185, pages 106977.
Crossref
Li Li Shi, Rebecca Bresnahan, Kirsty J Martin-McGill, JianCheng Dong, HengJian Ni & JinSong Geng. (2022) Felbamate add-on therapy for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews 2022:8.
Crossref
Pavlina Andreeva-Gateva, Zafer Sabit, Dimitar Bakalov, Serkan Sayiner, Radka Tafradjiiska-Hadjiolova, Stella Zaharinova, Silviya Abarova, Rumiana Koynova & Boris Tenchov. (2022) Effect of a Ketogenic Diet on Oxidative Posttranslational Protein Modifications and Brain Homogenate Denaturation in the Kindling Model of Epilepsy in Mice. Neurochemical Research 47:7, pages 1943-1955.
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Robin T. Varughese, Yash D. Shah, Shefali Karkare & Sanjeev V. Kothare. (2022) Adjunctive use of cenobamate for pediatric refractory focal-onset epilepsy: A single-center retrospective study. Epilepsy & Behavior 130, pages 108679.
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J. Horn, D. E. Mayer, S. Chen & E. A. Mayer. (2022) Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders. Translational Psychiatry 12:1.
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Mariangela Panebianco, Rebecca Bresnahan & Anthony G Marson. (2022) Pregabalin add-on for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews 2022:4.
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Keith A. Kwan Cheung, Murray D. Mitchell & Helen S. Heussler. (2021) Cannabidiol and Neurodevelopmental Disorders in Children. Frontiers in Psychiatry 12.
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Fengshi Tian, Jie Yang, Shiqi Zhao & Mohamad Sawan. (2021) A New Neuromorphic Computing Approach for Epileptic Seizure Prediction. A New Neuromorphic Computing Approach for Epileptic Seizure Prediction.
Alberto Williams-Medina, Michael Deblock & Damir Janigro. (2021) In vitro Models of the Blood–Brain Barrier: Tools in Translational Medicine. Frontiers in Medical Technology 2.
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Colin P Hawkes, Sani M Roy, Bassem Dekelbab, Britney Frazier, Monica Grover, Jaime Haidet, James Listman, Sarianne Madsen, Marian Roan, Celia Rodd, Aviva Sopher, Peter Tebben & Michael A Levine. (2021) Hypercalcemia in Children Using the Ketogenic Diet: A Multicenter Study. The Journal of Clinical Endocrinology & Metabolism 106:2, pages e485-e495.
Crossref
Damir Janigro & Nicola Marchi. 2021. Inflammation and Epilepsy: New Vistas. Inflammation and Epilepsy: New Vistas 1 20 .
Mariangela Panebianco, Hemanshu Prabhakar & Anthony G Marson. (2020) Rufinamide add-on therapy for drug-resistant epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Mohammed Hossain, Sherice Williams, Lisa Ferguson, William Bingaman, Arnab Ghosh, Imad M. Najm & Chaitali Ghosh. (2020) Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy. Molecular Neurobiology 57:11, pages 4511-4529.
Crossref
Eileen J. Mc Manus, Stacey Mc Coy, Christopher D. P. Lynch & Matthew C. L. Phillips. (2020) Ketogenic diet in drug‐resistant epilepsy with encephalopathy. Internal Medicine Journal 50:10, pages 1291-1292.
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Arpan R. Chakraborty, Nyle C. Almeida, Kiana Y. Prather, Christen M. O’Neal, Allison A. Wells, Sixia Chen & Andrew K. Conner. (2020) Resting‐state functional magnetic resonance imaging with independent component analysis for presurgical seizure onset zone localization: A systematic review and meta‐analysis. Epilepsia 61:9, pages 1958-1968.
Crossref
Shehryar R Sheikh, Nicholas Thompson, Feride Frech, Manoj Malhotra & Lara Jehi. (2020) Quantifying the burden of generalized tonic‐clonic seizures in patients with drug‐resistant epilepsy. Epilepsia 61:8, pages 1627-1637.
Crossref
Yankun Xu, Jie Yang, Shiqi Zhao, Hemmings Wu & Mohamad Sawan. (2020) An End-to-End Deep Learning Approach for Epileptic Seizure Prediction. An End-to-End Deep Learning Approach for Epileptic Seizure Prediction.
