273
Views
59
CrossRef citations to date
0
Altmetric
Theme: Schizophrenia - Review

Neurocognition and neuroimaging of persistent negative symptoms of schizophrenia

&
Pages 53-69 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Chiraz Azaiez, Aurélie Millier, Christophe Lançon, Emilie Clay, Pascal Auquier, Pierre-Michel Llorca & Mondher Toumi. (2018) Health related quality of life in patients having schizophrenia negative symptoms – a systematic review. Journal of Market Access & Health Policy 6:1.
Read now
Daphne Voineskos & Zafiris J Daskalakis. (2013) A primer on the treatment of schizophrenia through repetitive transcranial magnetic stimulation. Expert Review of Neurotherapeutics 13:10, pages 1079-1082.
Read now
Cindy L. Hovington, Alexander McGirr, Martin Lepage & Marcelo T. Berlim. (2013) Repetitive transcranial magnetic stimulation (rTMS) for treating major depression and schizophrenia: a systematic review of recent meta-analyses. Annals of Medicine 45:4, pages 308-321.
Read now

Articles from other publishers (56)

Alba Toll, Laura Blanco-Hinojo, Daniel Berge, Ana Manzano, Khadija El Abidi, Víctor Perez-Solà & Anna Mané. (2023) Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients. Frontiers in Psychiatry 14.
Crossref
Christy Au-Yeung, Danielle Penney, Jesse Rae, Hannah Carling, Libby Lassman & Martin Lepage. (2023) The relationship between negative symptoms and MATRICS neurocognitive domains: A meta-analysis and systematic review. Progress in Neuro-Psychopharmacology and Biological Psychiatry 127, pages 110833.
Crossref
Nina B. Paul, Gregory P. Strauss, Jessica J. Gates-Woodyatt, Kimberly A. Barchard & Daniel N. Allen. (2023) Two and five-factor models of negative symptoms in schizophrenia are differentially associated with trait affect, defeatist performance beliefs, and psychosocial functioning. European Archives of Psychiatry and Clinical Neuroscience 273:8, pages 1715-1724.
Crossref
Joseph Ghanem, Massimiliano Orri, Laura Moro, Katie M Lavigne, Delphine Raucher-Chéné, Ashok Malla, Ridha Joober & Martin Lepage. (2023) Exploring the Relationship Between Suicidality and Persistent Negative Symptoms Following a First Episode of Psychosis. Schizophrenia Bulletin.
Crossref
Meijuan Li, Guoshuai Luo, Yuying Qiu, Xue Zhang, Xiaoxiao Sun, Yanzhe Li, Yongping Zhao, Wei Sun, Shu Yang & Jie Li. (2023) Negative symptoms and neurocognition in drug-naïve schizophrenia: moderating role of plasma neutrophil gelatinase-associated lipocalin (NGAL) and interferon-gamma (INF-γ). European Archives of Psychiatry and Clinical Neuroscience.
Crossref
Olivier Percie du Sert, Joshua Unrau, Claudine J. Gauthier, Mallar Chakravarty, Ashok Malla, Martin Lepage & Delphine Raucher-Chéné. (2023) Cerebral blood flow in schizophrenia: A systematic review and meta-analysis of MRI-based studies. Progress in Neuro-Psychopharmacology and Biological Psychiatry 121, pages 110669.
Crossref
Sean P. Carruthers, Tamsyn E. Van Rheenen, James A. Karantonis & Susan L. Rossell. (2021) Characterising Demographic, Clinical and Functional Features of Cognitive Subgroups in Schizophrenia Spectrum Disorders: A Systematic Review. Neuropsychology Review 32:4, pages 807-827.
Crossref
Jacopo Lisoni, Giulia Baldacci, Gabriele Nibbio, Andrea Zucchetti, Elena Butti Lemmi Gigli, Arianna Savorelli, Michele Facchi, Paola Miotto, Giacomo Deste, Stefano Barlati & Antonio Vita. (2022) Effects of bilateral, bipolar-nonbalanced, frontal transcranial Direct Current Stimulation (tDCS) on negative symptoms and neurocognition in a sample of patients living with schizophrenia: Results of a randomized double-blind sham-controlled trial. Journal of Psychiatric Research 155, pages 430-442.
