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Review

Animal models of headache: from bedside to bench and back to bedside

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Pages 389-411 | Published online: 09 Jan 2014

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Giorgio Lambru, Anna P. Andreou, Martina Guglielmetti & Paolo Martelletti. (2018) Emerging drugs for migraine treatment: an update. Expert Opinion on Emerging Drugs 23:4, pages 301-318.
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Marcela Romero-Reyes & James M Uyanik. (2014) Orofacial pain management: current perspectives. Journal of Pain Research 7, pages 99-115.
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Jan Hoffmann, Simon Akerman & Peter J Goadsby. (2014) Efficacy and mechanism of anticonvulsant drugs in migraine. Expert Review of Clinical Pharmacology 7:2, pages 191-201.
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Sieneke Labruijere, Khatera Ibrahimi, Kayi Y Chan & Antoinette MaassenVanDenBrink. (2013) Discovery techniques for calcitonin gene-related peptide receptor antagonists for potential antimigraine therapies. Expert Opinion on Drug Discovery 8:11, pages 1309-1323.
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Articles from other publishers (51)

Michel D. Ferrari, Peter J. Goadsby, Rami Burstein, Tobias Kurth, Cenk Ayata, Andrew Charles, Messoud Ashina, Arn M. J. M. van den Maagdenberg & David W. Dodick. (2022) Migraine. Nature Reviews Disease Primers 8:1.
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Eleonóra Spekker, Masaru Tanaka, Ágnes Szabó & László Vécsei. (2021) Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research. Biomedicines 10:1, pages 76.
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C. Lucas. (2021) Migraine with aura. Revue Neurologique 177:7, pages 779-784.
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Giorgio Lambru, Silvia Benemei, Anna P. Andreou, Michelangelo Luciani, Gianluca Serafini, Antoinette Maassen van den Brink & Paolo Martelletti. (2020) Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine. Pain and Therapy 10:1, pages 1-13.
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Olivia Grech, Susan P. Mollan, Benjamin R. Wakerley, Daniel Fulton, Gareth G. Lavery & Alexandra J. Sinclair. (2021) The Role of Metabolism in Migraine Pathophysiology and Susceptibility. Life 11:5, pages 415.
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Anna P. Andreou, Charlotte Leese, Rosaria Greco, Chiara Demartini, Eve Corrie, Deniz Simsek, Anna Zanaboni, Ksenia Koroleva, Joseph O. Lloyd, Giorgio Lambru, Ciara Doran, Oleg Gafurov, Elizabeth Seward, Rashid Giniatullin, Cristina Tassorelli & Bazbek Davletov. (2020) Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine. Neurotherapeutics 18:1, pages 556-568.
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Hung-Ruei Tzeng, Ming Tatt Lee, Pi-Chuan Fan, Daniel E. Knutson, Tzu-Hsuan Lai, Werner Sieghart, James Cook & Lih-Chu Chiou. (2020) α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia. Neurotherapeutics 18:1, pages 569-585.
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Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu & Jin-Chung Chen. (2020) Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion. The Journal of Headache and Pain 21:1.
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Karl B. Alstadhaug & Anna P. Andreou. (2019) Caffeine and Primary (Migraine) Headaches—Friend or Foe?. Frontiers in Neurology 10.
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Anna P. Andreou & Lars Edvinsson. (2019) Mechanisms of migraine as a chronic evolutive condition. The Journal of Headache and Pain 20:1.
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Mario FP Peres, Marcelo M Valença, Fernanda G Amaral & José Cipolla-Neto. (2019) Current understanding of pineal gland structure and function in headache. Cephalalgia 39:13, pages 1700-1709.
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Elahe Mohammadi Vosough, Vafa Baradaran Rahimi, Seyyed Ali Masoud, Hamid Reza Mirkarimi, Maryam Kazemi Demneh, Alireza Abed, Hamid Reza Banafshe & Vahid Reza Askari. (2019) Evaluation of protective effects of non-selective cannabinoid receptor agonist WIN 55,212-2 against the nitroglycerine-induced acute and chronic animal models of migraine: A mechanistic study. Life Sciences 232, pages 116670.