Kirsty J Martin-McGill, Rebecca Bresnahan, Robert G Levy & Paul N Cooper. (2020) Ketogenic diets for drug-resistant epilepsy. Cochrane Database of Systematic Reviews 2020:6.
Crossref
Francesco Brigo, Stanley C Igwe & Nicola Luigi Bragazzi. (2020) Stiripentol add-on therapy for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Rajveer Singh, Kamalesh Chakravarty, Jitupam Baishya, Manoj K. Goyal & Parampreet Kharbanda. (2020) Management of Refractory Epilepsy. International Journal of Epilepsy 06:01, pages 15-23.
Crossref
Luisa Rocha, Christian Lizette Frías‐Soria, José G. Ortiz, Jerónimo Auzmendi & Alberto Lazarowski. (2020) Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?. Epilepsia Open 5:1, pages 36-49.
Crossref
Keith A. Kwan Cheung, Hassendrini Peiris, Geoffrey Wallace, Olivia J. Holland & Murray D. Mitchell. (2019) The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids. International Journal of Molecular Sciences 20:23, pages 6079.
Crossref
Matthew Charles Lee Phillips. 2019. Epilepsy - Advances in Diagnosis and Therapy. Epilepsy - Advances in Diagnosis and Therapy.
Li Li Shi, Rebecca Bresnahan, Kirsty J Martin-McGill, JianCheng Dong, HengJian Ni & JinSong Geng. (2019) Felbamate add-on therapy for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Mariangela Panebianco, Rebecca Bresnahan, Karla Hemming & Anthony G Marson. (2019) Pregabalin add-on for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Tristan Dale, Jenny Downs, Heather Olson, Ann Marie Bergin, Stephanie Smith & Helen Leonard. (2019) Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder. Epilepsy Research 151, pages 31-39.
Crossref
Avidesh Panday, Chrystal Calderon, Sherry Sandy & Devindra Ramnarine. (2019) Mesial temporal lobe epilepsy. International Journal of Surgery Case Reports 65, pages 275-278.
Crossref
Aaron Dadas, Jolewis Washington, Nicola Marchi & Damir Janigro. 2019. Nervous System Drug Delivery. Nervous System Drug Delivery 21 37 .
Kirsty J Martin-McGill, Cerian F Jackson, Rebecca Bresnahan, Robert G Levy & Paul N Cooper. (2018) Ketogenic diets for drug-resistant epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Chaitali Ghosh, Mohammed Hossain, Saurabh Mishra, Sameena Khan, Jorge Gonzalez‐Martinez, Nicola Marchi, Damir Janigro, William Bingaman & Imad Najm. (2018) Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood–brain barrier model. Epilepsia 59:11, pages 2049-2060.
Crossref
Gonçalo Campos, Ana Fortuna, Amílcar Falcão & Gilberto Alves. (2018) In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy. Epilepsy Research 146, pages 63-86.
Crossref
Francesco Brigo, Stanley C Igwe & Nicola Luigi Bragazzi. (2018) Stiripentol add-on therapy for focal refractory epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Mariangela Panebianco, Hemanshu Prabhakar & Anthony G Marson. (2018) Rufinamide add-on therapy for refractory epilepsy. Cochrane Database of Systematic Reviews.
Crossref
O. K. Fasil, R Rajesh & T. M. Thasleema. (2018) Epilepsy region localization in signal domain — A smart getup. Epilepsy region localization in signal domain — A smart getup.
Diogo Miguel Rombo, Joaquim Alexandre Ribeiro & Ana Maria Sebastião. 2018. The Adenosine Receptors. The Adenosine Receptors 309 350 .
Li Li Shi, JianCheng Dong, HengJian Ni, JinSong Geng & Taixiang Wu. (2017) Felbamate as an add-on therapy for refractory partial epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Glenn Dallérac, Julien Moulard, Jean-François Benoist, Stefan Rouach, Stéphane Auvin, Angèle Guilbot, Loïc Lenoir & Nathalie Rouach. (2017) Non-ketogenic combination of nutritional strategies provides robust protection against seizures. Scientific Reports 7:1.
Crossref
Ying Meng, Lior Elkaim, Justin Wang, Jessica Liu, Naif M. Alotaibi, George M. Ibrahim, Aria Fallah, Alexander G. Weil, Taufik A. Valiante, Andres M. Lozano & James T. Rutka. (2017) Social media in epilepsy: A quantitative and qualitative analysis. Epilepsy & Behavior 71, pages 79-84.