Crossref
Katie M. Lavigne, Delphine Raucher-Chéné, Michael D. Bodnar, Carolina Makowski, Ridha Joober, Ashok Malla, Alan C. Evans & Martin Lepage. (2022) Medial temporal lobe and basal ganglia volume trajectories in persistent negative symptoms following a first episode of psychosis. Progress in Neuro-Psychopharmacology and Biological Psychiatry 117, pages 110551.
Crossref
Elisa Rodríguez-Toscano, Kenia Martínez, David Fraguas, Joost Janssen, Laura Pina-Camacho, Bárbara Arias, Eduard Vieta, Gisela Mezquida, Silvia Amoretti, Miguel Bernardo, Josefina Castro-Fornieles, Manuel Jesús Cuesta-Zorita, Antonio Lobo, Ana González-Pinto, Iluminada Corripio Collado, Anna Mané, Celso Arango & Mara Parellada. (2022) Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis. Revista de Psiquiatría y Salud Mental (English Edition) 15:2, pages 74-87.
Crossref
Elisa Rodríguez-Toscano, Kenia Martínez, David Fraguas, Joost Janssen, Laura Pina-Camacho, Bárbara Arias, Eduard Vieta, Gisela Mezquida, Silvia Amoretti, Miguel Bernardo, Josefina Castro-Fornieles, Manuel Jesús Cuesta-Zorita, Antonio Lobo, Ana González-Pinto, Iluminada Corripio Collado, Anna Mané, Celso Arango & Mara Parellada. (2022) Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis. Revista de Psiquiatría y Salud Mental 15:2, pages 74-87.
Crossref
Magnus Johan Engen, Anja Vaskinn, Ingrid Melle, Ann Færden, Siv Hege Lyngstad, Camilla Bärthel Flaaten, Line Hustad Widing, Kristin Fjelnseth Wold, Gina Åsbø, Beathe Haatveit, Carmen Simonsen & Torill Ueland. (2022) Cognitive and Global Functioning in Patients With First-Episode Psychosis Stratified by Level of Negative Symptoms. A 10-Year Follow-Up Study. Frontiers in Psychiatry 13.
Crossref
Mihaela Fadgyas Stanculete & Octavia Capatina. 2022. Psychosis - Phenomenology, Psychopathology and Pathophysiology. Psychosis - Phenomenology, Psychopathology and Pathophysiology.
Delphine Raucher-Chéné, Elisabeth Thibaudeau, Geneviève Sauvé, Katie M. Lavigne & Martin Lepage. (2021) Understanding others as a mediator between verbal memory and negative symptoms in schizophrenia-spectrum disorder. Journal of Psychiatric Research 143, pages 429-435.
Crossref
Martin Lepage, Michael Bodnar, Delphine Raucher-Chéné, Katie M. Lavigne, Carolina Makowski, Ridha Joober & Ashok K. Malla. (2021) Neurocognitive functions in persistent negative symptoms following a first episode of psychosis. European Neuropsychopharmacology 47, pages 86-97.
Crossref
Matthias Kirschner, André Schmidt, Benazir Hodzic-Santor, Achim Burrer, Andrei Manoliu, Yashar Zeighami, Yvonne Yau, Nooshin Abbasi, Anke Maatz, Benedikt Habermeyer, Aslan Abivardi, Mihai Avram, Felix Brandl, Christian Sorg, Philipp Homan, Anita Riecher-Rössler, Stefan Borgwardt, Erich Seifritz, Alain Dagher & Stefan Kaiser. (2021) Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum. Schizophrenia Bulletin 47:3, pages 849-863.
Crossref
Beathe Haatveit, Lynn Mørch-Johnsen, Dag Alnæs, Magnus Johan Engen, Siv Hege Lyngstad, Ann Færden, Ingrid Agartz, Torill Ueland & Ingrid Melle. (2021) Divergent relationship between brain structure and cognitive functioning in patients with prominent negative symptomatology. Psychiatry Research: Neuroimaging 307, pages 111233.
