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Theme: Anxiety Disorders - Review

Augmentation strategies in obsessive–compulsive disorder

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Pages 187-203 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Aditya Hegde, Bangalore G. Kalyani, Shyam Sundar Arumugham, Janardhanan C. Narayanaswamy, Suresh Bada Math & Y. C. Janardhan Reddy. (2017) Aripiprazole augmentation in highly treatment-resistant obsessive–compulsive disorder – experience from a specialty clinic in India . International Journal of Psychiatry in Clinical Practice 21:1, pages 67-69.
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Hidehiro Umehara, Shusuke Numata, Makoto Kinoshita, Shinya Watanabe, Shutaro Nakaaki, Satsuki Sumitani & Tetsuro Ohmori. (2016) No association between BDNF Val66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population. Neuropsychiatric Disease and Treatment 12, pages 611-615.
Read now
Mariana Pizarro, Leonardo F Fontenelle, Daniel C Paravidino, Murat Yücel, Eurípedes C Miguel & Gabriela B de Menezes. (2014) An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder. Expert Opinion on Pharmacotherapy 15:10, pages 1391-1401.
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Shyam Sundar Arumugham & YC Janardhan Reddy. (2014) Commonly asked questions in the treatment of obsessive-compulsive disorder. Expert Review of Neurotherapeutics 14:2, pages 151-163.
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Articles from other publishers (43)

Mohan Gautam. (2023) Clinical Recommendations for Augmentation Agents in Obsessive-Compulsive Disorder Partially Responsive to Serotonin Reuptake Inhibitors. Journal of Clinical Psychopharmacology 43:4, pages 369-377.
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Rituparna Maiti, Archana Mishra, Anand Srinivasan & Biswa Ranjan Mishra. (2023) Pharmacological augmentation of serotonin reuptake inhibitors in patients with obsessive–compulsive disorder: A network meta‐analysis. Acta Psychiatrica Scandinavica.
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Asif Ahmad Bhat, Gaurav Gupta, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Sachin Kumar Singh & Kamal Dua. (2023) Neuropharmacological effect of risperidone: From chemistry to medicine. Chemico-Biological Interactions 369, pages 110296.
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Madhuri H. Nanjundaswamy, Lavanya P. Sharma & Shyam Sundar Arumugham. 2023. Handbook of Cognitive Behavioral Therapy by Disorder. Handbook of Cognitive Behavioral Therapy by Disorder 205 217 .
Sujita Kumar Kar & Vikas Menon. (2021) Early augmentation by using neuromodulation in psychiatric disorder: a kaleidoscopic view. CNS Spectrums 27:5, pages 530-532.
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Harsh Pathak, Swarna Buddha Nayok, Logesh Kanakaraj, Himanshu Ghanghoriya, Vanteemar S. Sreeraj, Shivarama Varambally & Ganesan Venkatasubramanian. (2022) Accelerated HD-tDCS for rapid response in treatment-resistant obsessive-compulsive disorder: A case report. Brain Stimulation 15:5, pages 1091-1092.
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Jennie M. Kuckertz, Richard J. McNally, Bradley C. Riemann, Claudia Van Borkulo, Benjamin W. Bellet, Jason W. Krompinger, Nathaniel Van Kirk & Martha J. Falkenstein. (2022) Does the network structure of obsessive-compulsive symptoms at treatment admission identify patients at risk for non-response?. Behaviour Research and Therapy 156, pages 104151.
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Hanife Olbrich, Ina Jahn, Katarina Stengler, Erich Seifritz & Michael Colla. (2022) Heart rate variability in obsessive compulsive disorder in comparison to healthy controls and as predictor of treatment response. Clinical Neurophysiology 138, pages 123-131.
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Shahla Akouchakian, Mohammad Javad Tarrahi & Elham Mohebati. (2021) Evaluation of Clonidine Augmentation Therapy for Obsessive-Compulsive Disorder Treatment; a Randomized Clinical Trial. Iranian Journal of Psychiatry and Behavioral Sciences 15:3.
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Bernhard Weidle, Tord Ivarsson, Fernando R. Asbahr, Rosa Calvo, David Mataix-Cols, Moira A. Rynn & Eric A. Storch. (2021) Specialty knowledge and competency standards for pharmacotherapy for pediatric obsessive-compulsive disorder. Psychiatry Research 299, pages 113858.
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Markian Pazuniak & Scott R. Pekrul. (2020) Obsessive–Compulsive Disorder in Autism Spectrum Disorder Across the Lifespan. Psychiatric Clinics of North America 43:4, pages 745-758.