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Giuseppe Tardiolo, Placido Bramanti & Emanuela Mazzon. (2019) Migraine: Experimental Models and Novel Therapeutic Approaches. International Journal of Molecular Sciences 20:12, pages 2932.
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Dara Bree & Dan Levy. (2018) Strides Toward Better Understanding of Post-Traumatic Headache Pathophysiology Using Animal Models. Current Pain and Headache Reports 22:10.
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Yonglie Zhao, Margarida Martins-Oliveira, Simon Akerman & Peter J Goadsby. (2017) Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation. Cephalalgia 38:7, pages 1215-1224.
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Nathan T Fried, Christina R Maxwell, Melanie B Elliott & Michael L Oshinsky. (2017) Region-specific disruption of the blood-brain barrier following repeated inflammatory dural stimulation in a rat model of chronic trigeminal allodynia. Cephalalgia 38:4, pages 674-689.
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Regina R. Berkovich, Alexey Y. Sokolov, Daniel M. Togasaki, Aida A. Yakupova, Paul-Henry Cesar & Soma Sahai-Srivastava. (2018) Dextromethorphan/Quinidine in Migraine Prophylaxis: An Open-label Observational Clinical Study. Clinical Neuropharmacology 41:2, pages 64-69.
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Hannah M. Harris, Jessica M. Carpenter, Jonathan R. Black, Todd A. Smitherman & Kenneth J. Sufka. (2017) The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification. Journal of Neuroscience Methods 284, pages 63-70.
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Henrik Winther Schytz, Richard Hargreaves & Messoud Ashina. (2017) Challenges in developing drugs for primary headaches. Progress in Neurobiology 152, pages 70-88.
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Sharon E. Mace. 2017. Observation Medicine. Observation Medicine 189 199 .
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M. G. Jones, A. P. Andreou, S. B. McMahon & D. Spanswick. (2016) Pharmacology of reflex blinks in the rat: a novel model for headache research. The Journal of Headache and Pain 17:1.
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Kenneth J. Sufka, Stephanie M. Staszko, Ainslee P. Johnson, Morgan E. Davis, Rachel E. Davis & Todd A. Smitherman. (2016) Clinically relevant behavioral endpoints in a recurrent nitroglycerin migraine model in rats. The Journal of Headache and Pain 17:1.
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Olga Kuzawińska, Krzysztof Lis, Grzegorz Cessak, Dagmara Mirowska-Guzel & Ewa Bałkowiec-Iskra. (2016) Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment. Neurologia i Neurochirurgia Polska 50:6, pages 463-467.
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Alycia F Tipton, Igal Tarash, Brenna McGuire, Andrew Charles & Amynah A Pradhan. (2016) The effects of acute and preventive migraine therapies in a mouse model of chronic migraine. Cephalalgia 36:11, pages 1048-1056.
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Margarida-Martins Oliveira, Simon Akerman, Isaura Tavares & Peter J. Goadsby. (2016) Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y1 receptor: implications for migraine. Pain 157:8, pages 1666-1673.
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Farooq H. Maniyar, Till Sprenger, Teshamae Monteith, Christoph J. Schankin & Peter J. Goadsby. (2015) The Premonitory Phase of Migraine – What Can We Learn From It?. Headache: The Journal of Head and Face Pain 55:5, pages 609-620.
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Anna P. Andreou, Philip R. Holland, Michele P. Lasalandra & Peter J. Goadsby. (2015) Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors. Pain 156:3, pages 439-450.
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Robin James Storer, Weera Supronsinchai & Anan Srikiatkhachorn. (2014) Animal Models of Chronic Migraine. Current Pain and Headache Reports 19:1.
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Anna P. Andreou & Michael L. Oshinsky. 2015. Pathophysiology of Headaches. Pathophysiology of Headaches 31 66 .
Marcela Romero-Reyes & Simon Akerman. (2014) Update on Animal Models of Migraine. Current Pain and Headache Reports 18:11.