Crossref
Leandro da Costa Lane Valiengo & Ulrich Palm. 2021. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders 501 510 .
Huan Huang, Zeng Botao, Yuchao Jiang, Yingying Tang, Tianhong Zhang, Xiaochen Tang, Lihua Xu, Junjie Wang, Jin Li, Zhenying Qian, Xu Liu, Huiling Wang, Cheng Luo, Chunbo Li, Jian Xu, Donald Goff & Jijun Wang. (2019) Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia. Brain Imaging and Behavior 14:5, pages 1350-1360.
Crossref
K Juston Osborne, Brian Kraus, Phoebe H Lam, Teresa Vargas & Vijay A Mittal. (2020) Contingent Negative Variation Blunting and Psychomotor Dysfunction in Schizophrenia: A Systematic Review. Schizophrenia Bulletin 46:5, pages 1144-1154.
Crossref
Achim Burrer, Fernando Caravaggio, Andrei Manoliu, Eric Plitman, Karoline Gütter, Benedikt Habermeyer, Philipp Stämpfli, Aslan Abivardi, André Schmidt, Stefan Borgwardt, Mallar Chakravarty, Martin Lepage, Alain Dagher, Ariel Graff-Guerrero, Erich Seifritz, Stefan Kaiser & Matthias Kirschner. (2020) Apathy is not associated with reduced ventral striatal volume in patients with schizophrenia. Schizophrenia Research 223, pages 279-288.
Crossref
Tji Tjian Chee, Louis Chua, Hamilton Morrin, Mao Fong Lim, Johnson Fam & Roger Ho. (2020) Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies. International Journal of Environmental Research and Public Health 17:17, pages 6227.
Crossref
Chuan-Chia Chang, Yu-Chen Kao, Che-Yi Chao, Nian-Sheng Tzeng & Hsin-An Chang. (2020) Examining bi-anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex coupled with bilateral extracephalic references as a treatment for negative symptoms in non-acute schizophrenia patients: A randomized, double-blind, sham-controlled trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry 96, pages 109715.
Crossref
Andre Aleman & Jozarni Dlabac-de Lange. 2020. Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences. Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences 79 95 .
Magnus Johan Engen, Carmen Simonsen, Ingrid Melle, Ann Færden, Siv Hege Lyngstad, Beathe Haatveit, Anja Vaskinn & Torill Ueland. (2019) Cognitive functioning in patients with first-episode psychosis stratified by level of negative symptoms: A 1-year follow-up study. Psychiatry Research 281, pages 112554.
Crossref
Armida Mucci, Silvana Galderisi, Antonella Amodio & Thomas Dierks. 2019. Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders. Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders 57 155 .
R. A. Paoli & M. Grottaroli. 2019. Clinical Cases in Psychiatry: Integrating Translational Neuroscience Approaches. Clinical Cases in Psychiatry: Integrating Translational Neuroscience Approaches 23 44 .
Ying Li, Wen-xiu Li, Ying-min Zou, Zhuo-ya Yang, Dong-jie Xie, Yin Yang, Simon S.Y. Lui, Gregory P. Strauss, Eric F.C. Cheung & Raymond C.K. Chan. (2018) Revisiting the persistent negative symptoms proxy score using the Clinical Assessment Interview for Negative Symptoms. Schizophrenia Research 202, pages 248-253.
Crossref
Edith J. Liemburg, Jozarni J. Dlabac-De Lange, Leonie Bais, Henderikus Knegtering & André Aleman. (2018) Effects of bilateral prefrontal rTMS on brain activation during social-emotional evaluation in schizophrenia: A double-blind, randomized, exploratory study. Schizophrenia Research 202, pages 210-211.
Crossref
Mingli Li, Wei Deng, Tushar Das, Yinfei Li, Liansheng Zhao, Xiaohong Ma, Yingcheng Wang, Hua Yu, Xiaojing Li, Ya-jing Meng, Qiang Wang, Lena Palaniyappan & Tao Li. (2017) Neural substrate of unrelenting negative symptoms in schizophrenia: a longitudinal resting-state fMRI study. European Archives of Psychiatry and Clinical Neuroscience 268:7, pages 641-651.