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Gulen Guler Aksu, Pinar Akdere Dogdu, Pelin Dag, Meryem Ozlem Kutuk & Fevziye Toros. (2020) Safe and Effective Use of Venlafaxine, Mirtazapine, and Aripiprazole in an Adolescent with Treatment-Resistant Obsessive-Compulsive Disorder. Psychiatric Annals 50:11, pages 509-512.
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Madhuri H. Nanjundaswamy, Shyam Sundar Arumugham, Janardhanan C. Narayanaswamy & Y.C. Janardhan Reddy. (2020) A prospective study of intensive in-patient treatment for obsessive-compulsive disorder. Psychiatry Research 291, pages 113303.
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Iris Sijercic, Kristen M. Whitfield, Stephanie E. Cassin & Martin M. Antony. (2020) A systematic review of cognitive-behavioral therapy for pharmacotherapy treatment-resistant obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders 26, pages 100532.
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Ali TalaeiFarhad Farid HosseiniZahra AghiliShahin AkhondzadehElham AsadpourNeema John MehramizFatemeh Forouzanfar. (2020) A comparative, single-blind, randomized study on quetiapine and aripiperazole augmentation in treatment of selective serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Canadian Journal of Physiology and Pharmacology 98:4, pages 236-242.
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Markian Pazuniak & Scott R. Pekrul. (2020) Obsessive–Compulsive Disorder in Autism Spectrum Disorder Across the Lifespan. Child and Adolescent Psychiatric Clinics of North America 29:2, pages 419-432.
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Sujita Kumar Kar, Suyash Dwivedi & Vivek Agarwal. (2019) Relevance of extended protocol and maintenance TMS in obsessive-compulsive disorder: A case report. Asian Journal of Psychiatry 42, pages 32-33.
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Dong-Dong Zhou, Xiao-Xin Zhou, Yao Li, Kai-Fu Zhang, Zhen Lv, Xiao-Rong Chen, Li-Yang Wan, Wo Wang, Gao-Mao Wang, Da-Qi Li, Ming Ai & Li Kuang. (2019) Augmentation agents to serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder: A network meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry 90, pages 277-287.
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Leonardo F. Fontenelle & Murat Yücel. 2018. A Transdiagnostic Approach to Obsessions, Compulsions and Related Phenomena. A Transdiagnostic Approach to Obsessions, Compulsions and Related Phenomena 1 13 .
Srinivas Balachander, Prabhath Gujjadi Kodancha, Shyam Sundar Arumugham, Jaisoorya T. Sekharan, Janardhanan C. Narayanaswamy & YC Janardhan Reddy. (2019) Effectiveness of Venlafaxine in Selective Serotonin Reuptake Inhibitor–Resistant Obsessive-Compulsive Disorder. Journal of Clinical Psychopharmacology 39:1, pages 82-85.
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Rachel Middleton, Michael G. Wheaton, Reilly Kayser & H. Blair Simpson. 2019. Treatment Resistance in Psychiatry. Treatment Resistance in Psychiatry 165 177 .
Michael H. Bloch. 2018. The Clinician's Guide to Cognitive-Behavioral Therapy for Childhood Obsessive-compulsive Disorder. The Clinician's Guide to Cognitive-Behavioral Therapy for Childhood Obsessive-compulsive Disorder 329 356 .
Tord Ivarsson, Gudmundur Skarphedinsson & Bernhard Weidle. 2018. The Clinician's Guide to Cognitive-Behavioral Therapy for Childhood Obsessive-compulsive Disorder. The Clinician's Guide to Cognitive-Behavioral Therapy for Childhood Obsessive-compulsive Disorder 155 183 .
Ulku Akyol Ardic, Eyup Sabri Ercan, Ayse Kutlu, Deniz Yuce, Melis Ipci & Sevim Berrin Inci. (2016) Successful Treatment Response with Aripiprazole Augmentation of SSRIs in Refractory Obsessive–Compulsive Disorder in Childhood. Child Psychiatry & Human Development 48:5, pages 699-704.
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Robert Hudak, Xenia Borue & Mehak Sharma. 2017. The Wiley Handbook of Obsessive Compulsive Disorders. The Wiley Handbook of Obsessive Compulsive Disorders 1039 1060 .
Bangalore G. Kalyani, Aditya Hegde, Shyam Sundar Arumugham, Janardhanan C. Narayanaswamy, Suresh Bada Math & Y.C. Janardhan Reddy. (2017) Is Ondansetron Augmentation Effective in Obsessive-Compulsive Disorder?. Journal of Clinical Psychopharmacology 37:3, pages 380-381.
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Isaac Zike, Tim Xu, Natalie Hong & Jeremy Veenstra-VanderWeele. (2017) Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology. Neuroscience 345, pages 256-273.
