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Drug Profile

Use of memantine for the treatment of dementia

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Pages 1359-1370 | Published online: 09 Jan 2014

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Fei Mao, Jianheng Li, Hui Wei, Ling Huang & Xingshu Li. (2015) Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 995-1001.
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Amy C. Ogilvie & Jordan L. Schultz. (2023) Memantine Use and Cognitive Decline in Huntington's Disease: An Enroll‐HD Study . Movement Disorders Clinical Practice 10:7, pages 1120-1125.
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Yancy Ferrer-Acosta, Sergio Rodriguez-Massó, Dinely Pérez, Vesna A. Eterovic, P.A. Ferchmin & Antonio Henrique Martins. (2022) Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult. Toxicology in Vitro 84, pages 105453.
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Carlen A. Yuen, Jing-Mei Hsu, Koen Van Besien, Ran Reshef, Fabio M. Iwamoto, Aya Haggiagi, Benjamin Liechty, Cenai Zhang, Sarah F. Wesley & Rajiv Magge. (2022) Axicabtagene Ciloleucel in Patients Ineligible for ZUMA-1 Because of CNS Involvement and/or HIV: A Multicenter Experience. Journal of Immunotherapy 45:5, pages 254-262.
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Nikita Subhash Hinge, Himanshu Kathuria & Murali Monohar Pandey. (2022) Engineering of structural and functional properties of nanotherapeutics and nanodiagnostics for intranasal brain targeting in Alzheimer's. Applied Materials Today 26, pages 101303.
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Yi XiaoTie-Song ZhangYing-Hua LiChen-Fei LiuShao-Jie Yang, Li-Ting ZengSheng-He HuangXiao-Yan DengLiang Peng. (2022) Memantine Promotes Bactericidal Effect of Neutrophils Against Infection with Pseudomonas aeruginosa and Its Drug-Resistant Strain, by Improving Reactive Oxygen Species Generation . Microbial Drug Resistance 28:1, pages 7-17.
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Agnieszka Jankowska, Maciej Pawłowski & Grażyna Chłoń-Rzepa. (2021) Diabetic Theory in Anti-Alzheimer’s Drug Research and Development. Part 2: Therapeutic Potential of cAMP-Specific Phosphodiesterase Inhibitors. Current Medicinal Chemistry 28:18, pages 3535-3553.
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Md. Sahab Uddin, Abdullah Al Mamun, Md. Tanvir Kabir, Ghulam Md Ashraf, May N. Bin-Jumah & Mohamed M. Abdel-Daim. (2020) Multi-Target Drug Candidates for Multifactorial Alzheimer’s Disease: AChE and NMDAR as Molecular Targets. Molecular Neurobiology 58:1, pages 281-303.
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Yanyue Wu, Zhiguo Lu, Yan Li, Jun Yang & Xin Zhang. (2020) Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection. Nanomaterials 10:8, pages 1441.
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Angela Georgia Catic. 2020. Dementia and Chronic Disease. Dementia and Chronic Disease 23 37 .
Rosa Purgatorio, Modesto de Candia, Annalisa De Palma, Francesco De Santis, Leonardo Pisani, Francesco Campagna, Saverio Cellamare, Cosimo Altomare & Marco Catto. (2018) Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity. Molecules 23:7, pages 1544.
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Yi-xiang Xu, Huan Wang, Xiao-kang Li, Sheng-nan Dong, Wen-wen Liu, Qi Gong, Tian-duan-yi Wang, Yun Tang, Jin Zhu, Jian Li, Hai-yan Zhang & Fei Mao. (2018) Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 143, pages 33-47.
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Xiaokang Li, Huan Wang, Yixiang Xu, Wenwen Liu, Qi Gong, Wei Wang, Xiaoxia Qiu, Jin Zhu, Fei Mao, Haiyan Zhang & Jian Li. (2017) Novel Vilazodone–Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation. ACS Chemical Neuroscience 8:12, pages 2708-2721.
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Leonardo Pisani, Annalisa De Palma, Nicola Giangregorio, Daniela V. Miniero, Paolo Pesce, Orazio Nicolotti, Francesco Campagna, Cosimo D. Altomare & Marco Catto. (2017) Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity. European Journal of Pharmaceutical Sciences 109, pages 381-388.