Crossref
Ying Li, Wen-xiu Li, Dong-jie Xie, Yi Wang, Eric F.C. Cheung & Raymond C.K. Chan. (2018) Grey matter reduction in the caudate nucleus in patients with persistent negative symptoms: An ALE meta-analysis. Schizophrenia Research 192, pages 9-15.
Crossref
Ezgi İnce & Alp Üçok. (2017) Relationship Between Persistent Negative Symptoms and Findings of Neurocognition and Neuroimaging in Schizophrenia. Clinical EEG and Neuroscience 49:1, pages 27-35.
Crossref
Nuwan C. Hettige, Ali Bani-Fatemi, James L. Kennedy & Vincenzo De Luca. (2017) Assessing the risk for suicide in schizophrenia according to migration, ethnicity and geographical ancestry. BMC Psychiatry 17:1.
Crossref
S. Moritz, J. P. Klein, T. Desler, H. Lill, J. Gallinat & B. C. Schneider. (2017) Neurocognitive deficits in schizophrenia. Are we making mountains out of molehills?. Psychological Medicine 47:15, pages 2602-2612.
Crossref
Miao Yu, Zhengjia Dai, Xiaowei Tang, Xiang Wang, Xiaobin Zhang, Weiwei Sha, Shuqiao Yao, Ni Shu, Xindi Wang, Jiaying Yang, Xiangyang Zhang, Xiangrong Zhang, Yong He & Zhijun Zhang. (2017) Convergence and Divergence of Brain Network Dysfunction in Deficit and Non-deficit Schizophrenia. Schizophrenia Bulletin 43:6, pages 1315-1328.
Crossref
Armida Mucci, Eleonora Merlotti, Alp Üçok, André Aleman & Silvana Galderisi. (2017) Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases. Schizophrenia Research 186, pages 19-28.
Crossref
Zhe Li, Wei Lei, Wei Deng, Zhong Zheng, Mingli Li, Xiaohong Ma, Qiang Wang, Chaohua Huang, Na Li, David A. Collier, Qiyong Gong & Tao Li. (2017) Aberrant spontaneous neural activity and correlation with evoked-brain potentials in first-episode, treatment-naïve patients with deficit and non-deficit schizophrenia. Psychiatry Research: Neuroimaging 261, pages 9-19.
Crossref
Jozarni J. Dlabac-de Lange, Edith J. Liemburg, Leonie Bais, Aida T. van de Poel-Mustafayeva, Elly S.M. de Lange-de Klerk, Henderikus Knegtering & André Aleman. (2017) Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: An Exploratory Study. Brain Stimulation 10:1, pages 59-64.
Crossref
Julia H. Meijer, Peter van Harten, Carin J. Meijer, Maarten W. Koeter, Richard Bruggeman, Wiepke Cahn, René S. Kahn & L. de Haan. (2014) Association between olfactory identification and parkinsonism in patients with non‐affective psychosis. Early Intervention in Psychiatry 10:5, pages 404-410.
Crossref
S.L. Farhat, C. Hochard, S. Orens, C. Gautier, T. Lambert, L. Geret & M.C. Bralet. (2016) MODen : programme d’éducation thérapeutique dans la schizophrénie centré sur l’équilibre alimentaire et le plaisir, sollicitant les fonctions cognitives : étude pilote. L'Encéphale 42:5, pages 410-414.
Crossref
Ulrich Palm, Daniel Keeser, Alkomiet Hasan, Michael J. Kupka, Janusch Blautzik, Nina Sarubin, Filipa Kaymakanova, Ina Unger, Peter Falkai, Thomas Meindl, Birgit Ertl-Wagner & Frank Padberg. (2016) Prefrontal Transcranial Direct Current Stimulation for Treatment of Schizophrenia With Predominant Negative Symptoms: A Double-Blind, Sham-Controlled Proof-of-Concept Study. Schizophrenia Bulletin 42:5, pages 1253-1261.