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Daniel Rutrick, Dan J. Stein, Ganesan Subramanian, Brian Smith, Maurizio Fava, Gregor Hasler, Jang-Ho Cha, Fabrizio Gasparini, Toni Donchev, Magdalena Ocwieja, Donald Johns & Baltazar Gomez-Mancilla. (2017) Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study. Advances in Therapy 34:2, pages 524-541.
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YC Janardhan Reddy, AShyam Sundar, JanardhananC Narayanaswamy & SureshBada Math. (2017) Clinical practice guidelines for Obsessive-Compulsive Disorder. Indian Journal of Psychiatry 59:5, pages 74.
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Aditya Hegde, Bangalore G. Kalyani, Shyam Sundar Arumugham, Janardhanan C. Narayanaswamy, Suresh Bada Math & Y.C. Janardhan Reddy. (2016) Effectiveness of Risperidone Augmentation in Obsessive-Compulsive Disorder. Journal of Clinical Psychopharmacology 36:4, pages 381-384.
Crossref
Joseph Bergman, Chanoch Miodownik, Paul P. Lerner, Einat Miodownik, Alexander Shulkin & Vladimir Lerner. (2016) Donepezil as Add-on Treatment for Resistant Obsessive-Compulsive Disorder: Retrospective Case Series. Clinical Neuropharmacology 39:4, pages 194-196.
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Hidehiro Umehara, Shusuke Numata, Atsushi Tajima, Akira Nishi, Masahito Nakataki, Issei Imoto, Satsuki Sumitani & Tetsuro Ohmori. (2016) Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder. PLOS ONE 11:6, pages e0157232.
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Antonio Bruno, Gianluca Pandolfo, Clemente Cedro, Giuseppa Gallo, Mariangela De Felice, Rocco A. Zoccali & Maria Rosaria A. Muscatello. (2016) Effect of Ziprasidone Augmentation of Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder. Clinical Neuropharmacology 39:1, pages 6-9.
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Tanya K. Murphy, S. Evelyn Stewart & Demian Obregon. 2016. The Medical Basis of Psychiatry. The Medical Basis of Psychiatry 169 193 .
Adam M. Reid, Joseph P.H. McNamara, Tanya K. Murphy, Andrew G. Guzick, Eric A. Storch, Gary R. Geffken & Regina Bussing. (2015) Side-effects of SSRIs disrupt multimodal treatment for pediatric OCD in a randomized-controlled trial. Journal of Psychiatric Research 71, pages 140-147.
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Gudmundur Skarphedinsson & Tord Ivarsson. (2015) Evidence-Based Treatments in Treatment-Naïve and Treatment-Resistant Pediatric Obsessive-Compulsive Disorder. Current Behavioral Neuroscience Reports 2:3, pages 127-136.
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Hidehiro Umehara, Shusuke Numata, Atsushi Tajima, Makoto Kinoshita, Shutaro Nakaaki, Issei Imoto, Satsuki Sumitani & Tetsuro Ohmori. (2015) No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population. Human Psychopharmacology: Clinical and Experimental 30:5, pages 372-376.
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Xenia Borue, Mehak Sharma & Robert Hudak. (2015) Biological treatments for obsessive-compulsive and related disorders. Journal of Obsessive-Compulsive and Related Disorders 6, pages 7-26.
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Phillip J. Seibell, Rebecca J. Hamblin & Eric Hollander. (2015) Obsessive-Compulsive Disorder: Overview and Standard Treatment Strategies. Psychiatric Annals 45:6, pages 297-302.
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Yu-Jie Chiou, Pao-Yen Lin & Yu Lee. (2015) Risperidone as Monotherapy for a Patient With Obsessive Compulsive Disorder Comorbid With Schizoaffective Disorder. Clinical Neuropharmacology 38:3, pages 114-116.
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Michael H. Bloch & Eric A. Storch. (2015) Assessment and Management of Treatment-Refractory Obsessive-Compulsive Disorder in Children. Journal of the American Academy of Child & Adolescent Psychiatry 54:4, pages 251-262.
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Kemal Utku YaziciIpek Percinel. (2014) The Role of Glutamatergic Dysfunction in Treatment-Resistant Obsessive-Compulsive Disorder: Treatment of an Adolescent Case with N -Acetylcysteine Augmentation . Journal of Child and Adolescent Psychopharmacology 24:9, pages 525-527.
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Catherine Kariuki-Nyuthe, Baltazar Gomez-Mancilla & Dan J. Stein. (2014) Obsessive compulsive disorder and the glutamatergic system. Current Opinion in Psychiatry 27:1, pages 32-37.
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