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Review

Using ‘omics’ to define pathogenesis and biomarkers of Parkinson’s disease

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Pages 925-942 | Published online: 09 Jan 2014

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Articles from other publishers (56)

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Alexandra Benchoua, Marie Lasbareilles & Johana Tournois. (2021) Contribution of Human Pluripotent Stem Cell-Based Models to Drug Discovery for Neurological Disorders. Cells 10:12, pages 3290.
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Alika Sarkar, Neeraj Rawat, Nidhi Sachan & Mahendra Pratap Singh. (2019) Unequivocal Biomarker for Parkinson’s Disease: A Hunt that Remains a Pester. Neurotoxicity Research 36:3, pages 627-644.
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Emily L. Gill, Jeremy P. Koelmel, Richard A. Yost, Michael S. Okun, Vinata Vedam-Mai & Timothy J. Garrett. (2018) Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s Disease: Current Progress and Future Perspectives. Analytical Chemistry 90:5, pages 2979-2986.
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Albert Stezin, Rajini M. Naduthota, Ragasudha Botta, Shriram Varadharajan, Abhishek Lenka, Jitender Saini, Ravi Yadav & Pramod Kumar Pal. (2017) Clinical utility of visualisation of nigrosome-1 in patients with Parkinson’s disease. European Radiology 28:2, pages 718-726.
Crossref
Sara RedenšekVita DolžanTanja Kunej. (2018) From Genomics to Omics Landscapes of Parkinson's Disease: Revealing the Molecular Mechanisms. OMICS: A Journal of Integrative Biology 22:1, pages 1-16.
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Peter A. LeWittJia LiMei LuLining GuoPeggy Auinger. (2017) Metabolomic biomarkers as strong correlates of Parkinson disease progression. Neurology 88:9, pages 862-869.
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Affif Zaccaria, Ali Bouamrani, Stephan Chabardès, Michèle El Atifi, Eric Seigneuret, Johannes A. Lobrinus, Michel Dubois-Dauphin, François Berger & Pierre R. Burkhard. (2016) Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease. Molecular Neurodegeneration 11:1.
Crossref
Sumit Sarkar, James Raymick & Syed Imam. (2016) Neuroprotective and Therapeutic Strategies against Parkinson’s Disease: Recent Perspectives. International Journal of Molecular Sciences 17:6, pages 904.
Crossref
Thomas F. Tropea & Claire Henchcliffe. 2016. Parkinson's Disease. Parkinson's Disease 249 264 .
. 2016. Parkinson's Disease. Parkinson's Disease 231 360 .
Marion Delenclos, Daryl R. Jones, Pamela J. McLean & Ryan J. Uitti. (2016) Biomarkers in Parkinson's disease: Advances and strategies. Parkinsonism & Related Disorders 22, pages S106-S110.
Crossref
Arvind Kumar Shukla, Ch. Ratnasekhar, Prakash Pragya, Hitesh Singh Chaouhan, Devendra Kumar Patel, Debapratim Kar Chowdhuri & Mohana Krishna Reddy Mudiam. (2014) Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster. Molecular Neurobiology 53:1, pages 254-269.
Crossref
Xiangmin Lin, Min Shi, Jeyaraj Gunasingh Masilamoni, Romel Dator, James Movius, Patrick Aro, Yoland Smith & Jing Zhang. (2015) Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1854:7, pages 779-787.
Crossref
Weijian Zhang, Lina Zhou, Peiyuan Yin, Jinbing Wang, Xin Lu, Xiaomei Wang, Jianguo Chen, Xiaohui Lin & Guowang Xu. (2015) A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma. Scientific Reports 5:1.
Crossref
Nadia Magdalinou, Andrew J Lees & Henrik Zetterberg. (2014) Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions. Journal of Neurology, Neurosurgery & Psychiatry 85:10, pages 1065-1075.
Crossref
Brigit E. Riley, Shyra J. Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E. Ivliev, Birgit Schüle, Jeff Alexander, William Wallace, Glenda M. Halliday, J. William Langston, Scott Braxton, Ted Yednock, Thomas Shaler & Jennifer A. Johnston. (2014) Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms. PLoS ONE 9:8, pages e102909.
Crossref
Tiziana Alberio, Kelly McMahon, Manuela Cuccurullo, Lee A. Gethings, Craig Lawless, Maurizio Zibetti, Leonardo Lopiano, Johannes P. C. Vissers & Mauro Fasano. (2014) Verification of a Parkinson’s Disease Protein Signature in T-Lymphocytes by Multiple Reaction Monitoring. Journal of Proteome Research 13:8, pages 3554-3561.
Crossref
Lien-Yu Hung, Hui-Wen Wu, Kuangwen Hsieh & Gwo-Bin Lee. (2014) Microfluidic platforms for discovery and detection of molecular biomarkers. Microfluidics and Nanofluidics 16:5, pages 941-963.
Crossref
Xing Zhang, Veronica M. Chiu, George Stoica, Gina Lungu, James O. Schenk & Herbert H. HillJr.Jr.. (2014) Metabolic Analysis of Striatal Tissues from Parkinson’s Disease-like Rats by Electrospray Ionization Ion Mobility Mass Spectrometry. Analytical Chemistry 86:6, pages 3075-3083.