Crossref
S. Guimond, M.M. Chakravarty, L. Bergeron-Gagnon, R. Patel & M. Lepage. (2016) Verbal memory impairments in schizophrenia associated with cortical thinning. NeuroImage: Clinical 11, pages 20-29.
Crossref
Silvana Galderisi, Eleonora Merlotti & Armida Mucci. (2015) Neurobiological background of negative symptoms. European Archives of Psychiatry and Clinical Neuroscience 265:7, pages 543-558.
Crossref
Cindy L. Hovington, Michael Bodnar, M. Mallar Chakravarty, Ridha Joober, Ashok K. Malla & Martin Lepage. (2015) Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms. Psychiatry Research: Neuroimaging 233:3, pages 402-408.
Crossref
Christoffer Rahm, Benny Liberg, Greg Reckless, Olga Ousdal, Ingrid Melle, Ole A. Andreassen & Ingrid Agartz. (2015) Negative symptoms in schizophrenia show association with amygdala volumes and neural activation during affective processing. Acta Neuropsychiatrica 27:4, pages 213-220.
Crossref
Lynn Mørch-Johnsen, Ragnar Nesvåg, Ann Faerden, Unn K. Haukvik, Kjetil N. Jørgensen, Elisabeth H. Lange, Ole A. Andreassen, Ingrid Melle & Ingrid Agartz. (2015) Brain structure abnormalities in first-episode psychosis patients with persistent apathy. Schizophrenia Research 164:1-3, pages 59-64.
Crossref
Bess YH Lam, Adrian Raine & Tatia MC Lee. (2014) The relationship between neurocognition and symptomatology in people with schizophrenia: social cognition as the mediator. BMC Psychiatry 14:1.
Crossref
Nuwan C. Hettige, Clement Zai, Monica Hazra, Carol Borlido, James L. Kennedy, John Strauss, Bernard Le Foll, Albert Wong, Gary Remington & Vincenzo De Luca. (2014) Use of candidate gene markers to guide antipsychotic dosage adjustment. Progress in Neuro-Psychopharmacology and Biological Psychiatry 54, pages 315-320.
Crossref
Alp Üçok & Ceylan Ergül. (2014) Persistent negative symptoms after first episode schizophrenia: A 2-year follow-up study. Schizophrenia Research 158:1-3, pages 241-246.
Crossref
Michael Bodnar, Cindy L. Hovington, Lisa Buchy, Ashok K. Malla, Ridha Joober & Martin Lepage. (2014) Cortical Thinning in Temporo-Parietal Junction (TPJ) in Non-Affective First-Episode of Psychosis Patients with Persistent Negative Symptoms. PLoS ONE 9:6, pages e101372.
Crossref
Mark J. Millan, Kevin Fone, Thomas Steckler & William P. Horan. (2014) Negative symptoms of schizophrenia: Clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment. European Neuropsychopharmacology 24:5, pages 645-692.
Crossref
Martin Lepage, Michael Bodnar & Christopher R Bowie. (2014) Neurocognition: Clinical and Functional Outcomes in Schizophrenia. The Canadian Journal of Psychiatry 59:1, pages 5-12.
Crossref
Cindy L. Hovington, Michael Bodnar, Ridha Joober, Ashok K. Malla & Martin Lepage. (2013) Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms. Schizophrenia Research 147:2-3, pages 223-229.
Crossref
Qingqing Xu, Xi Wu, Yuyu Xiong, Qinghe Xing, Lin He & Shengying Qin. (2013) Pharmacogenomics can improve antipsychotic treatment in schizophrenia. Frontiers of Medicine 7:2, pages 180-190.
Crossref
Vivek Bambole, Nilesh Shah, Shushma Sonavane, Megan Johnston & Amresh Shrivastava. (2013) Study of negatives symptoms in first episode schizophrenia. Open Journal of Psychiatry 03:03, pages 323-328.
Crossref
Cindy L Hovington, Michael Bodnar, Ridha Joober, Ashok K Malla & Martin Lepage. (2012) Identifying persistent negative symptoms in first episode psychosis. BMC Psychiatry 12:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.