Crossref
Chaitali GhoshMohammed HossainJesal SolankiImad M. NajmNicola Marchi & Damir Janigro. (2017) Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells. Epilepsia 58:4, pages 576-585.
Crossref
Kirsty Martin, Cerian F Jackson, Robert G Levy & Paul N Cooper. (2016) Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Hipólito Nzwalo, Inês Menezes Cordeiro, Ana Catarina Santos, Rita Peralta, Teresa Paiva & Carla Bentes. (2016) 24-hour rhythmicity of seizures in refractory focal epilepsy. Epilepsy & Behavior 55, pages 75-78.
Crossref
Francesco Brigo, Monica Storti & Stanley C Igwe. (2015) Stiripentol for focal refractory epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Mariangela Panebianco & Anthony G Marson. (2015) Rufinamide add-on therapy for refractory epilepsy. Cochrane Database of Systematic Reviews.
Crossref
Li Li Shi, JianCheng Dong, Hengjian Ni, JinSong Geng & Taixiang Wu. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
James L. LeachLili MilesDavid M. HenkelHansel M. GreinerMarcia K. KukrejaKatherine D. HollandDouglas F. RoseBin Zhang & Francesco T. Mangano. (2014) Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. Journal of Neurosurgery: Pediatrics 14:1, pages 68-80.
Crossref
Nicola Marchi, Tiziana Granata & Damir Janigro. (2014) Inflammatory pathways of seizure disorders. Trends in Neurosciences 37:2, pages 55-65.
Crossref
Francesco Brigo & Monica Storti. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Damir Janigro & Matthew C. Walker. 2014. Issues in Clinical Epileptology: A View from the Bench. Issues in Clinical Epileptology: A View from the Bench 253 264 .
Nicola Marchi & Mireille Lerner-Natoli. (2012) Cerebrovascular Remodeling and Epilepsy. The Neuroscientist 19:3, pages 304-312.
Crossref
Andreas V. Alexopoulos. (2013) Pharmacoresistant epilepsy: Definition and explanation. Epileptology 1:1, pages 38-42.
Crossref
Dawn Craig, Stephen Rice, Fiona Paton, David Fox & Nerys Woolacott. (2013) Retigabine for the Adjunctive Treatment of Adults with Partial-Onset Seizures in Epilepsy with and without Secondary Generalization. PharmacoEconomics 31:2, pages 101-110.
Crossref
Qi-Xiong Chen, Jing-Kun Miao, Chun Li, Xiao-Wen Li, Xiao-Mei Wu & Xiao-ping Zhang. (2013) Anticonvulsant Activity of Acute and Chronic Treatment with a-Asarone from <i>Acorus gramineus</i> in Seizure Models. Biological and Pharmaceutical Bulletin 36:1, pages 23-30.
Crossref
Nicola Marchi, Tiziana Granata, Chaitali Ghosh & Damir Janigro. (2012) Blood–brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches. Epilepsia 53:11, pages 1877-1886.
Crossref
Heidrun Potschka. (2012) Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport. Advanced Drug Delivery Reviews 64:10, pages 943-952.
Crossref
Chaitali Ghosh, Nicola Marchi, Mohammed Hossain, Peter Rasmussen, Andreas V. Alexopoulos, Jorge Gonzalez-Martinez, Hu Yang & Damir Janigro. (2012) A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain. Neurobiology of Disease 46:3, pages 692-700.
Crossref
Francesco Brigo & Monica Storti. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Chaitali Ghosh, Nicola Marchi, Nirav K. Desai, Vikram Puvenna, Mohammed Hossain, Jorge Gonzalez-Martinez, Andreas V. Alexopoulos & Damir Janigro. (2011) Cellular localization and functional significance of CYP3A4 in the human epileptic brain. Epilepsia 52:3, pages 562-571.
Crossref
Li Li Shi, JianCheng Dong, HengJian Ni, JinSong Geng & Taixiang Wu. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Heidrun Potschka. (2010) Modulating P‐glycoprotein regulation: Future perspectives for pharmacoresistant epilepsies?. Epilepsia 51:8, pages 1333-1347.
Crossref

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