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Tarek Mohamed, Mandeep K. Mann & Praveen P. N. Rao. (2017) Application of quinazoline and pyrido[3,2-d]pyrimidine templates to design multi-targeting agents in Alzheimer's disease. RSC Advances 7:36, pages 22360-22368.
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Xiaokang Li, Huan Wang, Zhengyu Lu, Xinyu Zheng, Wei Ni, Jin Zhu, Yan Fu, Fulin Lian, Naixia Zhang, Jian Li, Haiyan Zhang & Fei Mao. (2016) Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents. Journal of Medicinal Chemistry 59:18, pages 8326-8344.
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Christophe Genicot & Laurent Provins. 2016. Lead Generation. Lead Generation 513 546 .
Roberta Farina, Leonardo Pisani, Marco Catto, Orazio Nicolotti, Domenico Gadaleta, Nunzio Denora, Ramon Soto-Otero, Estefania Mendez-Alvarez, Carolina S. Passos, Giovanni Muncipinto, Cosimo D. Altomare, Alessandra Nurisso, Pierre-Alain Carrupt & Angelo Carotti. (2015) Structure-Based Design and Optimization of Multitarget-Directed 2 H -Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases . Journal of Medicinal Chemistry 58:14, pages 5561-5578.
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M.Y. Liu, S. Wang, W.F. Yao, Z.J. Zhang, X. Zhong, L. Sha, M. He, Z.H. Zheng & M.J. Wei. (2014) Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice. Neuroscience 273, pages 141-151.
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Jan Korabecny, Rafael Dolezal, Pavla Cabelova, Anna Horova, Eva Hruba, Jan Ricny, Lukas Sedlacek, Eugenie Nepovimova, Katarina Spilovska, Martin Andrs, Kamil Musilek, Veronika Opletalova, Vendula Sepsova, Daniela Ripova & Kamil Kuca. (2014) 7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies. European Journal of Medicinal Chemistry 82, pages 426-438.
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Guilherme Monteiro Gomes, Gerusa Duarte Dalmolin, Julia Bär, Anna Karpova, Carlos Fernando Mello, Michael R. Kreutz & Maribel Antonello Rubin. (2014) Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors. PLoS ONE 9:6, pages e99184.
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Fei Mao, Jianwen Chen, Qi Zhou, Zonghua Luo, Ling Huang & Xingshu Li. (2013) Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity. Bioorganic & Medicinal Chemistry Letters 23:24, pages 6737-6742.
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Kamalpreet Kour, Rupinder Kaur & Jasvinder Singh. (2013) Memantine for schizophrenia. Cochrane Database of Systematic Reviews.
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Hans J. Leis & Werner Windischhofer. (2012) Quantitative determination of memantine in human plasma by GC using negative ion chemical ionization MS detection after derivatization with a new reagent, o-(pentafluorobenzyloxycarbonyl)-2,3,4,5-tetrafluorobenzoyl chloride. Microchimica Acta 179:3-4, pages 249-255.
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Hans J. Leis & Werner Windischhofer. (2012) Determination of memantine in human plasma by GC using negative ion chemical ionization MS detection after derivatization with a new reagent. Microchimica Acta 178:3-4, pages 309-314.
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M. Rushaidhi, N.D. Collie, H. Zhang & P. Liu. (2012) Agmatine selectively improves behavioural function in aged male Sprague–Dawley rats. Neuroscience 218, pages 206-215.
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R Boada, C Hutaff-Lee, A Schrader, D Weitzenkamp, T A Benke, E J Goldson & A C S Costa. (2012) Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial. Translational Psychiatry 2:7, pages e141-e141.
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Daniel C. Mathews, Ioline D. Henter & Carlos A. ZarateJrJr. (2012) Targeting the Glutamatergic System to Treat Major Depressive Disorder. Drugs 72:10, pages 1313-1333.
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