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Expert Review of Neurotherapeutics Volume 11, 2011 - Issue 2
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Special Report

Efficacy and safety of ramelteon in Japanese adults with chronic insomnia: a randomized, double-blind, placebo-controlled study

Naohisa Uchimura Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan; Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan
,
Atsushi Ogawa Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan;[email protected]
,
Misako Hamamura Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan; Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan
,
Takamasa Hashimoto Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan; Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan
,
Hiroshi Nagata Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan; Takeda Pharmaceutical Company Limited, 1–1 Doshomachi 4-chome, Chuo-ku, Osaka , 540-8645, Japan
&
Makoto Uchiyama Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo, Japan; Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo, Japan
Pages 215-224 | Published online: 09 Jan 2014

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Gilberto Spadoni, Annalida Bedini, Simone Lucarini, Marco Mor & Silvia Rivara. (2015) Pharmacokinetic and pharmacodynamic evaluation of ramelteon: an insomnia therapy. Expert Opinion on Drug Metabolism & Toxicology 11:7, pages 1145-1156.
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Atsushi Ogawa, Shiro Hinotsu & Koji Kawakami. (2013) Does late morning waking-up affect sleep during the following night in patients with primary insomnia?. Biological Rhythm Research 44:6, pages 938-948.
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Articles from other publishers (22)

Julia Maruani, Eve Reynaud, Juliette Chambe, Laura Palagini, Patrice Bourgin & Pierre A. Geoffroy. (2023) Efficacy of melatonin and ramelteon for the acute and long‐term management of insomnia disorder in adults: A systematic review and meta‐analysis . Journal of Sleep Research 32:6.
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Janet M. Y. Cheung, Hannah Scott, Alexandria Muench, Ronald R. Grunstein, Andrew D. Krystal, Dieter Riemann & Michael Perlis. (2023) Comparative short‐term safety and efficacy of hypnotics: A quantitative risk–benefit analysis. Journal of Sleep Research.
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Luciano Ferreira Drager, Márcia Assis, Andrea Frota Rego Bacelar, Dalva Lucia Rollemberg Poyares, Silvia Gonçalves Conway, Gabriel Natan Pires, Alexandre Pinto de Azevedo, Alicia Carissimi, Allan Luiz Eckeli, Álvaro Pentagna, Carlos Maurício Oliveira Almeida, Clélia Maria Ribeiro Franco, Emmanuelle Silva Tavares Sobreira, Fernando Gustavo Stelzer, Giuliana Macedo Mendes, Gisele Richter Minhoto, Ila Marques Porto Linares, Ksdy Maiara Moura Sousa, Livia Leite Góes Gitaí, Lucia Sukys-Claudino, Manoel Alves Sobreira-Neto, Marcio Andrei Zanini, Regina Margis & Sandra Cristina Gonçalves Martinez. (2023) 2023 Guidelines on the Diagnosis and Treatment of Insomnia in Adults – Brazilian Sleep Association. Sleep Science 16:S 02.
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Bei Pan, Long Ge, Honghao Lai, Liangying Hou, Chen Tian, Qi Wang, Kelu Yang, Yao Lu, Hongfei Zhu, Mengting Li, Deren Wang, Xiuxia Li, Yuqing Zhang, Ya Gao, Ming Liu, Guowu Ding, Jinhui Tian & Kehu Yang. (2023) The Comparative Effectiveness and Safety of Insomnia Drugs: A Systematic Review and Network Meta-Analysis of 153 Randomized Trials. Drugs 83:7, pages 587-619.
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Heather McElroyBeth O’LearyMichael AdenaRenee CampbellAmir Abbas Tahami MonfaredGenevieve Meier. (2021) Comparative efficacy of lemborexant and other insomnia treatments: a network meta-analysis. Journal of Managed Care & Specialty Pharmacy 27:9, pages 1296-1308.
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Atsuro Oishi, Florence Gbahou & Ralf Jockers. 2021. The Human Hypothalamus: Anterior Region. The Human Hypothalamus: Anterior Region 345 356 .