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S E Erdener & T Dalkara. (2014) Modelling headache and migraine and its pharmacological manipulation. British Journal of Pharmacology 171:20, pages 4575-4594.
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Cristina Frange, Camila Hirotsu, Helena Hachul, Paula Araujo, Sergio Tufik & Monica L. Andersen. (2014) Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions. Current Pain and Headache Reports 18:8.
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Michael L. Oshinsky. (2014) Sensitization and ongoing activation in the trigeminal nucleus caudalis. Pain 155:7, pages 1181-1182.
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Nelly Boyer, Radhouane Dallel, Alain Artola & Lénaïc Monconduit. (2014) General trigeminospinal central sensitization and impaired descending pain inhibitory controls contribute to migraine progression. Pain 155:7, pages 1196-1205.
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Inger Jansen‐Olesen, Sarah Louise T. Christensen & Jes Olesen. 2014. In Vivo Models for Drug Discovery. In Vivo Models for Drug Discovery 231 260 .
JungWook Park, HeuiSoo Moon, Simon Akerman, Philip R. Holland, Michele P. Lasalandra, Anna P. Andreou, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg & Peter J. Goadsby. (2014) Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: A Fos protein study. Neurobiology of Disease 64, pages 1-7.
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I. Almazov, M. Burke & A. Mosek. (2014) Meningismus in children with chronic headache is most likely due to streptococcal infection. Medical Hypotheses 82:4, pages 490-492.
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Amynah A. Pradhan, Monique L. Smith, Brenna McGuire, Igal Tarash, Christopher J. Evans & Andrew Charles. (2014) Characterization of a novel model of chronic migraine. Pain 155:2, pages 269-274.
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Inger Jansen-Olesen, Peer Tfelt-Hansen & Jes Olesen. (2013) Animal Migraine Models for Drug Development: Status and Future Perspectives. CNS Drugs 27:12, pages 1049-1068.
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Hans-Christoph DienerOliver SummStefan EversIngo W Husstedt. 2013. Novel Approaches in Migraine Treatment. Novel Approaches in Migraine Treatment 108 118 .
Peter J. Goadsby. 2013. Headache. Headache 88 99 .
Marcela Romero-Reyes & Yi Ye. (2013) Pearls and pitfalls in experimental in vivo models of headache: Conscious behavioral research. Cephalalgia 33:8, pages 566-576.
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Robin J Storer & Peter J Goadsby. (2013) Topiramate is likely to act outside of the trigeminocervical complex. Cephalalgia 33:5, pages 291-300.
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Oliver Summ & Stefan Evers. (2013) Mechanism of Action of Indomethacin in Indomethacin-Responsive Headaches. Current Pain and Headache Reports 17:4.
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Michael L. Oshinsky, Menka M. Sanghvi, Christina R. Maxwell, Dorian Gonzalez, Rebecca J. Spangenberg, Marnie Cooper & Stephen D. Silberstein. (2012) Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache. Headache: The Journal of Head and Face Pain 52:9, pages 1336-1349.
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Alan M. Palmer & Mohammad S. Alavijeh. (2012) Translational CNS medicines research. Drug Discovery Today 17:19-20, pages 1068-1078.
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Anna P AndreouPeter J Goadsby. (2011) Topiramate in the treatment of migraine: A kainate (glutamate) receptor antagonist within the trigeminothalamic pathway. Cephalalgia 31:13, pages 1343-1358.
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Ria BholaPeter J Goadsby. (2010) A trans-cultural comparison of the organisation of care at headache centres world-wide. Cephalalgia 31:3, pages 316-330.
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Christina R. Maxwell, Rebecca Jay Spangenberg, Jan B. Hoek, Stephen D. Silberstein & Michael L. Oshinsky. (2010) Acetate Causes Alcohol Hangover Headache in Rats. PLoS ONE 5:12, pages e15963.
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Oliver Summ, Anna P. Andreou, Simon Akerman & Peter J. Goadsby. (2010) A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches. The Journal of Headache and Pain 11:6, pages 477-483.
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