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Editorial

Could PKR inhibition modulate human neurodegeneration?

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Pages 1455-1457 | Published online: 09 Jan 2014

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Apar Pataer, Bulent Ozpolat, RuPing Shao, Neil R. Cashman, Steven S. Plotkin, Charles E. Samuel, Steven H. Lin, Nashwa N. Kabil, Jing Wang, Mourad Majidi, Bingliang Fang, Jack A. Roth, Ara A. Vaporciyan, Ignacio I. Wistuba, Mien-Chie Hung & Stephen G. Swisher. (2019) Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene 39:4, pages 801-813.
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Shunit Gal-Ben-Ari, Iliana Barrera, Marcelo Ehrlich & Kobi Rosenblum. (2019) PKR: A Kinase to Remember. Frontiers in Molecular Neuroscience 11.
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Jacques Hugon, François Mouton-Liger, Julien Dumurgier & Claire Paquet. (2017) PKR involvement in Alzheimer’s disease. Alzheimer's Research & Therapy 9:1.
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Shakevia Johnson, Jeremy Duncan, Syed A. Hussain, Gang Chen, Jia Luo, Channing Mclaurin, Warren May, Grazyna Rajkowska, Xiao-Ming Ou, Craig A. Stockmeier & Jun Ming Wang. (2015) The IFN γ -PKR Pathway in the Prefrontal Cortex Reactions to Chronic Excessive Alcohol Use . Alcoholism: Clinical and Experimental Research 39:3, pages 476-484.
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Anne-Sophie Carret-Rebillat, Clarisse Pace, Sarah Gourmaud, Laura Ravasi, Samantha Montagne-Stora, Sophie Longueville, Marion Tible, Erika Sudol, Raymond Chuen-Chung Chang, Claire Paquet, François Mouton-Liger & Jacques Hugon. (2015) Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation. Scientific Reports 5:1.
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Juan A. Marchal, Gabriel J. Lopez, Macarena Peran, Ana Comino, Juan R. Delgado, Javier A. García‐García, Veronica Conde, Fernando M. Aranda, Carmen Rivas, Mariano Esteban & Maria A. Garcia. (2014) The impact of PKR activation: from neurodegeneration to cancer. The FASEB Journal 28:5, pages 1965-1974.
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Lauren S. Vaughn, Brittany Snee & Rekha C. Patel. (2014) Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells. Gene 536:1, pages 90-96.
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Julien Dumurgier, Francois Mouton-Liger, Pauline Lapalus, Magali Prevot, Jean-Louis Laplanche, Jacques Hugon & Claire Paquet. (2013) Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer’s Disease. PLoS ONE 8:1, pages e53587.
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Stéphanie Dabo & Eliane Meurs. (2012) dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection. Viruses 4:11, pages 2598-2635.
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François Mouton-Liger, Claire Paquet, Julien Dumurgier, Constantin Bouras, Laurent Pradier, Françoise Gray & Jacques Hugon. (2012) Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:6, pages 885-896.
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François Mouton-Liger, Claire Paquet, Julien Dumurgier, Pauline Lapalus, Françoise Gray, Jean-Louis Laplanche & Jacques Hugon. (2012) Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease. Biological Psychiatry 71:9, pages 829-835.
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Anindita Bose, François Mouton-Liger, Claire Paquet, Pierre Mazot, Marc Vigny, Françoise Gray & Jacques Hugon. (2011) Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease. Brain Pathology 21:2, pages 189-200.
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Agnieszka PindelAnthony Sadler. (2011) The Role of Protein Kinase R in the Interferon Response. Journal of Interferon & Cytokine Research 31:1, pages 59-70.
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François Mouton-Liger, Claire Paquet & Jacques Hugon. (2010) Biogenesis and regulation of microRNA: implication in Alzheimer’s disease. Future Neurology 5:6, pages 839-850.
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S.M. Kim, S.Y. Yoon, J.E. Choi, J.S. Park, J.M. Choi, T. Nguyen & D.H. Kim. (2010) Activation of eukaryotic initiation factor-2α-kinases in okadaic acid-treated neurons. Neuroscience 169:4, pages 1831-1839.
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Noëlla Arnaud, Stéphanie Dabo, Patrick Maillard, Agata Budkowska, Katerina I. Kalliampakou, Penelope Mavromara, Dominique Garcin, Jacques Hugon, Anne Gatignol, Daisuke Akazawa, Takaji Wakita & Eliane F. Meurs. (2010) Hepatitis C Virus Controls Interferon Production through PKR Activation. PLoS ONE 5:5, pages e10575.
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