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Systematic Review

Fentanyl for breakthrough pain: a systematic review

Pages 1197-1216 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Cristina Fernández-Fernández, Luis F Callado, Rocío Girón, Eva Sánchez, Amaia M Erdozain, José Antonio López-Moreno, Paula Morales, Fernando Rodríguez de Fonseca, Javier Fernández-Ruiz, Pilar Goya, J Javier Meana, M Isabel Martín & Nadine Jagerovic. (2014) Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. Drug Design, Development and Therapy 8, pages 263-277.
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Donald R Taylor. (2013) Single-dose fentanyl sublingual spray for breakthrough cancer pain. Clinical Pharmacology: Advances and Applications 5, pages 131-141.
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Sheila M. Seed, Kaelen C. Dunican, Ann M. Lynch & Alicia R. Desilets. (2012) An Update in Options for the Treatment of Pain: A Review of New Opioid Formulations. Hospital Practice 40:1, pages 166-175.
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Articles from other publishers (47)

Boris Hait. 2023. Pain Management - From Acute to Chronic and Beyond [Working Title]. Pain Management - From Acute to Chronic and Beyond [Working Title].
Serena Montanari, Lara Davani, Cristina Terenzi, Marco Maltoni, Vincenza Andrisano, Angela De Simone & Marianna Ricci. (2022) Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography – Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis 219, pages 114913.
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Jakub Trawiński, Paweł Szpot, Marcin Zawadzki & Robert Skibiński. (2021) Photochemical transformation of fentanyl under the simulated solar radiation – Enhancement of the process by heterogeneous photocatalysis and in silico analysis of toxicity. Science of The Total Environment 791, pages 148171.
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Francisco Villegas, Verónica Martínez-Borba, Carlos Suso-Ribera, Diana Castilla, Irene Zaragoza, Azucena García-Palacios & Carlos Ferrer. (2021) Characterizing Breakthrough Cancer Pain Using Ecological Momentary Assessment with a Smartphone App: Feasibility and Clinical Findings. International Journal of Environmental Research and Public Health 18:11, pages 5991.
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Stefan Wirz, Michael Schenk, Hannes Hofbauer, Hans-Christian Wartenberg, Marco Cascella & Kristin Kieselbach. (2020) Nicht-indikationsgemäßer Einsatz schnell freisetzender FentanylzubereitungenUse of rapid-onset fentanyl preparations beyond indication. Der Schmerz 35:2, pages 114-123.
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Tetsuji Noguchi, Yuma Umezaki, Rieko Takano, Teppei Fujimoto, Yuki Domon, Kazufumi Kubota, Kenjiro Ueda, Yumi Kawase, Koichi Yabe, Miki Yokoyama & Kousei Shimada. (2021) A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity. Bioorganic & Medicinal Chemistry Letters 36, pages 127790.
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Arpita Das, Dipasri Bhattacharya, Sankar Roy, Anirban Roy & Mohanchandra Mandal. (2019) BISPECTRAL INDEX (BIS) GUIDED COMPARISON BETWEEN CLINICAL EFFECTS OF ETOMIDATE AND FENTANYL VERSUS DEXMEDETOMIDINE AND FENTANYL FOR CONSCIOUS SEDATION IN ERCP PROCEDURE. Journal of Evolution of Medical and Dental Sciences 8:8, pages 500-505.
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Brian J. Anderson, Jerrold Lerman & Charles J. Coté. 2019. A Practice of Anesthesia for Infants and Children. A Practice of Anesthesia for Infants and Children 100 176.e45 .
Lucas Pieper, Julia Wager & Boris Zernikow. (2018) Intranasal fentanyl for respiratory distress in children and adolescents with life-limiting conditions. BMC Palliative Care 17:1.
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S. Mallory Burns, Christopher W. Cunningham & Susan L. Mercer. (2018) DARK Classics in Chemical Neuroscience: Fentanyl. ACS Chemical Neuroscience 9:10, pages 2428-2437.
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Evelien J. M. Kuip, Wendy H. Oldenmenger, Martine F. Thijs—Visser, Peter de Bruijn, Astrid W. Oosten, Esther Oomen—de Hoop, Stijn L. W. Koolen, Carin C. D. Van der Rijt & Ron H. J. Mathijssen. (2018) Effects of smoking and body mass index on the exposure of fentanyl in patients with cancer. PLOS ONE 13:6, pages e0198289.