Makoto Uchiyama. (2020) Restoration and Stress in Psychiatry休養・ストレスと精神医学. Journal of Nihon University Medical Association 79:6, pages 369-377.
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Senthil Kumaran Satyanarayanan, Yu-Chuan Chien, Jane Pei-Chen Chang, Shih-Yi Huang, Ta-Wei Guu, Huanxing Su & Kuan-Pin Su. (2020) Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety. Brain, Behavior, and Immunity 85, pages 142-151.
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Naohisa Uchimura, Keisuke Nakatome, Kouji Miyata & Makoto Uchiyama. (2019) Effect of ramelteon coadministered with antidepressant in patients with insomnia and major depressive disorder: an exploratory study. Sleep and Biological Rhythms 17:4, pages 397-405.
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Stefano Comai, Martha Lopez-Canul, Danilo De Gregorio, Ada Posner, Mohamed Ettaoussi, Fabrizia Claudia Guarnieri & Gabriella Gobbi. (2019) Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications, and perspectives. Pharmacological Research 144, pages 343-356.
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Mitsuaki NishikimiAtsushi NumaguchiKunihiko TakahashiYasuhiro MiyagawaKota MatsuiMichiko HigashiGo MakishiShigeyuki MatsuiNaoyuki Matsuda. (2018) Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial*. Critical Care Medicine 46:7, pages 1099-1105.
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Tobias Atkin, Stefano Comai & Gabriella Gobbi. (2018) Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery. Pharmacological Reviews 70:2, pages 197-245.
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Jennifer L. Schroeck, James Ford, Erin L. Conway, Kari E. Kurtzhalts, Megan E. Gee, Krista A. Vollmer & Kari A. Mergenhagen. (2016) Review of Safety and Efficacy of Sleep Medicines in Older Adults. Clinical Therapeutics 38:11, pages 2340-2372.
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Venkataramanujam Srinivasan, Rahimah Zakaria, Domenico de Berardis, Francisco López-Muñoz, Mohd Jamil Yaacob, Zahiruddin Othman & Amnon Brzezinski. 2016. Melatonin, Neuroprotective Agents and Antidepressant Therapy. Melatonin, Neuroprotective Agents and Antidepressant Therapy 203 217 .
Anthony Lequerica, Neil Jasey, Jaclyn N. Portelli Tremont & Nancy D. Chiaravalloti. (2015) Pilot Study on the Effect of Ramelteon on Sleep Disturbance After Traumatic Brain Injury: Preliminary Evidence From a Clinical Trial. Archives of Physical Medicine and Rehabilitation 96:10, pages 1802-1809.
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Akira Kuriyama, Michitaka Honda & Yasuaki Hayashino. (2014) Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Medicine 15:4, pages 385-392.
Crossref
Amnon Brzezinski. (2014) Possible Role of Exogenous Melatonin and Melatonin-Receptor-Agonists in the Treatment of Menopause―Associated Sleep Disturbances. Open Journal of Obstetrics and Gynecology 04:06, pages 309-320.
Crossref
Venkataramanujam Srinivasan, Rahimah Zakaria, Timo Partonen, Edward C. Lauterbach, Preetha Sharone Kuppuswamy, Amnon Brzezinski, Zahiruddin Othman & Atul Prasad. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 343 352 .
Amnon Brzezinski. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 263 273 .
J. Liu & L.-n. Wang. (2012) Ramelteon in the treatment of chronic insomnia: systematic review and meta-analysis. International Journal of Clinical Practice 66:9, pages 867-873.
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Daniel P. Cardinali, Venkataramanujan Srinivasan, Amnon Brzezinski & Gregory M. Brown. (2012) Melatonin and its analogs in insomnia and depression. Journal of Pineal Research 52:4, pages 365-375.
Crossref
Atsushi Ogawa, Shiro Hinotsu, Hisashi Urushihara & Koji Kawakami. (2011) Night-to-night variability of sleep latency significantly predicts the magnitude of subsequent change in sleep latency during placebo administration. Sleep Medicine 12:6, pages 565-571.
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