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Expert Review of Neurotherapeutics Volume 12, 2012 - Issue 7
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Theme: Scizophrenia - Review

d-serine and schizophrenia: an update

Emerson A Nunes Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
,
Erin M MacKenzie Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Centre for Psychiatric Assessment and Therapeutics (CPAT), Alberta Hospital Edmonton, Edmonton, Alberta, T6G 2G3, Canada; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Centre for Psychiatric Assessment and Therapeutics (CPAT), Alberta Hospital Edmonton, Edmonton, Alberta, T6G 2G3, Canada
,
David Rossolatos Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
,
Jorge Perez-Parada Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
,
Glen B Baker Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Centre for Psychiatric Assessment and Therapeutics (CPAT), Alberta Hospital Edmonton, Edmonton, Alberta, T6G 2G3, Canada; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Centre for Psychiatric Assessment and Therapeutics (CPAT), Alberta Hospital Edmonton, Edmonton, Alberta, T6G 2G3, Canada
&
Serdar M Dursun Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Centre for Psychiatric Assessment and Therapeutics (CPAT), Alberta Hospital Edmonton, Edmonton, Alberta, T6G 2G3, Canada; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada. [email protected]
Pages 801-812 | Published online: 09 Jan 2014

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Mathias Zink & Christoph U Correll. (2015) Glutamatergic agents for schizophrenia: current evidence and perspectives. Expert Review of Clinical Pharmacology 8:3, pages 335-352.
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William Z Potter. (2015) Optimizing early Go/No Go decisions in CNS drug development. Expert Review of Clinical Pharmacology 8:2, pages 155-157.
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Pierre Chue & Justine K Lalonde. (2014) Addressing the unmet needs of patients with persistent negative symptoms of schizophrenia: emerging pharmacological treatment options. Neuropsychiatric Disease and Treatment 10, pages 777-789.
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Reji Thomas, Glen Baker, Serdar Dursun, Kathryn Todd, Kamaldeep Dhami, James Chue & Pierre Chue. (2014) Glycine Reuptake Inhibitors in the Treatment of Negative Symptoms of Schizophrenia. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 24:3, pages 195-200.
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Kamaldeep Dhami, Marnie MacKay, Joao Paulo Maia-de-Oliveira, Jaime Hallak, Kathryn Todd, Glen Baker & Serdar Dursun. (2013) Novel Targets for Development of Drugs for Treating Schizophrenia: Focus on Glycine, D-Serine and Nitric Oxide. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 23:2, pages 129-137.
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Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini & Stefano Bruno. (2023) Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization. Biomolecules 13:8, pages 1219.
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Kai-Yin Lo, Yi-Fang Tsai, Chun-Hua Hsu & Chia-Yin Lee. (2022) Functional Characterization and Structural Modeling of a Novel Glycine Oxidase from Variovorax paradoxus Iso1. Applied and Environmental Microbiology 88:23.
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Regina F. Nasyrova, Aiperi K. Khasanova, Kuanysh S. Altynbekov, Azat R. Asadullin, Ekaterina A. Markina, Arseny J. Gayduk, German A. Shipulin, Marina M. Petrova & Natalia A. Shnayder. (2022) The Role of D-Serine and D-Aspartate in the Pathogenesis and Therapy of Treatment-Resistant Schizophrenia. Nutrients 14:23, pages 5142.
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Tommaso Nuzzo, Masae Sekine, Daniela Punzo, Mattia Miroballo, Masumi Katane, Yasuaki Saitoh, Alberto Galbusera, Massimo Pasqualetti, Francesco Errico, Alessandro Gozzi, Jean-Pierre Mothet, Hiroshi Homma & Alessandro Usiello. (2020) Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1868:12, pages 140531.
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Afaf Mikou, Alexandre Cabayé, Anne Goupil, Hugues-Olivier Bertrand, Jean-Pierre Mothet & Francine C. Acher. (2020) Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism. Scientific Reports 10:1.