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Luis Miguel Torres, Antonio Javier Jiménez, Ana Cabezón & Manuel Jesús Rodríguez. (2018) Prevalence and Characterization of Breakthrough Pain Associated with Chronic Low Back Pain in the South of Spain: A Cross-Sectional, Multicenter, Observational Study. Pain Research and Treatment 2018, pages 1-7.
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Shiv Kumar Yadav, Deo Kumar, Pravin Kumar, Pradeep Kumar Gupta & Rahul Bhattacharya. (2018) Biochemical, Oxidative, and Physiological Changes Caused by Acute Exposure of Fentanyl and Its 3 Analogs in Rodents. International Journal of Toxicology 37:1, pages 28-37.
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Alper Yenigun, Sinan Yilmaz, Remzi Dogan, Seda Sezen Goktas, Muhittin Calim & Orhan Ozturan. (2018) Demonstration of analgesic effect of intranasal ketamine and intranasal fentanyl for postoperative pain after pediatric tonsillectomy. International Journal of Pediatric Otorhinolaryngology 104, pages 182-185.
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Mellar Davis & Nathan Pennell. 2018. IASLC Thoracic Oncology. IASLC Thoracic Oncology 608 619.e8 .
Marcin Rojkiewicz, Milena Majchrzak, Rafał Celiński, Piotr Kuś & Mieczysław Sajewicz. (2017) Identification and physicochemical characterization of 4-fluorobutyrfentanyl (1-((4-fluorophenyl)(1-phenethylpiperidin-4-yl)amino)butan-1-one, 4-FBF) in seized materials and post-mortem biological samples. Drug Testing and Analysis 9:3, pages 405-414.
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Evelien J. M. Kuip, Maarten L. Zandvliet, Stijn L. W. Koolen, Ron H. J. Mathijssen & Carin C. D. van der Rijt. (2016) A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients. British Journal of Clinical Pharmacology 83:2, pages 294-313.
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Shaohua Li, Devora Cohen-Karni, Marina Kovaliov, Nestor Tomycz, Boyle Cheng, Donald Whiting & Saadyah Averick. (2017) Synthesis and biological evaluation of fentanyl acrylic derivatives. RSC Advances 7:32, pages 20015-20019.
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Ruben Vardanyan. 2017. Piperidine-Based Drug Discovery. Piperidine-Based Drug Discovery 147 221 .
David S Alberts, Christina Cognata Smith, Neha Parikh & Richard L Rauck. (2016) Fentanyl sublingual spray for breakthrough cancer pain in patients receiving transdermal fentanyl. Pain Management 6:5, pages 427-434.
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Joshua P. Thompson & Dennis F. Thompson. (2016) Nebulized Fentanyl in Acute Pain. Annals of Pharmacotherapy 50:10, pages 882-891.
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Harold Minkowitz, Janet Bull, R. Charles Brownlow, Neha Parikh & Richard Rauck. (2016) Long-term safety of fentanyl sublingual spray in opioid-tolerant patients with breakthrough cancer pain. Supportive Care in Cancer 24:6, pages 2669-2675.
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Sun Kyung Baek, Do Yeun Kim, Seok Yun Kang, Sun Jin Sym, Young Sung Kim & June Young Lee. (2016) A Korean Nationwide Survey for Breakthrough Cancer Pain in an Inpatient Setting. Cancer Research and Treatment 48:2, pages 768-774.
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Ying-Chao Chou, Yi-Shiun Cheng, Yung-Heng Hsu, Yi-Hsun Yu & Shih-Jung Liu. (2016) Biodegradable nanofiber-membrane for sustainable release of lidocaine at the femoral fracture site as a periosteal block: In vitro and in vivo studies in a rabbit model. Colloids and Surfaces B: Biointerfaces 140, pages 332-341.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 15 64 .
Ferenc Zádor & Maria Wollemann. (2015) Receptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors. Pharmacological Research 102, pages 254-263.
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Nieves del Pozo Alonso. (2015) Manejo de opioides para el dolor basal e irruptivo oncológico. Medicina Paliativa 22, pages 46-52.
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Gillian Bedard, Andrew Davies, Rachel McDonald, Philippa Hawley, Alison Buchanan, Marko Popovic, Erin Wong & Edward Chow. (2014) Breakthrough cancer pain: a comparison of surveys with European and Canadian patients. Supportive Care in Cancer 23:3, pages 791-796.
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Daniel S. Tsze, Yaffa M. Vitberg, Joel Berezow, Thomas J. Starc & Peter S. Dayan. (2014) Treatment of Tetralogy of Fallot Hypoxic Spell With Intranasal Fentanyl. Pediatrics 134:1, pages e266-e269.