Crossref
Gerald A. Dienel. 2014. From Molecules to Networks. From Molecules to Networks 53 117 .
Frazer Lowe. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 65 87 .
Peter A. LeWitt, Jia Li, Mei Lu, Thomas G. Beach, Charles H. Adler & Lining Guo. (2013) 3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis. Movement Disorders 28:12, pages 1653-1660.
Crossref
Sushil Sharma, Carolyn Seungyoun Moon, Azza Khogali, Ali Haidous, Anthony Chabenne, Comfort Ojo, Miriana Jelebinkov, Yousef Kurdi & Manuchair Ebadi. (2013) Biomarkers in Parkinson’s disease (recent update). Neurochemistry International 63:3, pages 201-229.
Crossref
Melissa P. Osborn, Youngja Park, Megan B. Parks, L. Goodwin Burgess, Karan Uppal, Kichun Lee, Dean P. Jones & Milam A. Brantley. (2013) Metabolome-Wide Association Study of Neovascular Age-Related Macular Degeneration. PLoS ONE 8:8, pages e72737.
Crossref
Affif Zaccaria, Ali Bouamrani, Laurent Selek, Michelle El Atifi, Anne Marie HesseAurélie Juhem, David Ratel, Herve Mathieu, Yohann CouteChristophe BruleyJerome GarinAlim L Benabid, Stephan Chabardes, Brigitte Piallat & François Berger. (2013) A Micro-Silicon Chip for in Vivo Cerebral Imprint in Monkey . ACS Chemical Neuroscience 4:3, pages 385-392.
Crossref
. (2013) Is clinical proteomics heading towards to “bench to bedside”?. Translational Proteomics 1:1, pages 53-56.
Crossref
Peter A. LeWitt, Bertrand R. Huber & Jing Zhang. 2013. Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future. Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future 161 184 .
Brian R Haas, Tessandra H Stewart & Jing Zhang. (2012) Premotor biomarkers for Parkinson's disease - a promising direction of research. Translational Neurodegeneration 1:1.
Crossref
Tiziana Alberio, Agnese C. Pippione, Cristoforo Comi, Simone Olgiati, Daniela Cecconi, Maurizio Zibetti, Leonardo Lopiano & Mauro Fasano. (2012) Dopaminergic therapies modulate the T-CELL proteome of patients with Parkinson's disease. IUBMB Life 64:10, pages 846-852.
Crossref
Karin D. van Dijk, Henk W. Berendse, Benjamin Drukarch, Silvina A. Fratantoni, Thang V. Pham, Sander R. Piersma, Evelien Huisman, John J.P. Brevé, Henk J. Groenewegen, Connie R. Jimenez & Wilma D.J. van de Berg. (2012) The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis. Brain Pathology 22:4, pages 485-498.
Crossref
Vaibhav Singh, Rogier Q. Hintzen, Theo M. Luider & Marcel P. Stoop. (2012) Proteomics technologies for biomarker discovery in multiple sclerosis. Journal of Neuroimmunology 248:1-2, pages 40-47.
Crossref
I. Ferrer, I. López-Gonzalez, M. Carmona, E. Dalfó, A. Pujol & A. Martínez. (2012) Neurochemistry and the non-motor aspects of PD. Neurobiology of Disease 46:3, pages 508-526.
Crossref
Brit Mollenhauer & Jing Zhang. (2012) Biochemical premotor biomarkers for Parkinson's disease. Movement Disorders 27:5, pages 644-650.
Crossref
Rivka Ravid & Isidro Ferrer. (2012) Brain banks as key part of biochemical and molecular studies on cerebral cortex involvement in Parkinson’s disease. The FEBS Journal 279:7, pages 1167-1176.
Crossref
Yoland Smith, Thomas Wichmann, Stewart A Factor & Mahlon R DeLong. (2011) Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa. Neuropsychopharmacology 37:1, pages 213-246.
Crossref
Claire Henchcliffe, Richard Dodel & M. Flint Beal. (2011) Biomarkers of Parkinson's disease and Dementia with Lewy bodies. Progress in Neurobiology 95:4, pages 601-613.
Crossref
Tiziana Alberio & Mauro Fasano. (2011) Proteomics in Parkinson's disease: An unbiased approach towards peripheral biomarkers and new therapies. Journal of Biotechnology 156:4, pages 325-337.
Crossref
Angelo D'Alessandro, Sara Rinalducci & Lello Zolla. (2011) Redox proteomics and drug development. Journal of Proteomics 74:12, pages 2575-2595.
Crossref
Jia Liu, Lawrence Litt, Mark R. Segal, Mark J. S. Kelly, Jeffrey G. Pelton & Myungwon Kim. (2011) Metabolomics of Oxidative Stress in Recent Studies of Endogenous and Exogenously Administered Intermediate Metabolites. International Journal of Molecular Sciences 12:10, pages 6469-6501.
Crossref
. (2011) Current World Literature. Current Opinion in Neurology 24:4, pages 409-413.
Crossref
Carol B. Fowler, Ingrid E. Chesnick, Cedric D. Moore, Timothy J. O'Leary & Jeffrey T. Mason. (2010) Elevated Pressure Improves the Extraction and Identification of Proteins Recovered from Formalin-Fixed, Paraffin-Embedded Tissue Surrogates. PLoS ONE 5:12, pages e14253.
Crossref
E. Dudley, M. Yousef, Y. Wang & W.J. Griffiths. 2010. 45 83 .

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