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Eisuke Hayakawa, Masahiro Ohgidani, Yoshinori Fujimura, Shigenobu Kanba, Daisuke Miura & Takahiro A. Kato. (2019) Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus. Schizophrenia Research 210, pages 326-328.
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Mary-Anne B. MacKay, Maryana Kravtsenyuk, Rejish Thomas, Nicholas D. Mitchell, Serdar M. Dursun & Glen B. Baker. (2019) D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?. Frontiers in Psychiatry 10.
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Ian R. Winship, Serdar M. Dursun, Glen B. Baker, Priscila A. Balista, Ludmyla Kandratavicius, Joao Paulo Maia-de-Oliveira, Jaime Hallak & John G. Howland. (2018) An Overview of Animal Models Related to Schizophrenia. The Canadian Journal of Psychiatry 64:1, pages 5-17.
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Melissa Quintero, Danijela Stanisic, Guilherme Cruz, João G. M. Pontes, Tássia Brena Barroso Carneiro Costa & Ljubica Tasic. 2019. Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders. Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders 271 293 .
Mary-Anne B. MacKay, John W. Paylor, James T. F. Wong, Ian R. Winship, Glen B. Baker & Serdar M. Dursun. (2018) Multidimensional Connectomics and Treatment-Resistant Schizophrenia: Linking Phenotypic Circuits to Targeted Therapeutics. Frontiers in Psychiatry 9.
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Ping Ping Qian, Shuai Wang, Kai Rui Feng & Yu Jie Ren. (2018) Molecular modeling studies of 1,2,4-triazine derivatives as novel h-DAAO inhibitors by 3D-QSAR, docking and dynamics simulations. RSC Advances 8:26, pages 14311-14327.
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Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko Yorita, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui & Akira Otaka. (2017) Elucidation of inhibitor-binding pockets of d -amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology . Organic & Biomolecular Chemistry 15:25, pages 5289-5297.
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Hui-Fei Zheng, Wen-Qiang Wang, Xin-Min Li, Gail Rauw & Glen B. Baker. (2016) Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature. Amino Acids 49:1, pages 57-65.
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Katsuya Sakimura, Kenji Nakao, Masato Yoshikawa, Motohisa Suzuki & Haruhide Kimura. (2016) A novel Na + -Independent alanine-serine-cysteine transporter 1 inhibitor inhibits both influx and efflux of D-Serine . Journal of Neuroscience Research 94:10, pages 888-895.
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Shouji Takahashi, Kozue Shimada, Shunsuke Nozawa, Masaru Goto, Katsumasa Abe & Yoshio Kera. (2015) Possible role of a histidine residue in the substrate specificity of yeast d-aspartate oxidase. Journal of Biochemistry, pages mvv108.
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Niyada Hin, Bridget Duvall, Dana Ferraris, Jesse Alt, Ajit G. Thomas, Rana Rais, Camilo Rojas, Ying Wu, Krystyna M. Wozniak, Barbara S. Slusher & Takashi Tsukamoto. (2015) 6-Hydroxy-1,2,4-triazine-3,5(2 H ,4 H )-dione Derivatives as Novel d -Amino Acid Oxidase Inhibitors . Journal of Medicinal Chemistry 58:18, pages 7258-7272.
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Mathias Zink, Susanne Englisch & Andrea Schmitt. (2014) Antipsychotic treatment modulates glutamate transport and NMDA receptor expression. European Archives of Psychiatry and Clinical Neuroscience 264:S1, pages 67-82.
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Bruce A. Semon. (2014) Dietary cyclic dipeptides, apoptosis and psychiatric disorders: A hypothesis. Medical Hypotheses 82:6, pages 740-743.
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Daniel C. Javitt. (2014) Current and Emergent Treatments for Symptoms and Neurocognitive Impairment in Schizophrenia. Current Treatment Options in Psychiatry 1:2, pages 107-120.
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Pierre S ChueGlen B Baker. (2013) Glycine reuptake inhibition: a promising therapeutic strategy in the treatment of schizophrenia?. Future Medicinal Chemistry 5:13, pages 1475-1477.
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