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Dominic Aldington & S Jagdish. (2014) The fentanyl ‘lozenge’ story: from books to battlefield. Journal of the Royal Army Medical Corps 160:2, pages 102-104.
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Mellar P. Davis & Eduardo Bruera. (2014) Trial Design for Breakthrough Pain: Is It Ethical to Have a Placebo in a Trial?. Clinical Therapeutics 36:5, pages 814-815.
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Claire Combe, Cindy Bourne, Marie Chiganne, Marie Geneste, Hassan Hida & Catherine Lacroix. (2014) Fentanyl transmuqueux : évaluation pratique de son utilisation auprès des patients et des soignants. Médecine Palliative : Soins de Support - Accompagnement - Éthique 13:2, pages 77-83.
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Ruben S VardanyanVictor J Hruby. (2014) Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Medicinal Chemistry 6:4, pages 385-412.
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Silvia Deandrea, Oscar Corli, Dario Consonni, Walter Villani, Maria Teresa Greco & Giovanni Apolone. (2014) Prevalence of Breakthrough Cancer Pain: A Systematic Review and a Pooled Analysis of Published Literature. Journal of Pain and Symptom Management 47:1, pages 57-76.
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M. Ramos Gracia, L. Catala Hortelano, M.J. Sala Langa, D. Gómez Sánchez, M.A. Conejero Morant & J. Saneugenio Gregori. (2014) Intoxicación accidental por fentanilo intranasal. Anales de Pediatría 80:1, pages 62-64.
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Carolyn A. Fairbanks & Cristina D. Peterson. 2014. Neurobiological Studies of Addiction in Chronic Pain States. Neurobiological Studies of Addiction in Chronic Pain States 81 107 .
Steffen T. Simon, Peyla Köskeroglu, Jan Gaertner & Raymond Voltz. (2013) Fentanyl for the Relief of Refractory Breathlessness: A Systematic Review. Journal of Pain and Symptom Management 46:6, pages 874-886.
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Martina Würdemann & Jens Christoffers. (2013) Nitrile Oxide versus Nitrone - Switching Regioselectivity of Intramolecular 1,3-Dipolar Cycloadditions towards the Preparation of Aminopiperidinecarboxylates. European Journal of Organic Chemistry 2013:32, pages 7421-7431.
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Gillian Bedard, Philippa Hawley, Liying Zhang, Marissa Slaven, Pierre Gagnon, Stuart Bisland, Margaret Bennett, Francois Tardif & Edward Chow. (2013) A survey of Canadian cancer patients’ perspectives on the characteristics and treatment of breakthrough pain. Supportive Care in Cancer 21:9, pages 2557-2563.
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Y. Escobar, A. Mañas, J. Juliá, R. Gálvez, F. Zaragozá, C. Margarit, R. López, A. Casas, A. Antón & J. J. Cruz. (2012) Optimal management of breakthrough cancer pain (BCP). Clinical and Translational Oncology 15:7, pages 526-534.
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Steffen T Simon, Irene J Higginson, Hamid Benalia, Marjolein Gysels, Fliss EM Murtagh, James Spicer & Claudia Bausewein. (2013) Episodes of breathlessness: Types and patterns – a qualitative study exploring experiences of patients with advanced diseases. Palliative Medicine 27:6, pages 524-532.
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Helmar Bornemann-Cimenti, Mischa Wejbora, Istvan S. Szilagyi & Andreas Sandner-Kiesling. (2013) Fentanyl for the Treatment of Tumor-Related Breakthrough Pain. Deutsches Ärzteblatt international.
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Peter Watts, Alan Smith & Michael Perelman. (2012) Nasal delivery of fentanyl. Drug Delivery and Translational Research 3:1, pages 75-83.
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Steffen T. SimonAnna Maria NiemandHamid BenaliaRaymond VoltzIrene J. HigginsonClaudia Bausewein. (2012) Acceptability and Preferences of Six Different Routes of Drug Application for Acute Breathlessness: A Comparison Study between the United Kingdom and Germany. Journal of Palliative Medicine 15:12, pages 1374-1381.
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Tim Geary, Anna Negus, Brian J. Anderson & Boris Zernikow. (2011) Perioperative management of the child on long‐term opioids. Pediatric Anesthesia 22:3, pages 189-202.
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Claudia F. ClavijoRachael Rzasa LynnUwe ChristiansJeffrey L. Galinkin. (2012) Intranasal Fentanyl for Breakthrough Pain Control. Clinical Medicine Insights: Therapeutics 4, pages CMT.S7298.
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