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Expert Review of Neurotherapeutics Volume 12, 2012 - Issue 7
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Theme: Scizophrenia - Review

Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery

Andra Mihali Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA
,
Shreya Subramani Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA
,
Genevieve Kaunitz Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA
,
Stephen Rayport Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Molecular Therapeutics, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 62, New York, NY 10032, USA. [email protected]
&
Inna Gaisler-Salomon Department of Psychology, University of Haifa, Psychobiology Labs, Rabin Building 5059, Haifa 31905, Israel. [email protected]; Department of Psychology, University of Haifa, Psychobiology Labs, Rabin Building 5059, Haifa 31905, Israel. [email protected]
Pages 785-799 | Published online: 09 Jan 2014

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Yujing Sun, Mingliang Wang, Hong Yu, Hong Su & Yuqiu Zhou. (2023) The relationship between self-esteem and mental disability in patients with schizophrenia: the mediating role of resilience and the moderating role of gender. Psychology, Health & Medicine 28:7, pages 1985-1996.
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Articles from other publishers (16)

Jiequan Wang, Yaru Liu, Yejun Gao, Jun Liang, Baoshi Wang, Quan Xia, Yawen Xie, Feng Shan & Qingrong Xia. (2023) Comprehensive bioinformatics analysis and molecular validation of lncRNAs-mediated ceRNAs network in schizophrenia. Life Sciences 312, pages 121205.
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Chia-Yuan Chang, Da-Zhong Luo, Ju-Chun Pei, Ming-Che Kuo, Yi-Chen Hsieh & Wen-Sung Lai. (2021) Not Just a Bystander: The Emerging Role of Astrocytes and Research Tools in Studying Cognitive Dysfunctions in Schizophrenia. International Journal of Molecular Sciences 22:10, pages 5343.
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Jonathan L. Hess, Daniel S. Tylee, Manuel Mattheisen, Anders D. Børglum, Thomas D. Als, Jakob Grove, Thomas Werge, Preben Bo Mortensen, Ole Mors, Merete Nordentoft, David M. Hougaard, Jonas Byberg-Grauholm, Marie Bækvad-Hansen, Tiffany A. Greenwood, Ming T. Tsuang, David Curtis, Stacy Steinberg, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Howard J. Edenberg, Peter Holmans, Stephen V. Faraone & Stephen J. Glatt. (2019) A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry 26:3, pages 800-815.
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Wei-Liang Wang, Yu-Qiu Zhou, Nan-Nan Chai, Guo-Hua Li & Dong-Wei Liu. (2020) Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia. BMC Psychiatry 20:1.
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Lauren Kosten, Golam M.I. Chowdhury, Susana Mingote, Steven Staelens, Douglas L. Rothman, Kevin L. Behar & Stephen Rayport. (2019) Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS. Neurochemistry International 129, pages 104508.
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Haotian Chen, Jianfeng Xu, Yue Mao, Lili Sun, Yujing Sun & Yuqiu Zhou. (2019) Positive Coping and Resilience as Mediators Between Negative Symptoms and Disability Among Patients With Schizophrenia. Frontiers in Psychiatry 10.
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Lauren Kosten, Steven Deleye, Sigrid Stroobants, Leonie Wyffels, Susana Mingote, Stephen Rayport & Steven Staelens. (2018) Molecular Imaging of mGluR5 Availability with [11C]ABP68 in Glutaminase Heterozygous Mice. Cellular and Molecular Neurobiology 39:2, pages 255-263.
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Susana Mingote, Nao Chuhma, Abigail Kalmbach, Gretchen M Thomsen, Yvonne Wang, Andra Mihali, Caroline Sferrazza, Ilana Zucker-Scharff, Anna-Claire Siena, Martha G Welch, José Lizardi-Ortiz, David Sulzer, Holly Moore, Inna Gaisler-Salomon & Stephen Rayport. (2017) Dopamine neuron dependent behaviors mediated by glutamate cotransmission. eLife 6.
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Kazunari Yoshida, Takefumi Suzuki, Yasushi Imasaka, Ken-ichiro Kubo, Yuya Mizuno, Juri Saruta, Keiichi Tsukinoki, Masaru Mimura & Hiroyuki Uchida. (2016) Resilience in schizophrenia: A comparative study between a remote island and an urban area in Japan. Schizophrenia Research 171:1-3, pages 92-96.
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Susana Mingote, Justine Masson, Celia Gellman, Gretchen M. Thomsen, Chyuan-Sheng Lin, Robert J. Merker, Inna Gaisler-Salomon, Yvonne Wang, Rachel Ernst, René Hen & Stephen Rayport. (2016) Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice. Frontiers in Systems Neuroscience 9.
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Laura MandelliElena ToscanoStefano PorcelliChiara FabbriAlessandro Serretti. (2016) Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors. Psychiatry Investigation 13:2, pages 247.
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Yavuz Ayhan, Ross McFarland & Mikhail V. Pletnikov. (2016) Animal models of gene–environment interaction in schizophrenia: A dimensional perspective. Progress in Neurobiology 136, pages 1-27.
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Yan Jouroukhin, Ross McFarland, Yavuz Ayhan & Mikhail V. Pletnikov. 2016. Modeling the Psychopathological Dimensions of Schizophrenia - From Molecules to Behavior. Modeling the Psychopathological Dimensions of Schizophrenia - From Molecules to Behavior 345 360 .
Sofya Abazyan & Mikhail V. Pletnikov. 2014. Behavioral Genetics of the Mouse. Behavioral Genetics of the Mouse 189 207 .
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Geetha Kannan, Akira Sawa & Mikhail V. Pletnikov. (2013) Mouse models of gene–environment interactions in schizophrenia. Neurobiology of Disease 57, pages 5-11.
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